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Platelet responsiveness to adrenaline, depressed

MedGen UID:
358151
•Concept ID:
C1868200
•
Finding
Synonym: PLATELET RESPONSIVENESS TO ADRENALINE, DEPRESSED
 
Monarch Initiative: MONDO:0008257
OMIM®: 173580

Professional guidelines

PubMed

Alpha 2-adrenoceptor-mediated inhibition of platelet adenylate cyclase and induction of aggregation in major depression. Effect of long-term cyclic antidepressant drug treatment.
García-Sevilla JA, Padró D, Giralt MT, Guimón J, Areso P
Arch Gen Psychiatry 1990 Feb;47(2):125-32. doi: 10.1001/archpsyc.1990.01810140025005. PMID: 1967926
Biochemical and functional evidence of supersensitive platelet alpha 2-adrenoceptors in major affective disorder. Effect of long-term lithium carbonate treatment.
García-Sevilla JA, Guimón J, García-Vallejo P, Fuster MJ
Arch Gen Psychiatry 1986 Jan;43(1):51-7. doi: 10.1001/archpsyc.1986.01800010053007. PMID: 3002293
Platelet and plasma amine oxidase inhibition and urinary amine excretion changes during phenelzine treatment.
Murphy DL, Brand E, Goldman T, Baker M, Wright C, van Kammen D, Gordon E
J Nerv Ment Dis 1977 Feb;164(2):129-34. doi: 10.1097/00005053-197702000-00008. PMID: 836485

Recent clinical studies

Etiology

SSRI-reduced platelet reactivity in non-responding patients with life-long Recurrent Depressive Disorder: Detection and involved mechanisms.
Aleksovski B, Neceva V, Vujović V, Manusheva N, Rendevski V, Novotni A, Filipce A, Spasovska A, Sofijanova A, Aleksovski V, Gjorgoski I
Thromb Res 2018 May;165:24-32. Epub 2018 Mar 10 doi: 10.1016/j.thromres.2018.03.006. PMID: 29549779
Platelet response to serotonin in patients with stable coronary heart disease.
Kim DA, McClure WG 3rd, Neighoff JB, Vaidya D, Williams MS
Am J Cardiol 2014 Jul 15;114(2):181-6. Epub 2014 May 2 doi: 10.1016/j.amjcard.2014.04.023. PMID: 24952926Free PMC Article
Platelet 5-HT2A receptor subresponsivity and lethality of attempted suicide in depressed in-patients.
Malone KM, Ellis SP, Currier D, John Mann J
Int J Neuropsychopharmacol 2007 Jun;10(3):335-43. Epub 2006 Aug 8 doi: 10.1017/S1461145706006997. PMID: 16893479
Infusion of methylene blue in human septic shock: a pilot, randomized, controlled study.
Kirov MY, Evgenov OV, Evgenov NV, Egorina EM, Sovershaev MA, Sveinbjørnsson B, Nedashkovsky EV, Bjertnaes LJ
Crit Care Med 2001 Oct;29(10):1860-7. doi: 10.1097/00003246-200110000-00002. PMID: 11588440
Rapid antidepressant response to alprazolam in depressed patients with high catecholamine output and heterologous desensitization of platelet adenylate cyclase.
Mooney JJ, Schatzberg AF, Cole JO, Kizuka PP, Salomon M, Lerbinger J, Pappalardo KM, Gerson B, Schildkraut JJ
Biol Psychiatry 1988 Mar 15;23(6):543-59. doi: 10.1016/0006-3223(88)90002-9. PMID: 2833319

Diagnosis

SSRI-reduced platelet reactivity in non-responding patients with life-long Recurrent Depressive Disorder: Detection and involved mechanisms.
Aleksovski B, Neceva V, Vujović V, Manusheva N, Rendevski V, Novotni A, Filipce A, Spasovska A, Sofijanova A, Aleksovski V, Gjorgoski I
Thromb Res 2018 May;165:24-32. Epub 2018 Mar 10 doi: 10.1016/j.thromres.2018.03.006. PMID: 29549779
Platelet response to serotonin in patients with stable coronary heart disease.
Kim DA, McClure WG 3rd, Neighoff JB, Vaidya D, Williams MS
Am J Cardiol 2014 Jul 15;114(2):181-6. Epub 2014 May 2 doi: 10.1016/j.amjcard.2014.04.023. PMID: 24952926Free PMC Article
Infusion of methylene blue in human septic shock: a pilot, randomized, controlled study.
Kirov MY, Evgenov OV, Evgenov NV, Egorina EM, Sovershaev MA, Sveinbjørnsson B, Nedashkovsky EV, Bjertnaes LJ
Crit Care Med 2001 Oct;29(10):1860-7. doi: 10.1097/00003246-200110000-00002. PMID: 11588440
Plasma cortisol, catecholamine and cyclic AMP levels, response to dexamethasone suppression test and platelet MAO activity in manic-depressive patients. A longitudinal study.
Maj M, Ariano MG, Arena F, Kemali D
Neuropsychobiology 1984;11(3):168-73. doi: 10.1159/000118071. PMID: 6089030
Shape change and aggregation of blood platelets: interaction between the effects of adenosine and diphosphate, 5-hydroxytryptamine and adrenaline.
Michal F, Motamed M
Br J Pharmacol 1976 Feb;56(2):209-18. doi: 10.1111/j.1476-5381.1976.tb07444.x. PMID: 1252669Free PMC Article

Therapy

Sex differences in platelet reactivity and cardiovascular and psychological response to mental stress in patients with stable ischemic heart disease: insights from the REMIT study.
Samad Z, Boyle S, Ersboll M, Vora AN, Zhang Y, Becker RC, Williams R, Kuhn C, Ortel TL, Rogers JG, O'Connor CM, Velazquez EJ, Jiang W; REMIT Investigators
J Am Coll Cardiol 2014 Oct 21;64(16):1669-78. doi: 10.1016/j.jacc.2014.04.087. PMID: 25323254Free PMC Article
Platelet response to serotonin in patients with stable coronary heart disease.
Kim DA, McClure WG 3rd, Neighoff JB, Vaidya D, Williams MS
Am J Cardiol 2014 Jul 15;114(2):181-6. Epub 2014 May 2 doi: 10.1016/j.amjcard.2014.04.023. PMID: 24952926Free PMC Article
Bench-to-bedside review: Beta-adrenergic modulation in sepsis.
de Montmollin E, Aboab J, Mansart A, Annane D
Crit Care 2009;13(5):230. Epub 2009 Oct 23 doi: 10.1186/cc8026. PMID: 19863760Free PMC Article
Infusion of methylene blue in human septic shock: a pilot, randomized, controlled study.
Kirov MY, Evgenov OV, Evgenov NV, Egorina EM, Sovershaev MA, Sveinbjørnsson B, Nedashkovsky EV, Bjertnaes LJ
Crit Care Med 2001 Oct;29(10):1860-7. doi: 10.1097/00003246-200110000-00002. PMID: 11588440
Rapid antidepressant response to alprazolam in depressed patients with high catecholamine output and heterologous desensitization of platelet adenylate cyclase.
Mooney JJ, Schatzberg AF, Cole JO, Kizuka PP, Salomon M, Lerbinger J, Pappalardo KM, Gerson B, Schildkraut JJ
Biol Psychiatry 1988 Mar 15;23(6):543-59. doi: 10.1016/0006-3223(88)90002-9. PMID: 2833319

Prognosis

Intervention of the Nuss Procedure on the Mental Health of Pectus Excavatum Patients.
Luo L, Xu B, Wang X, Tan B, Zhao J
Ann Thorac Cardiovasc Surg 2017 Aug 20;23(4):175-180. Epub 2017 Jun 16 doi: 10.5761/atcs.oa.17-00014. PMID: 28626162Free PMC Article
Platelet response to serotonin in patients with stable coronary heart disease.
Kim DA, McClure WG 3rd, Neighoff JB, Vaidya D, Williams MS
Am J Cardiol 2014 Jul 15;114(2):181-6. Epub 2014 May 2 doi: 10.1016/j.amjcard.2014.04.023. PMID: 24952926Free PMC Article
Anxiety is a better predictor of platelet reactivity in coronary artery disease patients than depression.
Zafar MU, Paz-Yepes M, Shimbo D, Vilahur G, Burg MM, Chaplin W, Fuster V, Davidson KW, Badimon JJ
Eur Heart J 2010 Jul;31(13):1573-82. Epub 2010 Jan 22 doi: 10.1093/eurheartj/ehp602. PMID: 20097703Free PMC Article
Infusion of methylene blue in human septic shock: a pilot, randomized, controlled study.
Kirov MY, Evgenov OV, Evgenov NV, Egorina EM, Sovershaev MA, Sveinbjørnsson B, Nedashkovsky EV, Bjertnaes LJ
Crit Care Med 2001 Oct;29(10):1860-7. doi: 10.1097/00003246-200110000-00002. PMID: 11588440

Clinical prediction guides

SSRI-reduced platelet reactivity in non-responding patients with life-long Recurrent Depressive Disorder: Detection and involved mechanisms.
Aleksovski B, Neceva V, Vujović V, Manusheva N, Rendevski V, Novotni A, Filipce A, Spasovska A, Sofijanova A, Aleksovski V, Gjorgoski I
Thromb Res 2018 May;165:24-32. Epub 2018 Mar 10 doi: 10.1016/j.thromres.2018.03.006. PMID: 29549779
Platelet 5-HT2A receptor subresponsivity and lethality of attempted suicide in depressed in-patients.
Malone KM, Ellis SP, Currier D, John Mann J
Int J Neuropsychopharmacol 2007 Jun;10(3):335-43. Epub 2006 Aug 8 doi: 10.1017/S1461145706006997. PMID: 16893479
Rapid antidepressant response to alprazolam in depressed patients with high catecholamine output and heterologous desensitization of platelet adenylate cyclase.
Mooney JJ, Schatzberg AF, Cole JO, Kizuka PP, Salomon M, Lerbinger J, Pappalardo KM, Gerson B, Schildkraut JJ
Biol Psychiatry 1988 Mar 15;23(6):543-59. doi: 10.1016/0006-3223(88)90002-9. PMID: 2833319
Plasma cortisol, catecholamine and cyclic AMP levels, response to dexamethasone suppression test and platelet MAO activity in manic-depressive patients. A longitudinal study.
Maj M, Ariano MG, Arena F, Kemali D
Neuropsychobiology 1984;11(3):168-73. doi: 10.1159/000118071. PMID: 6089030
Depressed responsiveness to adrenaline in platelets from apparently normal human donors: a familial trait.
Scrutton MC, Clare KA, Hutton RA, Bruckdorfer KR
Br J Haematol 1981 Oct;49(2):303-14. doi: 10.1111/j.1365-2141.1981.tb07227.x. PMID: 6794593

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