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Aculeiform cataract(CTRCT4)

MedGen UID:
Concept ID:
Disease or Syndrome; Finding
Synonyms: CTRCT4; Fasciculiform cataract; Frosted cataract; Needle-shaped cataract
HPO: HP:0010926
OMIM®: 115700


A kind of nuclear cataract characterized by fiberglasslike or needlelike crystals projecting in different directions, through or close to the axial region of the lens. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAculeiform cataract

Conditions with this feature

Cataract 2, multiple types
MedGen UID:
Concept ID:
Disease or Syndrome
Mutations in the CRYGC gene have been found to cause several types of cataract, which have been described as Coppock-like; embryonic, fetal, infantile nuclear; zonular pulverulent; and lamellar. Some patients also exhibit microcornea. Before it was known that mutations in the CRYGC gene cause several types of cataract, this entry was titled 'Cataract, Coppock-like,' with the symbol CCL.

Recent clinical studies


Basak A, Bateman O, Slingsby C, Pande A, Asherie N, Ogun O, Benedek GB, Pande J
J Mol Biol 2003 May 16;328(5):1137-47. doi: 10.1016/s0022-2836(03)00375-9. PMID: 12729747


Farmer EJ, Swann PG
J Am Optom Assoc 1983 Oct;54(10):913-4. PMID: 6630840


Vanita V, Singh D
Mol Cell Biochem 2012 Sep;368(1-2):167-72. Epub 2012 Jun 6 doi: 10.1007/s11010-012-1355-2. PMID: 22669729


Zenteno JC, Morales ME, Moran-Barroso V, Sanchez-Navarro A
Mol Vis 2005 Jun 30;11:438-42. PMID: 16030500

Clinical prediction guides

Zenteno JC, Morales ME, Moran-Barroso V, Sanchez-Navarro A
Mol Vis 2005 Jun 30;11:438-42. PMID: 16030500
Héon E, Priston M, Schorderet DF, Billingsley GD, Girard PO, Lubsen N, Munier FL
Am J Hum Genet 1999 Nov;65(5):1261-7. doi: 10.1086/302619. PMID: 10521291Free PMC Article

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