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Pleomorphic Hepatocellular Carcinoma

MedGen UID:
354057
•Concept ID:
C1709568
•
Neoplastic Process
Synonym: Hepatocellular carcinoma, pleomorphic type
SNOMED CT: Hepatocellular carcinoma, pleomorphic type (128650001)

Definition

A morphologic variant of hepatocellular carcinoma, characterized by the presence of malignant cells which show marked variation in their size and shape. Bizarre mononuclear or multinucleated giant cells are often present. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPleomorphic Hepatocellular Carcinoma

Professional guidelines

PubMed

Cytologic criteria to distinguish hepatocellular carcinoma from nonneoplastic liver.
Cohen MB, Haber MM, Holly EA, Ahn DK, Bottles K, Stoloff AC
Am J Clin Pathol 1991 Feb;95(2):125-30. doi: 10.1093/ajcp/95.2.125. PMID: 1704175

Recent clinical studies

Diagnosis

Pleomorphic hepatocellular carcinoma following consumption of hypericum perforatum in alcoholic cirrhosis.
Lampri ES, Ioachim E, Harissis H, Balasi E, Mitselou A, Malamou-Mitsi V
World J Gastroenterol 2014 Feb 28;20(8):2113-6. doi: 10.3748/wjg.v20.i8.2113. PMID: 24587684Free PMC Article
Genetic abnormalities in a pre and post-chemotherapy hepatoblastoma.
Mullarkey M, Breen CJ, McDermott M, O'Meara A, Stallings RL
Cytogenet Cell Genet 2001;95(1-2):9-11. doi: 10.1159/000057009. PMID: 11978962
A new human pleomorphic hepatocellular carcinoma cell line, KYN-2.
Yano H, Maruiwa M, Murakami T, Fukuda K, Ito Y, Sugihara S, Kojiro M
Acta Pathol Jpn 1988 Aug;38(8):953-66. doi: 10.1111/j.1440-1827.1988.tb02368.x. PMID: 2847482

Therapy

Pleomorphic hepatocellular carcinoma following consumption of hypericum perforatum in alcoholic cirrhosis.
Lampri ES, Ioachim E, Harissis H, Balasi E, Mitselou A, Malamou-Mitsi V
World J Gastroenterol 2014 Feb 28;20(8):2113-6. doi: 10.3748/wjg.v20.i8.2113. PMID: 24587684Free PMC Article
A pleomorphic hepatocellular carcinoma with biochemical features of fibrolamellar hepatocellular carcinoma.
Buamah PK, McArdle P, Bennett M, James OF, Lendrum R
J Surg Oncol 1986 Jun;32(2):93-5. doi: 10.1002/jso.2930320210. PMID: 3014229

Prognosis

Genetic abnormalities in a pre and post-chemotherapy hepatoblastoma.
Mullarkey M, Breen CJ, McDermott M, O'Meara A, Stallings RL
Cytogenet Cell Genet 2001;95(1-2):9-11. doi: 10.1159/000057009. PMID: 11978962

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