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Increased risk of hepatocellular carcinoma

MedGen UID:
349592
•Concept ID:
C1862761
•
Finding
Synonym: Increased hepatocellular carcinoma risk

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased risk of hepatocellular carcinoma

Professional guidelines

PubMed

Hereditary tyrosinemia type Ⅰ: newborn screening, diagnosis and treatment.
Tang Y, Kong Y
Zhejiang Da Xue Xue Bao Yi Xue Ban 2021 Aug 25;50(4):514-523. doi: 10.3724/zdxbyxb-2021-0255. PMID: 34704422Free PMC Article
Emerging therapeutic approaches for the treatment of NAFLD and type 2 diabetes mellitus.
Ferguson D, Finck BN
Nat Rev Endocrinol 2021 Aug;17(8):484-495. Epub 2021 Jun 15 doi: 10.1038/s41574-021-00507-z. PMID: 34131333Free PMC Article
Hepatitis C Genotype 3 Infection: Pathogenesis and Treatment Horizons.
Maddur H, Flamm SL
Clin Liver Dis 2017 Nov;21(4):645-657. Epub 2017 Aug 5 doi: 10.1016/j.cld.2017.06.009. PMID: 28987253

Recent clinical studies

Etiology

Cuproptosis-Related Risk Score Predicts Prognosis and Characterizes the Tumor Microenvironment in Hepatocellular Carcinoma.
Zhang Z, Zeng X, Wu Y, Liu Y, Zhang X, Song Z
Front Immunol 2022;13:925618. Epub 2022 Jul 11 doi: 10.3389/fimmu.2022.925618. PMID: 35898502Free PMC Article
Changing epidemiology of hepatocellular carcinoma in Asia.
Zhang CH, Cheng Y, Zhang S, Fan J, Gao Q
Liver Int 2022 Aug;42(9):2029-2041. Epub 2022 Apr 3 doi: 10.1111/liv.15251. PMID: 35319165
Current epidemiology in hepatocellular carcinoma.
Konyn P, Ahmed A, Kim D
Expert Rev Gastroenterol Hepatol 2021 Nov;15(11):1295-1307. Epub 2021 Oct 22 doi: 10.1080/17474124.2021.1991792. PMID: 34624198
A global view of hepatocellular carcinoma: trends, risk, prevention and management.
Yang JD, Hainaut P, Gores GJ, Amadou A, Plymoth A, Roberts LR
Nat Rev Gastroenterol Hepatol 2019 Oct;16(10):589-604. Epub 2019 Aug 22 doi: 10.1038/s41575-019-0186-y. PMID: 31439937Free PMC Article
The diagnosis and treatment of hepatocellular carcinoma.
Hartke J, Johnson M, Ghabril M
Semin Diagn Pathol 2017 Mar;34(2):153-159. Epub 2016 Dec 20 doi: 10.1053/j.semdp.2016.12.011. PMID: 28108047

Diagnosis

Global Epidemiology and Genetics of Hepatocellular Carcinoma.
Toh MR, Wong EYT, Wong SH, Ng AWT, Loo LH, Chow PK, Ngeow J
Gastroenterology 2023 Apr;164(5):766-782. Epub 2023 Feb 2 doi: 10.1053/j.gastro.2023.01.033. PMID: 36738977
Artificial intelligence for the prevention and clinical management of hepatocellular carcinoma.
Calderaro J, Seraphin TP, Luedde T, Simon TG
J Hepatol 2022 Jun;76(6):1348-1361. doi: 10.1016/j.jhep.2022.01.014. PMID: 35589255Free PMC Article
Combined hepatocellular-cholangiocarcinoma: An update.
Beaufrère A, Calderaro J, Paradis V
J Hepatol 2021 May;74(5):1212-1224. Epub 2021 Feb 3 doi: 10.1016/j.jhep.2021.01.035. PMID: 33545267
Epidemiology and surveillance for hepatocellular carcinoma: New trends.
Singal AG, Lampertico P, Nahon P
J Hepatol 2020 Feb;72(2):250-261. doi: 10.1016/j.jhep.2019.08.025. PMID: 31954490Free PMC Article
The diagnosis and treatment of hepatocellular carcinoma.
Hartke J, Johnson M, Ghabril M
Semin Diagn Pathol 2017 Mar;34(2):153-159. Epub 2016 Dec 20 doi: 10.1053/j.semdp.2016.12.011. PMID: 28108047

Therapy

A Meta-Analysis of Statin Use and Risk of Hepatocellular Carcinoma.
Wang Y, Wang W, Wang M, Shi J, Jia X, Dang S
Can J Gastroenterol Hepatol 2022;2022:5389044. Epub 2022 Mar 20 doi: 10.1155/2022/5389044. PMID: 35356132Free PMC Article
Recurrence of Hepatocellular Carcinoma After Liver Transplantation: Risk Factors and Predictive Models.
Straś WA, Wasiak D, Łągiewska B, Tronina O, Hreńczuk M, Gotlib J, Lisik W, Małkowski P
Ann Transplant 2022 Jan 26;27:e934924. doi: 10.12659/AOT.934924. PMID: 35078965Free PMC Article
Hepatocellular carcinoma in the setting of alcohol-related liver disease.
Ganne-Carrié N, Nahon P
J Hepatol 2019 Feb;70(2):284-293. doi: 10.1016/j.jhep.2018.10.008. PMID: 30658729
Hepatocellular carcinoma.
Marrero JA
Curr Opin Gastroenterol 2006 May;22(3):248-53. doi: 10.1097/01.mog.0000218961.86182.8c. PMID: 16550039
Hepatocellular carcinoma in cirrhosis: incidence and risk factors.
Fattovich G, Stroffolini T, Zagni I, Donato F
Gastroenterology 2004 Nov;127(5 Suppl 1):S35-50. doi: 10.1053/j.gastro.2004.09.014. PMID: 15508101

Prognosis

Global epidemiology of alcohol-associated cirrhosis and HCC: trends, projections and risk factors.
Huang DQ, Mathurin P, Cortez-Pinto H, Loomba R
Nat Rev Gastroenterol Hepatol 2023 Jan;20(1):37-49. Epub 2022 Oct 18 doi: 10.1038/s41575-022-00688-6. PMID: 36258033Free PMC Article
Changing epidemiology of hepatocellular carcinoma in Asia.
Zhang CH, Cheng Y, Zhang S, Fan J, Gao Q
Liver Int 2022 Aug;42(9):2029-2041. Epub 2022 Apr 3 doi: 10.1111/liv.15251. PMID: 35319165
Current epidemiology in hepatocellular carcinoma.
Konyn P, Ahmed A, Kim D
Expert Rev Gastroenterol Hepatol 2021 Nov;15(11):1295-1307. Epub 2021 Oct 22 doi: 10.1080/17474124.2021.1991792. PMID: 34624198
Global epidemiology of NAFLD-related HCC: trends, predictions, risk factors and prevention.
Huang DQ, El-Serag HB, Loomba R
Nat Rev Gastroenterol Hepatol 2021 Apr;18(4):223-238. Epub 2020 Dec 21 doi: 10.1038/s41575-020-00381-6. PMID: 33349658Free PMC Article
Epidemiology and surveillance for hepatocellular carcinoma: New trends.
Singal AG, Lampertico P, Nahon P
J Hepatol 2020 Feb;72(2):250-261. doi: 10.1016/j.jhep.2019.08.025. PMID: 31954490Free PMC Article

Clinical prediction guides

Cuproptosis-Related Risk Score Predicts Prognosis and Characterizes the Tumor Microenvironment in Hepatocellular Carcinoma.
Zhang Z, Zeng X, Wu Y, Liu Y, Zhang X, Song Z
Front Immunol 2022;13:925618. Epub 2022 Jul 11 doi: 10.3389/fimmu.2022.925618. PMID: 35898502Free PMC Article
Recurrence of Hepatocellular Carcinoma After Liver Transplantation: Risk Factors and Predictive Models.
Straś WA, Wasiak D, Łągiewska B, Tronina O, Hreńczuk M, Gotlib J, Lisik W, Małkowski P
Ann Transplant 2022 Jan 26;27:e934924. doi: 10.12659/AOT.934924. PMID: 35078965Free PMC Article
Combined hepatocellular-cholangiocarcinoma: An update.
Beaufrère A, Calderaro J, Paradis V
J Hepatol 2021 May;74(5):1212-1224. Epub 2021 Feb 3 doi: 10.1016/j.jhep.2021.01.035. PMID: 33545267
Hepatocellular carcinoma in the setting of alcohol-related liver disease.
Ganne-Carrié N, Nahon P
J Hepatol 2019 Feb;70(2):284-293. doi: 10.1016/j.jhep.2018.10.008. PMID: 30658729
Hepatocellular carcinoma in cirrhosis: incidence and risk factors.
Fattovich G, Stroffolini T, Zagni I, Donato F
Gastroenterology 2004 Nov;127(5 Suppl 1):S35-50. doi: 10.1053/j.gastro.2004.09.014. PMID: 15508101

Recent systematic reviews

Effect of sarcopenia on survival in patients with cirrhosis: A meta-analysis.
Tantai X, Liu Y, Yeo YH, Praktiknjo M, Mauro E, Hamaguchi Y, Engelmann C, Zhang P, Jeong JY, van Vugt JLA, Xiao H, Deng H, Gao X, Ye Q, Zhang J, Yang L, Cai Y, Liu Y, Liu N, Li Z, Han T, Kaido T, Sohn JH, Strassburg C, Berg T, Trebicka J, Hsu YC, IJzermans JNM, Wang J, Su GL, Ji F, Nguyen MH
J Hepatol 2022 Mar;76(3):588-599. Epub 2021 Nov 14 doi: 10.1016/j.jhep.2021.11.006. PMID: 34785325
Prediabetes and risk of mortality, diabetes-related complications and comorbidities: umbrella review of meta-analyses of prospective studies.
Schlesinger S, Neuenschwander M, Barbaresko J, Lang A, Maalmi H, Rathmann W, Roden M, Herder C
Diabetologia 2022 Feb;65(2):275-285. Epub 2021 Oct 31 doi: 10.1007/s00125-021-05592-3. PMID: 34718834Free PMC Article
Consumption of red meat and processed meat and cancer incidence: a systematic review and meta-analysis of prospective studies.
Farvid MS, Sidahmed E, Spence ND, Mante Angua K, Rosner BA, Barnett JB
Eur J Epidemiol 2021 Sep;36(9):937-951. Epub 2021 Aug 29 doi: 10.1007/s10654-021-00741-9. PMID: 34455534
Surveillance Imaging and Alpha Fetoprotein for Early Detection of Hepatocellular Carcinoma in Patients With Cirrhosis: A Meta-analysis.
Tzartzeva K, Obi J, Rich NE, Parikh ND, Marrero JA, Yopp A, Waljee AK, Singal AG
Gastroenterology 2018 May;154(6):1706-1718.e1. Epub 2018 Feb 6 doi: 10.1053/j.gastro.2018.01.064. PMID: 29425931Free PMC Article
Nonalcoholic fatty liver disease: a systematic review.
Rinella ME
JAMA 2015 Jun 9;313(22):2263-73. doi: 10.1001/jama.2015.5370. PMID: 26057287

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