U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pancreatic islet cell adenoma

MedGen UID:
342066
Concept ID:
C1851697
Neoplastic Process
HPO: HP:0008261

Definition

The presence of an adenoma of the pancreas with origin in a pancreatic B cell. [from HPO]

Conditions with this feature

Multiple endocrine neoplasia, type 1
MedGen UID:
9957
Concept ID:
C0025267
Neoplastic Process
Multiple endocrine neoplasia type 1 (MEN1) includes varying combinations of more than 20 endocrine and non-endocrine tumors. Endocrine tumors become evident either by overproduction of hormones by the tumor or by growth of the tumor itself. Parathyroid tumors are the most common MEN1-associated endocrinopathy; onset in 90% of individuals is between ages 20 and 25 years with hypercalcemia evident by age 50 years; hypercalcemia causes lethargy, depression, confusion, anorexia, constipation, nausea, vomiting, diuresis, dehydration, hypercalciuria, kidney stones, increased bone resorption/fracture risk, hypertension, and shortened QT interval. Pituitary tumors include prolactinoma (the most common), which manifests as oligomenorrhea/amenorrhea and galactorrhea in females and sexual dysfunction in males. Well-differentiated endocrine tumors of the gastro-entero-pancreatic (GEP) tract can manifest as Zollinger-Ellison syndrome (gastrinoma); hypoglycemia (insulinoma); hyperglycemia, anorexia, glossitis, anemia, diarrhea, venous thrombosis, and skin rash (glucagonoma); and watery diarrhea, hypokalemia, and achlorhydria syndrome (vasoactive intestinal peptide [VIP]-secreting tumor). Carcinoid tumors are non-hormone-secreting and can manifest as a large mass after age 50 years. Adrenocortical tumors can be associated with primary hypercortisolism or hyperaldosteronism. Non-endocrine tumors include facial angiofibromas, collagenomas, lipomas, meningiomas, ependymomas, and leiomyomas.

Professional guidelines

PubMed

Parbhu SK, Adler DG
Hosp Pract (1995) 2016 Aug;44(3):109-19. Epub 2016 Jul 18 doi: 10.1080/21548331.2016.1210474. PMID: 27404266
Tasyurek HM, Altunbas HA, Balci MK, Sanlioglu S
Diabetes Metab Res Rev 2014 Jul;30(5):354-71. doi: 10.1002/dmrr.2501. PMID: 24989141
Virgolini I, Traub-Weidinger T, Decristoforo C
Best Pract Res Clin Endocrinol Metab 2005 Jun;19(2):213-27. doi: 10.1016/j.beem.2004.09.001. PMID: 15763696

Recent clinical studies

Diagnosis

Guardado-Mendoza R, Dick EJ Jr, Jimenez-Ceja LM, Davalli A, Chavez AO, Folli F, Hubbard GB
J Med Primatol 2009 Dec;38(6):383-9. Epub 2009 Sep 28 doi: 10.1111/j.1600-0684.2009.00384.x. PMID: 19793179Free PMC Article
Hussain K, Cosgrove KE, Shepherd RM, Chapman JC, Swift SM, Smith VV, Kassem SA, Glaser B, Lindley KJ, Aynsley-Green A, Dunne MJ
Endocr Relat Cancer 2002 Dec;9(4):221-6. doi: 10.1677/erc.0.0090221. PMID: 12542400
Coffey GL, O'Sullivan DJ, Burke WJ
Clin Exp Neurol 1979;16:149-65. PMID: 233077
Said SI
Clin Endocrinol (Oxf) 1976;5 Suppl:201S-204S. doi: 10.1111/j.1365-2265.1976.tb03828.x. PMID: 29733
RICHARDSON JC, HILL FM
Neurology 1957 Nov;7(11):793-7. doi: 10.1212/wnl.7.11.793. PMID: 13483838

Therapy

Hussain K, Cosgrove KE, Shepherd RM, Chapman JC, Swift SM, Smith VV, Kassem SA, Glaser B, Lindley KJ, Aynsley-Green A, Dunne MJ
Endocr Relat Cancer 2002 Dec;9(4):221-6. doi: 10.1677/erc.0.0090221. PMID: 12542400

Prognosis

Guardado-Mendoza R, Dick EJ Jr, Jimenez-Ceja LM, Davalli A, Chavez AO, Folli F, Hubbard GB
J Med Primatol 2009 Dec;38(6):383-9. Epub 2009 Sep 28 doi: 10.1111/j.1600-0684.2009.00384.x. PMID: 19793179Free PMC Article

Clinical prediction guides

Hussain K, Cosgrove KE, Shepherd RM, Chapman JC, Swift SM, Smith VV, Kassem SA, Glaser B, Lindley KJ, Aynsley-Green A, Dunne MJ
Endocr Relat Cancer 2002 Dec;9(4):221-6. doi: 10.1677/erc.0.0090221. PMID: 12542400
BARRIS RW
Calif Med 1953 Mar;78(3):224-6. PMID: 13032800Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...