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Thyroid Gland Hyperfunctioning Adenoma

MedGen UID:
354255
Concept ID:
C1710419
Neoplastic Process
Synonyms: Thyroid Gland Hot Adenoma; Thyroid Gland Toxic (Hyperfunctioning) Adenoma; Thyroid Gland Toxic Adenoma

Definition

A thyroid gland adenoma producing thyroxin. It is associated with hyperthyroidism. Radioactive iodine scan reveals a hot nodule. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThyroid Gland Hyperfunctioning Adenoma

Professional guidelines

PubMed

Broos WAM, Wondergem M, van der Zant FM, Schaper NC, Knol RJJ
Nucl Med Commun 2020 Aug;41(8):776-782. doi: 10.1097/MNM.0000000000001217. PMID: 32453204
Verburg FA, de Keizer B, van Isselt JW
Anticancer Agents Med Chem 2007 Jul;7(4):399-409. doi: 10.2174/187152007781058578. PMID: 17630916
Walfish PG, Strawbridge HT, Rosen IB
Surgery 1985 Dec;98(6):1179-88. PMID: 4071393

Recent clinical studies

Etiology

Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Broos WAM, Wondergem M, van der Zant FM, Schaper NC, Knol RJJ
Nucl Med Commun 2020 Aug;41(8):776-782. doi: 10.1097/MNM.0000000000001217. PMID: 32453204
Kuan EC, Peng KA, Suh JD, Bergsneider M, Wang MB
Ear Nose Throat J 2017 Aug;96(8):E28-E30. doi: 10.1177/014556131709600808. PMID: 28846797
Shirodkar M, Jabbour SA
Int J Clin Pract 2008 Sep;62(9):1423-31. Epub 2008 Jul 24 doi: 10.1111/j.1742-1241.2008.01831.x. PMID: 18657198
Arturi F, Capula C, Chiefari E, Filetti S, Russo D
Exp Clin Endocrinol Diabetes 1998;106(3):234-6. doi: 10.1055/s-0029-1211982. PMID: 9710366

Diagnosis

Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Petranović Ovčariček P, Giovanella L, Carrió Gasset I, Hindié E, Huellner MW, Luster M, Piccardo A, Weber T, Talbot JN, Verburg FA
Eur J Nucl Med Mol Imaging 2021 Aug;48(9):2801-2822. Epub 2021 Apr 10 doi: 10.1007/s00259-021-05334-y. PMID: 33839893Free PMC Article
Shirodkar M, Jabbour SA
Int J Clin Pract 2008 Sep;62(9):1423-31. Epub 2008 Jul 24 doi: 10.1111/j.1742-1241.2008.01831.x. PMID: 18657198
Jabbour SA, Davidovici BB, Wolf R
Clin Dermatol 2006 Jul-Aug;24(4):299-316. doi: 10.1016/j.clindermatol.2006.04.005. PMID: 16828412
McDermott MT, Ridgway EC
Endocrinol Metab Clin North Am 1998 Mar;27(1):187-203. doi: 10.1016/s0889-8529(05)70306-6. PMID: 9534036

Therapy

Camera A, Magri F, Fonte R, Villani L, Della Porta MG, Fregoni V, Manna LL, Chiovato L
Thyroid 2010 Sep;20(9):1033-6. doi: 10.1089/thy.2010.0048. PMID: 20825299
Stepansky A, Gold-Deutch R, Poluksht N, Hagag P, Benbassat C, Mor A, Aharoni D, Wassermann I, Halpern Z, Halevy A
Isr Med Assoc J 2010 Apr;12(4):207-10. PMID: 20803878
Verburg FA, de Keizer B, van Isselt JW
Anticancer Agents Med Chem 2007 Jul;7(4):399-409. doi: 10.2174/187152007781058578. PMID: 17630916
Bahar G, Feinmesser R, Joshua BZ, Shpitzer T, Morgenstein S, Popovtzer A, Shvero J
Surgery 2006 Jun;139(6):821-6. doi: 10.1016/j.surg.2005.11.009. PMID: 16782440
Lupi A, Orsolon P, Cerisara D, Deantoni Migliorati G, Vianello Dri A
Minerva Endocrinol 2002 Mar;27(1):53-7. PMID: 11845114

Prognosis

Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Mantzoros I, Kyriakidou D, Galanos-Demiris K, Chatzakis C, Parpoudi S, Sapidis N, Loutzidou L, Ioannidis O, Angelopoulos S, Tsalis KG
Am J Case Rep 2018 Nov 8;19:1334-1337. doi: 10.12659/AJCR.911452. PMID: 30405093Free PMC Article
Stepansky A, Gold-Deutch R, Poluksht N, Hagag P, Benbassat C, Mor A, Aharoni D, Wassermann I, Halpern Z, Halevy A
Isr Med Assoc J 2010 Apr;12(4):207-10. PMID: 20803878
Verburg FA, de Keizer B, van Isselt JW
Anticancer Agents Med Chem 2007 Jul;7(4):399-409. doi: 10.2174/187152007781058578. PMID: 17630916
Foley TP Jr
Endocrinol Metab Clin North Am 1993 Sep;22(3):593-606. PMID: 8243449

Clinical prediction guides

Badziong J, Ting S, Synoracki S, Tiedje V, Brix K, Brabant G, Moeller LC, Schmid KW, Fuhrer D, Zwanziger D
Eur J Endocrinol 2017 Sep;177(3):243-250. Epub 2017 Jun 2 doi: 10.1530/EJE-17-0279. PMID: 28576880
Cornianu M, Stan V, Lazăr E, Dema A, Golu I, Tăban S, Vlad M, Faur A, Vărcuş F, Babău F
Rom J Morphol Embryol 2011;52(2):545-53. PMID: 21655641
Stepansky A, Gold-Deutch R, Poluksht N, Hagag P, Benbassat C, Mor A, Aharoni D, Wassermann I, Halpern Z, Halevy A
Isr Med Assoc J 2010 Apr;12(4):207-10. PMID: 20803878
Rijnberk A, Kooistra HS, Mol JA
Growth Horm IGF Res 2003 Aug;13 Suppl A:S158-64. doi: 10.1016/s1096-6374(03)00076-5. PMID: 12914747
Deleu S, Allory Y, Radulescu A, Pirson I, Carrasco N, Corvilain B, Salmon I, Franc B, Dumont JE, Van Sande J, Maenhaut C
Thyroid 2000 Feb;10(2):131-40. doi: 10.1089/thy.2000.10.131. PMID: 10718549

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