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Colon Traditional Serrated Adenoma

MedGen UID:
353551
•Concept ID:
C1707435
•
Neoplastic Process
Synonyms: Colon Serrated Adenoma; Colon Serrated Adenoma Type II; Colon TSA

Definition

An adenoma that arises from the colon. It is characterized by prominent serration of the glands. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVColon Traditional Serrated Adenoma

Professional guidelines

PubMed

Terminology, Molecular Features, Epidemiology, and Management of Serrated Colorectal Neoplasia.
Crockett SD, Nagtegaal ID
Gastroenterology 2019 Oct;157(4):949-966.e4. Epub 2019 Jul 16 doi: 10.1053/j.gastro.2019.06.041. PMID: 31323292
British Society of Gastroenterology position statement on serrated polyps in the colon and rectum.
East JE, Atkin WS, Bateman AC, Clark SK, Dolwani S, Ket SN, Leedham SJ, Phull PS, Rutter MD, Shepherd NA, Tomlinson I, Rees CJ
Gut 2017 Jul;66(7):1181-1196. Epub 2017 Apr 27 doi: 10.1136/gutjnl-2017-314005. PMID: 28450390Free PMC Article
Serrated polyps of the large intestine: current understanding of diagnosis, pathogenesis, and clinical management.
Rosty C, Hewett DG, Brown IS, Leggett BA, Whitehall VL
J Gastroenterol 2013 Mar;48(3):287-302. Epub 2012 Dec 4 doi: 10.1007/s00535-012-0720-y. PMID: 23208018Free PMC Article

Recent clinical studies

Etiology

The Frontiers of Serrated Polyps.
Bell PD, Anderson JC, Srivastava A
Am J Surg Pathol 2022 Jan 1;46(1):e64-e70. doi: 10.1097/PAS.0000000000001806. PMID: 34545859
Long-term Risk of Colorectal Cancer After Removal of Conventional Adenomas and Serrated Polyps.
He X, Hang D, Wu K, Nayor J, Drew DA, Giovannucci EL, Ogino S, Chan AT, Song M
Gastroenterology 2020 Mar;158(4):852-861.e4. Epub 2019 Jul 11 doi: 10.1053/j.gastro.2019.06.039. PMID: 31302144Free PMC Article
Terminology, Molecular Features, Epidemiology, and Management of Serrated Colorectal Neoplasia.
Crockett SD, Nagtegaal ID
Gastroenterology 2019 Oct;157(4):949-966.e4. Epub 2019 Jul 16 doi: 10.1053/j.gastro.2019.06.041. PMID: 31323292
An update on the morphology and molecular pathology of serrated colorectal polyps and associated carcinomas.
Pai RK, Bettington M, Srivastava A, Rosty C
Mod Pathol 2019 Oct;32(10):1390-1415. Epub 2019 Apr 25 doi: 10.1038/s41379-019-0280-2. PMID: 31028362
Cold snare polypectomy: Indications, devices, techniques, outcomes and future.
Horiuchi A, Ikuse T, Tanaka N
Dig Endosc 2019 Jul;31(4):372-377. Epub 2019 Jan 8 doi: 10.1111/den.13314. PMID: 30549318

Diagnosis

The Frontiers of Serrated Polyps.
Bell PD, Anderson JC, Srivastava A
Am J Surg Pathol 2022 Jan 1;46(1):e64-e70. doi: 10.1097/PAS.0000000000001806. PMID: 34545859
Serrated polyps of the colon and rectum: a concise review.
Monreal-Robles R, Jáquez-Quintana JO, Benavides-Salgado DE, González-González JA
Rev Gastroenterol Mex (Engl Ed) 2021 Jul-Sep;86(3):276-286. Epub 2021 Jun 9 doi: 10.1016/j.rgmxen.2021.06.001. PMID: 34116964
Serrated polyps of the colon and rectum: Remove or not?
Sano W, Hirata D, Teramoto A, Iwatate M, Hattori S, Fujita M, Sano Y
World J Gastroenterol 2020 May 21;26(19):2276-2285. doi: 10.3748/wjg.v26.i19.2276. PMID: 32476792Free PMC Article
Long-term Risk of Colorectal Cancer After Removal of Conventional Adenomas and Serrated Polyps.
He X, Hang D, Wu K, Nayor J, Drew DA, Giovannucci EL, Ogino S, Chan AT, Song M
Gastroenterology 2020 Mar;158(4):852-861.e4. Epub 2019 Jul 11 doi: 10.1053/j.gastro.2019.06.039. PMID: 31302144Free PMC Article
An update on the morphology and molecular pathology of serrated colorectal polyps and associated carcinomas.
Pai RK, Bettington M, Srivastava A, Rosty C
Mod Pathol 2019 Oct;32(10):1390-1415. Epub 2019 Apr 25 doi: 10.1038/s41379-019-0280-2. PMID: 31028362

Therapy

Sessile serrated adenoma/polyp detection rate of water exchange, Endocuff, and cap colonoscopy: A network meta-analysis.
Shao PP, Shao CR, Romero T, Leung FW
J Gastroenterol Hepatol 2021 Dec;36(12):3268-3277. Epub 2021 Oct 25 doi: 10.1111/jgh.15702. PMID: 34622488
Improving serrated adenoma detection rate in the colon by electronic chromoendoscopy and distal attachment: systematic review and meta-analysis.
Aziz M, Desai M, Hassan S, Fatima R, Dasari CS, Chandrasekar VT, Jegadeesan R, Duvvuri A, Patel H, Rai T, Sathyamurthy A, Kohli DR, Vennalaganti P, Nawras A, Wallace M, Sharma P
Gastrointest Endosc 2019 Nov;90(5):721-731.e1. Epub 2019 Jul 6 doi: 10.1016/j.gie.2019.06.041. PMID: 31288029
British Society of Gastroenterology position statement on serrated polyps in the colon and rectum.
East JE, Atkin WS, Bateman AC, Clark SK, Dolwani S, Ket SN, Leedham SJ, Phull PS, Rutter MD, Shepherd NA, Tomlinson I, Rees CJ
Gut 2017 Jul;66(7):1181-1196. Epub 2017 Apr 27 doi: 10.1136/gutjnl-2017-314005. PMID: 28450390Free PMC Article
Histological overlap between colorectal villous/tubulovillous and traditional serrated adenomas.
Hafezi-Bakhtiari S, Wang LM, Colling R, Serra S, Chetty R
Histopathology 2015 Jan;66(2):308-13. Epub 2014 Nov 13 doi: 10.1111/his.12555. PMID: 25257227
'Serrated' adenoma of the colorectum, with reference to its gastric differentiation and its malignant potential.
Yao T, Kouzuki T, Kajiwara M, Matsui N, Oya M, Tsuneyoshi M
J Pathol 1999 Apr;187(5):511-7. doi: 10.1002/(SICI)1096-9896(199904)187:5<511::AID-PATH308>3.0.CO;2-8. PMID: 10398114

Prognosis

The Frontiers of Serrated Polyps.
Bell PD, Anderson JC, Srivastava A
Am J Surg Pathol 2022 Jan 1;46(1):e64-e70. doi: 10.1097/PAS.0000000000001806. PMID: 34545859
Long-term Risk of Colorectal Cancer After Removal of Conventional Adenomas and Serrated Polyps.
He X, Hang D, Wu K, Nayor J, Drew DA, Giovannucci EL, Ogino S, Chan AT, Song M
Gastroenterology 2020 Mar;158(4):852-861.e4. Epub 2019 Jul 11 doi: 10.1053/j.gastro.2019.06.039. PMID: 31302144Free PMC Article
Terminology, Molecular Features, Epidemiology, and Management of Serrated Colorectal Neoplasia.
Crockett SD, Nagtegaal ID
Gastroenterology 2019 Oct;157(4):949-966.e4. Epub 2019 Jul 16 doi: 10.1053/j.gastro.2019.06.041. PMID: 31323292
Traditional serrated adenoma (TSA): morphological questions, queries and quandaries.
Chetty R
J Clin Pathol 2016 Jan;69(1):6-11. Epub 2015 Nov 9 doi: 10.1136/jclinpath-2015-203452. PMID: 26553935
Traditional serrated adenoma: an update.
Bettington ML, Chetty R
Hum Pathol 2015 Jul;46(7):933-8. Epub 2015 Apr 20 doi: 10.1016/j.humpath.2015.04.002. PMID: 26001333

Clinical prediction guides

Single-cell Transcriptomics Reveals Early Molecular and Immune Alterations Underlying the Serrated Neoplasia Pathway Toward Colorectal Cancer.
Zhou YJ, Lu XF, Chen H, Wang XY, Cheng W, Zhang QW, Chen JN, Wang XY, Jin JZ, Yan FR, Chen H, Li XB
Cell Mol Gastroenterol Hepatol 2023;15(2):393-424. Epub 2022 Oct 8 doi: 10.1016/j.jcmgh.2022.10.001. PMID: 36216310Free PMC Article
The Frontiers of Serrated Polyps.
Bell PD, Anderson JC, Srivastava A
Am J Surg Pathol 2022 Jan 1;46(1):e64-e70. doi: 10.1097/PAS.0000000000001806. PMID: 34545859
Serrated lesions: A challenging enemy.
Trovato A, Turshudzhyan A, Tadros M
World J Gastroenterol 2021 Sep 14;27(34):5625-5629. doi: 10.3748/wjg.v27.i34.5625. PMID: 34629791Free PMC Article
Sessile Serrated Polyps and Colon Cancer Prevention.
Rashtak S, Rego R, Sweetser SR, Sinicrope FA
Cancer Prev Res (Phila) 2017 May;10(5):270-278. Epub 2017 Mar 21 doi: 10.1158/1940-6207.CAPR-16-0264. PMID: 28325827
Traditional serrated adenoma (TSA): morphological questions, queries and quandaries.
Chetty R
J Clin Pathol 2016 Jan;69(1):6-11. Epub 2015 Nov 9 doi: 10.1136/jclinpath-2015-203452. PMID: 26553935

Recent systematic reviews

Effect of computer-aided colonoscopy on adenoma miss rates and polyp detection: A systematic review and meta-analysis.
Shah S, Park N, Chehade NEH, Chahine A, Monachese M, Tiritilli A, Moosvi Z, Ortizo R, Samarasena J
J Gastroenterol Hepatol 2023 Feb;38(2):162-176. Epub 2022 Dec 11 doi: 10.1111/jgh.16059. PMID: 36350048
Site-specific risk of colorectal neoplasms in patients with non-alcoholic fatty liver disease: A systematic review and meta-analysis.
Lin X, You F, Liu H, Fang Y, Jin S, Wang Q
PLoS One 2021;16(1):e0245921. Epub 2021 Jan 25 doi: 10.1371/journal.pone.0245921. PMID: 33493235Free PMC Article
Comparing endoscopic interventions to improve serrated adenoma detection rates during colonoscopy: a systematic review and network meta-analysis of randomized controlled trials.
Aziz M, Fatima R, Lee-Smith W, Khuder S, Nawras A
Eur J Gastroenterol Hepatol 2020 Oct;32(10):1284-1292. doi: 10.1097/MEG.0000000000001844. PMID: 32773510
Improving serrated adenoma detection rate in the colon by electronic chromoendoscopy and distal attachment: systematic review and meta-analysis.
Aziz M, Desai M, Hassan S, Fatima R, Dasari CS, Chandrasekar VT, Jegadeesan R, Duvvuri A, Patel H, Rai T, Sathyamurthy A, Kohli DR, Vennalaganti P, Nawras A, Wallace M, Sharma P
Gastrointest Endosc 2019 Nov;90(5):721-731.e1. Epub 2019 Jul 6 doi: 10.1016/j.gie.2019.06.041. PMID: 31288029
Changing pathological diagnosis from hyperplastic polyp to sessile serrated adenoma: systematic review and meta-analysis.
Niv Y
Eur J Gastroenterol Hepatol 2017 Dec;29(12):1327-1331. doi: 10.1097/MEG.0000000000000994. PMID: 29049128

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