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Neuropathy, painful

MedGen UID:: 342490
•Concept ID:: C1850383
•: Disease or Syndrome

Synonym:	Neuropathy, Painful

Monarch Initiative:	MONDO:0009752
OMIM®:	256870

Clinical features

From HPO

Lower limb muscle weakness

MedGen UID:: 324478
•Concept ID:: C1836296
•: Finding

Weakness of the muscles of the legs.

See: Feature record | Search on this feature

Peripheral neuropathy

MedGen UID:: 18386
•Concept ID:: C0031117
•: Disease or Syndrome

Peripheral neuropathy is a general term for any disorder of the peripheral nervous system. The main clinical features used to classify peripheral neuropathy are distribution, type (mainly demyelinating versus mainly axonal), duration, and course.

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Skeletal muscle atrophy

MedGen UID:: 892680
•Concept ID:: C0541794
•: Pathologic Function

The presence of skeletal muscular atrophy (which is also known as amyotrophy).

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Fever

MedGen UID:: 5169
•Concept ID:: C0015967
•: Sign or Symptom

Body temperature elevated above the normal range.

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Abnormality of limbs
- Lower limb muscle weakness
Abnormality of metabolism/homeostasis
- Fever
Abnormality of the musculoskeletal system
- Skeletal muscle atrophy
Abnormality of the nervous system
- Peripheral neuropathy

Professional guidelines

PubMed

The Treatment of Painful Diabetic Neuropathy.

Sloan G, Alam U, Selvarajah D, Tesfaye S
Curr Diabetes Rev 2022;18(5):e070721194556. doi: 10.2174/1573399817666210707112413. PMID: 34238163

EAN guidelines on central neurostimulation therapy in chronic pain conditions.

Cruccu G, Garcia-Larrea L, Hansson P, Keindl M, Lefaucheur JP, Paulus W, Taylor R, Tronnier V, Truini A, Attal N
Eur J Neurol 2016 Oct;23(10):1489-99. Epub 2016 Aug 11 doi: 10.1111/ene.13103. PMID: 27511815

Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments.

Tesfaye S, Boulton AJ, Dyck PJ, Freeman R, Horowitz M, Kempler P, Lauria G, Malik RA, Spallone V, Vinik A, Bernardi L, Valensi P; Toronto Diabetic Neuropathy Expert Group
Diabetes Care 2010 Oct;33(10):2285-93. doi: 10.2337/dc10-1303. PMID: 20876709 Free PMC Article

See all (45)

Recent clinical studies

Etiology

HIV-associated painful neuropathy: where are we?

Pires KL, Baranda MSM, Brum TMA, Pessôa B, Pupe CCB, Nascimento OJMD
Arq Neuropsiquiatr 2022 Jun;80(6):607-615. doi: 10.1590/0004-282X-ANP-2021-0079. PMID: 35946704 Free PMC Article

The Treatment of Painful Diabetic Neuropathy.

Sloan G, Alam U, Selvarajah D, Tesfaye S
Curr Diabetes Rev 2022;18(5):e070721194556. doi: 10.2174/1573399817666210707112413. PMID: 34238163

The neurobiology of acetyl-L-carnitine.

Traina G
Front Biosci (Landmark Ed) 2016 Jun 1;21(7):1314-29. doi: 10.2741/4459. PMID: 27100509

The role of sodium channels in painful diabetic and idiopathic neuropathy.

Lauria G, Ziegler D, Malik R, Merkies IS, Waxman SG, Faber CG; PROPANE Study group
Curr Diab Rep 2014 Oct;14(10):538. doi: 10.1007/s11892-014-0538-5. PMID: 25142720

Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments.

See all (49)

Diagnosis

The Treatment of Painful Diabetic Neuropathy.

Sloan G, Alam U, Selvarajah D, Tesfaye S
Curr Diabetes Rev 2022;18(5):e070721194556. doi: 10.2174/1573399817666210707112413. PMID: 34238163

Diabetic amyotrophy: a painful radiculoplexus neuropathy.

Llewelyn D, Llewelyn JG
Pract Neurol 2019 Apr;19(2):164-167. Epub 2018 Dec 8 doi: 10.1136/practneurol-2018-002105. PMID: 30530723

Clinical and preclinical perspectives on Chemotherapy-Induced Peripheral Neuropathy (CIPN): a narrative review.

Flatters SJL, Dougherty PM, Colvin LA
Br J Anaesth 2017 Oct 1;119(4):737-749. doi: 10.1093/bja/aex229. PMID: 29121279

Diabetic neuropathy.

Vinik AI, Nevoret ML, Casellini C, Parson H
Endocrinol Metab Clin North Am 2013 Dec;42(4):747-87. doi: 10.1016/j.ecl.2013.06.001. PMID: 24286949

Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments.

See all (58)

Therapy

TRPA1 modulation by Sigma-1 receptor prevents oxaliplatin-induced painful peripheral neuropathy.

Marcotti A, Fernández-Trillo J, González A, Vizcaíno-Escoto M, Ros-Arlanzón P, Romero L, Vela JM, Gomis A, Viana F, de la Peña E
Brain 2023 Feb 13;146(2):475-491. doi: 10.1093/brain/awac273. PMID: 35871491 Free PMC Article

The Treatment of Painful Diabetic Neuropathy.

Sloan G, Alam U, Selvarajah D, Tesfaye S
Curr Diabetes Rev 2022;18(5):e070721194556. doi: 10.2174/1573399817666210707112413. PMID: 34238163

Diabetic amyotrophy: a painful radiculoplexus neuropathy.

Llewelyn D, Llewelyn JG
Pract Neurol 2019 Apr;19(2):164-167. Epub 2018 Dec 8 doi: 10.1136/practneurol-2018-002105. PMID: 30530723

Clinical and preclinical perspectives on Chemotherapy-Induced Peripheral Neuropathy (CIPN): a narrative review.

Flatters SJL, Dougherty PM, Colvin LA
Br J Anaesth 2017 Oct 1;119(4):737-749. doi: 10.1093/bja/aex229. PMID: 29121279

Painful neuropathy: Mechanisms.

Lee-Kubli CA, Calcutt NA
Handb Clin Neurol 2014;126:533-57. doi: 10.1016/B978-0-444-53480-4.00034-5. PMID: 25410243

See all (53)

Prognosis

Oxaliplatin Neuropathy: Predictive Values of Skin Biopsy, QST and Nerve Conduction.

Krøigård T, Svendsen TK, Wirenfeldt M, Schrøder HD, Qvortrup C, Pfeiffer P, Gaist D, Sindrup SH
J Neuromuscul Dis 2021;8(4):679-688. doi: 10.3233/JND-210630. PMID: 33814460

Varied phenotypes and management of immune checkpoint inhibitor-associated neuropathies.

Dubey D, David WS, Amato AA, Reynolds KL, Clement NF, Chute DF, Cohen JV, Lawrence DP, Mooradian MJ, Sullivan RJ, Guidon AC
Neurology 2019 Sep 10;93(11):e1093-e1103. Epub 2019 Aug 12 doi: 10.1212/WNL.0000000000008091. PMID: 31405908

Augmented Corneal Nerve Fiber Branching in Painful Compared With Painless Diabetic Neuropathy.

Püttgen S, Bönhof GJ, Strom A, Müssig K, Szendroedi J, Roden M, Ziegler D
J Clin Endocrinol Metab 2019 Dec 1;104(12):6220-6228. doi: 10.1210/jc.2019-01072. PMID: 31390004

Sodium channel Nav1.8: Emerging links to human disease.

Han C, Huang J, Waxman SG
Neurology 2016 Feb 2;86(5):473-83. Epub 2016 Jan 8 doi: 10.1212/WNL.0000000000002333. PMID: 26747884

The role of sodium channels in painful diabetic and idiopathic neuropathy.

Lauria G, Ziegler D, Malik R, Merkies IS, Waxman SG, Faber CG; PROPANE Study group
Curr Diab Rep 2014 Oct;14(10):538. doi: 10.1007/s11892-014-0538-5. PMID: 25142720

See all (15)

Clinical prediction guides

TENS Improves Cisplatin-Induced Neuropathy in Lung Cancer Patients.

Tomanovic Vujadinovic S, Ilic N, Selakovic I, Nedeljkovic U, Krstic N, Mujovic N, Dubljanin Raspopovic E, Jovanovic D
Medicina (Kaunas) 2022 Oct 6;58(10) doi: 10.3390/medicina58101405. PMID: 36295566 Free PMC Article

HIV-associated painful neuropathy: where are we?

Pires KL, Baranda MSM, Brum TMA, Pessôa B, Pupe CCB, Nascimento OJMD
Arq Neuropsiquiatr 2022 Jun;80(6):607-615. doi: 10.1590/0004-282X-ANP-2021-0079. PMID: 35946704 Free PMC Article

Oxaliplatin Neuropathy: Predictive Values of Skin Biopsy, QST and Nerve Conduction.

Krøigård T, Svendsen TK, Wirenfeldt M, Schrøder HD, Qvortrup C, Pfeiffer P, Gaist D, Sindrup SH
J Neuromuscul Dis 2021;8(4):679-688. doi: 10.3233/JND-210630. PMID: 33814460

Meta-analysis comparing placebo responses in clinical trials of painful HIV-associated sensory neuropathy and diabetic polyneuropathy.

Kemp HI, Eliahoo J, Vase L, Nguyen S, Ben Abdallah A, Rice ASC, Finnerup NB, Haroutounian S
Scand J Pain 2020 Jul 28;20(3):439-449. doi: 10.1515/sjpain-2019-0152. PMID: 32106088

Gluten neuropathy: prevalence of neuropathic pain and the role of gluten-free diet.

Zis P, Sarrigiannis PG, Rao DG, Hadjivassiliou M
J Neurol 2018 Oct;265(10):2231-2236. Epub 2018 Jul 21 doi: 10.1007/s00415-018-8978-5. PMID: 30032386

See all (33)

Recent systematic reviews

Diagnostic controversies in recurrent painful ophthalmoplegic neuropathy: single case report with a systematic review.

Falsaperla R, Presti S, Lo Bianco M, Catanzaro S, Marino S, Ruggieri M
Ital J Pediatr 2022 Jun 3;48(1):82. doi: 10.1186/s13052-022-01274-x. PMID: 35659705 Free PMC Article

Systemic inflammatory biomarkers in painful diabetic neuropathy.

Baka P, Escolano-Lozano F, Birklein F
J Diabetes Complications 2021 Oct;35(10):108017. Epub 2021 Aug 8 doi: 10.1016/j.jdiacomp.2021.108017. PMID: 34389235

Meta-analysis comparing placebo responses in clinical trials of painful HIV-associated sensory neuropathy and diabetic polyneuropathy.

Kemp HI, Eliahoo J, Vase L, Nguyen S, Ben Abdallah A, Rice ASC, Finnerup NB, Haroutounian S
Scand J Pain 2020 Jul 28;20(3):439-449. doi: 10.1515/sjpain-2019-0152. PMID: 32106088

Pharmacotherapy for diabetic peripheral neuropathy pain and quality of life: A systematic review.

Waldfogel JM, Nesbit SA, Dy SM, Sharma R, Zhang A, Wilson LM, Bennett WL, Yeh HC, Chelladurai Y, Feldman D, Robinson KA
Neurology 2017 May 16;88(20):1958-1967. Epub 2017 Mar 24 doi: 10.1212/WNL.0000000000003882. PMID: 28341643

Inhaled Cannabis for Chronic Neuropathic Pain: A Meta-analysis of Individual Patient Data.

Andreae MH, Carter GM, Shaparin N, Suslov K, Ellis RJ, Ware MA, Abrams DI, Prasad H, Wilsey B, Indyk D, Johnson M, Sacks HS
J Pain 2015 Dec;16(12):1221-1232. Epub 2015 Sep 9 doi: 10.1016/j.jpain.2015.07.009. PMID: 26362106 Free PMC Article

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Neuropathy, painful

Clinical features

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Molecular resources

Consumer resources

Reviews

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