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Breast cancer, familial male

MedGen UID:
350535
Concept ID:
C1861906
Neoplastic Process
Synonym: Breast Cancer, Familial Male
 
OMIM®: 114480

Definition

A small percentage of all breast cancers cluster in families. These cancers are described as hereditary and are associated with inherited gene mutations. Hereditary breast cancers tend to develop earlier in life than noninherited (sporadic) cases, and new (primary) tumors are more likely to develop in both breasts.

In some cases, cancerous cells can invade surrounding breast tissue. In these cases, the condition is known as invasive breast cancer. Sometimes, tumors spread to other parts of the body. If breast cancer spreads, cancerous cells most often appear in the bones, liver, lungs, or brain. Tumors that begin at one site and then spread to other areas of the body are called metastatic cancers.

In its early stages, breast cancer usually does not cause pain and may exhibit no noticeable symptoms. As the cancer progresses, signs and symptoms can include a lump or thickening in or near the breast; a change in the size or shape of the breast; nipple discharge, tenderness, or retraction (turning inward); and skin irritation, dimpling, redness, or scaliness. However, these changes can occur as part of many different conditions. Having one or more of these symptoms does not mean that a person definitely has breast cancer.

Breast cancer is a disease in which certain cells in the breast become abnormal and multiply uncontrollably to form a tumor. Although breast cancer is much more common in women, this form of cancer can also develop in men. In both women and men, the most common form of breast cancer begins in cells lining the milk ducts (ductal cancer). In women, cancer can also develop in the glands that produce milk (lobular cancer). Most men have little or no lobular tissue, so lobular cancer in men is very rare.  [from MedlinePlus Genetics]

Recent clinical studies

Etiology

de Juan I, Palanca S, Domenech A, Feliubadaló L, Segura Á, Osorio A, Chirivella I, de la Hoya M, Sánchez AB, Infante M, Tena I, Díez O, Garcia-Casado Z, Vega A, Teulé À, Barroso A, Pérez P, Durán M, Carrasco E, Juan-Fita MJ, Murria R, Llop M, Barragan E, Izquierdo Á, Benítez J, Caldés T, Salas D, Bolufer P
Fam Cancer 2015 Dec;14(4):505-13. doi: 10.1007/s10689-015-9814-z. PMID: 26026974
Deb S, Wong SQ, Li J, Do H, Weiss J, Byrne D, Chakrabarti A, Bosma T; kConFab Investigators, Fellowes A, Dobrovic A, Fox SB
Br J Cancer 2014 Dec 9;111(12):2351-60. doi: 10.1038/bjc.2014.511. PMID: 25490678Free PMC Article
Deb S, Johansson I, Byrne D, Nilsson C; kConFab Investigators, Constable L, Fjällskog ML, Dobrovic A, Hedenfalk I, Fox SB
Mod Pathol 2014 Sep;27(9):1223-30. Epub 2014 Jan 24 doi: 10.1038/modpathol.2013.231. PMID: 24457463
Bouchardy C, Rapiti E, Fioretta G, Schubert H, Chappuis P, Vlastos G, Benhamou S
Swiss Med Wkly 2013;143:w13879. Epub 2013 Nov 12 doi: 10.4414/smw.2013.13879. PMID: 24222557
Deb S, Do H, Byrne D, Jene N; kConFab Investigators, Dobrovic A, Fox SB
Breast Cancer Res 2013;15(4):R69. doi: 10.1186/bcr3463. PMID: 23971979Free PMC Article

Diagnosis

Deb S, Johansson I, Byrne D, Nilsson C; kConFab Investigators, Constable L, Fjällskog ML, Dobrovic A, Hedenfalk I, Fox SB
Mod Pathol 2014 Sep;27(9):1223-30. Epub 2014 Jan 24 doi: 10.1038/modpathol.2013.231. PMID: 24457463
Bouchardy C, Rapiti E, Fioretta G, Schubert H, Chappuis P, Vlastos G, Benhamou S
Swiss Med Wkly 2013;143:w13879. Epub 2013 Nov 12 doi: 10.4414/smw.2013.13879. PMID: 24222557

Therapy

Bouchardy C, Rapiti E, Fioretta G, Schubert H, Chappuis P, Vlastos G, Benhamou S
Swiss Med Wkly 2013;143:w13879. Epub 2013 Nov 12 doi: 10.4414/smw.2013.13879. PMID: 24222557

Prognosis

de Juan I, Palanca S, Domenech A, Feliubadaló L, Segura Á, Osorio A, Chirivella I, de la Hoya M, Sánchez AB, Infante M, Tena I, Díez O, Garcia-Casado Z, Vega A, Teulé À, Barroso A, Pérez P, Durán M, Carrasco E, Juan-Fita MJ, Murria R, Llop M, Barragan E, Izquierdo Á, Benítez J, Caldés T, Salas D, Bolufer P
Fam Cancer 2015 Dec;14(4):505-13. doi: 10.1007/s10689-015-9814-z. PMID: 26026974
Deb S, Johansson I, Byrne D, Nilsson C; kConFab Investigators, Constable L, Fjällskog ML, Dobrovic A, Hedenfalk I, Fox SB
Mod Pathol 2014 Sep;27(9):1223-30. Epub 2014 Jan 24 doi: 10.1038/modpathol.2013.231. PMID: 24457463
Bouchardy C, Rapiti E, Fioretta G, Schubert H, Chappuis P, Vlastos G, Benhamou S
Swiss Med Wkly 2013;143:w13879. Epub 2013 Nov 12 doi: 10.4414/smw.2013.13879. PMID: 24222557

Clinical prediction guides

Bouchardy C, Rapiti E, Fioretta G, Schubert H, Chappuis P, Vlastos G, Benhamou S
Swiss Med Wkly 2013;143:w13879. Epub 2013 Nov 12 doi: 10.4414/smw.2013.13879. PMID: 24222557
Deb S, Do H, Byrne D, Jene N; kConFab Investigators, Dobrovic A, Fox SB
Breast Cancer Res 2013;15(4):R69. doi: 10.1186/bcr3463. PMID: 23971979Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2019
      UK NICE Clinical Guideline CG164, Familial breast cancer: classification, care and managing breast cancer and related risks in people with a family history of breast cancer, 2019

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