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Increased risk of hepatocellular carcinoma

MedGen UID:
349592
•Concept ID:
C1862761
•
Finding
Synonym: Increased hepatocellular carcinoma risk

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased risk of hepatocellular carcinoma

Professional guidelines

PubMed

Risk of Hepatocellular Carcinoma in Patients with Various HFE Genotypes.
Natarajan Y, Patel P, Chu J, Yu X, Hernaez R, El-Serag H, Kanwal F
Dig Dis Sci 2023 Jan;68(1):312-322. Epub 2022 Jul 5 doi: 10.1007/s10620-022-07602-9. PMID: 35790703
Emerging therapeutic approaches for the treatment of NAFLD and type 2 diabetes mellitus.
Ferguson D, Finck BN
Nat Rev Endocrinol 2021 Aug;17(8):484-495. Epub 2021 Jun 15 doi: 10.1038/s41574-021-00507-z. PMID: 34131333Free PMC Article
Hepatitis C Genotype 3 Infection: Pathogenesis and Treatment Horizons.
Maddur H, Flamm SL
Clin Liver Dis 2017 Nov;21(4):645-657. Epub 2017 Aug 5 doi: 10.1016/j.cld.2017.06.009. PMID: 28987253

Recent clinical studies

Etiology

Global trends in hepatocellular carcinoma epidemiology: implications for screening, prevention and therapy.
Singal AG, Kanwal F, Llovet JM
Nat Rev Clin Oncol 2023 Dec;20(12):864-884. Epub 2023 Oct 26 doi: 10.1038/s41571-023-00825-3. PMID: 37884736
Predictors of early and late hepatocellular carcinoma recurrence.
Nevola R, Ruocco R, Criscuolo L, Villani A, Alfano M, Beccia D, Imbriani S, Claar E, Cozzolino D, Sasso FC, Marrone A, Adinolfi LE, Rinaldi L
World J Gastroenterol 2023 Feb 28;29(8):1243-1260. doi: 10.3748/wjg.v29.i8.1243. PMID: 36925456Free PMC Article
Current epidemiology in hepatocellular carcinoma.
Konyn P, Ahmed A, Kim D
Expert Rev Gastroenterol Hepatol 2021 Nov;15(11):1295-1307. Epub 2021 Oct 22 doi: 10.1080/17474124.2021.1991792. PMID: 34624198
A global view of hepatocellular carcinoma: trends, risk, prevention and management.
Yang JD, Hainaut P, Gores GJ, Amadou A, Plymoth A, Roberts LR
Nat Rev Gastroenterol Hepatol 2019 Oct;16(10):589-604. Epub 2019 Aug 22 doi: 10.1038/s41575-019-0186-y. PMID: 31439937Free PMC Article
The diagnosis and treatment of hepatocellular carcinoma.
Hartke J, Johnson M, Ghabril M
Semin Diagn Pathol 2017 Mar;34(2):153-159. Epub 2016 Dec 20 doi: 10.1053/j.semdp.2016.12.011. PMID: 28108047

Diagnosis

Global trends in hepatocellular carcinoma epidemiology: implications for screening, prevention and therapy.
Singal AG, Kanwal F, Llovet JM
Nat Rev Clin Oncol 2023 Dec;20(12):864-884. Epub 2023 Oct 26 doi: 10.1038/s41571-023-00825-3. PMID: 37884736
Global Epidemiology and Genetics of Hepatocellular Carcinoma.
Toh MR, Wong EYT, Wong SH, Ng AWT, Loo LH, Chow PK, Ngeow J
Gastroenterology 2023 Apr;164(5):766-782. Epub 2023 Feb 2 doi: 10.1053/j.gastro.2023.01.033. PMID: 36738977
Artificial intelligence for the prevention and clinical management of hepatocellular carcinoma.
Calderaro J, Seraphin TP, Luedde T, Simon TG
J Hepatol 2022 Jun;76(6):1348-1361. doi: 10.1016/j.jhep.2022.01.014. PMID: 35589255Free PMC Article
Epidemiology and surveillance for hepatocellular carcinoma: New trends.
Singal AG, Lampertico P, Nahon P
J Hepatol 2020 Feb;72(2):250-261. doi: 10.1016/j.jhep.2019.08.025. PMID: 31954490Free PMC Article
The diagnosis and treatment of hepatocellular carcinoma.
Hartke J, Johnson M, Ghabril M
Semin Diagn Pathol 2017 Mar;34(2):153-159. Epub 2016 Dec 20 doi: 10.1053/j.semdp.2016.12.011. PMID: 28108047

Therapy

Predictors of early and late hepatocellular carcinoma recurrence.
Nevola R, Ruocco R, Criscuolo L, Villani A, Alfano M, Beccia D, Imbriani S, Claar E, Cozzolino D, Sasso FC, Marrone A, Adinolfi LE, Rinaldi L
World J Gastroenterol 2023 Feb 28;29(8):1243-1260. doi: 10.3748/wjg.v29.i8.1243. PMID: 36925456Free PMC Article
Entecavir plus Biejia-Ruangan compound reduces the risk of hepatocellular carcinoma in Chinese patients with chronic hepatitis B.
Ji D, Chen Y, Bi J, Shang Q, Liu H, Wang JB, Tan L, Wang J, Chen Y, Li Q, Long Q, Song L, Jiang L, Xiao G, Yu Z, Chen L, Wang X, Chen D, Li Z, Dong Z, Yang Y
J Hepatol 2022 Dec;77(6):1515-1524. Epub 2022 Aug 18 doi: 10.1016/j.jhep.2022.07.018. PMID: 35985545
Adjuvant immunotherapy with autologous cytokine-induced killer cells for hepatocellular carcinoma.
Lee JH, Lee JH, Lim YS, Yeon JE, Song TJ, Yu SJ, Gwak GY, Kim KM, Kim YJ, Lee JW, Yoon JH
Gastroenterology 2015 Jun;148(7):1383-91.e6. Epub 2015 Mar 4 doi: 10.1053/j.gastro.2015.02.055. PMID: 25747273
Hepatocellular carcinoma.
Marrero JA
Curr Opin Gastroenterol 2006 May;22(3):248-53. doi: 10.1097/01.mog.0000218961.86182.8c. PMID: 16550039
Hepatocellular carcinoma in cirrhosis: incidence and risk factors.
Fattovich G, Stroffolini T, Zagni I, Donato F
Gastroenterology 2004 Nov;127(5 Suppl 1):S35-50. doi: 10.1053/j.gastro.2004.09.014. PMID: 15508101

Prognosis

Predictors of early and late hepatocellular carcinoma recurrence.
Nevola R, Ruocco R, Criscuolo L, Villani A, Alfano M, Beccia D, Imbriani S, Claar E, Cozzolino D, Sasso FC, Marrone A, Adinolfi LE, Rinaldi L
World J Gastroenterol 2023 Feb 28;29(8):1243-1260. doi: 10.3748/wjg.v29.i8.1243. PMID: 36925456Free PMC Article
Global epidemiology of alcohol-associated cirrhosis and HCC: trends, projections and risk factors.
Huang DQ, Mathurin P, Cortez-Pinto H, Loomba R
Nat Rev Gastroenterol Hepatol 2023 Jan;20(1):37-49. Epub 2022 Oct 18 doi: 10.1038/s41575-022-00688-6. PMID: 36258033Free PMC Article
Current epidemiology in hepatocellular carcinoma.
Konyn P, Ahmed A, Kim D
Expert Rev Gastroenterol Hepatol 2021 Nov;15(11):1295-1307. Epub 2021 Oct 22 doi: 10.1080/17474124.2021.1991792. PMID: 34624198
Global epidemiology of NAFLD-related HCC: trends, predictions, risk factors and prevention.
Huang DQ, El-Serag HB, Loomba R
Nat Rev Gastroenterol Hepatol 2021 Apr;18(4):223-238. Epub 2020 Dec 21 doi: 10.1038/s41575-020-00381-6. PMID: 33349658Free PMC Article
Epidemiology and surveillance for hepatocellular carcinoma: New trends.
Singal AG, Lampertico P, Nahon P
J Hepatol 2020 Feb;72(2):250-261. doi: 10.1016/j.jhep.2019.08.025. PMID: 31954490Free PMC Article

Clinical prediction guides

Predictors of early and late hepatocellular carcinoma recurrence.
Nevola R, Ruocco R, Criscuolo L, Villani A, Alfano M, Beccia D, Imbriani S, Claar E, Cozzolino D, Sasso FC, Marrone A, Adinolfi LE, Rinaldi L
World J Gastroenterol 2023 Feb 28;29(8):1243-1260. doi: 10.3748/wjg.v29.i8.1243. PMID: 36925456Free PMC Article
Integrating genetic variants into clinical models for hepatocellular carcinoma risk stratification in cirrhosis.
Nahon P, Bamba-Funck J, Layese R, Trépo E, Zucman-Rossi J, Cagnot C, Ganne-Carrié N, Chaffaut C, Guyot E, Ziol M, Sutton A, Audureau E; ANRS CO12 CirVir and CIRRAL groups
J Hepatol 2023 Mar;78(3):584-595. Epub 2022 Nov 22 doi: 10.1016/j.jhep.2022.11.003. PMID: 36427656
Cuproptosis-Related Risk Score Predicts Prognosis and Characterizes the Tumor Microenvironment in Hepatocellular Carcinoma.
Zhang Z, Zeng X, Wu Y, Liu Y, Zhang X, Song Z
Front Immunol 2022;13:925618. Epub 2022 Jul 11 doi: 10.3389/fimmu.2022.925618. PMID: 35898502Free PMC Article
Combined hepatocellular-cholangiocarcinoma: An update.
Beaufrère A, Calderaro J, Paradis V
J Hepatol 2021 May;74(5):1212-1224. Epub 2021 Feb 3 doi: 10.1016/j.jhep.2021.01.035. PMID: 33545267
Hepatocellular carcinoma in cirrhosis: incidence and risk factors.
Fattovich G, Stroffolini T, Zagni I, Donato F
Gastroenterology 2004 Nov;127(5 Suppl 1):S35-50. doi: 10.1053/j.gastro.2004.09.014. PMID: 15508101

Recent systematic reviews

Effect of sarcopenia on survival in patients with cirrhosis: A meta-analysis.
Tantai X, Liu Y, Yeo YH, Praktiknjo M, Mauro E, Hamaguchi Y, Engelmann C, Zhang P, Jeong JY, van Vugt JLA, Xiao H, Deng H, Gao X, Ye Q, Zhang J, Yang L, Cai Y, Liu Y, Liu N, Li Z, Han T, Kaido T, Sohn JH, Strassburg C, Berg T, Trebicka J, Hsu YC, IJzermans JNM, Wang J, Su GL, Ji F, Nguyen MH
J Hepatol 2022 Mar;76(3):588-599. Epub 2021 Nov 14 doi: 10.1016/j.jhep.2021.11.006. PMID: 34785325
Consumption of red meat and processed meat and cancer incidence: a systematic review and meta-analysis of prospective studies.
Farvid MS, Sidahmed E, Spence ND, Mante Angua K, Rosner BA, Barnett JB
Eur J Epidemiol 2021 Sep;36(9):937-951. Epub 2021 Aug 29 doi: 10.1007/s10654-021-00741-9. PMID: 34455534
Obesity and the risk of primary liver cancer: A systematic review and meta-analysis.
Sohn W, Lee HW, Lee S, Lim JH, Lee MW, Park CH, Yoon SK
Clin Mol Hepatol 2021 Jan;27(1):157-174. Epub 2020 Nov 26 doi: 10.3350/cmh.2020.0176. PMID: 33238333Free PMC Article
Surveillance Imaging and Alpha Fetoprotein for Early Detection of Hepatocellular Carcinoma in Patients With Cirrhosis: A Meta-analysis.
Tzartzeva K, Obi J, Rich NE, Parikh ND, Marrero JA, Yopp A, Waljee AK, Singal AG
Gastroenterology 2018 May;154(6):1706-1718.e1. Epub 2018 Feb 6 doi: 10.1053/j.gastro.2018.01.064. PMID: 29425931Free PMC Article
Nonalcoholic fatty liver disease: a systematic review.
Rinella ME
JAMA 2015 Jun 9;313(22):2263-73. doi: 10.1001/jama.2015.5370. PMID: 26057287

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