U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Juvenile type ovarian granulosa cell tumor

MedGen UID:
340891
Concept ID:
C1855515
Neoplastic Process
Synonym: Juvenile ovarian granulosa cell tumor
 
HPO: HP:0031919

Definition

Juvenile granulosa cell ovarian tumor (JGCOT) is a rare sex cord stromal tumor, occuring most frequently in premenarchal girls or young women. In contrast to adult granulosa cell tumor, JGCOT has a high mitotic index and more aggressive tumor growth. Microscopically it is seen as diffuse and regularly distributed neoplastic cells with a wide cytoplasm and pleomorphic hyperchromatic nucleus. Follicle formation, in various sizes and shapes, is important in JGCOT. Call-Exner bodies are infrequently seen in JGCOT in contrast to the adult type. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVJuvenile type ovarian granulosa cell tumor

Conditions with this feature

Tumor predisposition syndrome 2
MedGen UID:
1823959
Concept ID:
C5774186
Disease or Syndrome
Tumor predisposition syndrome-2 (TPDS2) is an autosomal recessive cancer predisposition syndrome characterized by the onset of various types of tumors or malignancies in young adulthood. The most common clinical manifestations include acute myeloid leukemia (AML), myelodysplastic syndrome, colorectal adenomatous polyposis and carcinoma, and uveal melanoma, although other tumors and malignancies have been reported (summary by Palles et al., 2022). For a discussion of genetic heterogeneity of TPDS, see TPDS1 (614327).

Professional guidelines

PubMed

Boussios S, Moschetta M, Zarkavelis G, Papadaki A, Kefas A, Tatsi K
Crit Rev Oncol Hematol 2017 Dec;120:43-51. Epub 2017 Oct 16 doi: 10.1016/j.critrevonc.2017.10.007. PMID: 29198337
Schultz KAP, Harris AK, Finch M, Dehner LP, Brown JB, Gershenson DM, Young RH, Field A, Yu W, Turner J, Cost NG, Schneider DT, Stewart DR, Frazier AL, Messinger Y, Hill DA
Gynecol Oncol 2017 Dec;147(3):521-527. Epub 2017 Oct 14 doi: 10.1016/j.ygyno.2017.09.034. PMID: 29037807Free PMC Article
Hayes-Jordan A, Lopez C, Green HL, Xiao LC, Huh W, Herzog CE
Pediatr Surg Int 2016 Jan;32(1):71-3. doi: 10.1007/s00383-015-3814-9. PMID: 26500075Free PMC Article

Recent clinical studies

Etiology

Hammer PM, Wang A, Beard C, Zdravkovic S, Tenney T, Liang B, Das I, Bremer R, Wang LC, McCluggage WG, Stewart CJR, Howitt BE
Mod Pathol 2023 Nov;36(11):100318. Epub 2023 Aug 25 doi: 10.1016/j.modpat.2023.100318. PMID: 37634867
Young RH
Hum Pathol 2020 Jan;95:169-206. Epub 2019 Oct 22 doi: 10.1016/j.humpath.2019.09.002. PMID: 31654691
Young RH
Pathology 2018 Jan;50(1):5-15. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.007. PMID: 29132723
Boussios S, Moschetta M, Zarkavelis G, Papadaki A, Kefas A, Tatsi K
Crit Rev Oncol Hematol 2017 Dec;120:43-51. Epub 2017 Oct 16 doi: 10.1016/j.critrevonc.2017.10.007. PMID: 29198337
Elbachiri M, Taleb A, Derrabi N, Bouchbika Z, Benchakroun N, Jouhadi H, Tawfiq N, Sahraoui S, Benider A
Pan Afr Med J 2017;26:198. Epub 2017 Apr 4 doi: 10.11604/pamj.2017.26.198.11523. PMID: 28674591Free PMC Article

Diagnosis

Young RH
Hum Pathol 2020 Jan;95:169-206. Epub 2019 Oct 22 doi: 10.1016/j.humpath.2019.09.002. PMID: 31654691
Lim D, Oliva E
Semin Diagn Pathol 2019 Jul;36(4):246-259. Epub 2019 Feb 1 doi: 10.1053/j.semdp.2019.01.003. PMID: 30772079
Goudie C, Witkowski L, Vairy S, McCluggage WG, Foulkes WD
J Med Genet 2018 Jan;55(1):1-10. Epub 2017 Nov 24 doi: 10.1136/jmedgenet-2017-104926. PMID: 29175835
Young RH
Pathology 2018 Jan;50(1):5-15. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.007. PMID: 29132723
Boussios S, Moschetta M, Zarkavelis G, Papadaki A, Kefas A, Tatsi K
Crit Rev Oncol Hematol 2017 Dec;120:43-51. Epub 2017 Oct 16 doi: 10.1016/j.critrevonc.2017.10.007. PMID: 29198337

Therapy

How JA, Jazaeri A, Westin SN, Sood AK, Ramondetta LM, Xu M, Abonofal A, Karp DD, Subbiah V, Stephen B, Rodon JA, Yang F, Naing A
Invest New Drugs 2021 Jun;39(3):829-835. Epub 2021 Jan 7 doi: 10.1007/s10637-020-01043-9. PMID: 33415580Free PMC Article
Elbachiri M, Taleb A, Derrabi N, Bouchbika Z, Benchakroun N, Jouhadi H, Tawfiq N, Sahraoui S, Benider A
Pan Afr Med J 2017;26:198. Epub 2017 Apr 4 doi: 10.11604/pamj.2017.26.198.11523. PMID: 28674591Free PMC Article
Hayes-Jordan A, Lopez C, Green HL, Xiao LC, Huh W, Herzog CE
Pediatr Surg Int 2016 Jan;32(1):71-3. doi: 10.1007/s00383-015-3814-9. PMID: 26500075Free PMC Article

Prognosis

Birgersson M, Indukuri R, Antonson P, Nalvarte I, Archer A, Williams C
Endocrinology 2023 Apr 17;164(6) doi: 10.1210/endocr/bqad063. PMID: 37075218Free PMC Article
Kilinc YB, Sari L, Toprak H, Gultekin MA, Karabulut UE, Sahin N
Curr Med Imaging 2021;17(6):790-797. doi: 10.2174/1573405616666201228153755. PMID: 33371855
Young RH
Hum Pathol 2020 Jan;95:169-206. Epub 2019 Oct 22 doi: 10.1016/j.humpath.2019.09.002. PMID: 31654691
Boussios S, Moschetta M, Zarkavelis G, Papadaki A, Kefas A, Tatsi K
Crit Rev Oncol Hematol 2017 Dec;120:43-51. Epub 2017 Oct 16 doi: 10.1016/j.critrevonc.2017.10.007. PMID: 29198337
Elbachiri M, Taleb A, Derrabi N, Bouchbika Z, Benchakroun N, Jouhadi H, Tawfiq N, Sahraoui S, Benider A
Pan Afr Med J 2017;26:198. Epub 2017 Apr 4 doi: 10.11604/pamj.2017.26.198.11523. PMID: 28674591Free PMC Article

Clinical prediction guides

Kilinc YB, Sari L, Toprak H, Gultekin MA, Karabulut UE, Sahin N
Curr Med Imaging 2021;17(6):790-797. doi: 10.2174/1573405616666201228153755. PMID: 33371855
Young RH
Hum Pathol 2020 Jan;95:169-206. Epub 2019 Oct 22 doi: 10.1016/j.humpath.2019.09.002. PMID: 31654691
Young RH
Arch Pathol Lab Med 2018 Dec;142(12):1459-1484. doi: 10.5858/arpa.2018-0291-RA. PMID: 30500284
Kondi-Pafiti A, Grapsa D, Kairi-Vassilatou E, Carvounis E, Hasiakos D, Kontogianni K, Fotiou S
Eur J Gynaecol Oncol 2010;31(1):94-8. PMID: 20349790
Leibl S, Bodo K, Gogg-Kammerer M, Hrzenjak A, Petru E, Winter R, Denk H, Moinfar F
Gynecol Oncol 2006 Apr;101(1):18-23. Epub 2005 Dec 5 doi: 10.1016/j.ygyno.2005.10.009. PMID: 16330088

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...