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Small Intestinal Villous Adenoma

MedGen UID:
354183
•Concept ID:
C1710115
•
Neoplastic Process

Definition

A neoplasm that arises from the glandular epithelium of the small intestine. It is characterized by a villous architectural pattern. The neoplastic glandular cells have dysplastic features. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSmall Intestinal Villous Adenoma

Professional guidelines

PubMed

Endoscopy and EUS are key for effective surveillance and management of duodenal adenomas in familial adenomatous polyposis.
Gluck N, Strul H, Rozner G, Leshno M, Santo E
Gastrointest Endosc 2015 Apr;81(4):960-6. Epub 2014 Oct 24 doi: 10.1016/j.gie.2014.08.029. PMID: 25440680
Double balloon enteroscopy in children: diagnosis, treatment, and safety.
Thomson M, Venkatesh K, Elmalik K, van der Veer W, Jaacobs M
World J Gastroenterol 2010 Jan 7;16(1):56-62. doi: 10.3748/wjg.v16.i1.56. PMID: 20039449Free PMC Article
Duodenal polyps: diagnosis and management.
Reddy RR, Schuman BM, Priest RJ
J Clin Gastroenterol 1981 Jun;3(2):139-47. doi: 10.1097/00004836-198106000-00007. PMID: 7240690

Recent clinical studies

Etiology

Natural history of diminutive and small colorectal polyps: a systematic literature review.
Vleugels JLA, Hazewinkel Y, Fockens P, Dekker E
Gastrointest Endosc 2017 Jun;85(6):1169-1176.e1. Epub 2016 Dec 23 doi: 10.1016/j.gie.2016.12.014. PMID: 28024986
Adenoma of the papilla and ampulla--premalignant lesions?
Wittekind C, Tannapfel A
Langenbecks Arch Surg 2001 Apr;386(3):172-5. doi: 10.1007/s004230100234. PMID: 11382317
Colorectal polyps and their relationship to cancer.
Kim EC, Lance P
Gastroenterol Clin North Am 1997 Mar;26(1):1-17. doi: 10.1016/s0889-8553(05)70280-6. PMID: 9119435
Local resection for ampullary tumors. Is there a place for it?
Asbun HJ, Rossi RL, Munson JL
Arch Surg 1993 May;128(5):515-20. doi: 10.1001/archsurg.1993.01420170045006. PMID: 8098205
Duodenal villous tumors.
Bjork KJ, Davis CJ, Nagorney DM, Mucha P Jr
Arch Surg 1990 Aug;125(8):961-5. doi: 10.1001/archsurg.1990.01410200019001. PMID: 2378560

Diagnosis

Risk of Small Bowel Adenocarcinoma, Adenomas, and Carcinoids in a Nationwide Cohort of Individuals With Celiac Disease.
Emilsson L, Semrad C, Lebwohl B, Green PHR, Ludvigsson JF
Gastroenterology 2020 Nov;159(5):1686-1694.e2. Epub 2020 Jul 15 doi: 10.1053/j.gastro.2020.07.007. PMID: 32679218
Villous Morphology in Urinary Bladder Biopsy: An Approach to Diagnosis.
Mitra S, Ayyanar P, Kaur G
Int J Surg Pathol 2020 Feb;28(1):4-12. Epub 2019 Aug 13 doi: 10.1177/1066896919868527. PMID: 31409167
Natural history of diminutive and small colorectal polyps: a systematic literature review.
Vleugels JLA, Hazewinkel Y, Fockens P, Dekker E
Gastrointest Endosc 2017 Jun;85(6):1169-1176.e1. Epub 2016 Dec 23 doi: 10.1016/j.gie.2016.12.014. PMID: 28024986
Colorectal polyps and their relationship to cancer.
Kim EC, Lance P
Gastroenterol Clin North Am 1997 Mar;26(1):1-17. doi: 10.1016/s0889-8553(05)70280-6. PMID: 9119435
Local resection for ampullary tumors. Is there a place for it?
Asbun HJ, Rossi RL, Munson JL
Arch Surg 1993 May;128(5):515-20. doi: 10.1001/archsurg.1993.01420170045006. PMID: 8098205

Therapy

Risk of Small Bowel Adenocarcinoma, Adenomas, and Carcinoids in a Nationwide Cohort of Individuals With Celiac Disease.
Emilsson L, Semrad C, Lebwohl B, Green PHR, Ludvigsson JF
Gastroenterology 2020 Nov;159(5):1686-1694.e2. Epub 2020 Jul 15 doi: 10.1053/j.gastro.2020.07.007. PMID: 32679218
Double balloon enteroscopy in children: diagnosis, treatment, and safety.
Thomson M, Venkatesh K, Elmalik K, van der Veer W, Jaacobs M
World J Gastroenterol 2010 Jan 7;16(1):56-62. doi: 10.3748/wjg.v16.i1.56. PMID: 20039449Free PMC Article
Outcome of laparoscopic colectomy for polyps not suitable for endoscopic resection.
Pokala N, Delaney CP, Kiran RP, Brady K, Senagore AJ
Surg Endosc 2007 Mar;21(3):400-3. Epub 2006 Dec 16 doi: 10.1007/s00464-006-9069-8. PMID: 17180271
Impact of grade of dysplasia in villous adenomas of Vater's papilla.
Heidecke CD, Rosenberg R, Bauer M, Werner M, Weigert N, Ulm K, Roder JD, Siewert JR
World J Surg 2002 Jun;26(6):709-14. Epub 2002 Mar 26 doi: 10.1007/s00268-002-6215-x. PMID: 12053224
Local resection for ampullary tumors. Is there a place for it?
Asbun HJ, Rossi RL, Munson JL
Arch Surg 1993 May;128(5):515-20. doi: 10.1001/archsurg.1993.01420170045006. PMID: 8098205

Prognosis

The malignant colonic polyp Review of biological, clinical parameters and treatment.
Del Rio P, Cozzani F, Viani L, Nisi P, Rossini M, Sianesi M
Ann Ital Chir 2015;86:396-405. PMID: 26567607
Vater's papilla and periampullary area villous adenoma: personal experience about nine cases and review of the literature.
Motton G, Veraldi GF, Fracastoro G, Ricci F, Laterza E, Dorrucci V, Cordiano C
Hepatogastroenterology 1996 Mar-Apr;43(8):448-55. PMID: 8714243
Local resection for ampullary tumors. Is there a place for it?
Asbun HJ, Rossi RL, Munson JL
Arch Surg 1993 May;128(5):515-20. doi: 10.1001/archsurg.1993.01420170045006. PMID: 8098205
Duodenal villous tumors.
Bjork KJ, Davis CJ, Nagorney DM, Mucha P Jr
Arch Surg 1990 Aug;125(8):961-5. doi: 10.1001/archsurg.1990.01410200019001. PMID: 2378560
The adenoma-carcinoma sequence.
Day DW
Scand J Gastroenterol Suppl 1984;104:99-107. PMID: 6597553

Clinical prediction guides

Risk of Small Bowel Adenocarcinoma, Adenomas, and Carcinoids in a Nationwide Cohort of Individuals With Celiac Disease.
Emilsson L, Semrad C, Lebwohl B, Green PHR, Ludvigsson JF
Gastroenterology 2020 Nov;159(5):1686-1694.e2. Epub 2020 Jul 15 doi: 10.1053/j.gastro.2020.07.007. PMID: 32679218
Laparoscopic Pancreas-Sparing Duodenectomy with Roux en Y Reconstruction for Duodenal Polyposis.
Copaescu C, Smeu B, Constantin A, Saftoiu A
Chirurgia (Bucur) 2019 Jul-Aug;114(4):494-505. doi: 10.21614/chirurgia.114.4.502. PMID: 31511136
Clinicopathological characteristics of non-ampullary duodenal tumors and their phenotypic classification.
Yoshida M, Shimoda T, Abe M, Kakushima N, Kawata N, Takizawa K, Ono H, Sugino T
Pathol Int 2019 Jul;69(7):398-406. Epub 2019 Jul 21 doi: 10.1111/pin.12829. PMID: 31328367
Natural history of diminutive and small colorectal polyps: a systematic literature review.
Vleugels JLA, Hazewinkel Y, Fockens P, Dekker E
Gastrointest Endosc 2017 Jun;85(6):1169-1176.e1. Epub 2016 Dec 23 doi: 10.1016/j.gie.2016.12.014. PMID: 28024986
Clinical significance of small colorectal adenoma less than 10 mm: the KASID study.
Yoo TW, Park DI, Kim YH, Kim HS, Kim WH, Kim TI, Kim HJ, Yang SK, Byeon JS, Lee MS, Jung IK, Chung MK, Jung SA, Jeen YT, Choi JH, Choi H, Han DS, Song JS
Hepatogastroenterology 2007 Mar;54(74):418-21. PMID: 17523287

Recent systematic reviews

Natural history of diminutive and small colorectal polyps: a systematic literature review.
Vleugels JLA, Hazewinkel Y, Fockens P, Dekker E
Gastrointest Endosc 2017 Jun;85(6):1169-1176.e1. Epub 2016 Dec 23 doi: 10.1016/j.gie.2016.12.014. PMID: 28024986
Incidence of advanced adenomas at surveillance colonoscopy in patients with a personal history of colon adenomas: a meta-analysis and systematic review.
Saini SD, Kim HM, Schoenfeld P
Gastrointest Endosc 2006 Oct;64(4):614-26. doi: 10.1016/j.gie.2006.06.057. PMID: 16996358

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