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Leukemia (both ALL and AML)

MedGen UID:
348707
•Concept ID:
C1860794
•
Neoplastic Process

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLeukemia (both ALL and AML)

Professional guidelines

PubMed

Acute myeloid leukemia: 2023 update on diagnosis, risk-stratification, and management.
Shimony S, Stahl M, Stone RM
Am J Hematol 2023 Mar;98(3):502-526. Epub 2023 Jan 13 doi: 10.1002/ajh.26822. PMID: 36594187
Diagnosis and Treatment of Myelodysplastic Syndromes: A Review.
Sekeres MA, Taylor J
JAMA 2022 Sep 6;328(9):872-880. doi: 10.1001/jama.2022.14578. PMID: 36066514
Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN.
Döhner H, Wei AH, Appelbaum FR, Craddock C, DiNardo CD, Dombret H, Ebert BL, Fenaux P, Godley LA, Hasserjian RP, Larson RA, Levine RL, Miyazaki Y, Niederwieser D, Ossenkoppele G, Röllig C, Sierra J, Stein EM, Tallman MS, Tien HF, Wang J, Wierzbowska A, Löwenberg B
Blood 2022 Sep 22;140(12):1345-1377. doi: 10.1182/blood.2022016867. PMID: 35797463

Recent clinical studies

Etiology

The International Consensus Classification of acute myeloid leukemia.
Weinberg OK, Porwit A, Orazi A, Hasserjian RP, Foucar K, Duncavage EJ, Arber DA
Virchows Arch 2023 Jan;482(1):27-37. Epub 2022 Oct 20 doi: 10.1007/s00428-022-03430-4. PMID: 36264379
Neonatal Leukemia.
Brown PA
Clin Perinatol 2021 Mar;48(1):15-33. doi: 10.1016/j.clp.2020.11.002. PMID: 33583502
Acute myeloid leukemia.
Rubnitz JE, Gibson B, Smith FO
Hematol Oncol Clin North Am 2010 Feb;24(1):35-63. doi: 10.1016/j.hoc.2009.11.008. PMID: 20113895
Acute myeloid leukemia: epidemiology and etiology.
Deschler B, Lübbert M
Cancer 2006 Nov 1;107(9):2099-107. doi: 10.1002/cncr.22233. PMID: 17019734
Flow cytometry in the diagnosis of acute leukemia.
Weir EG, Borowitz MJ
Semin Hematol 2001 Apr;38(2):124-38. doi: 10.1016/s0037-1963(01)90046-0. PMID: 11309694

Diagnosis

The International Consensus Classification of acute myeloid leukemia.
Weinberg OK, Porwit A, Orazi A, Hasserjian RP, Foucar K, Duncavage EJ, Arber DA
Virchows Arch 2023 Jan;482(1):27-37. Epub 2022 Oct 20 doi: 10.1007/s00428-022-03430-4. PMID: 36264379
How I Diagnose Acute Leukemia of Ambiguous Lineage.
Weinberg OK, Arber DA
Am J Clin Pathol 2022 Jul 1;158(1):27-34. doi: 10.1093/ajcp/aqac070. PMID: 35775438
Acute Myeloid Leukemia: A Review.
Pelcovits A, Niroula R
R I Med J (2013) 2020 Apr 1;103(3):38-40. PMID: 32236160
Leukemias in Children.
Seth R, Singh A
Indian J Pediatr 2015 Sep;82(9):817-24. Epub 2015 Feb 15 doi: 10.1007/s12098-015-1695-5. PMID: 25680783
Acute myeloid leukemia.
Rubnitz JE, Gibson B, Smith FO
Hematol Oncol Clin North Am 2010 Feb;24(1):35-63. doi: 10.1016/j.hoc.2009.11.008. PMID: 20113895

Therapy

Towards precision medicine for AML.
Döhner H, Wei AH, Löwenberg B
Nat Rev Clin Oncol 2021 Sep;18(9):577-590. Epub 2021 May 18 doi: 10.1038/s41571-021-00509-w. PMID: 34006997
Acute Myeloid Leukemia: A Review.
Pelcovits A, Niroula R
R I Med J (2013) 2020 Apr 1;103(3):38-40. PMID: 32236160
CPX-351 (vyxeos) in AML.
Alfayez M, Kantarjian H, Kadia T, Ravandi-Kashani F, Daver N
Leuk Lymphoma 2020 Feb;61(2):288-297. Epub 2019 Sep 24 doi: 10.1080/10428194.2019.1660970. PMID: 31547736
Minimal/measurable residual disease in AML: a consensus document from the European LeukemiaNet MRD Working Party.
Schuurhuis GJ, Heuser M, Freeman S, Béné MC, Buccisano F, Cloos J, Grimwade D, Haferlach T, Hills RK, Hourigan CS, Jorgensen JL, Kern W, Lacombe F, Maurillo L, Preudhomme C, van der Reijden BA, Thiede C, Venditti A, Vyas P, Wood BL, Walter RB, Döhner K, Roboz GJ, Ossenkoppele GJ
Blood 2018 Mar 22;131(12):1275-1291. Epub 2018 Jan 12 doi: 10.1182/blood-2017-09-801498. PMID: 29330221Free PMC Article
Treatment of Relapsed/Refractory Acute Myeloid Leukemia.
Bose P, Vachhani P, Cortes JE
Curr Treat Options Oncol 2017 Mar;18(3):17. doi: 10.1007/s11864-017-0456-2. PMID: 28286924

Prognosis

Incidence, Survival, and Risk Factors for Adults with Acute Myeloid Leukemia Not Otherwise Specified and Acute Myeloid Leukemia with Recurrent Genetic Abnormalities: Analysis of the Surveillance, Epidemiology, and End Results (SEER) Database, 2001-2013.
Song X, Peng Y, Wang X, Chen Y, Jin L, Yang T, Qian M, Ni W, Tong X, Lan J
Acta Haematol 2018;139(2):115-127. Epub 2018 Feb 16 doi: 10.1159/000486228. PMID: 29455198
Acute myeloid leukemia in the elderly: therapeutic options and choice.
Webster JA, Pratz KW
Leuk Lymphoma 2018 Feb;59(2):274-287. Epub 2017 Jun 2 doi: 10.1080/10428194.2017.1330956. PMID: 28573892Free PMC Article
Hematopoietic stem cell transplantation for acute myeloid leukemia: A review.
Kassim AA, Savani BN
Hematol Oncol Stem Cell Ther 2017 Dec;10(4):245-251. Epub 2017 Jun 20 doi: 10.1016/j.hemonc.2017.05.021. PMID: 28666104
Acute Myeloid Leukemia: analysis of epidemiological profile and survival rate.
de Lima MC, da Silva DB, Freund AP, Dacoregio JS, Costa Tel J, Costa I, Faraco D, Silva ML
J Pediatr (Rio J) 2016 May-Jun;92(3):283-9. Epub 2016 Feb 3 doi: 10.1016/j.jped.2015.08.008. PMID: 26850325
Acute myeloid leukemia: epidemiology and etiology.
Deschler B, Lübbert M
Cancer 2006 Nov 1;107(9):2099-107. doi: 10.1002/cncr.22233. PMID: 17019734

Clinical prediction guides

Prognosis and Characterization of Immune Microenvironment in Acute Myeloid Leukemia Through Identification of an Autophagy-Related Signature.
Fu D, Zhang B, Wu S, Zhang Y, Xie J, Ning W, Jiang H
Front Immunol 2021;12:695865. Epub 2021 May 31 doi: 10.3389/fimmu.2021.695865. PMID: 34135913Free PMC Article
Therapeutic implications of menin inhibition in acute leukemias.
Issa GC, Ravandi F, DiNardo CD, Jabbour E, Kantarjian HM, Andreeff M
Leukemia 2021 Sep;35(9):2482-2495. Epub 2021 Jun 15 doi: 10.1038/s41375-021-01309-y. PMID: 34131281
The leukaemia stem cell: similarities, differences and clinical prospects in CML and AML.
Vetrie D, Helgason GV, Copland M
Nat Rev Cancer 2020 Mar;20(3):158-173. Epub 2020 Jan 6 doi: 10.1038/s41568-019-0230-9. PMID: 31907378
A 17-gene stemness score for rapid determination of risk in acute leukaemia.
Ng SW, Mitchell A, Kennedy JA, Chen WC, McLeod J, Ibrahimova N, Arruda A, Popescu A, Gupta V, Schimmer AD, Schuh AC, Yee KW, Bullinger L, Herold T, Görlich D, Büchner T, Hiddemann W, Berdel WE, Wörmann B, Cheok M, Preudhomme C, Dombret H, Metzeler K, Buske C, Löwenberg B, Valk PJ, Zandstra PW, Minden MD, Dick JE, Wang JC
Nature 2016 Dec 15;540(7633):433-437. Epub 2016 Dec 7 doi: 10.1038/nature20598. PMID: 27926740
Flow cytometry in the diagnosis of acute leukemia.
Weir EG, Borowitz MJ
Semin Hematol 2001 Apr;38(2):124-38. doi: 10.1016/s0037-1963(01)90046-0. PMID: 11309694

Recent systematic reviews

Hematopoietic Cell Transplantation in the Treatment of Newly Diagnosed Adult Acute Myeloid Leukemia: An Evidence-Based Review from the American Society of Transplantation and Cellular Therapy.
Dholaria B, Savani BN, Hamilton BK, Oran B, Liu HD, Tallman MS, Ciurea SO, Holtzman NG, Ii GLP, Devine SM, Mannis G, Grunwald MR, Appelbaum F, Rodriguez C, El Chaer F, Shah N, Hashmi SK, Kharfan-Dabaja MA, DeFilipp Z, Aljurf M, AlShaibani A, Inamoto Y, Jain T, Majhail N, Perales MA, Mohty M, Hamadani M, Carpenter PA, Nagler A
Transplant Cell Ther 2021 Jan;27(1):6-20. Epub 2020 Sep 20 doi: 10.1016/j.bbmt.2020.09.020. PMID: 32966881
The efficacy and adverse events of venetoclax in combination with hypomethylating agents treatment for patients with acute myeloid leukemia and myelodysplastic syndrome: a systematic review and meta-analysis.
Liu B, Guo Y, Deng L, Qiao Y, Jian J
Hematology 2020 Dec;25(1):414-423. doi: 10.1080/16078454.2020.1843752. PMID: 33191860
Association of Measurable Residual Disease With Survival Outcomes in Patients With Acute Myeloid Leukemia: A Systematic Review and Meta-analysis.
Short NJ, Zhou S, Fu C, Berry DA, Walter RB, Freeman SD, Hourigan CS, Huang X, Nogueras Gonzalez G, Hwang H, Qi X, Kantarjian H, Ravandi F
JAMA Oncol 2020 Dec 1;6(12):1890-1899. doi: 10.1001/jamaoncol.2020.4600. PMID: 33030517Free PMC Article
Aerobic physical exercise for adult patients with haematological malignancies.
Knips L, Bergenthal N, Streckmann F, Monsef I, Elter T, Skoetz N
Cochrane Database Syst Rev 2019 Jan 31;1(1):CD009075. doi: 10.1002/14651858.CD009075.pub3. PMID: 30702150Free PMC Article
Therapy for children and adults with mixed phenotype acute leukemia: a systematic review and meta-analysis.
Maruffi M, Sposto R, Oberley MJ, Kysh L, Orgel E
Leukemia 2018 Jul;32(7):1515-1528. Epub 2018 Feb 27 doi: 10.1038/s41375-018-0058-4. PMID: 29550836Free PMC Article

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