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Transient unilateral blurring of vision

MedGen UID:
356249
Concept ID:
C1865332
Finding
Synonym: Hemianopic blurring of vision
 
HPO: HP:0001125

Definition

Transient blurring of vision associated with the aura phase of migraine. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTransient unilateral blurring of vision

Conditions with this feature

Migraine, familial hemiplegic, 1
MedGen UID:
331388
Concept ID:
C1832884
Disease or Syndrome
Familial hemiplegic migraine (FHM) falls within the category of migraine with aura. In migraine with aura (including FHM) the neurologic symptoms of aura are unequivocally localizable to the cerebral cortex or brain stem and include visual disturbance (most common), sensory loss (e.g., numbness or paresthesias of the face or an extremity), and dysphasia (difficulty with speech). FHM must include motor involvement, such as hemiparesis (weakness of an extremity). Hemiparesis occurs with at least one other symptom during FHM aura. Neurologic deficits with FHM attacks can be prolonged for hours to days and may outlast the associated migrainous headache. FHM is often earlier in onset than typical migraine, frequently beginning in the first or second decade; the frequency of attacks tends to decrease with age. Approximately 40%-50% of families with CACNA1A-FHM have cerebellar signs ranging from nystagmus to progressive, usually late-onset mild ataxia.
Migraine, familial hemiplegic, 2
MedGen UID:
355962
Concept ID:
C1865322
Disease or Syndrome
Familial hemiplegic migraine (FHM) falls within the category of migraine with aura. In migraine with aura (including FHM) the neurologic symptoms of aura are unequivocally localizable to the cerebral cortex or brain stem and include visual disturbance (most common), sensory loss (e.g., numbness or paresthesias of the face or an extremity), and dysphasia (difficulty with speech). FHM must include motor involvement, such as hemiparesis (weakness of an extremity). Hemiparesis occurs with at least one other symptom during FHM aura. Neurologic deficits with FHM attacks can be prolonged for hours to days and may outlast the associated migrainous headache. FHM is often earlier in onset than typical migraine, frequently beginning in the first or second decade; the frequency of attacks tends to decrease with age. Approximately 40%-50% of families with CACNA1A-FHM have cerebellar signs ranging from nystagmus to progressive, usually late-onset mild ataxia.

Recent clinical studies

Etiology

Cozzupoli GM, Salgarello T, Giudiceandrea A, Rizzo S
Eur J Ophthalmol 2022 Jan;32(1):NP83-NP88. Epub 2020 Dec 18 doi: 10.1177/1120672120980689. PMID: 33339478
Amort M, Fluri F, Schäfer J, Weisskopf F, Katan M, Burow A, Bucher HC, Bonati LH, Lyrer PA, Engelter ST
Cerebrovasc Dis 2011;32(1):57-64. Epub 2011 May 25 doi: 10.1159/000327034. PMID: 21613786
Lim WK, Chee SP, Nussenblatt RB
Graefes Arch Clin Exp Ophthalmol 2005 Jun;243(6):607-9. Epub 2005 Jan 19 doi: 10.1007/s00417-004-0998-4. PMID: 15657772
Hicks PA, Leavitt JA, Mokri B
Ophthalmology 1994 Nov;101(11):1786-92. PMID: 7800357
Gaul JJ, Marks SJ, Weinberger J
Stroke 1986 May-Jun;17(3):393-8. doi: 10.1161/01.str.17.3.393. PMID: 3520977

Diagnosis

Cozzupoli GM, Salgarello T, Giudiceandrea A, Rizzo S
Eur J Ophthalmol 2022 Jan;32(1):NP83-NP88. Epub 2020 Dec 18 doi: 10.1177/1120672120980689. PMID: 33339478
Harsfort D, Hagen EM, Hansen RM
Spinal Cord Ser Cases 2021 May 28;7(1):47. doi: 10.1038/s41394-021-00410-9. PMID: 34050128Free PMC Article
Amort M, Fluri F, Schäfer J, Weisskopf F, Katan M, Burow A, Bucher HC, Bonati LH, Lyrer PA, Engelter ST
Cerebrovasc Dis 2011;32(1):57-64. Epub 2011 May 25 doi: 10.1159/000327034. PMID: 21613786
Hicks PA, Leavitt JA, Mokri B
Ophthalmology 1994 Nov;101(11):1786-92. PMID: 7800357
Gaul JJ, Marks SJ, Weinberger J
Stroke 1986 May-Jun;17(3):393-8. doi: 10.1161/01.str.17.3.393. PMID: 3520977

Therapy

Rissardo JP, Caprara ALF, Silveira JOF
Neurologist 2019 Jan;24(1):29-32. doi: 10.1097/NRL.0000000000000219. PMID: 30586032
Hashemi SB, Shishegar M, Nikeghbalian S, Salahi H, Bahador A, Kazemi K, Dehghani M, Kakaei F, Gholami S, Janghorban P, Malek-Hosseini SA
Transplant Proc 2009 Sep;41(7):2933-5. doi: 10.1016/j.transproceed.2009.07.008. PMID: 19765479
Lim WK, Chee SP, Nussenblatt RB
Graefes Arch Clin Exp Ophthalmol 2005 Jun;243(6):607-9. Epub 2005 Jan 19 doi: 10.1007/s00417-004-0998-4. PMID: 15657772
Niehaus L, Neuhauser H, Meyer BU
Clin Neurol Neurosurg 1998 Mar;100(1):31-2. doi: 10.1016/s0303-8467(97)00105-4. PMID: 9637201
Hicks PA, Leavitt JA, Mokri B
Ophthalmology 1994 Nov;101(11):1786-92. PMID: 7800357

Prognosis

Amort M, Fluri F, Schäfer J, Weisskopf F, Katan M, Burow A, Bucher HC, Bonati LH, Lyrer PA, Engelter ST
Cerebrovasc Dis 2011;32(1):57-64. Epub 2011 May 25 doi: 10.1159/000327034. PMID: 21613786
Hashemi SB, Shishegar M, Nikeghbalian S, Salahi H, Bahador A, Kazemi K, Dehghani M, Kakaei F, Gholami S, Janghorban P, Malek-Hosseini SA
Transplant Proc 2009 Sep;41(7):2933-5. doi: 10.1016/j.transproceed.2009.07.008. PMID: 19765479
Lim WK, Chee SP, Nussenblatt RB
Graefes Arch Clin Exp Ophthalmol 2005 Jun;243(6):607-9. Epub 2005 Jan 19 doi: 10.1007/s00417-004-0998-4. PMID: 15657772
Bianchi PE, Guagliano R, Salati R, Traselli G
Ophthalmologica 1997;211(6):391-3. doi: 10.1159/000310838. PMID: 9380361
Hicks PA, Leavitt JA, Mokri B
Ophthalmology 1994 Nov;101(11):1786-92. PMID: 7800357

Clinical prediction guides

Amort M, Fluri F, Schäfer J, Weisskopf F, Katan M, Burow A, Bucher HC, Bonati LH, Lyrer PA, Engelter ST
Cerebrovasc Dis 2011;32(1):57-64. Epub 2011 May 25 doi: 10.1159/000327034. PMID: 21613786
Bianchi PE, Guagliano R, Salati R, Traselli G
Ophthalmologica 1997;211(6):391-3. doi: 10.1159/000310838. PMID: 9380361

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