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Anal Necrotic Lesion

MedGen UID:
352158
•Concept ID:
C1697981
•
Disease or Syndrome

Definition

A necrotic process involving the area of the anus. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnal Necrotic Lesion

Professional guidelines

PubMed

Risk and management of intra-abdominal abscess in Crohn's disease treated with infliximab.
Yoneno K, Hisamatsu T, Matsuoka K, Okamoto S, Takayama T, Ichikawa R, Sujino T, Miyoshi J, Takabayashi K, Mikami Y, Mizuno S, Wada Y, Yajima T, Naganuma M, Inoue N, Iwao Y, Ogata H, Hasegawa H, Kitagawa Y, Hibi T, Kanai T
Digestion 2014;89(3):201-8. Epub 2014 May 1 doi: 10.1159/000360618. PMID: 24803137
Retrorectal developmental cysts in adults: clinical and radiologic-histopathologic review, differential diagnosis, and treatment.
Dahan H, Arrivé L, Wendum D, Docou le Pointe H, Djouhri H, Tubiana JM
Radiographics 2001 May-Jun;21(3):575-84. doi: 10.1148/radiographics.21.3.g01ma13575. PMID: 11353107
Management of perianal Crohn's disease.
Rutgeerts P
Can J Gastroenterol 2000 Sep;14 Suppl C:7C-12C. doi: 10.1155/2000/985045. PMID: 11023554

Recent clinical studies

Etiology

Natural History of Anal Ulcerations in Pediatric-Onset Crohn's Disease: Long-Term Follow-Up of a Population-Based Study.
Mortreux P, Leroyer A, Dupont C, Ley D, Bertrand V, Spyckerelle C, Guillon N, Wils P, Gower-Rousseau C, Savoye G, Fumery M, Turck D, Siproudhis L, Sarter H
Am J Gastroenterol 2023 Sep 1;118(9):1671-1678. Epub 2023 Apr 25 doi: 10.14309/ajg.0000000000002301. PMID: 37104674
Assessment of serum phenylalanine and tyrosine isomers in patients with ST-segment elevation vs non-ST-segment elevation myocardial infarction.
Al-Sadoon I, Wittmann I, Kun S, Ahmann M, Konyi A, Verzár Z
J Clin Lab Anal 2021 Feb;35(2):e23613. Epub 2020 Oct 11 doi: 10.1002/jcla.23613. PMID: 33043503Free PMC Article
Complications of colorectal resection for endometriosis.
Bouaziz J, Soriano D
Minerva Ginecol 2017 Oct;69(5):477-487. Epub 2017 Apr 4 doi: 10.23736/S0026-4784.17.04052-7. PMID: 28381079
CD11c+CD123Low dendritic cell subset and the triad TNF-α/IL-17A/IFN-γ integrate mucosal and peripheral cellular responses in HIV patients with high-grade anal intraepithelial neoplasia: a systems biology approach.
Guimarães AG, da Costa AG, Martins-Filho OA, Pimentel JP, Zauli DA, Peruhype-Magalhães V, Teixeira-Carvalho A, Béla SR, Xavier MA, Coelho-Dos-Reis JG, Abranches JS, Guimarães JJ, Malheiro A, Ferreira LC
J Acquir Immune Defic Syndr 2015 Feb 1;68(2):112-22. doi: 10.1097/QAI.0000000000000412. PMID: 25590266
Hidradenitis suppurativa.
Revuz J
J Eur Acad Dermatol Venereol 2009 Sep;23(9):985-98. doi: 10.1111/j.1468-3083.2009.03356.x. PMID: 19682181

Diagnosis

Natural History of Anal Ulcerations in Pediatric-Onset Crohn's Disease: Long-Term Follow-Up of a Population-Based Study.
Mortreux P, Leroyer A, Dupont C, Ley D, Bertrand V, Spyckerelle C, Guillon N, Wils P, Gower-Rousseau C, Savoye G, Fumery M, Turck D, Siproudhis L, Sarter H
Am J Gastroenterol 2023 Sep 1;118(9):1671-1678. Epub 2023 Apr 25 doi: 10.14309/ajg.0000000000002301. PMID: 37104674
Anorectal malignant amelanotic melanoma: Report of a rare aggressive primary tumor.
Husain M, Rashid T, Ahmad MM, Hassan MJ
J Cancer Res Ther 2022 Jan-Mar;18(1):249-252. doi: 10.4103/jcrt.JCRT_461_20. PMID: 35381792
The Combination Strategy of Transarterial Chemoembolization and Radiofrequency Ablation or Microwave Ablation against Hepatocellular Carcinoma.
Xu Z, Xie H, Zhou L, Chen X, Zheng S
Anal Cell Pathol (Amst) 2019;2019:8619096. Epub 2019 Aug 26 doi: 10.1155/2019/8619096. PMID: 31534899Free PMC Article
Hidradenitis suppurativa.
Revuz J
J Eur Acad Dermatol Venereol 2009 Sep;23(9):985-98. doi: 10.1111/j.1468-3083.2009.03356.x. PMID: 19682181
Retrorectal developmental cysts in adults: clinical and radiologic-histopathologic review, differential diagnosis, and treatment.
Dahan H, Arrivé L, Wendum D, Docou le Pointe H, Djouhri H, Tubiana JM
Radiographics 2001 May-Jun;21(3):575-84. doi: 10.1148/radiographics.21.3.g01ma13575. PMID: 11353107

Therapy

Management of perianal fistulas in Crohn's disease: a 2021 update of the French National Society of Coloproctology consensus.
Bouchard D, Pigot F, de Parades V, Staumont G, Abramowitz L, Siproudhis L; Members of the SNFCP; Members of the GETAID
Tech Coloproctol 2022 Oct;26(10):805-811. Epub 2022 Aug 21 doi: 10.1007/s10151-022-02678-x. PMID: 35988122
Magnetic Targeting of HU-MSCs in the Treatment of Glucocorticoid-Associated Osteonecrosis of the Femoral Head Through Akt/Bcl2/Bad/Caspase-3 Pathway.
Duan L, Zuo J, Zhang F, Li B, Xu Z, Zhang H, Yang B, Song W, Jiang J
Int J Nanomedicine 2020;15:3605-3620. Epub 2020 May 21 doi: 10.2147/IJN.S244453. PMID: 32547017Free PMC Article
Anoperineal lesions in Crohn's disease: French recommendations for clinical practice.
Bouchard D, Abramowitz L, Bouguen G, Brochard C, Dabadie A, de Parades V, Eléouet-Kaplan M, Fathallah N, Faucheron JL, Maggiori L, Panis Y, Pigot F, Rouméguère P, Sénéjoux A, Siproudhis L, Staumont G, Suduca JM, Vinson-Bonnet B, Zeitoun JD
Tech Coloproctol 2017 Sep;21(9):683-691. Epub 2017 Sep 19 doi: 10.1007/s10151-017-1684-y. PMID: 28929282
Hidradenitis suppurativa.
Revuz J
J Eur Acad Dermatol Venereol 2009 Sep;23(9):985-98. doi: 10.1111/j.1468-3083.2009.03356.x. PMID: 19682181
Management of perianal Crohn's disease.
Rutgeerts P
Can J Gastroenterol 2000 Sep;14 Suppl C:7C-12C. doi: 10.1155/2000/985045. PMID: 11023554

Prognosis

Natural History of Anal Ulcerations in Pediatric-Onset Crohn's Disease: Long-Term Follow-Up of a Population-Based Study.
Mortreux P, Leroyer A, Dupont C, Ley D, Bertrand V, Spyckerelle C, Guillon N, Wils P, Gower-Rousseau C, Savoye G, Fumery M, Turck D, Siproudhis L, Sarter H
Am J Gastroenterol 2023 Sep 1;118(9):1671-1678. Epub 2023 Apr 25 doi: 10.14309/ajg.0000000000002301. PMID: 37104674
The Conundrum of an Accumulating Acuminatum.
Cimmino A, Walters E, Gubler A, Ibrahim A
Am J Case Rep 2020 Feb 23;21:e920516. doi: 10.12659/AJCR.920516. PMID: 32088723Free PMC Article
Risk factors associated with postoperative recurrence and repeat surgery in Japanese patients with Crohn's disease.
Kusaka J, Shiga H, Kuroha M, Kimura T, Kakuta Y, Endo K, Kinouchi Y, Shimosegawa T
Int J Colorectal Dis 2017 Oct;32(10):1407-1413. Epub 2017 Jul 22 doi: 10.1007/s00384-017-2867-8. PMID: 28735411
Hemorrhagic bullae are not only skin deep.
Hsiao CT, Lin LJ, Shiao CJ, Hsiao KY, Chen IC
Am J Emerg Med 2008 Mar;26(3):316-9. doi: 10.1016/j.ajem.2007.07.014. PMID: 18358943
Management of perianal Crohn's disease.
Rutgeerts P
Can J Gastroenterol 2000 Sep;14 Suppl C:7C-12C. doi: 10.1155/2000/985045. PMID: 11023554

Clinical prediction guides

Natural History of Anal Ulcerations in Pediatric-Onset Crohn's Disease: Long-Term Follow-Up of a Population-Based Study.
Mortreux P, Leroyer A, Dupont C, Ley D, Bertrand V, Spyckerelle C, Guillon N, Wils P, Gower-Rousseau C, Savoye G, Fumery M, Turck D, Siproudhis L, Sarter H
Am J Gastroenterol 2023 Sep 1;118(9):1671-1678. Epub 2023 Apr 25 doi: 10.14309/ajg.0000000000002301. PMID: 37104674
Human adipose and synovial mesenchymal stem cells improve osteoarthritis in rats by reducing chondrocyte reactive oxygen species and inhibiting inflammatory response.
Liu X, Liu Y, He H, Xiang W, He C
J Clin Lab Anal 2022 May;36(5):e24353. Epub 2022 Mar 21 doi: 10.1002/jcla.24353. PMID: 35312120Free PMC Article
Complications of colorectal resection for endometriosis.
Bouaziz J, Soriano D
Minerva Ginecol 2017 Oct;69(5):477-487. Epub 2017 Apr 4 doi: 10.23736/S0026-4784.17.04052-7. PMID: 28381079
Hemorrhagic bullae are not only skin deep.
Hsiao CT, Lin LJ, Shiao CJ, Hsiao KY, Chen IC
Am J Emerg Med 2008 Mar;26(3):316-9. doi: 10.1016/j.ajem.2007.07.014. PMID: 18358943
Management of perianal Crohn's disease.
Rutgeerts P
Can J Gastroenterol 2000 Sep;14 Suppl C:7C-12C. doi: 10.1155/2000/985045. PMID: 11023554

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