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Lung sarcomatoid carcinoma

MedGen UID:
353871
•Concept ID:
C1708781
•
Neoplastic Process
Synonyms: Lung Sarcomatoid Carcinoma; lung sarcomatoid carcinoma; Pseudosarcomatous carcinoma of lung; Sarcomatoid carcinoma of lung; sarcomatoid carcinoma of the lung
SNOMED CT: Pseudosarcomatous carcinoma of lung (1260072008); Sarcomatoid carcinoma of lung (1260072008)
 
Monarch Initiative: MONDO:0006279

Definition

A rare, aggressive, poorly differentiated, non-small cell lung carcinoma characterized by the presence of a sarcomatoid component often associated with giant cell differentiation. There is a male to female ratio of 4:1. Clinical symptoms include cough, hemoptysis, chest pain, progressive dyspnea and fever secondary to recurrent pneumonia. Cigarette smoking is a major risk factor. [from NCI]

Professional guidelines

PubMed

Value of immunohistochemistry in the differential diagnosis of pleural sarcomatoid mesothelioma from lung sarcomatoid carcinoma.
Takeshima Y, Amatya VJ, Kushitani K, Kaneko M, Inai K
Histopathology 2009 May;54(6):667-76. doi: 10.1111/j.1365-2559.2009.03298.x. PMID: 19438742

Recent clinical studies

Etiology

Efficacy of Immune Checkpoint Inhibitors in Lung Sarcomatoid Carcinoma.
Domblides C, Leroy K, Monnet I, Mazières J, Barlesi F, Gounant V, Baldacci S, Mennecier B, Toffart AC, Audigier-Valette C, Doucet L, Giroux-Leprieur E, Guisier F, Ricordel C, Molinier O, Perol M, Pichon E, Robinet G, Templement-Grangerat D, Ruppert AM, Rabbe N, Antoine M, Wislez M
J Thorac Oncol 2020 May;15(5):860-866. Epub 2020 Jan 25 doi: 10.1016/j.jtho.2020.01.014. PMID: 31991225
Overexpression of p53R2 is associated with poor prognosis in lung sarcomatoid carcinoma.
Chen J, Xiao Y, Cai X, Liu J, Chen K, Zhang X
BMC Cancer 2017 Dec 15;17(1):855. doi: 10.1186/s12885-017-3811-6. PMID: 29246119Free PMC Article
A three-gene signature and clinical outcome in esophageal squamous cell carcinoma.
Sun LL, Wu JY, Wu ZY, Shen JH, Xu XE, Chen B, Wang SH, Li EM, Xu LY
Int J Cancer 2015 Mar 15;136(6):E569-77. Epub 2014 Sep 24 doi: 10.1002/ijc.29211. PMID: 25220908Free PMC Article
Efficacy of first-line chemotherapy in patients with advanced lung sarcomatoid carcinoma.
Vieira T, Girard N, Ung M, Monnet I, Cazes A, Bonnette P, Duruisseaux M, Mazieres J, Antoine M, Cadranel J, Wislez M
J Thorac Oncol 2013 Dec;8(12):1574-7. doi: 10.1097/01.JTO.0000437008.00554.90. PMID: 24389441
The value of biomarkers in patients with sarcomatoid carcinoma of the lung: molecular analysis of 33 cases.
Jiang X, Liu Y, Chen C, Zhan Z, Yan Q, Guo Y, Wang Q, Li K
Clin Lung Cancer 2012 Jul;13(4):288-96. Epub 2011 Dec 13 doi: 10.1016/j.cllc.2011.11.004. PMID: 22169481

Diagnosis

GATA3 is a useful immunohistochemical marker for distinguishing sarcomatoid malignant mesothelioma from lung sarcomatoid carcinoma and organizing pleuritis.
Piao ZH, Zhou XC, Chen JY
Virchows Arch 2021 Aug;479(2):257-263. Epub 2021 Feb 11 doi: 10.1007/s00428-021-03048-y. PMID: 33570661
MUC4, a novel immunohistochemical marker identified by gene expression profiling, differentiates pleural sarcomatoid mesothelioma from lung sarcomatoid carcinoma.
Amatya VJ, Kushitani K, Mawas AS, Miyata Y, Okada M, Kishimoto T, Inai K, Takeshima Y
Mod Pathol 2017 May;30(5):672-681. Epub 2017 Jan 27 doi: 10.1038/modpathol.2016.181. PMID: 28128276
Nivolumab-induced organizing pneumonitis in a patient with lung sarcomatoid carcinoma.
Gounant V, Brosseau S, Naltet C, Opsomer MA, Antoine M, Danel C, Khalil A, Cadranel J, Zalcman G
Lung Cancer 2016 Sep;99:162-5. Epub 2016 Jul 15 doi: 10.1016/j.lungcan.2016.07.010. PMID: 27565934
Lung Sarcomatoid Carcinoma Metastasis to Skin: A Case Report and Review of the Literature.
Xu X, Lin M, Wang S, Jin Z, Han S, Liu X, Gao Y
Cancer Invest 2016 Jul 2;34(6):286-92. Epub 2016 Jun 27 doi: 10.1080/07357907.2016.1193744. PMID: 27348718
Value of immunohistochemistry in the differential diagnosis of pleural sarcomatoid mesothelioma from lung sarcomatoid carcinoma.
Takeshima Y, Amatya VJ, Kushitani K, Kaneko M, Inai K
Histopathology 2009 May;54(6):667-76. doi: 10.1111/j.1365-2559.2009.03298.x. PMID: 19438742

Therapy

Efficacy of Immune Checkpoint Inhibitors in Lung Sarcomatoid Carcinoma.
Domblides C, Leroy K, Monnet I, Mazières J, Barlesi F, Gounant V, Baldacci S, Mennecier B, Toffart AC, Audigier-Valette C, Doucet L, Giroux-Leprieur E, Guisier F, Ricordel C, Molinier O, Perol M, Pichon E, Robinet G, Templement-Grangerat D, Ruppert AM, Rabbe N, Antoine M, Wislez M
J Thorac Oncol 2020 May;15(5):860-866. Epub 2020 Jan 25 doi: 10.1016/j.jtho.2020.01.014. PMID: 31991225
Lazarus-type tumour response to therapy with nivolumab for sarcomatoid carcinomas of the lung.
Roesel C, Kambartel K, Kopeika U, Berzins A, Voshaar T, Krbek T
Curr Oncol 2019 Apr;26(2):e270-e273. Epub 2019 Apr 1 doi: 10.3747/co.26.4377. PMID: 31043837Free PMC Article
Nivolumab-induced organizing pneumonitis in a patient with lung sarcomatoid carcinoma.
Gounant V, Brosseau S, Naltet C, Opsomer MA, Antoine M, Danel C, Khalil A, Cadranel J, Zalcman G
Lung Cancer 2016 Sep;99:162-5. Epub 2016 Jul 15 doi: 10.1016/j.lungcan.2016.07.010. PMID: 27565934
Efficacy of first-line chemotherapy in patients with advanced lung sarcomatoid carcinoma.
Vieira T, Girard N, Ung M, Monnet I, Cazes A, Bonnette P, Duruisseaux M, Mazieres J, Antoine M, Cadranel J, Wislez M
J Thorac Oncol 2013 Dec;8(12):1574-7. doi: 10.1097/01.JTO.0000437008.00554.90. PMID: 24389441

Prognosis

GATA3 is a useful immunohistochemical marker for distinguishing sarcomatoid malignant mesothelioma from lung sarcomatoid carcinoma and organizing pleuritis.
Piao ZH, Zhou XC, Chen JY
Virchows Arch 2021 Aug;479(2):257-263. Epub 2021 Feb 11 doi: 10.1007/s00428-021-03048-y. PMID: 33570661
Efficacy of Immune Checkpoint Inhibitors in Lung Sarcomatoid Carcinoma.
Domblides C, Leroy K, Monnet I, Mazières J, Barlesi F, Gounant V, Baldacci S, Mennecier B, Toffart AC, Audigier-Valette C, Doucet L, Giroux-Leprieur E, Guisier F, Ricordel C, Molinier O, Perol M, Pichon E, Robinet G, Templement-Grangerat D, Ruppert AM, Rabbe N, Antoine M, Wislez M
J Thorac Oncol 2020 May;15(5):860-866. Epub 2020 Jan 25 doi: 10.1016/j.jtho.2020.01.014. PMID: 31991225
Overexpression of p53R2 is associated with poor prognosis in lung sarcomatoid carcinoma.
Chen J, Xiao Y, Cai X, Liu J, Chen K, Zhang X
BMC Cancer 2017 Dec 15;17(1):855. doi: 10.1186/s12885-017-3811-6. PMID: 29246119Free PMC Article
PD-L1 expression in pleomorphic, spindle cell and giant cell carcinoma of the lung is related to TTF-1, p40 expression and might indicate a worse prognosis.
Yvorel V, Patoir A, Casteillo F, Tissot C, Fournel P, Stachowicz ML, Karpathiou G, Tiffet O, Péoc'h M, Forest F
PLoS One 2017;12(7):e0180346. Epub 2017 Jul 3 doi: 10.1371/journal.pone.0180346. PMID: 28671973Free PMC Article
Efficacy of first-line chemotherapy in patients with advanced lung sarcomatoid carcinoma.
Vieira T, Girard N, Ung M, Monnet I, Cazes A, Bonnette P, Duruisseaux M, Mazieres J, Antoine M, Cadranel J, Wislez M
J Thorac Oncol 2013 Dec;8(12):1574-7. doi: 10.1097/01.JTO.0000437008.00554.90. PMID: 24389441

Clinical prediction guides

GATA3 is a useful immunohistochemical marker for distinguishing sarcomatoid malignant mesothelioma from lung sarcomatoid carcinoma and organizing pleuritis.
Piao ZH, Zhou XC, Chen JY
Virchows Arch 2021 Aug;479(2):257-263. Epub 2021 Feb 11 doi: 10.1007/s00428-021-03048-y. PMID: 33570661
Overexpression of p53R2 is associated with poor prognosis in lung sarcomatoid carcinoma.
Chen J, Xiao Y, Cai X, Liu J, Chen K, Zhang X
BMC Cancer 2017 Dec 15;17(1):855. doi: 10.1186/s12885-017-3811-6. PMID: 29246119Free PMC Article
MUC4, a novel immunohistochemical marker identified by gene expression profiling, differentiates pleural sarcomatoid mesothelioma from lung sarcomatoid carcinoma.
Amatya VJ, Kushitani K, Mawas AS, Miyata Y, Okada M, Kishimoto T, Inai K, Takeshima Y
Mod Pathol 2017 May;30(5):672-681. Epub 2017 Jan 27 doi: 10.1038/modpathol.2016.181. PMID: 28128276
A three-gene signature and clinical outcome in esophageal squamous cell carcinoma.
Sun LL, Wu JY, Wu ZY, Shen JH, Xu XE, Chen B, Wang SH, Li EM, Xu LY
Int J Cancer 2015 Mar 15;136(6):E569-77. Epub 2014 Sep 24 doi: 10.1002/ijc.29211. PMID: 25220908Free PMC Article
The value of biomarkers in patients with sarcomatoid carcinoma of the lung: molecular analysis of 33 cases.
Jiang X, Liu Y, Chen C, Zhan Z, Yan Q, Guo Y, Wang Q, Li K
Clin Lung Cancer 2012 Jul;13(4):288-96. Epub 2011 Dec 13 doi: 10.1016/j.cllc.2011.11.004. PMID: 22169481

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