Trichilemmal cyst 1(TRICY1)

MedGen UID:: 351222
•Concept ID:: C1864801
•: Disease or Syndrome

Synonyms:	PILAR CYST; TRICHOLEMMAL CYST; TRICY1

Cytogenetic location:	3p24-p21.2

OMIM®:	609649

Definition

Trichilemmal cysts, also known as pilar cysts or tricholemmal cysts, are derived from the outer root sheath of the deeper parts of a hair follicle and consist of a well-keratinized epidermal wall surrounding semisolid hair keratin. They occur predominantly on the scalp, are easily enucleated, and appear as a firm, smooth, white-walled cyst without a punctum (McGavran and Binnington, 1966; Pinkus, 1969; Leppard and Sanderson, 1976). [from OMIM]

Clinical features

From HPO

Abnormality of the skin

MedGen UID:: 11449
•Concept ID:: C0037268
•: Congenital Abnormality

An abnormality of the skin.

See: Feature record | Search on this feature

Abnormality of the integument
- Abnormality of the skin

Professional guidelines

PubMed

Genotype-Phenotype Correlation in Trichilemmal Cysts.

Yousaf A, Tallman R, Katzman S, Brady C, Fang W, Kolodney MS
J Invest Dermatol 2021 Dec;141(12):2983-2985. Epub 2021 Jun 8 doi: 10.1016/j.jid.2021.05.018. PMID: 34116061 Free PMC Article

Hereditary trichilemmal cysts: a proposal for the assessment of diagnostic clinical criteria.

Seidenari S, Pellacani G, Nasti S, Tomasi A, Pastorino L, Ghiorzo P, Ruini C, Bianchi-Scarrà G, Pollio A, Mandel VD, Ponti G
Clin Genet 2013 Jul;84(1):65-9. Epub 2012 Nov 8 doi: 10.1111/cge.12040. PMID: 23061468

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Recent clinical studies

Etiology

Trichilemmal Cysts With Divergent Ductal Differentiation: A Series of 4 Cases.

Khan I, Fraga GR, Dai H
Am J Dermatopathol 2021 Jul 1;43(7):493-496. doi: 10.1097/DAD.0000000000001839. PMID: 33201018

A large helmet-shaped proliferating trichilemmal tumor of the scalp: Is definitive radiotherapy the treatment? A case report.

Parambeth HK, Udhayam N, Agarwal S, Gupta S, Giridhar P, Rath GK
J Egypt Natl Canc Inst 2019 Dec 11;31(1):7. doi: 10.1186/s43046-019-0007-y. PMID: 32372190

Incidence and clinical significance of lesions presenting as a scalp mass in adult patients.

Türk CÇ, Bacanlı A, Kara NN
Acta Neurochir (Wien) 2015 Feb;157(2):217-23. Epub 2014 Nov 9 doi: 10.1007/s00701-014-2266-7. PMID: 25380646

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Diagnosis

Trichilemmal Cysts With Divergent Ductal Differentiation: A Series of 4 Cases.

Khan I, Fraga GR, Dai H
Am J Dermatopathol 2021 Jul 1;43(7):493-496. doi: 10.1097/DAD.0000000000001839. PMID: 33201018

Proliferating trichilemmal cyst with clinical, radiological, macroscopic, and microscopic correlation.

Valerio E, Parro FHS, Macedo MP, Pinto CAL
An Bras Dermatol 2019;94(4):452-454. Epub 2019 Oct 17 doi: 10.1590/abd1806-4841.20198199. PMID: 31644620 Free PMC Article

Multiple Trichilemmal Cysts of the Scalp.

Friedrich RE, Wilczak W
Anticancer Res 2019 Aug;39(8):4253-4258. doi: 10.21873/anticanres.13588. PMID: 31366514

Nevus Trichilemmocysticus: A Mild Case.

Faria Sanchez PC, Sakai Valente NY, Simonsen Nico MM
Am J Dermatopathol 2019 Sep;41(9):692-694. doi: 10.1097/DAD.0000000000001196. PMID: 29794484

Incidence and clinical significance of lesions presenting as a scalp mass in adult patients.

Türk CÇ, Bacanlı A, Kara NN
Acta Neurochir (Wien) 2015 Feb;157(2):217-23. Epub 2014 Nov 9 doi: 10.1007/s00701-014-2266-7. PMID: 25380646

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