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Leukemia (both ALL and AML)

MedGen UID:
348707
•Concept ID:
C1860794
•
Neoplastic Process

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLeukemia (both ALL and AML)

Professional guidelines

PubMed

Polycythemia vera: 2024 update on diagnosis, risk-stratification, and management.
Tefferi A, Barbui T
Am J Hematol 2023 Sep;98(9):1465-1487. Epub 2023 Jun 26 doi: 10.1002/ajh.27002. PMID: 37357958
Acute myeloid leukemia: 2023 update on diagnosis, risk-stratification, and management.
Shimony S, Stahl M, Stone RM
Am J Hematol 2023 Mar;98(3):502-526. Epub 2023 Jan 13 doi: 10.1002/ajh.26822. PMID: 36594187
Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN.
Döhner H, Wei AH, Appelbaum FR, Craddock C, DiNardo CD, Dombret H, Ebert BL, Fenaux P, Godley LA, Hasserjian RP, Larson RA, Levine RL, Miyazaki Y, Niederwieser D, Ossenkoppele G, Röllig C, Sierra J, Stein EM, Tallman MS, Tien HF, Wang J, Wierzbowska A, Löwenberg B
Blood 2022 Sep 22;140(12):1345-1377. doi: 10.1182/blood.2022016867. PMID: 35797463

Recent clinical studies

Etiology

Relapsed pediatric acute myeloid leukaemia: state-of-the-art in 2023.
Egan G, Tasian SK
Haematologica 2023 Sep 1;108(9):2275-2288. doi: 10.3324/haematol.2022.281106. PMID: 36861399Free PMC Article
The International Consensus Classification of acute myeloid leukemia.
Weinberg OK, Porwit A, Orazi A, Hasserjian RP, Foucar K, Duncavage EJ, Arber DA
Virchows Arch 2023 Jan;482(1):27-37. Epub 2022 Oct 20 doi: 10.1007/s00428-022-03430-4. PMID: 36264379
Neonatal Leukemia.
Brown PA
Clin Perinatol 2021 Mar;48(1):15-33. doi: 10.1016/j.clp.2020.11.002. PMID: 33583502
Acute myeloid leukemia.
Rubnitz JE, Gibson B, Smith FO
Hematol Oncol Clin North Am 2010 Feb;24(1):35-63. doi: 10.1016/j.hoc.2009.11.008. PMID: 20113895
Acute myeloid leukemia: epidemiology and etiology.
Deschler B, Lübbert M
Cancer 2006 Nov 1;107(9):2099-107. doi: 10.1002/cncr.22233. PMID: 17019734

Diagnosis

Relapsed pediatric acute myeloid leukaemia: state-of-the-art in 2023.
Egan G, Tasian SK
Haematologica 2023 Sep 1;108(9):2275-2288. doi: 10.3324/haematol.2022.281106. PMID: 36861399Free PMC Article
The International Consensus Classification of acute myeloid leukemia.
Weinberg OK, Porwit A, Orazi A, Hasserjian RP, Foucar K, Duncavage EJ, Arber DA
Virchows Arch 2023 Jan;482(1):27-37. Epub 2022 Oct 20 doi: 10.1007/s00428-022-03430-4. PMID: 36264379
Acute Myeloid Leukemia: A Review.
Pelcovits A, Niroula R
R I Med J (2013) 2020 Apr 1;103(3):38-40. PMID: 32236160
Leukemias in Children.
Seth R, Singh A
Indian J Pediatr 2015 Sep;82(9):817-24. Epub 2015 Feb 15 doi: 10.1007/s12098-015-1695-5. PMID: 25680783
Acute myeloid leukemia.
Rubnitz JE, Gibson B, Smith FO
Hematol Oncol Clin North Am 2010 Feb;24(1):35-63. doi: 10.1016/j.hoc.2009.11.008. PMID: 20113895

Therapy

Myelodysplastic syndromes: 2023 update on diagnosis, risk-stratification, and management.
Garcia-Manero G
Am J Hematol 2023 Aug;98(8):1307-1325. Epub 2023 Jun 8 doi: 10.1002/ajh.26984. PMID: 37288607
Relapsed pediatric acute myeloid leukaemia: state-of-the-art in 2023.
Egan G, Tasian SK
Haematologica 2023 Sep 1;108(9):2275-2288. doi: 10.3324/haematol.2022.281106. PMID: 36861399Free PMC Article
Towards precision medicine for AML.
Döhner H, Wei AH, Löwenberg B
Nat Rev Clin Oncol 2021 Sep;18(9):577-590. Epub 2021 May 18 doi: 10.1038/s41571-021-00509-w. PMID: 34006997
Acute Myeloid Leukemia: A Review.
Pelcovits A, Niroula R
R I Med J (2013) 2020 Apr 1;103(3):38-40. PMID: 32236160
CPX-351 (vyxeos) in AML.
Alfayez M, Kantarjian H, Kadia T, Ravandi-Kashani F, Daver N
Leuk Lymphoma 2020 Feb;61(2):288-297. Epub 2019 Sep 24 doi: 10.1080/10428194.2019.1660970. PMID: 31547736

Prognosis

Real-world experience of CPX-351 as first-line treatment for patients with acute myeloid leukemia.
Rautenberg C, Stölzel F, Röllig C, Stelljes M, Gaidzik V, Lauseker M, Kriege O, Verbeek M, Unglaub JM, Thol F, Krause SW, Hänel M, Neuerburg C, Vucinic V, Jehn CF, Severmann J, Wass M, Fransecky L, Chemnitz J, Holtick U, Schäfer-Eckart K, Schröder J, Kraus S, Krüger W, Kaiser U, Scholl S, Koch K, Henning L, Kobbe G, Haas R, Alakel N, Röhnert MA, Sockel K, Hanoun M, Platzbecker U, Holderried TAW, Morgner A, Heuser M, Sauer T, Götze KS, Wagner-Drouet E, Döhner K, Döhner H, Schliemann C, Schetelig J, Bornhäuser M, Germing U, Schroeder T, Middeke JM
Blood Cancer J 2021 Oct 4;11(10):164. doi: 10.1038/s41408-021-00558-5. PMID: 34608129Free PMC Article
Is there a standard of care for relapsed AML?
Medeiros BC
Best Pract Res Clin Haematol 2018 Dec;31(4):384-386. Epub 2018 Sep 20 doi: 10.1016/j.beha.2018.09.006. PMID: 30466752
Acute myeloid leukemia: epidemiology and etiology.
Deschler B, Lübbert M
Cancer 2006 Nov 1;107(9):2099-107. doi: 10.1002/cncr.22233. PMID: 17019734
Fetal and neonatal leukemia.
Isaacs H Jr
J Pediatr Hematol Oncol 2003 May;25(5):348-61. doi: 10.1097/00043426-200305000-00002. PMID: 12759620
The childhood leukemias.
Colby-Graham MF, Chordas C
J Pediatr Nurs 2003 Apr;18(2):87-95. doi: 10.1053/jpdn.2003.9. PMID: 12720205

Clinical prediction guides

Immune dysfunction signatures predict outcomes and define checkpoint blockade-unresponsive microenvironments in acute myeloid leukemia.
Rutella S, Vadakekolathu J, Mazziotta F, Reeder S, Yau TO, Mukhopadhyay R, Dickins B, Altmann H, Kramer M, Knaus HA, Blazar BR, Radojcic V, Zeidner JF, Arruda A, Wang B, Abbas HA, Minden MD, Tasian SK, Bornhäuser M, Gojo I, Luznik L
J Clin Invest 2022 Nov 1;132(21) doi: 10.1172/JCI159579. PMID: 36099049Free PMC Article
Prognosis and Characterization of Immune Microenvironment in Acute Myeloid Leukemia Through Identification of an Autophagy-Related Signature.
Fu D, Zhang B, Wu S, Zhang Y, Xie J, Ning W, Jiang H
Front Immunol 2021;12:695865. Epub 2021 May 31 doi: 10.3389/fimmu.2021.695865. PMID: 34135913Free PMC Article
Management of Disseminated Intravascular Coagulation in Acute Leukemias.
Ten Cate H, Leader A
Hamostaseologie 2021 Apr;41(2):120-126. Epub 2021 Apr 15 doi: 10.1055/a-1393-8302. PMID: 33860520
The leukaemia stem cell: similarities, differences and clinical prospects in CML and AML.
Vetrie D, Helgason GV, Copland M
Nat Rev Cancer 2020 Mar;20(3):158-173. Epub 2020 Jan 6 doi: 10.1038/s41568-019-0230-9. PMID: 31907378
A 17-gene stemness score for rapid determination of risk in acute leukaemia.
Ng SW, Mitchell A, Kennedy JA, Chen WC, McLeod J, Ibrahimova N, Arruda A, Popescu A, Gupta V, Schimmer AD, Schuh AC, Yee KW, Bullinger L, Herold T, Görlich D, Büchner T, Hiddemann W, Berdel WE, Wörmann B, Cheok M, Preudhomme C, Dombret H, Metzeler K, Buske C, Löwenberg B, Valk PJ, Zandstra PW, Minden MD, Dick JE, Wang JC
Nature 2016 Dec 15;540(7633):433-437. Epub 2016 Dec 7 doi: 10.1038/nature20598. PMID: 27926740

Recent systematic reviews

Therapies for acute myeloid leukemia in patients ineligible for standard induction chemotherapy: a systematic review.
Heuser M, Fernandez C, Hauch O, Klibanov OM, Chaudhary T, Rives V
Future Oncol 2023 Apr;19(11):789-810. Epub 2023 May 12 doi: 10.2217/fon-2022-1286. PMID: 37170899
The efficacy and safety of venetoclax and azacytidine combination treatment in patients with acute myeloid leukemia and myelodysplastic syndrome: systematic review and meta-analysis.
Du Y, Li C, Yan J
Hematology 2023 Dec;28(1):2198098. doi: 10.1080/16078454.2023.2198098. PMID: 37036307
Treatment outcomes for newly diagnosed, treatment-naïve TP53-mutated acute myeloid leukemia: a systematic review and meta-analysis.
Daver NG, Iqbal S, Renard C, Chan RJ, Hasegawa K, Hu H, Tse P, Yan J, Zoratti MJ, Xie F, Ramsingh G
J Hematol Oncol 2023 Mar 6;16(1):19. doi: 10.1186/s13045-023-01417-5. PMID: 36879351Free PMC Article
Association of Measurable Residual Disease With Survival Outcomes in Patients With Acute Myeloid Leukemia: A Systematic Review and Meta-analysis.
Short NJ, Zhou S, Fu C, Berry DA, Walter RB, Freeman SD, Hourigan CS, Huang X, Nogueras Gonzalez G, Hwang H, Qi X, Kantarjian H, Ravandi F
JAMA Oncol 2020 Dec 1;6(12):1890-1899. doi: 10.1001/jamaoncol.2020.4600. PMID: 33030517Free PMC Article
Aerobic physical exercise for adult patients with haematological malignancies.
Knips L, Bergenthal N, Streckmann F, Monsef I, Elter T, Skoetz N
Cochrane Database Syst Rev 2019 Jan 31;1(1):CD009075. doi: 10.1002/14651858.CD009075.pub3. PMID: 30702150Free PMC Article

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