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Trichilemmal cyst 1(TRICY1)

MedGen UID:
351222
Concept ID:
C1864801
Disease or Syndrome
Synonyms: PILAR CYST; TRICHOLEMMAL CYST; TRICY1
 
Cytogenetic location: 3p24-p21.2
 
OMIM®: 609649

Definition

Trichilemmal cysts, also known as pilar cysts or tricholemmal cysts, are derived from the outer root sheath of the deeper parts of a hair follicle and consist of a well-keratinized epidermal wall surrounding semisolid hair keratin. They occur predominantly on the scalp, are easily enucleated, and appear as a firm, smooth, white-walled cyst without a punctum (McGavran and Binnington, 1966; Pinkus, 1969; Leppard and Sanderson, 1976). [from OMIM]

Clinical features

From HPO
Abnormality of the skin
MedGen UID:
1845238
Concept ID:
C5848159
Anatomical Abnormality
An abnormality of the skin.

Professional guidelines

PubMed

Yousaf A, Tallman R, Katzman S, Brady C, Fang W, Kolodney MS
J Invest Dermatol 2021 Dec;141(12):2983-2985. Epub 2021 Jun 8 doi: 10.1016/j.jid.2021.05.018. PMID: 34116061Free PMC Article
Seidenari S, Pellacani G, Nasti S, Tomasi A, Pastorino L, Ghiorzo P, Ruini C, Bianchi-Scarrà G, Pollio A, Mandel VD, Ponti G
Clin Genet 2013 Jul;84(1):65-9. Epub 2012 Nov 8 doi: 10.1111/cge.12040. PMID: 23061468

Recent clinical studies

Etiology

Khan I, Fraga GR, Dai H
Am J Dermatopathol 2021 Jul 1;43(7):493-496. doi: 10.1097/DAD.0000000000001839. PMID: 33201018
Parambeth HK, Udhayam N, Agarwal S, Gupta S, Giridhar P, Rath GK
J Egypt Natl Canc Inst 2019 Dec 11;31(1):7. doi: 10.1186/s43046-019-0007-y. PMID: 32372190
Türk CÇ, Bacanlı A, Kara NN
Acta Neurochir (Wien) 2015 Feb;157(2):217-23. Epub 2014 Nov 9 doi: 10.1007/s00701-014-2266-7. PMID: 25380646

Diagnosis

Friedrich RE, Wilczak W
Anticancer Res 2019 Aug;39(8):4253-4258. doi: 10.21873/anticanres.13588. PMID: 31366514
Faria Sanchez PC, Sakai Valente NY, Simonsen Nico MM
Am J Dermatopathol 2019 Sep;41(9):692-694. doi: 10.1097/DAD.0000000000001196. PMID: 29794484
Weiffenbach A, Katz K, Rupley K, Carter A, Gottlieb A, Shulman K
J Drugs Dermatol 2018 Dec 1;17(12):1325-1327. PMID: 30586266
Melikoglu C, Eren F, Keklik B, Aslan C, Sutcu M, Zeynep Tarini E
Hand Surg 2014;19(1):131-3. doi: 10.1142/S0218810414720113. PMID: 24641757
Ogul H, Keles S, Yildirim K, Bassorgun CI, Eren S, Kantarci M
J Craniofac Surg 2014 Jan;25(1):e21-3. doi: 10.1097/SCS.0b013e3182a2ed5a. PMID: 24275781

Prognosis

Türk CÇ, Bacanlı A, Kara NN
Acta Neurochir (Wien) 2015 Feb;157(2):217-23. Epub 2014 Nov 9 doi: 10.1007/s00701-014-2266-7. PMID: 25380646

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