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Cluster headache

MedGen UID:
3503
Concept ID:
C0009088
Disease or Syndrome
Synonym: Cluster headache syndrome
SNOMED CT: Cluster headache (193031009); Cluster headache syndrome (193031009); Migrainous neuralgia (193031009); Horton's headache (193031009); Vasomotor headache (193031009); Histamine cephalgia (193031009); Neuralgic migraine (193031009); Histamine headache (193031009); Horton's neuralgia (193031009); Ciliary neuralgia (193947008); Chronic cluster headache (230473009)
 
HPO: HP:0012199
Monarch Initiative: MONDO:0043537

Definition

A type of headache characterized by repeated attacks of unilateral pain lasting 15 to 180 minutes and associated with local autonomic signs. [from HPO]

Term Hierarchy

Conditions with this feature

Cluster headache, familial
MedGen UID:
350040
Concept ID:
C1861513
Disease or Syndrome
The Headache Classification Committee of the International Headache Society (1988) listed the following criteria for cluster headache (CH): at least 5 attacks of severe unilateral orbital, supraorbital, and/or temporal pain, lasting 15 to 180 minutes, associated with at least 1 of 8 local autonomic signs, and occurring once every other day to 8 per day. Approximately 85% of CH patients have the episodic subtype, in which the headaches occur in cluster periods lasting from 7 days to 1 year and separated by attack-free intervals of 1 month or more. The remainder of patients have the chronic subtype, in which attacks recur for greater than 1 year without remission or with remissions lasting less than 1 month (Lipton et al., 2004).

Professional guidelines

PubMed

Schindler EAD, Burish MJ
BMJ 2022 Mar 16;376:e059577. doi: 10.1136/bmj-2020-059577. PMID: 35296510
Diener HC, May A
Drugs 2022 Jan;82(1):33-42. Epub 2021 Dec 17 doi: 10.1007/s40265-021-01658-z. PMID: 34919214Free PMC Article
Hoffmann J, May A
Lancet Neurol 2018 Jan;17(1):75-83. Epub 2017 Nov 23 doi: 10.1016/S1474-4422(17)30405-2. PMID: 29174963

Curated

UK NICE Guideline CG150, Headaches in over 12s: diagnosis and management, 2021

Recent clinical studies

Etiology

Burish M
Continuum (Minneap Minn) 2024 Apr 1;30(2):391-410. doi: 10.1212/CON.0000000000001411. PMID: 38568490
Coppola G, Magis D, Casillo F, Sebastianelli G, Abagnale C, Cioffi E, Di Lenola D, Di Lorenzo C, Serrao M
Curr Pain Headache Rep 2022 Mar;26(3):267-278. Epub 2022 Feb 7 doi: 10.1007/s11916-022-01025-x. PMID: 35129825Free PMC Article
Diener HC, May A
Drugs 2022 Jan;82(1):33-42. Epub 2021 Dec 17 doi: 10.1007/s40265-021-01658-z. PMID: 34919214Free PMC Article
Cheema S, Matharu M
Neurol India 2021 Mar-Apr;69(Supplement):S124-S134. doi: 10.4103/0028-3886.315983. PMID: 34003158
Dueland AN
Headache 2015 Jul-Aug;55(7):1045-9. Epub 2015 Jun 29 doi: 10.1111/head.12621. PMID: 26121267

Diagnosis

Schindler EAD, Burish MJ
BMJ 2022 Mar 16;376:e059577. doi: 10.1136/bmj-2020-059577. PMID: 35296510
Cheema S, Matharu M
Neurol India 2021 Mar-Apr;69(Supplement):S124-S134. doi: 10.4103/0028-3886.315983. PMID: 34003158
Suri H, Ailani J
Curr Neurol Neurosci Rep 2021 May 5;21(7):31. doi: 10.1007/s11910-021-01114-1. PMID: 33948734
May A, Schwedt TJ, Magis D, Pozo-Rosich P, Evers S, Wang SJ
Nat Rev Dis Primers 2018 Mar 1;4:18006. doi: 10.1038/nrdp.2018.6. PMID: 29493566
Hoffmann J, May A
Lancet Neurol 2018 Jan;17(1):75-83. Epub 2017 Nov 23 doi: 10.1016/S1474-4422(17)30405-2. PMID: 29174963

Therapy

Kooijman NI, Willegers T, Reuser A, Mulleners WM, Kramers C, Vissers KCP, van der Wal SEI
Pain Pract 2023 Apr;23(4):447-458. Epub 2023 Jan 11 doi: 10.1111/papr.13203. PMID: 36597700
Schindler EAD, Burish MJ
BMJ 2022 Mar 16;376:e059577. doi: 10.1136/bmj-2020-059577. PMID: 35296510
Vuralli D, Ayata C, Bolay H
J Headache Pain 2018 Nov 15;19(1):109. doi: 10.1186/s10194-018-0933-4. PMID: 30442090Free PMC Article
Millstine D, Chen CY, Bauer B
BMJ 2017 May 16;357:j1805. doi: 10.1136/bmj.j1805. PMID: 28512119
Robbins MS, Starling AJ, Pringsheim TM, Becker WJ, Schwedt TJ
Headache 2016 Jul;56(7):1093-106. doi: 10.1111/head.12866. PMID: 27432623

Prognosis

Kim SA, Choi SY, Youn MS, Pozo-Rosich P, Lee MJ
Cephalalgia 2023 Sep;43(9):3331024231201577. doi: 10.1177/03331024231201577. PMID: 37728577
Messina R, Christensen RH, Cetta I, Ashina M, Filippi M
J Headache Pain 2023 May 24;24(1):58. doi: 10.1186/s10194-023-01590-5. PMID: 37221469Free PMC Article
Onderwater GLJ, Van Dongen RM, Zielman R, Terwindt GM, Ferrari MD
Handb Clin Neurol 2017;146:267-284. doi: 10.1016/B978-0-12-804279-3.00016-2. PMID: 29110775
Costa A, Antonaci F, Ramusino MC, Nappi G
Curr Neuropharmacol 2015;13(3):304-23. doi: 10.2174/1570159x13666150309233556. PMID: 26411963Free PMC Article
Leroux E, Ducros A
Orphanet J Rare Dis 2008 Jul 23;3:20. doi: 10.1186/1750-1172-3-20. PMID: 18651939Free PMC Article

Clinical prediction guides

Diener HC, Tassorelli C, Dodick DW
JAMA Neurol 2023 Mar 1;80(3):308-319. doi: 10.1001/jamaneurol.2022.4804. PMID: 36648786
Terrier LM, Hadjikhani N, Destrieux C
J Neurol 2022 Jul;269(7):3443-3460. Epub 2022 Mar 6 doi: 10.1007/s00415-022-11002-4. PMID: 35249132
Giamberardino MA, Affaitati G, Costantini R, Guglielmetti M, Martelletti P
Intern Emerg Med 2020 Jan;15(1):109-117. Epub 2020 Jan 1 doi: 10.1007/s11739-019-02266-2. PMID: 31893348
Ferini-Strambi L, Galbiati A, Combi R
Neurol Sci 2019 May;40(Suppl 1):107-113. doi: 10.1007/s10072-019-03837-z. PMID: 30906963
Onderwater GLJ, Van Dongen RM, Zielman R, Terwindt GM, Ferrari MD
Handb Clin Neurol 2017;146:267-284. doi: 10.1016/B978-0-12-804279-3.00016-2. PMID: 29110775

Recent systematic reviews

Musubire AK, Cheema S, Ray JC, Hutton EJ, Matharu M
J Headache Pain 2023 Apr 4;24(1):36. doi: 10.1186/s10194-023-01572-7. PMID: 37016284Free PMC Article
Membrilla JA, Roa J, Díaz-de-Terán J
J Neurol 2023 Feb;270(2):689-710. Epub 2022 Oct 31 doi: 10.1007/s00415-022-11436-w. PMID: 36310189
Xu J, Sun Z, Wu J, Rana M, Garza J, Zhu AC, Chakravarthy KV, Abd-Elsayed A, Rosenquist E, Basi H, Christo P, Cheng J
Pain Physician 2021 Mar;24(2):E131-E152. PMID: 33740342Free PMC Article
Robbins MS, Starling AJ, Pringsheim TM, Becker WJ, Schwedt TJ
Headache 2016 Jul;56(7):1093-106. doi: 10.1111/head.12866. PMID: 27432623
Matharu M
BMJ Clin Evid 2010 Feb 9;2010 PMID: 21718584Free PMC Article

Supplemental Content

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    Clinical resources

    Practice guidelines

    • PubMed
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    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2021
      UK NICE Guideline CG150, Headaches in over 12s: diagnosis and management, 2021

    Consumer resources

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