U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cardiac septal defects with coarctation of the aorta

MedGen UID:
347855
•Concept ID:
C1859331
•
Disease or Syndrome
Synonym: Cardiac Septal Defects with Coarctation of the Aorta
 
Monarch Initiative: MONDO:0008912
OMIM®: 212090

Clinical features

From HPO
Coarctation of aorta
MedGen UID:
1617
•Concept ID:
C0003492
•
Congenital Abnormality
Coarctation of the aorta is a narrowing or constriction of a segment of the aorta.
See: Feature record | Search on this feature
Atrial septal defect, ostium secundum type
MedGen UID:
91034
•Concept ID:
C0344724
•
Congenital Abnormality
A kind of atrial septum defect arising from an enlarged foramen ovale, inadequate growth of the septum secundum, or excessive absorption of the septum primum.
See: Feature record | Search on this feature
Perimembranous ventricular septal defect
MedGen UID:
87490
•Concept ID:
C0344925
•
Congenital Abnormality
A ventricular septal defect that is confluent with and involves the membranous septum and is bordered by an atrioventricular valve, not including the type 3 VSDs.
See: Feature record | Search on this feature

Professional guidelines

PubMed

Prenatal detection of aortic coarctation in a well-organized screening setting: Are we there yet?
Zwanenburg F, Ten Harkel ADJ, Snoep MC, Bet BB, Linskens IH, Knobbe I, Pajkrt E, Blom NA, Clur SB, Haak MC
Prenat Diagn 2023 May;43(5):620-628. Epub 2023 Jan 5 doi: 10.1002/pd.6291. PMID: 36549919
Prenatal diagnosis of hypoplastic aortic arch without intracardiac malformations: The nevada experience.
Evans WN, Acherman RJ, Ciccolo ML, Lehoux J, Rothman A, Galindo A, Restrepo H
J Card Surg 2022 Nov;37(11):3705-3710. Epub 2022 Sep 1 doi: 10.1111/jocs.16834. PMID: 36047366
Management of women with epilepsy: from preconception to post-partum.
Laganà AS, Triolo O, D'Amico V, Cartella SM, Sofo V, Salmeri FM, Vrtačnik Bokal E, Spina E
Arch Gynecol Obstet 2016 Mar;293(3):493-503. Epub 2015 Nov 30 doi: 10.1007/s00404-015-3968-7. PMID: 26626184

Recent clinical studies

Etiology

Major heart defects: the diagnostic evaluations of first-year-olds.
Pavlicek J, Klaskova E, Kapralova S, Palatova AM, Piegzova A, Spacek R, Gruszka T
BMC Pediatr 2021 Nov 30;21(1):528. doi: 10.1186/s12887-021-02997-2. PMID: 34847867Free PMC Article
Risk Factors for Coarctation of the Aorta on Prenatal Ultrasound: A Systematic Review and Meta-Analysis.
Familiari A, Morlando M, Khalil A, Sonesson SE, Scala C, Rizzo G, Del Sordo G, Vassallo C, Elena Flacco M, Manzoli L, Lanzone A, Scambia G, Acharya G, D'Antonio F
Circulation 2017 Feb 21;135(8):772-785. Epub 2016 Dec 29 doi: 10.1161/CIRCULATIONAHA.116.024068. PMID: 28034902
Aortopulmonary window.
Barnes ME, Mitchell ME, Tweddell JS
Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2011;14(1):67-74. doi: 10.1053/j.pcsu.2011.01.017. PMID: 21444051
Pediatric cardiac interventions.
Hijazi ZM, Awad SM
JACC Cardiovasc Interv 2008 Dec;1(6):603-11. doi: 10.1016/j.jcin.2008.07.007. PMID: 19463373
Fetal echocardiography.
Srinivasan S
Indian J Pediatr 2000 Mar;67(3 Suppl):S20-5. PMID: 11129916

Diagnosis

Prenatal diagnosis of hypoplastic aortic arch without intracardiac malformations: The nevada experience.
Evans WN, Acherman RJ, Ciccolo ML, Lehoux J, Rothman A, Galindo A, Restrepo H
J Card Surg 2022 Nov;37(11):3705-3710. Epub 2022 Sep 1 doi: 10.1111/jocs.16834. PMID: 36047366
Risk Factors for Coarctation of the Aorta on Prenatal Ultrasound: A Systematic Review and Meta-Analysis.
Familiari A, Morlando M, Khalil A, Sonesson SE, Scala C, Rizzo G, Del Sordo G, Vassallo C, Elena Flacco M, Manzoli L, Lanzone A, Scambia G, Acharya G, D'Antonio F
Circulation 2017 Feb 21;135(8):772-785. Epub 2016 Dec 29 doi: 10.1161/CIRCULATIONAHA.116.024068. PMID: 28034902
Aortopulmonary window.
Barnes ME, Mitchell ME, Tweddell JS
Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2011;14(1):67-74. doi: 10.1053/j.pcsu.2011.01.017. PMID: 21444051
Pediatric cardiac interventions.
Hijazi ZM, Awad SM
JACC Cardiovasc Interv 2008 Dec;1(6):603-11. doi: 10.1016/j.jcin.2008.07.007. PMID: 19463373
Fetal echocardiography.
Srinivasan S
Indian J Pediatr 2000 Mar;67(3 Suppl):S20-5. PMID: 11129916

Therapy

Single-stage off-pump repair of coarctation of the aorta and ventricular septal defects in children.
Kulyabin YY, Voitov AV, Nichay NR, Soynov IA, Zubritskiy AV, Bogachev-Prokophiev AV
Interact Cardiovasc Thorac Surg 2022 Jul 9;35(2) doi: 10.1093/icvts/ivac186. PMID: 35758623Free PMC Article
Risk Factors for Coarctation of the Aorta on Prenatal Ultrasound: A Systematic Review and Meta-Analysis.
Familiari A, Morlando M, Khalil A, Sonesson SE, Scala C, Rizzo G, Del Sordo G, Vassallo C, Elena Flacco M, Manzoli L, Lanzone A, Scambia G, Acharya G, D'Antonio F
Circulation 2017 Feb 21;135(8):772-785. Epub 2016 Dec 29 doi: 10.1161/CIRCULATIONAHA.116.024068. PMID: 28034902
Management of women with epilepsy: from preconception to post-partum.
Laganà AS, Triolo O, D'Amico V, Cartella SM, Sofo V, Salmeri FM, Vrtačnik Bokal E, Spina E
Arch Gynecol Obstet 2016 Mar;293(3):493-503. Epub 2015 Nov 30 doi: 10.1007/s00404-015-3968-7. PMID: 26626184
Pediatric cardiac interventions.
Hijazi ZM, Awad SM
JACC Cardiovasc Interv 2008 Dec;1(6):603-11. doi: 10.1016/j.jcin.2008.07.007. PMID: 19463373
Interventional catheterization.
Nakanishi T
Curr Opin Cardiol 2000 Jul;15(4):211-5. doi: 10.1097/00001573-200007000-00002. PMID: 11139083

Prognosis

Risk Factors for Coarctation of the Aorta on Prenatal Ultrasound: A Systematic Review and Meta-Analysis.
Familiari A, Morlando M, Khalil A, Sonesson SE, Scala C, Rizzo G, Del Sordo G, Vassallo C, Elena Flacco M, Manzoli L, Lanzone A, Scambia G, Acharya G, D'Antonio F
Circulation 2017 Feb 21;135(8):772-785. Epub 2016 Dec 29 doi: 10.1161/CIRCULATIONAHA.116.024068. PMID: 28034902
The role of cardiovascular magnetic resonance in adults with congenital heart disease.
Kilner PJ
Prog Cardiovasc Dis 2011 Nov-Dec;54(3):295-304. doi: 10.1016/j.pcad.2011.07.006. PMID: 22014496Free PMC Article
Aortopulmonary window.
Barnes ME, Mitchell ME, Tweddell JS
Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2011;14(1):67-74. doi: 10.1053/j.pcsu.2011.01.017. PMID: 21444051
Fetal echocardiography.
Srinivasan S
Indian J Pediatr 2000 Mar;67(3 Suppl):S20-5. PMID: 11129916
Hypoplastic left heart syndrome.
Simpson JM
Ultrasound Obstet Gynecol 2000 Apr;15(4):271-8. doi: 10.1046/j.1469-0705.2000.00086.x. PMID: 10895443

Clinical prediction guides

Maternal age and the prevalence of congenital heart defects in Europe, 1995-2015: A register-based study.
Mamasoula C, Bigirumurame T, Chadwick T, Addor MC, Cavero-Carbonell C, Dias CM, Echevarría-González-de-Garibay LJ, Gatt M, Khoshnood B, Klungsoyr K, Randall K, Stoianova S, Haeusler M, Nelen V, Neville AJ, Perthus I, Pierini A, Bertaut-Nativel B, Rissmann A, Rouget F, Schaub B, Tucker D, Wellesley D, Zymak-Zakutnia N, Barisic I, de Walle HEK, Lanzoni M, Sayers G, Mullaney C, Pennington L, Rankin J
Birth Defects Res 2023 Apr 1;115(6):583-594. Epub 2023 Feb 3 doi: 10.1002/bdr2.2152. PMID: 36734416
Geographical and Socioeconomic Factors Influence the Birth Prevalence of Congenital Heart Disease: A Population-based Cross-sectional Study in Eastern China.
Pan F, Li J, Lou H, Li J, Jin Y, Wu T, Pan L, An J, Xu J, Cheng W, Tao L, Lei Y, Huang C, Yin F, Chen J, Zhu J, Shu Q, Xu W
Curr Probl Cardiol 2022 Nov;47(11):101341. Epub 2022 Jul 31 doi: 10.1016/j.cpcardiol.2022.101341. PMID: 35921873
The Impact of Technology on the Diagnosis of Congenital Malformations.
Straub L, Huybrechts KF, Bateman BT, Mogun H, Gray KJ, Holmes LB, Hernandez-Diaz S
Am J Epidemiol 2019 Nov 1;188(11):1892-1901. doi: 10.1093/aje/kwz153. PMID: 31241162Free PMC Article
Risk Factors for Coarctation of the Aorta on Prenatal Ultrasound: A Systematic Review and Meta-Analysis.
Familiari A, Morlando M, Khalil A, Sonesson SE, Scala C, Rizzo G, Del Sordo G, Vassallo C, Elena Flacco M, Manzoli L, Lanzone A, Scambia G, Acharya G, D'Antonio F
Circulation 2017 Feb 21;135(8):772-785. Epub 2016 Dec 29 doi: 10.1161/CIRCULATIONAHA.116.024068. PMID: 28034902
The role of cardiovascular magnetic resonance in adults with congenital heart disease.
Kilner PJ
Prog Cardiovasc Dis 2011 Nov-Dec;54(3):295-304. doi: 10.1016/j.pcad.2011.07.006. PMID: 22014496Free PMC Article

Recent systematic reviews

Neonatal management of aortic coarctation with ventricular septal defect: a systematic review and meta-analysis.
Kasdi R, Bounader K, Lemdani M
J Cardiovasc Surg (Torino) 2020 Aug;61(4):478-488. Epub 2020 Apr 29 doi: 10.23736/S0021-9509.20.11075-9. PMID: 32352247
Risk Factors for Coarctation of the Aorta on Prenatal Ultrasound: A Systematic Review and Meta-Analysis.
Familiari A, Morlando M, Khalil A, Sonesson SE, Scala C, Rizzo G, Del Sordo G, Vassallo C, Elena Flacco M, Manzoli L, Lanzone A, Scambia G, Acharya G, D'Antonio F
Circulation 2017 Feb 21;135(8):772-785. Epub 2016 Dec 29 doi: 10.1161/CIRCULATIONAHA.116.024068. PMID: 28034902
Ambient air pollution and risk of congenital anomalies: a systematic review and meta-analysis.
Vrijheid M, Martinez D, Manzanares S, Dadvand P, Schembari A, Rankin J, Nieuwenhuijsen M
Environ Health Perspect 2011 May;119(5):598-606. Epub 2010 Dec 3 doi: 10.1289/ehp.1002946. PMID: 21131253Free PMC Article
Unicuspid aortic valve in children: a systematic review spanning four decades.
Mookadam F, Thota VR, Lopez AM, Emani UR, Tajik AJ
J Heart Valve Dis 2010 Nov;19(6):678-83. PMID: 21214089
Long-term prognosis of congenital heart defects: a systematic review.
Verheugt CL, Uiterwaal CS, Grobbee DE, Mulder BJ
Int J Cardiol 2008 Dec 17;131(1):25-32. Epub 2008 Aug 6 doi: 10.1016/j.ijcard.2008.06.023. PMID: 18687485

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • OMIM
      Related records in OMIM
    • PubMed (OMIM)
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...