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Accelerated bone age after puberty

MedGen UID:
348195
Concept ID:
C1860825
Finding
HPO: HP:0002805

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAccelerated bone age after puberty

Conditions with this feature

Trichorhinophalangeal dysplasia type I
MedGen UID:
140929
Concept ID:
C0432233
Disease or Syndrome
Trichorhinophalangeal syndrome (TRPS) comprises TRPS I (caused by a heterozygous pathogenic variant in TRPS1) and TRPS II (caused by contiguous gene deletion of TRPS1, RAD21, and EXT1). Both types of TRPS are characterized by distinctive facial features; ectodermal features (fine, sparse, depigmented, and slow growing hair; dystrophic nails; and small breasts); and skeletal findings (short stature; short feet; brachydactyly with ulnar or radial deviation of the fingers; and early, marked hip dysplasia). TRPS II is characterized by multiple osteochondromas (typically first observed clinically on the scapulae and around the elbows and knees between ages 1 month and 6 years) and an increased risk of mild-to-moderate intellectual disability.
Trichorhinophalangeal syndrome, type III
MedGen UID:
349899
Concept ID:
C1860823
Disease or Syndrome
Trichorhinophalangeal syndrome (TRPS) is characterized by craniofacial and skeletal abnormalities. Craniofacial features include sparse, slowly growing scalp hair, laterally sparse eyebrows, a bulbous tip of the nose, protruding ears, long flat philtrum, and thin upper vermillion border. The most typical radiographic findings in TRPS are cone-shaped epiphyses, predominantly at the middle phalanges. Hip malformations such as coxa plana, coxa magna, or coxa vara are present in over 70% of patients. In older patients, the hip abnormalities resemble degenerative arthrosis. TRPS3 differs from TRPS1 by the presence of severe brachydactyly, due to short metacarpals, and severe short stature (summary by Ludecke et al., 2001).

Professional guidelines

PubMed

Heger S, Sippell WG, Partsch CJ
Endocr Dev 2005;8:94-125. doi: 10.1159/000084097. PMID: 15722620
Antoniazzi F, Zamboni G
Paediatr Drugs 2004;6(4):211-31. doi: 10.2165/00148581-200406040-00002. PMID: 15339200
Hecker TM, Aris RM
Drugs 2004;64(2):133-47. doi: 10.2165/00003495-200464020-00002. PMID: 14717616

Recent clinical studies

Etiology

Huang S, Su Z, Su H, Jiao Y, Su Q, Yao Y, Zhou L, Zheng X, Zhang X
Sci Rep 2022 Sep 7;12(1):15166. doi: 10.1038/s41598-022-19470-4. PMID: 36071136Free PMC Article
Wang Y, Ge J, Ma J, Qiao L, Li T
Medicine (Baltimore) 2020 Aug 21;99(34):e21635. doi: 10.1097/MD.0000000000021635. PMID: 32846772Free PMC Article
Lazar L, Pertzelan A, Weintrob N, Phillip M, Kauli R
J Clin Endocrinol Metab 2001 Sep;86(9):4127-32. doi: 10.1210/jcem.86.9.7852. PMID: 11549638
Garibaldi LR, Aceto T Jr, Weber C
Acta Endocrinol (Copenh) 1993 Apr;128(4):345-50. doi: 10.1530/acta.0.1280345. PMID: 8498153
Zachmann M, Ferrandez A, Mürset G, Gnehm HE, Prader A
J Pediatr 1976 Jan;88(1):116-23. doi: 10.1016/s0022-3476(76)80742-1. PMID: 173825

Diagnosis

Xu D, Zhou X, Wang J, Cao X, Liu T
BMC Pediatr 2022 Jul 28;22(1):453. doi: 10.1186/s12887-022-03481-1. PMID: 35902824Free PMC Article
Wang Y, Ge J, Ma J, Qiao L, Li T
Medicine (Baltimore) 2020 Aug 21;99(34):e21635. doi: 10.1097/MD.0000000000021635. PMID: 32846772Free PMC Article
Coutant R, Donzeau A, Decrequy A, Louvigné M, Bouhours-Nouet N
Ann Endocrinol (Paris) 2017 Jun;78(2):98-103. Epub 2017 May 5 doi: 10.1016/j.ando.2017.04.006. PMID: 28483364
Heger S, Sippell WG, Partsch CJ
Endocr Dev 2005;8:94-125. doi: 10.1159/000084097. PMID: 15722620
Antoniazzi F, Zamboni G
Paediatr Drugs 2004;6(4):211-31. doi: 10.2165/00148581-200406040-00002. PMID: 15339200

Therapy

Prezioso G, Petraroli M, Bergonzani M, Davino G, Labate M, Ormitti F, Anghinoni M, Sesenna E, Esposito S
Front Endocrinol (Lausanne) 2021;12:685888. Epub 2021 May 26 doi: 10.3389/fendo.2021.685888. PMID: 34122353Free PMC Article
Antoniazzi F, Zamboni G
Paediatr Drugs 2004;6(4):211-31. doi: 10.2165/00148581-200406040-00002. PMID: 15339200
Hecker TM, Aris RM
Drugs 2004;64(2):133-47. doi: 10.2165/00003495-200464020-00002. PMID: 14717616
Lazar L, Pertzelan A, Weintrob N, Phillip M, Kauli R
J Clin Endocrinol Metab 2001 Sep;86(9):4127-32. doi: 10.1210/jcem.86.9.7852. PMID: 11549638
Hokken-Koelega AC, Saenger P, Cappa M, Greggio N; International Workshop on Management of Puberty for Optimum Auxological Results
J Pediatr Endocrinol Metab 2001 Jul;14 Suppl 2:945-52. doi: 10.1515/jpem-2001-s206. PMID: 11529400

Prognosis

Zhai X, Duan L, Yao Y, Xing B, Deng K, Wang L, Feng F, Liang Z, You H, Yang H, Lu L, Chen S, Wang R, Pan H, Zhu H
Front Endocrinol (Lausanne) 2021;12:672394. Epub 2021 Oct 29 doi: 10.3389/fendo.2021.672394. PMID: 34777239Free PMC Article
Carwile JL, Willett WC, Wang M, Rich-Edwards J, Frazier AL, Michels KB
J Nutr 2015 Aug;145(8):1900-8. Epub 2015 Jul 1 doi: 10.3945/jn.115.214270. PMID: 26136590Free PMC Article
Heger S, Sippell WG, Partsch CJ
Endocr Dev 2005;8:94-125. doi: 10.1159/000084097. PMID: 15722620
Antoniazzi F, Zamboni G
Paediatr Drugs 2004;6(4):211-31. doi: 10.2165/00148581-200406040-00002. PMID: 15339200
Zachmann M, Ferrandez A, Mürset G, Gnehm HE, Prader A
J Pediatr 1976 Jan;88(1):116-23. doi: 10.1016/s0022-3476(76)80742-1. PMID: 173825

Clinical prediction guides

Huang S, Su Z, Su H, Jiao Y, Su Q, Yao Y, Zhou L, Zheng X, Zhang X
Sci Rep 2022 Sep 7;12(1):15166. doi: 10.1038/s41598-022-19470-4. PMID: 36071136Free PMC Article
Oyachi M, Watanabe Y, Kitayama K, Yamada Y, Higuchi S, Kawakita R, Yorifuji T
J Pediatr Endocrinol Metab 2022 Feb 23;35(2):163-168. Epub 2021 Sep 20 doi: 10.1515/jpem-2021-0313. PMID: 34536343
Carwile JL, Willett WC, Wang M, Rich-Edwards J, Frazier AL, Michels KB
J Nutr 2015 Aug;145(8):1900-8. Epub 2015 Jul 1 doi: 10.3945/jn.115.214270. PMID: 26136590Free PMC Article
Antoniazzi F, Zamboni G
Paediatr Drugs 2004;6(4):211-31. doi: 10.2165/00148581-200406040-00002. PMID: 15339200
Hokken-Koelega AC, Saenger P, Cappa M, Greggio N; International Workshop on Management of Puberty for Optimum Auxological Results
J Pediatr Endocrinol Metab 2001 Jul;14 Suppl 2:945-52. doi: 10.1515/jpem-2001-s206. PMID: 11529400

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