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Episodic hypertension

MedGen UID:
347389
Concept ID:
C1857175
Finding
Synonym: Hypertension, episodic
 
HPO: HP:0000875

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEpisodic hypertension

Conditions with this feature

Pheochromocytoma
MedGen UID:
18419
Concept ID:
C0031511
Neoplastic Process
Hereditary paraganglioma-pheochromocytoma (PGL/PCC) syndromes are characterized by paragangliomas (tumors that arise from neuroendocrine tissues distributed along the paravertebral axis from the base of the skull to the pelvis) and pheochromocytomas (paragangliomas that are confined to the adrenal medulla). Sympathetic paragangliomas cause catecholamine excess; parasympathetic paragangliomas are most often nonsecretory. Extra-adrenal parasympathetic paragangliomas are located predominantly in the skull base and neck (referred to as head and neck PGL [HNPGL]) and sometimes in the upper mediastinum; approximately 95% of such tumors are nonsecretory. In contrast, sympathetic extra-adrenal paragangliomas are generally confined to the lower mediastinum, abdomen, and pelvis, and are typically secretory. Pheochromocytomas, which arise from the adrenal medulla, typically lead to catecholamine excess. Symptoms of PGL/PCC result from either mass effects or catecholamine hypersecretion (e.g., sustained or paroxysmal elevations in blood pressure, headache, episodic profuse sweating, forceful palpitations, pallor, and apprehension or anxiety). The risk for developing metastatic disease is greater for extra-adrenal sympathetic paragangliomas than for pheochromocytomas.
Pheochromocytoma-islet cell tumor syndrome
MedGen UID:
401431
Concept ID:
C1868392
Neoplastic Process
Central hypoventilation syndrome, congenital, 3
MedGen UID:
1794174
Concept ID:
C5561964
Disease or Syndrome
Congenital central hypoventilation syndrome-3 (CCHS3) is an autosomal recessive disorder characterized by slow and shallow breathing due to a deficiency in autonomic control of respiration. Affected individuals present in the neonatal period with respiratory insufficiency and absence of the hypercapnic reflex that stimulates breathing. Patients also have gastrointestinal problems manifest as feeding difficulties and diarrhea or constipation. Other features may include poor heat tolerance and paroxysmal hypertension (Hernandez-Miranda et al., 2018). For a discussion of genetic heterogeneity of CCHS, see CCHS1 (209880).

Professional guidelines

PubMed

Joynt KE, Moslehi JJ, Baughman KL
Cardiol Rev 2009 Jul-Aug;17(4):159-64. doi: 10.1097/CRD.0b013e3181a6de40. PMID: 19525677
White WB
Blood Press Monit 2002 Feb;7(1):27-31. doi: 10.1097/00126097-200202000-00005. PMID: 12040239
Pescini A, Simoni A
Biomed Pharmacother 1991;45(8):327-32. doi: 10.1016/0753-3322(91)90061-w. PMID: 1773020

Recent clinical studies

Etiology

Kuo MJM, Nazari MA, Jha A, Pacak K
Front Endocrinol (Lausanne) 2022;13:936178. Epub 2022 Jul 12 doi: 10.3389/fendo.2022.936178. PMID: 35903274Free PMC Article
Kanbay M, Turkmen K, Ecder T, Covic A
Int Urol Nephrol 2012 Feb;44(1):173-82. Epub 2011 Jul 6 doi: 10.1007/s11255-011-0027-6. PMID: 21732053
Rothwell PM
Lancet 2010 Mar 13;375(9718):938-48. doi: 10.1016/S0140-6736(10)60309-1. PMID: 20226991
Rothwell PM, Howard SC, Dolan E, O'Brien E, Dobson JE, Dahlöf B, Sever PS, Poulter NR
Lancet 2010 Mar 13;375(9718):895-905. doi: 10.1016/S0140-6736(10)60308-X. PMID: 20226988
Pescini A, Simoni A
Biomed Pharmacother 1991;45(8):327-32. doi: 10.1016/0753-3322(91)90061-w. PMID: 1773020

Diagnosis

Kuo MJM, Nazari MA, Jha A, Pacak K
Front Endocrinol (Lausanne) 2022;13:936178. Epub 2022 Jul 12 doi: 10.3389/fendo.2022.936178. PMID: 35903274Free PMC Article
Garcha AS, Cohen DL
Adv Chronic Kidney Dis 2015 May;22(3):218-23. doi: 10.1053/j.ackd.2014.11.002. PMID: 25908471
Kanbay M, Turkmen K, Ecder T, Covic A
Int Urol Nephrol 2012 Feb;44(1):173-82. Epub 2011 Jul 6 doi: 10.1007/s11255-011-0027-6. PMID: 21732053
Rothwell PM
Lancet 2010 Mar 13;375(9718):938-48. doi: 10.1016/S0140-6736(10)60309-1. PMID: 20226991
Rothwell PM, Howard SC, Dolan E, O'Brien E, Dobson JE, Dahlöf B, Sever PS, Poulter NR
Lancet 2010 Mar 13;375(9718):895-905. doi: 10.1016/S0140-6736(10)60308-X. PMID: 20226988

Therapy

Siddiqui M, Dominiczak AF, Touyz RM, Carey RM, Basile J, Heslin MJ, Winokur T, Calhoun DA, Oparil S, Dudenbostel T
Hypertension 2020 Sep;76(3):614-621. Epub 2020 Jul 20 doi: 10.1161/HYPERTENSIONAHA.120.15243. PMID: 32683905Free PMC Article
Garcha AS, Cohen DL
Adv Chronic Kidney Dis 2015 May;22(3):218-23. doi: 10.1053/j.ackd.2014.11.002. PMID: 25908471
Rothwell PM
Lancet 2010 Mar 13;375(9718):938-48. doi: 10.1016/S0140-6736(10)60309-1. PMID: 20226991
Rothwell PM, Howard SC, Dolan E, O'Brien E, Dobson JE, Dahlöf B, Sever PS, Poulter NR
Lancet 2010 Mar 13;375(9718):895-905. doi: 10.1016/S0140-6736(10)60308-X. PMID: 20226988
Diamond AL, Callison RC, Shokri J, Cruz-Flores S, Kinsella LJ
Neurocrit Care 2005;2(3):288-91. doi: 10.1385/NCC:2:3:288. PMID: 16159077

Prognosis

Kanbay M, Turkmen K, Ecder T, Covic A
Int Urol Nephrol 2012 Feb;44(1):173-82. Epub 2011 Jul 6 doi: 10.1007/s11255-011-0027-6. PMID: 21732053
Rothwell PM
Lancet 2010 Mar 13;375(9718):938-48. doi: 10.1016/S0140-6736(10)60309-1. PMID: 20226991
Rothwell PM, Howard SC, Dolan E, O'Brien E, Dobson JE, Dahlöf B, Sever PS, Poulter NR
Lancet 2010 Mar 13;375(9718):895-905. doi: 10.1016/S0140-6736(10)60308-X. PMID: 20226988
Rizos DP, Ziegler MG
Clin Exp Hypertens 2005 Aug;27(6):491-6. doi: 10.1081/CEH-200067675. PMID: 16081341
Pescini A, Simoni A
Biomed Pharmacother 1991;45(8):327-32. doi: 10.1016/0753-3322(91)90061-w. PMID: 1773020

Clinical prediction guides

Kuo MJM, Nazari MA, Jha A, Pacak K
Front Endocrinol (Lausanne) 2022;13:936178. Epub 2022 Jul 12 doi: 10.3389/fendo.2022.936178. PMID: 35903274Free PMC Article
Kanbay M, Turkmen K, Ecder T, Covic A
Int Urol Nephrol 2012 Feb;44(1):173-82. Epub 2011 Jul 6 doi: 10.1007/s11255-011-0027-6. PMID: 21732053
Rothwell PM
Lancet 2010 Mar 13;375(9718):938-48. doi: 10.1016/S0140-6736(10)60309-1. PMID: 20226991
Rothwell PM, Howard SC, Dolan E, O'Brien E, Dobson JE, Dahlöf B, Sever PS, Poulter NR
Lancet 2010 Mar 13;375(9718):895-905. doi: 10.1016/S0140-6736(10)60308-X. PMID: 20226988
Pescini A, Simoni A
Biomed Pharmacother 1991;45(8):327-32. doi: 10.1016/0753-3322(91)90061-w. PMID: 1773020

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