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Storm syndrome

MedGen UID:
350029
•Concept ID:
C1861452
•
Disease or Syndrome
Synonym: Pleiotropic, autosomal dominant disorder affecting connective tissue
 
Monarch Initiative: MONDO:0008496
OMIM®: 185069

Professional guidelines

PubMed

Spontaneous NLRP3 inflammasome-driven IL-1-β secretion is induced in severe COVID-19 patients and responds to anakinra treatment.
Bertoni A, Penco F, Mollica H, Bocca P, Prigione I, Corcione A, Cangelosi D, Schena F, Del Zotto G, Amaro A, Paladino N, Pontali E, Feasi M, Signa S, Bustaffa M, Caorsi R, Palmeri S, Contini P, De Palma R, Pfeffer U, Uva P, Rubartelli A, Gattorno M, Volpi S
J Allergy Clin Immunol 2022 Oct;150(4):796-805. Epub 2022 Jul 11 doi: 10.1016/j.jaci.2022.05.029. PMID: 35835255Free PMC Article
Cytokine storm in COVID-19: pathogenesis and overview of anti-inflammatory agents used in treatment.
Soy M, Keser G, Atagündüz P, Tabak F, Atagündüz I, Kayhan S
Clin Rheumatol 2020 Jul;39(7):2085-2094. Epub 2020 May 30 doi: 10.1007/s10067-020-05190-5. PMID: 32474885Free PMC Article
COVID-19: Immunology and treatment options.
Felsenstein S, Herbert JA, McNamara PS, Hedrich CM
Clin Immunol 2020 Jun;215:108448. Epub 2020 Apr 27 doi: 10.1016/j.clim.2020.108448. PMID: 32353634Free PMC Article

Recent clinical studies

Etiology

Immune-based therapeutic approaches in COVID-19.
Moeinafshar A, Yazdanpanah N, Rezaei N
Biomed Pharmacother 2022 Jul;151:113107. Epub 2022 May 16 doi: 10.1016/j.biopha.2022.113107. PMID: 35594701Free PMC Article
Malignancy-associated haemophagocytic lymphohistiocytosis.
Setiadi A, Zoref-Lorenz A, Lee CY, Jordan MB, Chen LYC
Lancet Haematol 2022 Mar;9(3):e217-e227. Epub 2022 Jan 31 doi: 10.1016/S2352-3026(21)00366-5. PMID: 35101205
COVID-19-associated opportunistic infections: a snapshot on the current reports.
Abdoli A, Falahi S, Kenarkoohi A
Clin Exp Med 2022 Aug;22(3):327-346. Epub 2021 Aug 23 doi: 10.1007/s10238-021-00751-7. PMID: 34424451Free PMC Article
Cytokine storm in COVID-19: pathogenesis and overview of anti-inflammatory agents used in treatment.
Soy M, Keser G, Atagündüz P, Tabak F, Atagündüz I, Kayhan S
Clin Rheumatol 2020 Jul;39(7):2085-2094. Epub 2020 May 30 doi: 10.1007/s10067-020-05190-5. PMID: 32474885Free PMC Article
The genetics of macrophage activation syndrome.
Schulert GS, Cron RQ
Genes Immun 2020 May;21(3):169-181. Epub 2020 Apr 15 doi: 10.1038/s41435-020-0098-4. PMID: 32291394

Diagnosis

Cytokine Storm Syndrome.
Cron RQ, Goyal G, Chatham WW
Annu Rev Med 2023 Jan 27;74:321-337. Epub 2022 Oct 13 doi: 10.1146/annurev-med-042921-112837. PMID: 36228171
Malignancy-associated haemophagocytic lymphohistiocytosis.
Setiadi A, Zoref-Lorenz A, Lee CY, Jordan MB, Chen LYC
Lancet Haematol 2022 Mar;9(3):e217-e227. Epub 2022 Jan 31 doi: 10.1016/S2352-3026(21)00366-5. PMID: 35101205
COVID-19-associated opportunistic infections: a snapshot on the current reports.
Abdoli A, Falahi S, Kenarkoohi A
Clin Exp Med 2022 Aug;22(3):327-346. Epub 2021 Aug 23 doi: 10.1007/s10238-021-00751-7. PMID: 34424451Free PMC Article
Hemophagocytic lymphohistiocytosis: a review inspired by the COVID-19 pandemic.
Soy M, Atagündüz P, Atagündüz I, Sucak GT
Rheumatol Int 2021 Jan;41(1):7-18. Epub 2020 Jun 25 doi: 10.1007/s00296-020-04636-y. PMID: 32588191Free PMC Article
SARS-CoV-2-triggered neutrophil extracellular traps mediate COVID-19 pathology.
Veras FP, Pontelli MC, Silva CM, Toller-Kawahisa JE, de Lima M, Nascimento DC, Schneider AH, Caetité D, Tavares LA, Paiva IM, Rosales R, Colón D, Martins R, Castro IA, Almeida GM, Lopes MIF, Benatti MN, Bonjorno LP, Giannini MC, Luppino-Assad R, Almeida SL, Vilar F, Santana R, Bollela VR, Auxiliadora-Martins M, Borges M, Miranda CH, Pazin-Filho A, da Silva LLP, Cunha LD, Zamboni DS, Dal-Pizzol F, Leiria LO, Siyuan L, Batah S, Fabro A, Mauad T, Dolhnikoff M, Duarte-Neto A, Saldiva P, Cunha TM, Alves-Filho JC, Arruda E, Louzada-Junior P, Oliveira RD, Cunha FQ
J Exp Med 2020 Dec 7;217(12) doi: 10.1084/jem.20201129. PMID: 32926098Free PMC Article

Therapy

Spontaneous NLRP3 inflammasome-driven IL-1-β secretion is induced in severe COVID-19 patients and responds to anakinra treatment.
Bertoni A, Penco F, Mollica H, Bocca P, Prigione I, Corcione A, Cangelosi D, Schena F, Del Zotto G, Amaro A, Paladino N, Pontali E, Feasi M, Signa S, Bustaffa M, Caorsi R, Palmeri S, Contini P, De Palma R, Pfeffer U, Uva P, Rubartelli A, Gattorno M, Volpi S
J Allergy Clin Immunol 2022 Oct;150(4):796-805. Epub 2022 Jul 11 doi: 10.1016/j.jaci.2022.05.029. PMID: 35835255Free PMC Article
COVID-19-associated opportunistic infections: a snapshot on the current reports.
Abdoli A, Falahi S, Kenarkoohi A
Clin Exp Med 2022 Aug;22(3):327-346. Epub 2021 Aug 23 doi: 10.1007/s10238-021-00751-7. PMID: 34424451Free PMC Article
COVID-19: biologic and immunosuppressive therapy in gastroenterology and hepatology.
Neurath MF
Nat Rev Gastroenterol Hepatol 2021 Oct;18(10):705-715. Epub 2021 Jun 29 doi: 10.1038/s41575-021-00480-y. PMID: 34188251Free PMC Article
Lymphopenia in COVID-19: Therapeutic opportunities.
Fathi N, Rezaei N
Cell Biol Int 2020 Sep;44(9):1792-1797. Epub 2020 Jun 3 doi: 10.1002/cbin.11403. PMID: 32458561Free PMC Article
COVID-19: Immunology and treatment options.
Felsenstein S, Herbert JA, McNamara PS, Hedrich CM
Clin Immunol 2020 Jun;215:108448. Epub 2020 Apr 27 doi: 10.1016/j.clim.2020.108448. PMID: 32353634Free PMC Article

Prognosis

Is severe COVID-19 a cytokine storm syndrome: a hyperinflammatory debate.
Mehta P, Fajgenbaum DC
Curr Opin Rheumatol 2021 Sep 1;33(5):419-430. doi: 10.1097/BOR.0000000000000822. PMID: 34264880Free PMC Article
COVID-19 and cytokine storm syndrome: can what we know about interleukin-6 in ovarian cancer be applied?
Macciò A, Oppi S, Madeddu C
J Ovarian Res 2021 Feb 8;14(1):28. doi: 10.1186/s13048-021-00772-6. PMID: 33550983Free PMC Article
Confronting the controversy: interleukin-6 and the COVID-19 cytokine storm syndrome.
Chen LYC, Hoiland RL, Stukas S, Wellington CL, Sekhon MS
Eur Respir J 2020 Oct;56(4) Epub 2020 Oct 1 doi: 10.1183/13993003.03006-2020. PMID: 32883678Free PMC Article
Cytokine storm in COVID-19: pathogenesis and overview of anti-inflammatory agents used in treatment.
Soy M, Keser G, Atagündüz P, Tabak F, Atagündüz I, Kayhan S
Clin Rheumatol 2020 Jul;39(7):2085-2094. Epub 2020 May 30 doi: 10.1007/s10067-020-05190-5. PMID: 32474885Free PMC Article
COVID-19: Immunology and treatment options.
Felsenstein S, Herbert JA, McNamara PS, Hedrich CM
Clin Immunol 2020 Jun;215:108448. Epub 2020 Apr 27 doi: 10.1016/j.clim.2020.108448. PMID: 32353634Free PMC Article

Clinical prediction guides

Cytokine Responses to Adenovirus and Adenovirus Vectors.
Atasheva S, Shayakhmetov DM
Viruses 2022 Apr 24;14(5) doi: 10.3390/v14050888. PMID: 35632630Free PMC Article
Pathophysiology of COVID-19-associated acute kidney injury.
Legrand M, Bell S, Forni L, Joannidis M, Koyner JL, Liu K, Cantaluppi V
Nat Rev Nephrol 2021 Nov;17(11):751-764. Epub 2021 Jul 5 doi: 10.1038/s41581-021-00452-0. PMID: 34226718Free PMC Article
The 'cytokine storm': molecular mechanisms and therapeutic prospects.
Karki R, Kanneganti TD
Trends Immunol 2021 Aug;42(8):681-705. Epub 2021 Jul 1 doi: 10.1016/j.it.2021.06.001. PMID: 34217595Free PMC Article
The multifaceted role of plasminogen in inflammation.
Heissig B, Salama Y, Takahashi S, Osada T, Hattori K
Cell Signal 2020 Nov;75:109761. Epub 2020 Aug 28 doi: 10.1016/j.cellsig.2020.109761. PMID: 32861744Free PMC Article
COVID-19: Immunology and treatment options.
Felsenstein S, Herbert JA, McNamara PS, Hedrich CM
Clin Immunol 2020 Jun;215:108448. Epub 2020 Apr 27 doi: 10.1016/j.clim.2020.108448. PMID: 32353634Free PMC Article

Recent systematic reviews

Cepacia syndrome in cystic fibrosis: A systematic review of the literature and possible new perspectives in treatment.
Daccò V, Alicandro G, Consales A, Rosazza C, Sciarrabba CS, Cariani L, Colombo C
Pediatr Pulmonol 2023 May;58(5):1337-1343. Epub 2023 Mar 8 doi: 10.1002/ppul.26359. PMID: 36815622
Use of therapeutic plasma exchange in COVID-19: A systematic review of current evidence.
Carlson N, Szpirt WM
Ther Apher Dial 2022 Dec;26 Suppl 1(Suppl 1):3-11. Epub 2022 Dec 5 doi: 10.1111/1744-9987.13779. PMID: 36468346Free PMC Article
Biomarkers of cytokine storm as red flags for severe and fatal COVID-19 cases: A living systematic review and meta-analysis.
Melo AKG, Milby KM, Caparroz ALMA, Pinto ACPN, Santos RRP, Rocha AP, Ferreira GA, Souza VA, Valadares LDA, Vieira RMRA, Pileggi GS, Trevisani VFM
PLoS One 2021;16(6):e0253894. Epub 2021 Jun 29 doi: 10.1371/journal.pone.0253894. PMID: 34185801Free PMC Article
Tocilizumab and COVID-19: a meta-analysis of 2120 patients with severe disease and implications for clinical trial methodologies.
Sarfraz A, Sarfraz Z, Sarfraz M, Aftab H, Pervaiz Z
Turk J Med Sci 2021 Jun 28;51(3):890-897. doi: 10.3906/sag-2010-131. PMID: 33244947Free PMC Article
Mortality in tocilizumab-treated patients with COVID-19: a systematic review and meta-analysis.
Berardicurti O, Ruscitti P, Ursini F, D'Andrea S, Ciaffi J, Meliconi R, Iagnocco A, Cipriani P, Giacomelli R
Clin Exp Rheumatol 2020 Nov-Dec;38(6):1247-1254. Epub 2020 Dec 3 PMID: 33275094

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