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Familial focal alopecia(ALPF)

MedGen UID:
350835
Concept ID:
C1863092
Disease or Syndrome
Synonym: Alopecia, Familial Focal
 
Monarch Initiative: MONDO:0007084
OMIM®: 104110

Clinical features

From HPO
Patchy alopecia
MedGen UID:
350774
Concept ID:
C1862862
Finding
Transient, non-scarring hair loss and preservation of the hair follicle located in in well-defined patches.

Professional guidelines

PubMed

Sterkens A, Lambert J, Bervoets A
Clin Exp Med 2021 May;21(2):215-230. Epub 2021 Jan 1 doi: 10.1007/s10238-020-00673-w. PMID: 33386567
Hon KL, Luk DCK, Leung AKC, Ng C, Loo SKF
Recent Pat Inflamm Allergy Drug Discov 2020;14(2):117-132. doi: 10.2174/1872213X14999200728145822. PMID: 32723274
Hatzis J, Gourgiotou K, Tosca A, Varelzidis A, Stratigos J
Dermatologica 1988;177(3):146-8. doi: 10.1159/000248532. PMID: 3169339

Recent clinical studies

Etiology

Almashaqbeh SS, Aljammal DS, Alharahsheh HM, Alqudah SF, Alkrimeen RA
Med Arch 2022 Aug;76(4):301-304. doi: 10.5455/medarh.2022.76.301-304. PMID: 36313953Free PMC Article
Clebak KT, Mendez-Miller M, Croad J
Am Fam Physician 2020 Apr 1;101(7):399-406. PMID: 32227823
Malki L, Sarig O, Romano MT, Méchin MC, Peled A, Pavlovsky M, Warshauer E, Samuelov L, Uwakwe L, Briskin V, Mohamad J, Gat A, Isakov O, Rabinowitz T, Shomron N, Adir N, Simon M, McMichael A, Dlova NC, Betz RC, Sprecher E
N Engl J Med 2019 Feb 28;380(9):833-841. Epub 2019 Feb 13 doi: 10.1056/NEJMoa1816614. PMID: 30763140
Horlenko O, Lenchenko A, Kossey G, Tomey A, Debretseni O
Georgian Med News 2018 Dec;(285):47-51. PMID: 30702069
Brown L, Skopit S
J Drugs Dermatol 2018 Aug 1;17(8):914-917. PMID: 30124734

Diagnosis

Karrakchou B, Fliti A, Meziane M, Senouci K
BMJ Case Rep 2023 Jan 31;16(1) doi: 10.1136/bcr-2022-250782. PMID: 36720517Free PMC Article
Almashaqbeh SS, Aljammal DS, Alharahsheh HM, Alqudah SF, Alkrimeen RA
Med Arch 2022 Aug;76(4):301-304. doi: 10.5455/medarh.2022.76.301-304. PMID: 36313953Free PMC Article
Sterkens A, Lambert J, Bervoets A
Clin Exp Med 2021 May;21(2):215-230. Epub 2021 Jan 1 doi: 10.1007/s10238-020-00673-w. PMID: 33386567
Narayanan MJ, Rangasamy S, Narayanan V
Handb Clin Neurol 2015;132:271-80. doi: 10.1016/B978-0-444-62702-5.00020-2. PMID: 26564087
Zimmerman EE, Crawford P
Am Fam Physician 2012 Dec 15;86(12):1118-24. PMID: 23316984

Therapy

Shimizu T, Sands J, Yoh K, Spira A, Garon EB, Kitazono S, Johnson ML, Meric-Bernstam F, Tolcher AW, Yamamoto N, Greenberg J, Kawasaki Y, Zebger-Gong H, Kobayashi F, Phillips P, Lisberg AE, Heist RS
J Clin Oncol 2023 Oct 10;41(29):4678-4687. Epub 2023 Jun 16 doi: 10.1200/JCO.23.00059. PMID: 37327461Free PMC Article
Hoimes CJ, Flaig TW, Milowsky MI, Friedlander TW, Bilen MA, Gupta S, Srinivas S, Merchan JR, McKay RR, Petrylak DP, Sasse C, Moreno BH, Yu Y, Carret AS, Rosenberg JE
J Clin Oncol 2023 Jan 1;41(1):22-31. Epub 2022 Aug 30 doi: 10.1200/JCO.22.01643. PMID: 36041086Free PMC Article
Javle M, Roychowdhury S, Kelley RK, Sadeghi S, Macarulla T, Weiss KH, Waldschmidt DT, Goyal L, Borbath I, El-Khoueiry A, Borad MJ, Yong WP, Philip PA, Bitzer M, Tanasanvimon S, Li A, Pande A, Soifer HS, Shepherd SP, Moran S, Zhu AX, Bekaii-Saab TS, Abou-Alfa GK
Lancet Gastroenterol Hepatol 2021 Oct;6(10):803-815. Epub 2021 Aug 3 doi: 10.1016/S2468-1253(21)00196-5. PMID: 34358484
Sterkens A, Lambert J, Bervoets A
Clin Exp Med 2021 May;21(2):215-230. Epub 2021 Jan 1 doi: 10.1007/s10238-020-00673-w. PMID: 33386567
Howell MD, Kuo FI, Smith PA
Front Immunol 2019;10:2342. Epub 2019 Oct 9 doi: 10.3389/fimmu.2019.02342. PMID: 31649667Free PMC Article

Prognosis

Sterkens A, Lambert J, Bervoets A
Clin Exp Med 2021 May;21(2):215-230. Epub 2021 Jan 1 doi: 10.1007/s10238-020-00673-w. PMID: 33386567
Hon KL, Luk DCK, Leung AKC, Ng C, Loo SKF
Recent Pat Inflamm Allergy Drug Discov 2020;14(2):117-132. doi: 10.2174/1872213X14999200728145822. PMID: 32723274
Malki L, Sarig O, Romano MT, Méchin MC, Peled A, Pavlovsky M, Warshauer E, Samuelov L, Uwakwe L, Briskin V, Mohamad J, Gat A, Isakov O, Rabinowitz T, Shomron N, Adir N, Simon M, McMichael A, Dlova NC, Betz RC, Sprecher E
N Engl J Med 2019 Feb 28;380(9):833-841. Epub 2019 Feb 13 doi: 10.1056/NEJMoa1816614. PMID: 30763140
Brown L, Skopit S
J Drugs Dermatol 2018 Aug 1;17(8):914-917. PMID: 30124734
Wollina U, Hercogovấ J, Fioranelli M, Gianfaldoni S, Chokoeva AA, Tchernev G, Tirant M, Novotny F, Roccia MG, Maximov GK, França K, Lotti T
J Biol Regul Homeost Agents 2016 Apr-Jun;30(2 Suppl 3):83-7. PMID: 27498663

Clinical prediction guides

Abdel-Salam GMH, Afifi HH, Abdel-Hamid MS, Ahmed NEB, Taher MB, El-Kamah G, Thiele H, Nürnberg PN, Bolz HJ
J Hum Genet 2023 Sep;68(9):607-613. Epub 2023 Apr 28 doi: 10.1038/s10038-023-01152-2. PMID: 37106064
Kozicka K, Łukasik A, Jaworek A, Pastuszczak M, Spałkowska M, Kłosowicz A, Dyduch G, Wojas-Pelc A
Pol Merkur Lekarski 2020 Dec 22;48(288):427-430. PMID: 33387431
Malki L, Sarig O, Romano MT, Méchin MC, Peled A, Pavlovsky M, Warshauer E, Samuelov L, Uwakwe L, Briskin V, Mohamad J, Gat A, Isakov O, Rabinowitz T, Shomron N, Adir N, Simon M, McMichael A, Dlova NC, Betz RC, Sprecher E
N Engl J Med 2019 Feb 28;380(9):833-841. Epub 2019 Feb 13 doi: 10.1056/NEJMoa1816614. PMID: 30763140
Zimmerman EE, Crawford P
Am Fam Physician 2012 Dec 15;86(12):1118-24. PMID: 23316984
Al-Mutairi N, Eldin ON
Indian J Dermatol Venereol Leprol 2011 Jul-Aug;77(4):489-93. doi: 10.4103/0378-6323.82411. PMID: 21727697

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