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Multicentric ossification of proximal humeral epiphyses

MedGen UID:
Concept ID:
HPO: HP:0004997

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMulticentric ossification of proximal humeral epiphyses

Conditions with this feature

Dyggve-Melchior-Clausen syndrome
MedGen UID:
Concept ID:
Disease or Syndrome
Dyggve-Melchior-Clausen disease (DMC) is an autosomal recessive disorder characterized by progressive spondyloepimetaphyseal dysplasia and impaired intellectual development. Short-trunk dwarfism and microcephaly are present, and specific radiologic appearances most likely reflect abnormalities of the growth plates, including platyspondyly with notched end plates, metaphyseal irregularities, laterally displaced capital femoral epiphyses, and small iliac wings with lacy iliac crests (summary by El Ghouzzi et al., 2003).

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