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Autonomic erectile dysfunction

MedGen UID:
358232
Concept ID:
C1868524
Finding
Synonym: Impotence due to autonomic dysfunction
 
HPO: HP:0008652

Definition

Impotence (inability to develop or maintain an erection) resulting from abnormal functioning of the autonomic nervous system. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAutonomic erectile dysfunction

Conditions with this feature

Adult-onset autosomal dominant demyelinating leukodystrophy
MedGen UID:
356995
Concept ID:
C1868512
Disease or Syndrome
LMNB1-related autosomal dominant leukodystrophy (ADLD) is a slowly progressive disorder of central nervous system white matter characterized by onset of autonomic dysfunction in the fourth to fifth decade, followed by pyramidal and cerebellar abnormalities resulting in spasticity, ataxia, and tremor. Autonomic dysfunction can include bladder dysfunction, constipation, postural hypotension, erectile dysfunction, and (less often) impaired sweating. Pyramidal signs are often more prominent in the lower extremities (e.g., spastic weakness, hypertonia, clonus, brisk deep tendon reflexes, and bilateral Babinski signs). Cerebellar signs typically appear at the same time as the pyramidal signs and include gait ataxia, dysdiadochokinesia, intention tremor, dysmetria, and nystagmus. Many individuals have sensory deficits starting in the lower limbs. Pseudobulbar palsy with dysarthria, dysphagia, and forced crying and laughing may appear in the seventh or eighth decade. Although cognitive function is usually preserved or only mildly impaired early in the disease course, dementia and psychiatric manifestations can occur as late manifestations. Affected individuals may survive for decades after onset.

Professional guidelines

PubMed

Coon EA, Ahlskog JE
Mayo Clin Proc 2021 Mar;96(3):708-719. doi: 10.1016/j.mayocp.2020.10.005. PMID: 33673922
Chen Z, Li G, Liu J
Neurobiol Dis 2020 Feb;134:104700. Epub 2019 Dec 3 doi: 10.1016/j.nbd.2019.104700. PMID: 31809788
Andersson KE
Pharmacol Rev 2011 Dec;63(4):811-59. Epub 2011 Aug 31 doi: 10.1124/pr.111.004515. PMID: 21880989

Recent clinical studies

Etiology

Goldney J, Sargeant JA, Davies MJ
Diabetologia 2023 Oct;66(10):1832-1845. Epub 2023 Aug 19 doi: 10.1007/s00125-023-05988-3. PMID: 37597048Free PMC Article
Postuma RB, Iranzo A, Hu M, Högl B, Boeve BF, Manni R, Oertel WH, Arnulf I, Ferini-Strambi L, Puligheddu M, Antelmi E, Cochen De Cock V, Arnaldi D, Mollenhauer B, Videnovic A, Sonka K, Jung KY, Kunz D, Dauvilliers Y, Provini F, Lewis SJ, Buskova J, Pavlova M, Heidbreder A, Montplaisir JY, Santamaria J, Barber TR, Stefani A, St Louis EK, Terzaghi M, Janzen A, Leu-Semenescu S, Plazzi G, Nobili F, Sixel-Doering F, Dusek P, Bes F, Cortelli P, Ehgoetz Martens K, Gagnon JF, Gaig C, Zucconi M, Trenkwalder C, Gan-Or Z, Lo C, Rolinski M, Mahlknecht P, Holzknecht E, Boeve AR, Teigen LN, Toscano G, Mayer G, Morbelli S, Dawson B, Pelletier A
Brain 2019 Mar 1;142(3):744-759. doi: 10.1093/brain/awz030. PMID: 30789229Free PMC Article
Seppi K, Ray Chaudhuri K, Coelho M, Fox SH, Katzenschlager R, Perez Lloret S, Weintraub D, Sampaio C; the collaborators of the Parkinson's Disease Update on Non-Motor Symptoms Study Group on behalf of the Movement Disorders Society Evidence-Based Medicine Committee
Mov Disord 2019 Feb;34(2):180-198. Epub 2019 Jan 17 doi: 10.1002/mds.27602. PMID: 30653247Free PMC Article
Braffett BH, Wessells H, Sarma AV
Curr Diab Rep 2016 Dec;16(12):119. doi: 10.1007/s11892-016-0824-5. PMID: 27766580
Vinik AI, Maser RE, Mitchell BD, Freeman R
Diabetes Care 2003 May;26(5):1553-79. doi: 10.2337/diacare.26.5.1553. PMID: 12716821

Diagnosis

Mishriky BM, Cummings DM, Powell JR
Prim Care 2022 Jun;49(2):239-254. Epub 2022 Apr 22 doi: 10.1016/j.pop.2021.11.008. PMID: 35595480
Nativi-Nicolau JN, Karam C, Khella S, Maurer MS
Heart Fail Rev 2022 May;27(3):785-793. Epub 2021 Feb 20 doi: 10.1007/s10741-021-10080-2. PMID: 33609196Free PMC Article
Chen Z, Li G, Liu J
Neurobiol Dis 2020 Feb;134:104700. Epub 2019 Dec 3 doi: 10.1016/j.nbd.2019.104700. PMID: 31809788
Postuma RB, Iranzo A, Hu M, Högl B, Boeve BF, Manni R, Oertel WH, Arnulf I, Ferini-Strambi L, Puligheddu M, Antelmi E, Cochen De Cock V, Arnaldi D, Mollenhauer B, Videnovic A, Sonka K, Jung KY, Kunz D, Dauvilliers Y, Provini F, Lewis SJ, Buskova J, Pavlova M, Heidbreder A, Montplaisir JY, Santamaria J, Barber TR, Stefani A, St Louis EK, Terzaghi M, Janzen A, Leu-Semenescu S, Plazzi G, Nobili F, Sixel-Doering F, Dusek P, Bes F, Cortelli P, Ehgoetz Martens K, Gagnon JF, Gaig C, Zucconi M, Trenkwalder C, Gan-Or Z, Lo C, Rolinski M, Mahlknecht P, Holzknecht E, Boeve AR, Teigen LN, Toscano G, Mayer G, Morbelli S, Dawson B, Pelletier A
Brain 2019 Mar 1;142(3):744-759. doi: 10.1093/brain/awz030. PMID: 30789229Free PMC Article
Vinik AI, Maser RE, Mitchell BD, Freeman R
Diabetes Care 2003 May;26(5):1553-79. doi: 10.2337/diacare.26.5.1553. PMID: 12716821

Therapy

Goldney J, Sargeant JA, Davies MJ
Diabetologia 2023 Oct;66(10):1832-1845. Epub 2023 Aug 19 doi: 10.1007/s00125-023-05988-3. PMID: 37597048Free PMC Article
Chen Z, Li G, Liu J
Neurobiol Dis 2020 Feb;134:104700. Epub 2019 Dec 3 doi: 10.1016/j.nbd.2019.104700. PMID: 31809788
Postuma RB, Iranzo A, Hu M, Högl B, Boeve BF, Manni R, Oertel WH, Arnulf I, Ferini-Strambi L, Puligheddu M, Antelmi E, Cochen De Cock V, Arnaldi D, Mollenhauer B, Videnovic A, Sonka K, Jung KY, Kunz D, Dauvilliers Y, Provini F, Lewis SJ, Buskova J, Pavlova M, Heidbreder A, Montplaisir JY, Santamaria J, Barber TR, Stefani A, St Louis EK, Terzaghi M, Janzen A, Leu-Semenescu S, Plazzi G, Nobili F, Sixel-Doering F, Dusek P, Bes F, Cortelli P, Ehgoetz Martens K, Gagnon JF, Gaig C, Zucconi M, Trenkwalder C, Gan-Or Z, Lo C, Rolinski M, Mahlknecht P, Holzknecht E, Boeve AR, Teigen LN, Toscano G, Mayer G, Morbelli S, Dawson B, Pelletier A
Brain 2019 Mar 1;142(3):744-759. doi: 10.1093/brain/awz030. PMID: 30789229Free PMC Article
Seppi K, Ray Chaudhuri K, Coelho M, Fox SH, Katzenschlager R, Perez Lloret S, Weintraub D, Sampaio C; the collaborators of the Parkinson's Disease Update on Non-Motor Symptoms Study Group on behalf of the Movement Disorders Society Evidence-Based Medicine Committee
Mov Disord 2019 Feb;34(2):180-198. Epub 2019 Jan 17 doi: 10.1002/mds.27602. PMID: 30653247Free PMC Article
Vinik AI, Maser RE, Mitchell BD, Freeman R
Diabetes Care 2003 May;26(5):1553-79. doi: 10.2337/diacare.26.5.1553. PMID: 12716821

Prognosis

Carella MC, Forleo C, Stanca A, Carulli E, Basile P, Carbonara U, Amati F, Mushtaq S, Baggiano A, Pontone G, Ciccone MM, Guaricci AI
Curr Heart Fail Rep 2023 Dec;20(6):530-541. Epub 2023 Nov 14 doi: 10.1007/s11897-023-00632-y. PMID: 37962749Free PMC Article
Chen Z, Li G, Liu J
Neurobiol Dis 2020 Feb;134:104700. Epub 2019 Dec 3 doi: 10.1016/j.nbd.2019.104700. PMID: 31809788
Postuma RB, Iranzo A, Hu M, Högl B, Boeve BF, Manni R, Oertel WH, Arnulf I, Ferini-Strambi L, Puligheddu M, Antelmi E, Cochen De Cock V, Arnaldi D, Mollenhauer B, Videnovic A, Sonka K, Jung KY, Kunz D, Dauvilliers Y, Provini F, Lewis SJ, Buskova J, Pavlova M, Heidbreder A, Montplaisir JY, Santamaria J, Barber TR, Stefani A, St Louis EK, Terzaghi M, Janzen A, Leu-Semenescu S, Plazzi G, Nobili F, Sixel-Doering F, Dusek P, Bes F, Cortelli P, Ehgoetz Martens K, Gagnon JF, Gaig C, Zucconi M, Trenkwalder C, Gan-Or Z, Lo C, Rolinski M, Mahlknecht P, Holzknecht E, Boeve AR, Teigen LN, Toscano G, Mayer G, Morbelli S, Dawson B, Pelletier A
Brain 2019 Mar 1;142(3):744-759. doi: 10.1093/brain/awz030. PMID: 30789229Free PMC Article
Colosimo C
Nat Rev Neurol 2011 May;7(5):295-8. Epub 2011 Feb 22 doi: 10.1038/nrneurol.2011.5. PMID: 21343894
Chitaley K, Kupelian V, Subak L, Wessells H
J Urol 2009 Dec;182(6 Suppl):S45-50. doi: 10.1016/j.juro.2009.07.089. PMID: 19846136Free PMC Article

Clinical prediction guides

Carella MC, Forleo C, Stanca A, Carulli E, Basile P, Carbonara U, Amati F, Mushtaq S, Baggiano A, Pontone G, Ciccone MM, Guaricci AI
Curr Heart Fail Rep 2023 Dec;20(6):530-541. Epub 2023 Nov 14 doi: 10.1007/s11897-023-00632-y. PMID: 37962749Free PMC Article
Goldney J, Sargeant JA, Davies MJ
Diabetologia 2023 Oct;66(10):1832-1845. Epub 2023 Aug 19 doi: 10.1007/s00125-023-05988-3. PMID: 37597048Free PMC Article
Agochukwu-Mmonu N, Pop-Busui R, Wessells H, Sarma AV
Auton Neurosci 2020 Dec;229:102736. Epub 2020 Oct 16 doi: 10.1016/j.autneu.2020.102736. PMID: 33197694Free PMC Article
Chen Z, Li G, Liu J
Neurobiol Dis 2020 Feb;134:104700. Epub 2019 Dec 3 doi: 10.1016/j.nbd.2019.104700. PMID: 31809788
Postuma RB, Iranzo A, Hu M, Högl B, Boeve BF, Manni R, Oertel WH, Arnulf I, Ferini-Strambi L, Puligheddu M, Antelmi E, Cochen De Cock V, Arnaldi D, Mollenhauer B, Videnovic A, Sonka K, Jung KY, Kunz D, Dauvilliers Y, Provini F, Lewis SJ, Buskova J, Pavlova M, Heidbreder A, Montplaisir JY, Santamaria J, Barber TR, Stefani A, St Louis EK, Terzaghi M, Janzen A, Leu-Semenescu S, Plazzi G, Nobili F, Sixel-Doering F, Dusek P, Bes F, Cortelli P, Ehgoetz Martens K, Gagnon JF, Gaig C, Zucconi M, Trenkwalder C, Gan-Or Z, Lo C, Rolinski M, Mahlknecht P, Holzknecht E, Boeve AR, Teigen LN, Toscano G, Mayer G, Morbelli S, Dawson B, Pelletier A
Brain 2019 Mar 1;142(3):744-759. doi: 10.1093/brain/awz030. PMID: 30789229Free PMC Article

Recent systematic reviews

Julian TH, Syeed R, Glascow N, Zis P
Clin Auton Res 2020 Feb;30(1):29-41. Epub 2019 Jun 20 doi: 10.1007/s10286-019-00618-8. PMID: 31222483Free PMC Article
Chochina L, Naudet F, Chéhensse C, Manunta A, Damphousse M, Bonan I, Giuliano F
Sex Med Rev 2016 Jul;4(3):257-269. Epub 2016 Mar 29 doi: 10.1016/j.sxmr.2016.02.005. PMID: 27871959

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