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Cold-induced sweating syndrome 2(CISS2)

MedGen UID:
342816
Concept ID:
C1853198
Disease or Syndrome
Synonyms: CISS2; CLCF1-Related Cold-Induced Sweating Syndrome including Crisponi Syndrome; CRISPONI/COLD-INDUCED SWEATING SYNDROME 2
 
Gene (location): CLCF1 (11q13.2)
 
Monarch Initiative: MONDO:0012467
OMIM®: 610313

Disease characteristics

Cold-induced sweating syndrome (CISS) and its infantile presentation, Crisponi syndrome(CS) is characterized by dysmorphic features (distinctive facies, lower facial weakness, flexion deformity at the elbows, camptodactyly with fisted hands, misshapen feet, and overriding toes); intermittent contracture of facial and oropharyngeal muscles when crying or being handled with puckering of lips and drooling of foamy saliva often associated with laryngospasm and respiratory distress; excessive startling and opisthotonus-like posturing with unexpected tactile or auditory stimuli; poor suck reflex and severely impaired swallowing; and a scaly erythematous rash. During the first decade of life, children with CISS/CS develop profuse sweating of the face, arms, and chest with ambient temperatures below 18º to 22º C, and with other stimuli including nervousness or ingestion of sweets. Affected individuals sweat very little in hot environments and may feel overheated. Progressive thoracolumbar kyphoscoliosis occurs, requiring intervention in the second decade. [from GeneReviews]
Authors:
Angelika F Hahn  |  Per Morten Knappskog   view full author information

Additional descriptions

From OMIM
Crisponi/cold-induced sweating syndrome is an autosomal recessive disorder characterized in the neonatal period by orofacial weakness with impaired sucking and swallowing resulting in poor feeding necessitating medical intervention. Affected infants show a tendency to startle, with contractions of the facial muscles in response to tactile stimuli or during crying, trismus, abundant salivation, and opisthotonus. During the first year, most infants have spiking fevers. These features, referred to as 'Crisponi syndrome' in infancy, can result in early death without advanced care. After the first 2 years, the abnormal muscle contractions and fevers abate, and most patients show normal psychomotor development. From childhood onward, the most disabling symptoms stem from impaired thermoregulation and disabling abnormal sweating, which can be treated with clonidine. Patients have hyperhidrosis, mainly of the upper body, in response to cold temperatures, and sweat very little with heat. Other features include characteristic facial anomalies, such as round face, chubby cheeks, micrognathia, high-arched palate, low-set ears, and depressed nasal bridge, dental decay, camptodactyly, and progressive kyphoscoliosis (summary by Hahn et al., 2010). Buers et al. (2020) provided a detailed review of Crisponi/CISS, including clinical features and evolution of the disease, noting that signs and symptoms in infancy can be severe and result in early death; clinical and genetic diagnoses. The authors also discussed pathogenesis, differential diagnosis, and recommended management and treatment. Buers et al. (2020) provided a detailed review of Crisponi/CISS, including clinical features, diagnosis, and evolution of the disease, differential diagnosis, pathogenesis, and recommended management and treatment. For a discussion of genetic heterogeneity of Crisponi/cold-induced sweating syndrome, see CISS1 (272430).  http://www.omim.org/entry/610313
From MedlinePlus Genetics
Cold-induced sweating syndrome is characterized by problems with regulating body temperature and other abnormalities affecting many parts of the body. In infancy, the features of this condition are often known as Crisponi syndrome. Researchers originally thought that cold-induced sweating syndrome and Crisponi syndrome were separate disorders, but it is now widely believed that they represent the same condition at different times during life.

Infants with Crisponi syndrome have unusual facial features, including a flat nasal bridge, upturned nostrils, a long space between the nose and upper lip (philtrum), a high arched roof of the mouth (palate), a small chin (micrognathia), and low-set ears. The muscles in the lower part of the face are weak, leading to severe feeding difficulties, excessive drooling, and breathing problems. Other physical abnormalities associated with Crisponi syndrome include a scaly skin rash, an inability to fully extend the elbows, overlapping fingers and tightly fisted hands, and malformations of the feet and toes. Affected infants startle easily and often tense their facial muscles into a grimace-like expression. By six months of age, infants with Crisponi syndrome develop unexplained high fevers that increase the risk of seizures and sudden death.

Many of the health problems associated with Crisponi syndrome improve with time, and affected individuals who survive the newborn period go on to develop other features of cold-induced sweating syndrome in early childhood. Within the first decade of life, affected individuals begin having episodes of profuse sweating (hyperhidrosis) and shivering involving the face, torso, and arms. The excessive sweating is usually triggered by exposure to temperatures below about 65 or 70 degrees Fahrenheit, but it can also be triggered by nervousness or eating sugary foods. Paradoxically, affected individuals tend not to sweat in warmer conditions, instead becoming flushed and overheated in hot environments.

Adolescents with cold-induced sweating syndrome typically develop abnormal side-to-side and front-to-back curvature of the spine (scoliosis and kyphosis, often called kyphoscoliosis when they occur together). Although infants may develop life-threatening fevers, affected individuals who survive infancy have a normal life expectancy.  https://medlineplus.gov/genetics/condition/cold-induced-sweating-syndrome

Clinical features

From HPO
Cubitus valgus
MedGen UID:
490152
Concept ID:
C0158465
Acquired Abnormality
Abnormal positioning in which the elbows are turned out.
Limited elbow extension
MedGen UID:
401158
Concept ID:
C1867103
Finding
Limited ability to straighten the arm at the elbow joint.
Clinodactyly
MedGen UID:
1644094
Concept ID:
C4551485
Congenital Abnormality
An angulation of a digit at an interphalangeal joint in the plane of the palm (finger) or sole (toe).
2-3 toe syndactyly
MedGen UID:
1645640
Concept ID:
C4551570
Congenital Abnormality
Syndactyly with fusion of toes two and three.
Feeding difficulties
MedGen UID:
65429
Concept ID:
C0232466
Finding
Impaired ability to eat related to problems gathering food and getting ready to suck, chew, or swallow it.
Protruding ear
MedGen UID:
343309
Concept ID:
C1855285
Finding
Angle formed by the plane of the ear and the mastoid bone greater than the 97th centile for age (objective); or, outer edge of the helix more than 2 cm from the mastoid at the point of maximum distance (objective).
Sensorimotor neuropathy
MedGen UID:
207266
Concept ID:
C1112256
Disease or Syndrome
Weakness of facial musculature
MedGen UID:
98103
Concept ID:
C0427055
Disease or Syndrome
Reduced strength of one or more muscles innervated by the facial nerve (the seventh cranial nerve).
Thoracolumbar scoliosis
MedGen UID:
196671
Concept ID:
C0749379
Anatomical Abnormality
Lumbar hyperlordosis
MedGen UID:
263149
Concept ID:
C1184923
Finding
An abnormal accentuation of the inward curvature of the spine in the lumbar region.
High palate
MedGen UID:
66814
Concept ID:
C0240635
Congenital Abnormality
Height of the palate more than 2 SD above the mean (objective) or palatal height at the level of the first permanent molar more than twice the height of the teeth (subjective).
Cold-induced sweating
MedGen UID:
1370740
Concept ID:
C4476686
Finding
Sweating provoked by cold temperature rather than by heat.

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  

Professional guidelines

PubMed

Buers I, Persico I, Schöning L, Nitschke Y, Di Rocco M, Loi A, Sahi PK, Utine GE, Bayraktar-Tanyeri B, Zampino G, Crisponi G, Rutsch F, Crisponi L
Clin Genet 2020 Jan;97(1):209-221. Epub 2019 Sep 16 doi: 10.1111/cge.13639. PMID: 31497877

Recent clinical studies

Etiology

Testani E, Della Marca G, La Torraca I, Vollono C, Crisponi G, Zampino G, Valeriani M
Muscle Nerve 2016 Jun;54(1):100-3. Epub 2016 Feb 26 doi: 10.1002/mus.24976. PMID: 26565815
Hahn AF, Waaler PE, Kvistad PH, Bamforth JS, Miles JH, McLeod JG, Knappskog PM, Boman H
J Neurol Sci 2010 Jun 15;293(1-2):68-75. Epub 2010 Apr 18 doi: 10.1016/j.jns.2010.02.028. PMID: 20400119
Herholz J, Crisponi L, Mallick BN, Rutsch F
Dev Med Child Neurol 2010 May;52(5):494-7. Epub 2010 Feb 24 doi: 10.1111/j.1469-8749.2010.03630.x. PMID: 20187881
Crisponi L, Crisponi G, Meloni A, Toliat MR, Nurnberg G, Usala G, Uda M, Masala M, Hohne W, Becker C, Marongiu M, Chiappe F, Kleta R, Rauch A, Wollnik B, Strasser F, Reese T, Jakobs C, Kurlemann G, Cao A, Nurnberg P, Rutsch F
Am J Hum Genet 2007 May;80(5):971-81. Epub 2007 Mar 30 doi: 10.1086/516843. PMID: 17436252Free PMC Article

Diagnosis

Kolkiran A, Ürel-Demir G, Şimşek-Kiper PÖ, Utine GE
Eur J Med Genet 2021 Jul;64(7):104229. Epub 2021 Apr 25 doi: 10.1016/j.ejmg.2021.104229. PMID: 33910095
Buers I, Persico I, Schöning L, Nitschke Y, Di Rocco M, Loi A, Sahi PK, Utine GE, Bayraktar-Tanyeri B, Zampino G, Crisponi G, Rutsch F, Crisponi L
Clin Genet 2020 Jan;97(1):209-221. Epub 2019 Sep 16 doi: 10.1111/cge.13639. PMID: 31497877
Angius A, Uva P, Oppo M, Buers I, Persico I, Onano S, Cuccuru G, Van Allen MI, Hulait G, Aubertin G, Muntoni F, Fry AE, Annerén G, Stattin EL, Palomares-Bralo M, Santos-Simarro F, Cucca F, Crisponi G, Rutsch F, Crisponi L
Clin Genet 2019 May;95(5):607-614. Epub 2019 Mar 28 doi: 10.1111/cge.13532. PMID: 30859550
Bayraktar-Tanyeri B, Hepokur M, Bayraktar S, Persico I, Crisponi L
Clin Dysmorphol 2017 Apr;26(2):66-72. doi: 10.1097/MCD.0000000000000163. PMID: 27977424
Alhashem AM, Majeed-Saidan MA, Ammari AN, Alrakaf MS, Nojoom M, Maddirevula S, Faqeih E, Alkuraya FS, Garne E, Kurdi AM
Am J Med Genet A 2016 May;170A(5):1236-41. Epub 2016 Jan 24 doi: 10.1002/ajmg.a.37569. PMID: 26804344

Therapy

El-Dokla AM, Ferdous J, Ali ST, Alam K
J Clin Neuromuscul Dis 2017 Dec;19(2):76-79. doi: 10.1097/CND.0000000000000184. PMID: 29189552
Hahn AF, Waaler PE, Kvistad PH, Bamforth JS, Miles JH, McLeod JG, Knappskog PM, Boman H
J Neurol Sci 2010 Jun 15;293(1-2):68-75. Epub 2010 Apr 18 doi: 10.1016/j.jns.2010.02.028. PMID: 20400119
Herholz J, Crisponi L, Mallick BN, Rutsch F
Dev Med Child Neurol 2010 May;52(5):494-7. Epub 2010 Feb 24 doi: 10.1111/j.1469-8749.2010.03630.x. PMID: 20187881
Yamazaki M, Kosho T, Kawachi S, Mikoshiba M, Takahashi J, Sano R, Oka K, Yoshida K, Watanabe T, Kato H, Komatsu M, Kawamura R, Wakui K, Knappskog PM, Boman H, Fukushima Y
Am J Med Genet A 2010 Mar;152A(3):764-9. doi: 10.1002/ajmg.a.33315. PMID: 20186812
Crisponi L, Crisponi G, Meloni A, Toliat MR, Nurnberg G, Usala G, Uda M, Masala M, Hohne W, Becker C, Marongiu M, Chiappe F, Kleta R, Rauch A, Wollnik B, Strasser F, Reese T, Jakobs C, Kurlemann G, Cao A, Nurnberg P, Rutsch F
Am J Hum Genet 2007 May;80(5):971-81. Epub 2007 Mar 30 doi: 10.1086/516843. PMID: 17436252Free PMC Article

Prognosis

Piras R, Chiappe F, Torraca IL, Buers I, Usala G, Angius A, Akin MA, Basel-Vanagaite L, Benedicenti F, Chiodin E, El Assy O, Feingold-Zadok M, Guibert J, Kamien B, Kasapkara CS, Kiliç E, Boduroğlu K, Kurtoglu S, Manzur AY, Onal EE, Paderi E, Roche CH, Tümer L, Unal S, Utine GE, Zanda G, Zankl A, Zampino G, Crisponi G, Crisponi L, Rutsch F
Hum Mutat 2014 Apr;35(4):424-33. Epub 2014 Mar 6 doi: 10.1002/humu.22522. PMID: 24488861
Herholz J, Meloni A, Marongiu M, Chiappe F, Deiana M, Herrero CR, Zampino G, Hamamy H, Zalloum Y, Waaler PE, Crisponi G, Crisponi L, Rutsch F
Eur J Hum Genet 2011 May;19(5):525-33. Epub 2011 Feb 16 doi: 10.1038/ejhg.2010.253. PMID: 21326283Free PMC Article
Herholz J, Crisponi L, Mallick BN, Rutsch F
Dev Med Child Neurol 2010 May;52(5):494-7. Epub 2010 Feb 24 doi: 10.1111/j.1469-8749.2010.03630.x. PMID: 20187881
Dagoneau N, Bellais S, Blanchet P, Sarda P, Al-Gazali LI, Di Rocco M, Huber C, Djouadi F, Le Goff C, Munnich A, Cormier-Daire V
Am J Hum Genet 2007 May;80(5):966-70. Epub 2007 Mar 13 doi: 10.1086/513608. PMID: 17436251Free PMC Article
Nannenberg EA, Bijlmer R, Van Geel BM, Hennekam RC
Am J Med Genet A 2005 Feb 15;133A(1):90-2. doi: 10.1002/ajmg.a.30536. PMID: 15637710

Clinical prediction guides

A R, Chandran S, Ghatak AR, Thomas N, Danda S
Indian J Pediatr 2022 Nov;89(11):1148-1150. Epub 2022 Aug 19 doi: 10.1007/s12098-022-04263-4. PMID: 35984556
Yilmaz Gulec E, Turgut GT, Gezdirici A, Karaman V, Ozturk FN, Avci S, Kalayci T, Senturk L, Ayaz A, Kayserili H, Uyguner ZO, Altunoğlu U
Clin Genet 2022 Sep;102(3):201-217. Epub 2022 Jul 12 doi: 10.1111/cge.14177. PMID: 35699517
Hahn AF, Waaler PE, Kvistad PH, Bamforth JS, Miles JH, McLeod JG, Knappskog PM, Boman H
J Neurol Sci 2010 Jun 15;293(1-2):68-75. Epub 2010 Apr 18 doi: 10.1016/j.jns.2010.02.028. PMID: 20400119
Yamazaki M, Kosho T, Kawachi S, Mikoshiba M, Takahashi J, Sano R, Oka K, Yoshida K, Watanabe T, Kato H, Komatsu M, Kawamura R, Wakui K, Knappskog PM, Boman H, Fukushima Y
Am J Med Genet A 2010 Mar;152A(3):764-9. doi: 10.1002/ajmg.a.33315. PMID: 20186812
Dagoneau N, Bellais S, Blanchet P, Sarda P, Al-Gazali LI, Di Rocco M, Huber C, Djouadi F, Le Goff C, Munnich A, Cormier-Daire V
Am J Hum Genet 2007 May;80(5):966-70. Epub 2007 Mar 13 doi: 10.1086/513608. PMID: 17436251Free PMC Article

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