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Chondrocalcinosis due to apatite crystal deposition

MedGen UID:
349317
•Concept ID:
C1861580
•
Disease or Syndrome
Synonym: Familial apatite disease
 
Monarch Initiative: MONDO:0007320
OMIM®: 118610

Clinical features

From HPO
Costochondral pain
MedGen UID:
867229
•Concept ID:
C4021587
•
Finding
Chest wall pain in the area of the costochondral junctions.
See: Feature record | Search on this feature
Osteoarthritis of the small joints of the hand
MedGen UID:
870919
•Concept ID:
C4025381
•
Disease or Syndrome
See: Feature record | Search on this feature
Arthropathy
MedGen UID:
7190
•Concept ID:
C0022408
•
Disease or Syndrome
Any disorder of the joints.
See: Feature record | Search on this feature
Intervertebral disk calcification
MedGen UID:
451050
•Concept ID:
C0410607
•
Disease or Syndrome
The presence of abnormal calcium deposition of the intervertebral disk.
See: Feature record | Search on this feature
Chondrocalcinosis
MedGen UID:
154303
•Concept ID:
C0553730
•
Disease or Syndrome
Radiographic evidence of articular calcification that represent calcium pyrophosphate depositions in soft tissue surrounding joints and at the insertions of tendons near joints (Entheses/Sharpey fibers) .
See: Feature record | Search on this feature
Costal cartilage calcification
MedGen UID:
344533
•Concept ID:
C1855608
•
Finding
Calcification of the costal cartilages, which are bars of hyaline cartilage found at the anterior ends of the ribs which serve to prolong the ribs forward and contribute to the elasticity of the walls of the thorax.
See: Feature record | Search on this feature
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Professional guidelines

PubMed

Clinical Utility of Multi-Energy Spectral Photon-Counting Computed Tomography in Crystal Arthritis.
Stamp LK, Anderson NG, Becce F, Rajeswari M, Polson M, Guyen O, Viry A, Choi C, Kirkbride TE, Raja AY
Arthritis Rheumatol 2019 Jul;71(7):1158-1162. Epub 2019 May 28 doi: 10.1002/art.40848. PMID: 30714678

Recent clinical studies

Etiology

Imaging of Crystal Disorders:: Calcium Pyrophosphate Dihydrate Crystal Deposition Disease, Calcium Hydroxyapatite Crystal Deposition Disease and Gout Pathophysiology, Imaging, and Diagnosis.
Reijnierse M, Schwabl C, Klauser A
Radiol Clin North Am 2022 Jul;60(4):641-656. doi: 10.1016/j.rcl.2022.03.007. PMID: 35672096
Prevalence and incidence of non-gout crystal arthropathy in southern Sweden.
Hameed M, Turkiewicz A, Englund M, Jacobsson L, Kapetanovic MC
Arthritis Res Ther 2019 Dec 17;21(1):291. doi: 10.1186/s13075-019-2077-6. PMID: 31847885Free PMC Article
Dual-energy computed tomography in calcium pyrophosphate deposition: initial clinical experience.
Pascart T, Norberciak L, Legrand J, Becce F, Budzik JF
Osteoarthritis Cartilage 2019 Sep;27(9):1309-1314. Epub 2019 May 27 doi: 10.1016/j.joca.2019.05.007. PMID: 31146015
Metabolism of extracellular pyrophosphate.
Ryan LM, Rosenthal AK
Curr Opin Rheumatol 2003 May;15(3):311-4. doi: 10.1097/00002281-200305000-00020. PMID: 12707586
Crystal deposition and osteoarthritis.
Olmez N, Schumacher HR Jr
Curr Rheumatol Rep 1999 Dec;1(2):107-11. doi: 10.1007/s11926-999-0006-4. PMID: 11123023

Diagnosis

Imaging of Crystal Disorders:: Calcium Pyrophosphate Dihydrate Crystal Deposition Disease, Calcium Hydroxyapatite Crystal Deposition Disease and Gout Pathophysiology, Imaging, and Diagnosis.
Reijnierse M, Schwabl C, Klauser A
Radiol Clin North Am 2022 Jul;60(4):641-656. doi: 10.1016/j.rcl.2022.03.007. PMID: 35672096
Diagnosis and clinical manifestations of calcium pyrophosphate and basic calcium phosphate crystal deposition diseases.
Ea HK, Lioté F
Rheum Dis Clin North Am 2014 May;40(2):207-29. Epub 2014 Mar 4 doi: 10.1016/j.rdc.2014.01.011. PMID: 24703344
Oxalate crystal deposition disease.
Maldonado I, Prasad V, Reginato AJ
Curr Rheumatol Rep 2002 Jun;4(3):257-64. doi: 10.1007/s11926-002-0074-1. PMID: 12010612
Crystal-induced arthritis: an overview.
Schumacher HR
Am J Med 1996 Feb 26;100(2A):46S-52S. doi: 10.1016/s0002-9343(97)89546-0. PMID: 8604727
Crystal arthritis.
Poór G
Baillieres Clin Rheumatol 1995 May;9(2):397-406. doi: 10.1016/s0950-3579(05)80197-9. PMID: 7656347

Therapy

What is new about crystals other than monosodium urate?
Fam AG
Curr Opin Rheumatol 2000 May;12(3):228-34. doi: 10.1097/00002281-200005000-00013. PMID: 10803754
Crystal-induced arthritis: an overview.
Schumacher HR
Am J Med 1996 Feb 26;100(2A):46S-52S. doi: 10.1016/s0002-9343(97)89546-0. PMID: 8604727
Crystal arthritis: a clinician's view.
Hall S
Aust Fam Physician 1991 Dec;20(12):1717-24. PMID: 1805773
Calcium pyrophosphate crystal deposition in hyaline cartilage. Ultrastructural analysis and implications for pathogenesis.
Pritzker KP, Cheng PT, Renlund RC
J Rheumatol 1988;15(5):828-35. PMID: 2845077
Arthropathy and cutaneous calcinosis in hemodialysis oxalosis.
Reginato AJ, Ferreiro Seoane JL, Barbazan Alvarez C, Mitja Piferrer J, Vidal Meijon L, Pascual Turon R, Vasconez F, Rivera ER, Clayburne G, Rothfuss S
Arthritis Rheum 1986 Nov;29(11):1387-96. doi: 10.1002/art.1780291112. PMID: 3778544

Prognosis

Prevalence and incidence of non-gout crystal arthropathy in southern Sweden.
Hameed M, Turkiewicz A, Englund M, Jacobsson L, Kapetanovic MC
Arthritis Res Ther 2019 Dec 17;21(1):291. doi: 10.1186/s13075-019-2077-6. PMID: 31847885Free PMC Article
Familial and clinical aspects of calcium pyrophosphate deposition disease.
Reginato AJ, Tamesis E, Netter P
Curr Rheumatol Rep 1999 Dec;1(2):112-20. doi: 10.1007/s11926-999-0007-3. PMID: 11123024
Crystal deposition and osteoarthritis.
Olmez N, Schumacher HR Jr
Curr Rheumatol Rep 1999 Dec;1(2):107-11. doi: 10.1007/s11926-999-0006-4. PMID: 11123023
Crystal arthritis.
Poór G
Baillieres Clin Rheumatol 1995 May;9(2):397-406. doi: 10.1016/s0950-3579(05)80197-9. PMID: 7656347
Arthropathy and cutaneous calcinosis in hemodialysis oxalosis.
Reginato AJ, Ferreiro Seoane JL, Barbazan Alvarez C, Mitja Piferrer J, Vidal Meijon L, Pascual Turon R, Vasconez F, Rivera ER, Clayburne G, Rothfuss S
Arthritis Rheum 1986 Nov;29(11):1387-96. doi: 10.1002/art.1780291112. PMID: 3778544

Clinical prediction guides

Dual-energy computed tomography in calcium pyrophosphate deposition: initial clinical experience.
Pascart T, Norberciak L, Legrand J, Becce F, Budzik JF
Osteoarthritis Cartilage 2019 Sep;27(9):1309-1314. Epub 2019 May 27 doi: 10.1016/j.joca.2019.05.007. PMID: 31146015
Revisiting spatial distribution and biochemical composition of calcium-containing crystals in human osteoarthritic articular cartilage.
Nguyen C, Bazin D, Daudon M, Chatron-Colliet A, Hannouche D, Bianchi A, Côme D, So A, Busso N, Busso N, Lioté F, Ea HK
Arthritis Res Ther 2013;15(5):R103. doi: 10.1186/ar4283. PMID: 24004678Free PMC Article
Oxalate crystal deposition disease.
Maldonado I, Prasad V, Reginato AJ
Curr Rheumatol Rep 2002 Jun;4(3):257-64. doi: 10.1007/s11926-002-0074-1. PMID: 12010612
Familial osteoarthritis and Milwaukee shoulder associated with calcium pyrophosphate and apatite crystal deposition.
Pons-Estel BA, Gimenez C, Sacnun M, Gentiletti S, Battagliotti CA, de la Pena LS, Williams CJ, Reginato AJ
J Rheumatol 2000 Feb;27(2):471-80. PMID: 10685816
Calcium pyrophosphate crystal deposition in hyaline cartilage. Ultrastructural analysis and implications for pathogenesis.
Pritzker KP, Cheng PT, Renlund RC
J Rheumatol 1988;15(5):828-35. PMID: 2845077

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