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Precocious puberty in males

MedGen UID:
Concept ID:
Synonyms: Early onset of puberty in males; Male precocious puberty
HPO: HP:0008185


The onset of puberty before the age of 9 years in boys. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Precocious puberty in males

Conditions with this feature

Deficiency of steroid 11-beta-monooxygenase
MedGen UID:
Concept ID:
Disease or Syndrome
Congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency is an autosomal recessive disorder of corticosteroid biosynthesis resulting in androgen excess, virilization, and hypertension. The defect causes decreased synthesis of cortisol and corticosterone in the zona fasciculata of the adrenal gland, resulting in accumulation of the precursors 11-deoxycortisol and 11-deoxycorticosterone; the latter is a potent salt-retaining mineralocorticoid that leads to arterial hypertension (White et al., 1991). CAH due to 11-beta-hydroxylase deficiency accounts for approximately 5 to 8% of all CAH cases; approximately 90% of cases are caused by 21-hydroxylase deficiency (201910) (White et al., 1991).
Gonadotropin-independent familial sexual precocity
MedGen UID:
Concept ID:
Disease or Syndrome
Familial male precocious puberty is a gonadotropin-independent disorder that is inherited in an autosomal dominant, male-limited pattern. Affected males generally exhibit signs of puberty by age 4 years (Shenker et al., 1993).

Professional guidelines


Cheuiche AV, da Silveira LG, de Paula LCP, Lucena IRS, Silveiro SP
Eur J Pediatr 2021 Oct;180(10):3073-3087. Epub 2021 Mar 21 doi: 10.1007/s00431-021-04022-1. PMID: 33745030
Aguirre RS, Eugster EA
Best Pract Res Clin Endocrinol Metab 2018 Aug;32(4):343-354. Epub 2018 May 26 doi: 10.1016/j.beem.2018.05.008. PMID: 30086862
Latronico AC, Brito VN, Carel JC
Lancet Diabetes Endocrinol 2016 Mar;4(3):265-274. Epub 2016 Feb 4 doi: 10.1016/S2213-8587(15)00380-0. PMID: 26852255

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