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Lung Carcinosarcoma

MedGen UID:
354456
•Concept ID:
C1711276
•
Neoplastic Process
Synonyms: Carcinosarcoma of lung; Pulmonary Carcinosarcoma
SNOMED CT: Carcinosarcoma of lung (1255658004)

Definition

A morphologic variant of lung sarcomatoid carcinoma composed of a mixture of non-small cell lung carcinoma and a sarcomatous component. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLung Carcinosarcoma

Professional guidelines

PubMed

Treatment of Lung Carcinosarcoma and Other Rare Histologic Subtypes of Non-small Cell Lung Cancer.
Yang H, Lin Y, Liang Y
Curr Treat Options Oncol 2017 Aug 10;18(9):54. doi: 10.1007/s11864-017-0494-9. PMID: 28795312

Recent clinical studies

Diagnosis

First case report of erlotinib plus ramucirumab treatment for lung carcinosarcoma with EGFR L858R mutation.
Ishibashi N, Tabata T, Nonomura R, Oshima Y, Sasaki T, Mitomo H, Sugawara T, Sagawa M
Thorac Cancer 2023 Dec;14(34):3415-3418. Epub 2023 Oct 14 doi: 10.1111/1759-7714.15134. PMID: 37837329Free PMC Article
Treatment of Lung Carcinosarcoma and Other Rare Histologic Subtypes of Non-small Cell Lung Cancer.
Yang H, Lin Y, Liang Y
Curr Treat Options Oncol 2017 Aug 10;18(9):54. doi: 10.1007/s11864-017-0494-9. PMID: 28795312
Coexistence of a lung carcinosarcoma and hydatid cyst.
Misthos P, Kanakis MA, Horti M, Kakaris S, Lioulias A
Updates Surg 2013 Sep;65(3):253-4. Epub 2012 Mar 10 doi: 10.1007/s13304-012-0145-4. PMID: 22407550
Lung carcinosarcoma.
Vidal Losada MJ, Bernal Monterde V, Amores Arriaga B, Ferrer Pérez AI, Serrano Solares S, Tobeña Puyal M
Clin Transl Oncol 2010 Apr;12(4):303-5. doi: 10.1007/s12094-010-0508-6. PMID: 20462841
An immunohistological comparison of primary lung carcinosarcoma and sarcoma.
Cupples J, Wright J
Pathol Res Pract 1990 Jun;186(3):326-9. doi: 10.1016/S0344-0338(11)80290-6. PMID: 1696005

Therapy

First case report of erlotinib plus ramucirumab treatment for lung carcinosarcoma with EGFR L858R mutation.
Ishibashi N, Tabata T, Nonomura R, Oshima Y, Sasaki T, Mitomo H, Sugawara T, Sagawa M
Thorac Cancer 2023 Dec;14(34):3415-3418. Epub 2023 Oct 14 doi: 10.1111/1759-7714.15134. PMID: 37837329Free PMC Article
Treatment of Lung Carcinosarcoma and Other Rare Histologic Subtypes of Non-small Cell Lung Cancer.
Yang H, Lin Y, Liang Y
Curr Treat Options Oncol 2017 Aug 10;18(9):54. doi: 10.1007/s11864-017-0494-9. PMID: 28795312
Lung Carcinosarcoma Masked by Tracheobronchial Aspergillosis.
Zhou XM, Li P, Zhao L, Shi WJ
Intern Med 2015;54(15):1905-7. Epub 2015 Aug 1 doi: 10.2169/internalmedicine.54.3945. PMID: 26234234
Lung carcinosarcoma with liposarcoma element: autopsy case.
Kitazawa R, Kitazawa S, Nishimura Y, Kondo T, Obayashi C
Pathol Int 2006 Aug;56(8):449-52. doi: 10.1111/j.1440-1827.2006.01987.x. PMID: 16872439

Prognosis

A resected case of pulmonary carcinosarcoma.
Goto T, Maeshima A, Tajima A, Kato R
Ann Thorac Cardiovasc Surg 2010 Jun;16(3):190-3. PMID: 20930681
Lung carcinosarcoma.
Vidal Losada MJ, Bernal Monterde V, Amores Arriaga B, Ferrer Pérez AI, Serrano Solares S, Tobeña Puyal M
Clin Transl Oncol 2010 Apr;12(4):303-5. doi: 10.1007/s12094-010-0508-6. PMID: 20462841
Lung carcinosarcoma with liposarcoma element: autopsy case.
Kitazawa R, Kitazawa S, Nishimura Y, Kondo T, Obayashi C
Pathol Int 2006 Aug;56(8):449-52. doi: 10.1111/j.1440-1827.2006.01987.x. PMID: 16872439

Clinical prediction guides

A resected case of pulmonary carcinosarcoma.
Goto T, Maeshima A, Tajima A, Kato R
Ann Thorac Cardiovasc Surg 2010 Jun;16(3):190-3. PMID: 20930681

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