U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Clear Cell Variant Thyroid Gland Papillary Carcinoma

MedGen UID:
353544
•Concept ID:
C1707410
•
Neoplastic Process

Definition

A morphologic variant of papillary carcinoma of the thyroid gland characterized by the predominance of malignant follicular clear cells. These cells have the nuclear features that characterize the papillary carcinomas of the thyroid gland. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVClear Cell Variant Thyroid Gland Papillary Carcinoma

Recent clinical studies

Etiology

Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
TROP-2 and 5hmC expression in follicular-patterned thyroid neoplasm emphasizing tiny well-formed papillae.
Seok JY, Fan X
Ann Diagn Pathol 2022 Apr;57:151903. Epub 2022 Jan 31 doi: 10.1016/j.anndiagpath.2022.151903. PMID: 35121239
Prognostic significance of cell-adhesion molecules in histological variants of papillary thyroid carcinoma.
Andriescu EC, Căruntu ID, Giuşcă SE, Lozneanu L, Ciobanu Apostol DG
Rom J Morphol Embryol 2018;59(3):721-727. PMID: 30534810
The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia.
Srigley JR, Delahunt B, Eble JN, Egevad L, Epstein JI, Grignon D, Hes O, Moch H, Montironi R, Tickoo SK, Zhou M, Argani P; ISUP Renal Tumor Panel
Am J Surg Pathol 2013 Oct;37(10):1469-89. doi: 10.1097/PAS.0b013e318299f2d1. PMID: 24025519
Clear-cell carcinomas of thyroid gland: a clinicopathological study of 13 cases.
Schröder S, Böcker W
Histopathology 1986 Jan;10(1):75-89. doi: 10.1111/j.1365-2559.1986.tb02462.x. PMID: 3957248

Diagnosis

Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Cribriform-morular variant of thyroid carcinoma: a neoplasm with distinctive phenotype associated with the activation of the WNT/β-catenin pathway.
Cameselle-Teijeiro JM, Peteiro-González D, Caneiro-Gómez J, Sánchez-Ares M, Abdulkader I, Eloy C, Melo M, Amendoeira I, Soares P, Sobrinho-Simões M
Mod Pathol 2018 Aug;31(8):1168-1179. Epub 2018 May 21 doi: 10.1038/s41379-018-0070-2. PMID: 29785019
Cribriform-morular variant of papillary thyroid carcinoma.
Pradhan D, Sharma A, Mohanty SK
Pathol Res Pract 2015 Oct;211(10):712-6. Epub 2015 Jul 3 doi: 10.1016/j.prp.2015.04.011. PMID: 26293799
Variants of Papillary Thyroid Carcinoma: Multiple Faces of a Familiar Tumor.
Sak SD
Turk Patoloji Derg 2015;31 Suppl 1:34-47. doi: 10.5146/tjpath.2015.01313. PMID: 26177316
The many faces and mimics of papillary thyroid carcinoma.
Albores-Saavedra J, Wu J
Endocr Pathol 2006 Spring;17(1):1-18. doi: 10.1385/ep:17:1:1. PMID: 16760576

Therapy

Breast Tumor Resembling the Tall Cell Variant of Papillary Thyroid Carcinoma: Molecular Characterization by Next-Generation Sequencing and Histopathological Comparison With Tall Cell Papillary Carcinoma of Thyroid.
Zhong E, Scognamiglio T, D'Alfonso T, Song W, Tran H, Baek I, Hoda SA
Int J Surg Pathol 2019 Apr;27(2):134-141. Epub 2018 Sep 18 doi: 10.1177/1066896918800779. PMID: 30227763
Euthyroid status after total thyroidectomy due to functioning lung metastases from a clear cell variant of papillary thyroid carcinoma.
Lee JI, Chung YJ, Park SJ, Ryu HS, Cho BY
Thyroid 2012 Oct;22(10):1084-7. Epub 2012 Aug 8 doi: 10.1089/thy.2011.0437. PMID: 22873179

Prognosis

Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Cribriform-morular variant of thyroid carcinoma: a neoplasm with distinctive phenotype associated with the activation of the WNT/β-catenin pathway.
Cameselle-Teijeiro JM, Peteiro-González D, Caneiro-Gómez J, Sánchez-Ares M, Abdulkader I, Eloy C, Melo M, Amendoeira I, Soares P, Sobrinho-Simões M
Mod Pathol 2018 Aug;31(8):1168-1179. Epub 2018 May 21 doi: 10.1038/s41379-018-0070-2. PMID: 29785019
Cribriform-morular variant of papillary thyroid carcinoma.
Pradhan D, Sharma A, Mohanty SK
Pathol Res Pract 2015 Oct;211(10):712-6. Epub 2015 Jul 3 doi: 10.1016/j.prp.2015.04.011. PMID: 26293799
Variants of Papillary Thyroid Carcinoma: Multiple Faces of a Familiar Tumor.
Sak SD
Turk Patoloji Derg 2015;31 Suppl 1:34-47. doi: 10.5146/tjpath.2015.01313. PMID: 26177316
The many faces and mimics of papillary thyroid carcinoma.
Albores-Saavedra J, Wu J
Endocr Pathol 2006 Spring;17(1):1-18. doi: 10.1385/ep:17:1:1. PMID: 16760576

Clinical prediction guides

TROP-2 and 5hmC expression in follicular-patterned thyroid neoplasm emphasizing tiny well-formed papillae.
Seok JY, Fan X
Ann Diagn Pathol 2022 Apr;57:151903. Epub 2022 Jan 31 doi: 10.1016/j.anndiagpath.2022.151903. PMID: 35121239
Cribriform-Morular Thyroid Carcinoma Is a Distinct Thyroid Malignancy of Uncertain Cytogenesis.
Boyraz B, Sadow PM, Asa SL, Dias-Santagata D, Nosé V, Mete O
Endocr Pathol 2021 Sep;32(3):327-335. Epub 2021 May 21 doi: 10.1007/s12022-021-09683-0. PMID: 34019236Free PMC Article
Cribriform-morular variant of thyroid carcinoma: a neoplasm with distinctive phenotype associated with the activation of the WNT/β-catenin pathway.
Cameselle-Teijeiro JM, Peteiro-González D, Caneiro-Gómez J, Sánchez-Ares M, Abdulkader I, Eloy C, Melo M, Amendoeira I, Soares P, Sobrinho-Simões M
Mod Pathol 2018 Aug;31(8):1168-1179. Epub 2018 May 21 doi: 10.1038/s41379-018-0070-2. PMID: 29785019
Variants of Papillary Thyroid Carcinoma: Multiple Faces of a Familiar Tumor.
Sak SD
Turk Patoloji Derg 2015;31 Suppl 1:34-47. doi: 10.5146/tjpath.2015.01313. PMID: 26177316
Cribriform morular variant of papillary thyroid carcinoma: clinical and cytomorphological features on fine-needle aspiration.
Boonyaarunnate T, Olson MT, Bishop JA, Yang GC, Ali SZ
Acta Cytol 2013;57(2):127-33. Epub 2013 Feb 28 doi: 10.1159/000345879. PMID: 23406819

Supplemental Content

Table of contents

    Practice guidelines

    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...