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Dermatitis, atopic(ATOD1)

MedGen UID:
350353
Concept ID:
C1864155
Disease or Syndrome
Synonym: Dermatitis, Atopic, 1
 
Monarch Initiative: MONDO:0011292
OMIM®: 603165

Clinical features

From HPO
Asthma
MedGen UID:
2109
Concept ID:
C0004096
Disease or Syndrome
Asthma is characterized by increased responsiveness of the tracheobronchial tree to multiple stimuli, leading to narrowing of the air passages with resultant dyspnea, cough, and wheezing.
Conjunctivitis
MedGen UID:
1093
Concept ID:
C0009763
Disease or Syndrome
Inflammation of the conjunctiva.
Atopic eczema
MedGen UID:
41502
Concept ID:
C0011615
Disease or Syndrome
Atopic dermatitis (ATOD), also known as eczema, is a common chronic pruritic inflammatory skin disease with a strong genetic component. Onset typically occurs during the first 2 years of life (review by Soderhall et al., 2007). Genetic Heterogeneity of Atopic Dermatitis Many inflammatory diseases, such as atopic eczema, are genetically complex, with multiple alleles at several loci thought to be involved in their pathogenesis. Several susceptibility loci for atopic dermatitis have been identified: ATOD1 on chromosome 3q21, ATOD2 (605803) on chromosome 1q21, ATOD3 (605804) on chromosome 20p, ATOD4 (605805) on chromosome 17q25.3, ATOD5 (603165) on chromosome 13q12-q14, ATOD6 (605845) on chromosome 5q31-q33, ATOD7 (613064) on chromosome 11q13.5, ATOD8 (613518) on chromosome 4q22.1, and ATOD9 (613519) on chromosome 3p24.
Eczematoid dermatitis
MedGen UID:
3968
Concept ID:
C0013595
Disease or Syndrome
Eczema is a form of dermatitis that is characterized by scaly, pruritic, erythematous lesions located on flexural surfaces.
Recurrent skin infections
MedGen UID:
377848
Concept ID:
C1853193
Disease or Syndrome
Infections of the skin that happen multiple times.
Allergic rhinitis
MedGen UID:
382012
Concept ID:
C2607914
Disease or Syndrome
It is characterized by one or more symptoms including sneezing, itching, nasal congestion, and rhinorrhea.
Food intolerance
MedGen UID:
57440
Concept ID:
C0149696
Finding
A detrimental reaction to a food, beverage, food additive, or compound found in foods that produces symptoms in one or more body organs and systems that is not mediated by an immune reaction.
Abnormality of metabolism/homeostasis
MedGen UID:
867398
Concept ID:
C4021768
Finding
Infra-orbital fold
MedGen UID:
869032
Concept ID:
C4023449
Finding
Elevated ridge(s) of skin starting well below the medial aspect of the lower lid that curves gradually upward toward and/or across the nasal bridge.
Ichthyosis
MedGen UID:
7002
Concept ID:
C0020757
Disease or Syndrome
An abnormality of the skin characterized the presence of excessive amounts of dry surface scales on the skin resulting from an abnormality of keratinization.
Pallor
MedGen UID:
10547
Concept ID:
C0030232
Finding
Abnormally pale skin.
Pruritus
MedGen UID:
19534
Concept ID:
C0033774
Sign or Symptom
Pruritus is an itch or a sensation that makes a person want to scratch. This term refers to an abnormally increased disposition to experience pruritus.
Dry skin
MedGen UID:
56250
Concept ID:
C0151908
Sign or Symptom
Skin characterized by the lack of natural or normal moisture.
Facial erythema
MedGen UID:
65986
Concept ID:
C0239488
Finding
Redness of the skin of the face, caused by hyperemia of the capillaries in the lower layers of the skin.
Keratosis pilaris
MedGen UID:
82664
Concept ID:
C0263383
Disease or Syndrome
An anomaly of the hair follicles of the skin that typically presents as small, rough, brown folliculocentric papules distributed over characteristic areas of the skin, particularly the outer-upper arms and thighs.
Flexural lichenification
MedGen UID:
870427
Concept ID:
C4024873
Disease or Syndrome
Lichenification affecting primarily flexural areas of the skin.
Keratoconus
MedGen UID:
44015
Concept ID:
C0022578
Disease or Syndrome
A cone-shaped deformity of the cornea characterized by the presence of corneal distortion secondary to thinning of the apex.
Cataract
MedGen UID:
39462
Concept ID:
C0086543
Disease or Syndrome
A cataract is an opacity or clouding that develops in the crystalline lens of the eye or in its capsule.

Professional guidelines

PubMed

Wise SK, Damask C, Roland LT, Ebert C, Levy JM, Lin S, Luong A, Rodriguez K, Sedaghat AR, Toskala E, Villwock J, Abdullah B, Akdis C, Alt JA, Ansotegui IJ, Azar A, Baroody F, Benninger MS, Bernstein J, Brook C, Campbell R, Casale T, Chaaban MR, Chew FT, Chambliss J, Cianferoni A, Custovic A, Davis EM, DelGaudio JM, Ellis AK, Flanagan C, Fokkens WJ, Franzese C, Greenhawt M, Gill A, Halderman A, Hohlfeld JM, Incorvaia C, Joe SA, Joshi S, Kuruvilla ME, Kim J, Klein AM, Krouse HJ, Kuan EC, Lang D, Larenas-Linnemann D, Laury AM, Lechner M, Lee SE, Lee VS, Loftus P, Marcus S, Marzouk H, Mattos J, McCoul E, Melen E, Mims JW, Mullol J, Nayak JV, Oppenheimer J, Orlandi RR, Phillips K, Platt M, Ramanathan M Jr, Raymond M, Rhee CS, Reitsma S, Ryan M, Sastre J, Schlosser RJ, Schuman TA, Shaker MS, Sheikh A, Smith KA, Soyka MB, Takashima M, Tang M, Tantilipikorn P, Taw MB, Tversky J, Tyler MA, Veling MC, Wallace D, Wang Y, White A, Zhang L
Int Forum Allergy Rhinol 2023 Apr;13(4):293-859. Epub 2023 Mar 6 doi: 10.1002/alr.23090. PMID: 36878860
Wollenberg A, Werfel T, Ring J, Ott H, Gieler U, Weidinger S
Dtsch Arztebl Int 2023 Mar 31;120(13):224-234. doi: 10.3238/arztebl.m2023.0011. PMID: 36747484Free PMC Article
Frazier W, Bhardwaj N
Am Fam Physician 2020 May 15;101(10):590-598. PMID: 32412211

Recent clinical studies

Etiology

Napolitano M, Fabbrocini G, Martora F, Genco L, Noto M, Patruno C
Dermatol Ther 2022 Dec;35(12):e15901. Epub 2022 Oct 13 doi: 10.1111/dth.15901. PMID: 36200594Free PMC Article
Williams HC, Chalmers J
Acta Derm Venereol 2020 Jun 9;100(12):adv00166. doi: 10.2340/00015555-3516. PMID: 32419030Free PMC Article
Avena-Woods C
Am J Manag Care 2017 Jun;23(8 Suppl):S115-S123. PMID: 28978208
Weidinger S, Novak N
Lancet 2016 Mar 12;387(10023):1109-1122. Epub 2015 Sep 13 doi: 10.1016/S0140-6736(15)00149-X. PMID: 26377142
Nutten S
Ann Nutr Metab 2015;66 Suppl 1:8-16. Epub 2015 Apr 24 doi: 10.1159/000370220. PMID: 25925336

Diagnosis

Schuler CF 4th, Billi AC, Maverakis E, Tsoi LC, Gudjonsson JE
J Allergy Clin Immunol 2023 May;151(5):1145-1154. Epub 2022 Nov 22 doi: 10.1016/j.jaci.2022.10.023. PMID: 36428114Free PMC Article
Ramírez-Marín HA, Silverberg JI
Pediatr Dermatol 2022 May;39(3):345-353. Epub 2022 Mar 16 doi: 10.1111/pde.14971. PMID: 35297082
Ständer S
N Engl J Med 2021 Mar 25;384(12):1136-1143. doi: 10.1056/NEJMra2023911. PMID: 33761208
Torres T, Ferreira EO, Gonçalo M, Mendes-Bastos P, Selores M, Filipe P
Acta Med Port 2019 Sep 2;32(9):606-613. doi: 10.20344/amp.11963. PMID: 31493365
Avena-Woods C
Am J Manag Care 2017 Jun;23(8 Suppl):S115-S123. PMID: 28978208

Therapy

Reich K, Silverberg JI, Papp KA, Deleuran M, Katoh N, Strober B, Beck LA, de Bruin-Weller M, Werfel T, Zhang F, Biswas P, DiBonaventura MD, Chan G, Johnson S, Farooqui SA, Kerkmann U, Clibborn C
J Eur Acad Dermatol Venereol 2023 Oct;37(10):2056-2066. Epub 2023 Jul 11 doi: 10.1111/jdv.19280. PMID: 37335885
Crocetti L, Floresta G, Cilibrizzi A, Giovannoni MP
Molecules 2022 Aug 4;27(15) doi: 10.3390/molecules27154964. PMID: 35956914Free PMC Article
Simpson EL, Papp KA, Blauvelt A, Chu CY, Hong HC, Katoh N, Calimlim BM, Thyssen JP, Chiou AS, Bissonnette R, Stein Gold LF, Wegzyn C, Hu X, Liu M, Liu J, Tenorio AR, Chu AD, Guttman-Yassky E
JAMA Dermatol 2022 Apr 1;158(4):404-413. doi: 10.1001/jamadermatol.2022.0029. PMID: 35262646Free PMC Article
Nakajima S, Kabata H, Kabashima K, Asano K
Allergol Int 2020 Apr;69(2):197-203. Epub 2020 Jan 21 doi: 10.1016/j.alit.2020.01.001. PMID: 31974038
Hoare C, Li Wan Po A, Williams H
Health Technol Assess 2000;4(37):1-191. PMID: 11134919Free PMC Article

Prognosis

Tian J, Zhang D, Yang Y, Huang Y, Wang L, Yao X, Lu Q
Br J Dermatol 2023 Dec 20;190(1):55-61. doi: 10.1093/bjd/ljad339. PMID: 37705227
Endre KMA, Landrø L, LeBlanc M, Gjersvik P, Lødrup Carlsen KC, Haugen G, Hedlin G, Jonassen CM, Nordlund B, Rudi K, Skjerven HO, Staff AC, Söderhäll C, Vettukattil R, Rehbinder EM
Br J Dermatol 2022 Jan;186(1):50-58. Epub 2021 May 6 doi: 10.1111/bjd.19831. PMID: 33511639
El Hachem M, Naldi L, Neri I, Pedone MP, Fanelli F, Galeone C
Ital J Dermatol Venerol 2021 Dec;156(6):650-658. Epub 2020 Oct 16 doi: 10.23736/S2784-8671.20.06669-9. PMID: 33070573
Bylund S, Kobyletzki LB, Svalstedt M, Svensson Å
Acta Derm Venereol 2020 Jun 9;100(12):adv00160. doi: 10.2340/00015555-3510. PMID: 32412646Free PMC Article
Ridolo E, Incorvaia C, Martignago I, Caminati M, Canonica GW, Senna G
Clin Rev Allergy Immunol 2019 Jun;56(3):322-332. doi: 10.1007/s12016-017-8661-0. PMID: 29306980

Clinical prediction guides

Vestergaard C, Skovsgaard C, Johansen C, Deleuran M, Thyssen JP
Am J Clin Dermatol 2024 Jan;25(1):91-98. Epub 2023 Dec 11 doi: 10.1007/s40257-023-00827-y. PMID: 38079107
Kwatra SG, Yosipovitch G, Legat FJ, Reich A, Paul C, Simon D, Naldi L, Lynde C, De Bruin-Weller MS, Nahm WK, Sauder M, Gharib R, Barbarot S, Szepietowski JC, Conrad C, Fleischer A, Laquer VT, Misery L, Serra-Baldrich E, Lapeere H, Ahmad F, Jabbar Lopez ZK, Piketty C, Ständer S; OLYMPIA 2 Investigators
N Engl J Med 2023 Oct 26;389(17):1579-1589. doi: 10.1056/NEJMoa2301333. PMID: 37888917
Ali F, Vyas J, Finlay AY
Acta Derm Venereol 2020 Jun 9;100(12):adv00161. doi: 10.2340/00015555-3511. PMID: 32412644Free PMC Article
Beck LA, Thaçi D, Hamilton JD, Graham NM, Bieber T, Rocklin R, Ming JE, Ren H, Kao R, Simpson E, Ardeleanu M, Weinstein SP, Pirozzi G, Guttman-Yassky E, Suárez-Fariñas M, Hager MD, Stahl N, Yancopoulos GD, Radin AR
N Engl J Med 2014 Jul 10;371(2):130-9. doi: 10.1056/NEJMoa1314768. PMID: 25006719
Dermatology 1993;186(1):23-31. doi: 10.1159/000247298. PMID: 8435513

Recent systematic reviews

Tian J, Zhang D, Yang Y, Huang Y, Wang L, Yao X, Lu Q
Br J Dermatol 2023 Dec 20;190(1):55-61. doi: 10.1093/bjd/ljad339. PMID: 37705227
Chu AWL, Wong MM, Rayner DG, Guyatt GH, Díaz Martinez JP, Ceccacci R, Zhao IX, McMullen E, Srivastava A, Wang J, Wen A, Wang FC, Brignardello-Petersen R, Izcovich A, Oykhman P, Wheeler KE, Wang J, Spergel JM, Singh JA, Silverberg JI, Ong PY, O'Brien M, Martin SA, Lio PA, Lind ML, LeBovidge J, Kim E, Huynh J, Greenhawt M, Gardner DD, Frazier WT, Ellison K, Chen L, Capozza K, De Benedetto A, Boguniewicz M, Smith Begolka W, Asiniwasis RN, Schneider LC, Chu DK
J Allergy Clin Immunol 2023 Dec;152(6):1470-1492. Epub 2023 Sep 9 doi: 10.1016/j.jaci.2023.08.029. PMID: 37678577
Drucker AM, Morra DE, Prieto-Merino D, Ellis AG, Yiu ZZN, Rochwerg B, Di Giorgio S, Arents BWM, Burton T, Spuls PI, Schmitt J, Flohr C
JAMA Dermatol 2022 May 1;158(5):523-532. doi: 10.1001/jamadermatol.2022.0455. PMID: 35293977Free PMC Article
Silverberg JI, Thyssen JP, Fahrbach K, Mickle K, Cappelleri JC, Romero W, Cameron MC, Myers DE, Clibborn C, DiBonaventura M
J Eur Acad Dermatol Venereol 2021 Sep;35(9):1797-1810. Epub 2021 Jun 12 doi: 10.1111/jdv.17351. PMID: 33991374Free PMC Article
Bylund S, Kobyletzki LB, Svalstedt M, Svensson Å
Acta Derm Venereol 2020 Jun 9;100(12):adv00160. doi: 10.2340/00015555-3510. PMID: 32412646Free PMC Article

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