From HPO
Abnormal foot morphology- MedGen UID:
- 1762829
- •Concept ID:
- C5399834
- •
- Anatomical Abnormality
An abnormality of the skeleton of foot.
Clonus- MedGen UID:
- 40341
- •Concept ID:
- C0009024
- •
- Sign or Symptom
A series of rhythmic and involuntary muscle contractions (at a frequency of about 5 to 7 Hz) that occur in response to an abruptly applied and sustained stretch.
Babinski sign- MedGen UID:
- 19708
- •Concept ID:
- C0034935
- •
- Finding
Upturning of the big toe (and sometimes fanning of the other toes) in response to stimulation of the sole of the foot. If the Babinski sign is present it can indicate damage to the corticospinal tract.
Spastic paraplegia- MedGen UID:
- 20882
- •Concept ID:
- C0037772
- •
- Disease or Syndrome
Spasticity and weakness of the leg and hip muscles.
Hyperreflexia- MedGen UID:
- 57738
- •Concept ID:
- C0151889
- •
- Finding
Hyperreflexia is the presence of hyperactive stretch reflexes of the muscles.
Spastic gait- MedGen UID:
- 115907
- •Concept ID:
- C0231687
- •
- Finding
Spasticity is manifested by increased stretch reflex which is intensified with movement velocity. This results in excessive and inappropriate muscle activation which can contribute to muscle hypertonia. Spastic gait is characterized by manifestations such as muscle hypertonia, stiff knee, and circumduction of the leg.
Peripheral axonal neuropathy- MedGen UID:
- 266071
- •Concept ID:
- C1263857
- •
- Disease or Syndrome
An abnormality characterized by disruption of the normal functioning of peripheral axons.
Lower limb spasticity- MedGen UID:
- 220865
- •Concept ID:
- C1271100
- •
- Finding
Spasticity (velocity-dependent increase in tonic stretch reflexes with increased muscle tone and hyperexcitable tendon reflexes) in the muscles of the lower limbs, hips, and pelvis
Atrophy of the spinal cord- MedGen UID:
- 235592
- •Concept ID:
- C1389102
- •
- Disease or Syndrome
Distal sensory impairment of all modalities- MedGen UID:
- 322937
- •Concept ID:
- C1836527
- •
- Finding
Reduced ability to sense pain, temperature, touch, vibration stimuli in the distal regions of the extremities.
Distal sensory impairment- MedGen UID:
- 335722
- •Concept ID:
- C1847584
- •
- Finding
An abnormal reduction in sensation in the distal portions of the extremities.
Decreased motor nerve conduction velocity- MedGen UID:
- 388130
- •Concept ID:
- C1858729
- •
- Finding
A type of decreased nerve conduction velocity that affects the motor neuron.
Decreased amplitude of sensory action potentials- MedGen UID:
- 870496
- •Concept ID:
- C4024943
- •
- Finding
A reduction in the amplitude of sensory nerve action potential. This feature is measured by nerve conduction studies.
Distal amyotrophy- MedGen UID:
- 338530
- •Concept ID:
- C1848736
- •
- Disease or Syndrome
Muscular atrophy affecting muscles in the distal portions of the extremities.
Foot osteomyelitis- MedGen UID:
- 1370023
- •Concept ID:
- C4049342
- •
- Disease or Syndrome
An infection of bone of the foot.
Hypotriglyceridemia- MedGen UID:
- 488913
- •Concept ID:
- C0542037
- •
- Disease or Syndrome
An decrease in the level of triglycerides in the blood.
Decreased circulating apolipoprotein B concentration- MedGen UID:
- 1814242
- •Concept ID:
- C5676671
- •
- Finding
Reduced circulating level of apolipoprotein B, which is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100.
Acral ulceration- MedGen UID:
- 1648438
- •Concept ID:
- C4732740
- •
- Finding
A type of digital ulcer that manifests as an open sore on the surface of the skin at the tip of a finger or toe.
- Abnormality of limbs
- Abnormality of metabolism/homeostasis
- Abnormality of the immune system
- Abnormality of the integument
- Abnormality of the musculoskeletal system
- Abnormality of the nervous system