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Bile duct papillary neoplasm

MedGen UID:: 360303
•Concept ID:: C1879344
•: Neoplastic Process

Synonyms:	Bile Duct Intraductal Papillary Neoplasm; Bile Duct IPN; bile duct papillary epithelial neoplasm; bile duct papillary neoplasm; Bile Duct Papillomatosis; bile duct papillomatosis; Biliary papillomatosis; Biliary Papillomatosis; biliary papillomatosis; intraductal papillary neoplasm; IPN
SNOMED CT:	Biliary papillomatosis (128663007); Biliary papillomatosis (1187632006)

Monarch Initiative:	MONDO:0003455

Definition

An intraductal papillary neoplasm that arises from the epithelium of the intrahepatic or extrahepatic bile ducts. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVBile duct papillary neoplasm

Disorder by Site
- Disorder of gastrointestinal tract
  - Hepatobiliary disorder
    - Biliary System Disorder
      - Bile duct disorder
        Bile duct neoplasm
        Bile duct papillary neoplasm
        Bile Duct Intraductal Papillary Neoplasm with an Associated Invasive Carcinoma
        Extrahepatic Bile Duct Intraductal Papillary Neoplasm with an Associated Invasive Carcinoma
        Intrahepatic Bile Duct Intraductal Papillary Neoplasm with an Associated Invasive Carcinoma
        Bile Duct Intraductal Papillary Neoplasm, High Grade
        Bile Duct Intraductal Papillary Neoplasm, Low Grade
        Extrahepatic biliary papillomatosis
        Intrahepatic biliary papillomatosis

Professional guidelines

PubMed

The Diagnosis and Treatment of Ampullary Carcinoma.

Walter D, Schnitzbauer AA, Schulze F, Trojan J
Dtsch Arztebl Int 2023 Oct 27;120(43):729-735. doi: 10.3238/arztebl.m2023.0195. PMID: 37656482 Free PMC Article

Hepatic Cysts: Reappraisal of the Classification, Terminology, Differential Diagnosis, and Clinicopathologic Characteristics in 258 Cases.

Armutlu A, Quigley B, Choi H, Basturk O, Akkas G, Pehlivanoglu B, Memis B, Jang KT, Erkan M, Erkan B, Balci S, Saka B, Bagci P, Farris AB, Kooby DA, Martin D, Kalb B, Maithel SK, Sarmiento J, Reid MD, Adsay NV
Am J Surg Pathol 2022 Sep 1;46(9):1219-1233. Epub 2022 Jul 4 doi: 10.1097/PAS.0000000000001930. PMID: 35778790

Cystic biliary tumors of the liver: diagnostic criteria and common pitfalls.

Shyu S, Singhi AD
Hum Pathol 2021 Jun;112:70-83. Epub 2020 Dec 28 doi: 10.1016/j.humpath.2020.12.010. PMID: 33383041 Free PMC Article

See all (23)

Recent clinical studies

Etiology

Biliary papillomatosis.

Gelders F, Struyve M, van Malenstein H
Acta Gastroenterol Belg 2023 Jul-Sep;86(3):483-485. doi: 10.51821/86.3.11733. PMID: 37814564

The World Health Organization Reporting System for Pancreaticobiliary Cytopathology.

Pitman MB, Centeno BA, Reid MD, Siddiqui MT, Layfield LJ, Perez-Machado M, Weynand B, Stelow EB, Lozano MD, Fukushima N, Cree IA, Mehrotra R, Schmitt FC, Field AS
Acta Cytol 2023;67(3):304-320. Epub 2022 Dec 14 doi: 10.1159/000527912. PMID: 36516741

Intrahepatic cholangiocarcinoma: typical features, uncommon variants, and controversial related entities.

Zen Y
Hum Pathol 2023 Feb;132:197-207. Epub 2022 Jun 11 doi: 10.1016/j.humpath.2022.06.001. PMID: 35697170

Anatomical, histomorphological and molecular classification of cholangiocarcinoma.

Kendall T, Verheij J, Gaudio E, Evert M, Guido M, Goeppert B, Carpino G
Liver Int 2019 May;39 Suppl 1:7-18. doi: 10.1111/liv.14093. PMID: 30882996

Intraductal papillary neoplasm of the bile duct.

Wan XS, Xu YY, Qian JY, Yang XB, Wang AQ, He L, Zhao HT, Sang XT
World J Gastroenterol 2013 Dec 14;19(46):8595-604. doi: 10.3748/wjg.v19.i46.8595. PMID: 24379576 Free PMC Article

See all (427)

Diagnosis

Intraductal papillary neoplasm of the bile duct: The new frontier of biliary pathology.

Mocchegiani F, Vincenzi P, Conte G, Nicolini D, Rossi R, Cacciaguerra AB, Vivarelli M
World J Gastroenterol 2023 Oct 14;29(38):5361-5373. doi: 10.3748/wjg.v29.i38.5361. PMID: 37900587 Free PMC Article

The Diagnosis and Treatment of Ampullary Carcinoma.

Walter D, Schnitzbauer AA, Schulze F, Trojan J
Dtsch Arztebl Int 2023 Oct 27;120(43):729-735. doi: 10.3238/arztebl.m2023.0195. PMID: 37656482 Free PMC Article

Intraductal papillary neoplasms of the bile duct: a European retrospective multicenter observational study (EUR-IPNB study).

Lluís N, Serradilla-Martín M, Achalandabaso M, Jehaes F, Dasari BVM, Mambrilla-Herrero S, Sparrelid E, Balakrishnan A, Hoogwater FJH, Amaral MJ, Andersson B, Berrevoet F, Doussot A, López-López V, Alsammani M, Detry O, Domingo-Del Pozo C, Machairas N, Pekli D, Alcázar-López CF, Asbun H, Björnsson B, Christophides T, Díez-Caballero A, Francart D, Noel CB, Sousa-Silva D, Toledo-Martínez E, Tzimas GN, Yaqub S, Cauchy F, Prieto-Calvo M, D'Souza MA, Spiers HVM, van den Heuvel MC, Charco R, Lesurtel M, Ramia JM
Int J Surg 2023 Apr 1;109(4):760-771. doi: 10.1097/JS9.0000000000000280. PMID: 36917142 Free PMC Article

Bile duct dysplasia and associated invasive carcinoma: clinicopathological features, diagnosis, and practical challenges.

Liu Y, Yeh MM
Hum Pathol 2023 Feb;132:158-168. Epub 2022 Jun 14 doi: 10.1016/j.humpath.2022.06.012. PMID: 35714833

Anatomical, histomorphological and molecular classification of cholangiocarcinoma.

Kendall T, Verheij J, Gaudio E, Evert M, Guido M, Goeppert B, Carpino G
Liver Int 2019 May;39 Suppl 1:7-18. doi: 10.1111/liv.14093. PMID: 30882996

See all (708)

Therapy

Association between Repeated Praziquantel treatment and Papillary, and Intrahepatic Cholangiocarcinoma.

Luvira V, Kamsa-Ard S, Kamsa-Ard S, Luvira V, Srisuk T, Pugkhem A, Pairojkul C, Bhudhisawasdi V
Ann Hepatol 2018 Aug 24;17(5):802-809. doi: 10.5604/01.3001.0012.3140. PMID: 30145559

Intraductal papillary neoplasm of the bile duct : case report and review of the literature.

Apostolopoulos P, Ekmektzoglou KA, Paraskeva K, Dimopoulos K, Paparaskeva K, Alexandrakis G
Acta Gastroenterol Belg 2018 Jan-Mar;81(1):97-99. PMID: 29562383

Endoscopic ampullectomy: a technical review.

Espinel J, Pinedo E, Ojeda V, Guerra Del Río M
Rev Esp Enferm Dig 2016 May;108(5):271-8. doi: 10.17235/reed.2016.3867/2015. PMID: 27187501

Endoscopic papillectomy: indications, techniques, and results.

De Palma GD
World J Gastroenterol 2014 Feb 14;20(6):1537-43. doi: 10.3748/wjg.v20.i6.1537. PMID: 24587629 Free PMC Article

ERCP.

Cotton PB
Gut 1977 Apr;18(4):316-41. doi: 10.1136/gut.18.4.316. PMID: 324875 Free PMC Article

See all (87)

Prognosis

Intraductal papillary neoplasm of the bile duct: The new frontier of biliary pathology.

The Diagnosis and Treatment of Ampullary Carcinoma.

Walter D, Schnitzbauer AA, Schulze F, Trojan J
Dtsch Arztebl Int 2023 Oct 27;120(43):729-735. doi: 10.3238/arztebl.m2023.0195. PMID: 37656482 Free PMC Article

The World Health Organization Reporting System for Pancreaticobiliary Cytopathology.

Intraductal papillary neoplasm of the bile duct - A comprehensive review.

Krawczyk M, Ziarkiewicz-Wróblewska B, Podgórska J, Grzybowski J, Gierej B, Krawczyk P, Grąt M, Kornasiewicz O, Skalski M, Wróblewski T
Adv Med Sci 2021 Mar;66(1):138-147. Epub 2021 Feb 6 doi: 10.1016/j.advms.2021.01.005. PMID: 33556909

Intraductal papillary neoplasm of the bile duct.

Wan XS, Xu YY, Qian JY, Yang XB, Wang AQ, He L, Zhao HT, Sang XT
World J Gastroenterol 2013 Dec 14;19(46):8595-604. doi: 10.3748/wjg.v19.i46.8595. PMID: 24379576 Free PMC Article

See all (433)

Clinical prediction guides

Intraductal papillary neoplasms of the bile duct: a European retrospective multicenter observational study (EUR-IPNB study).

Development of intraductal papillary neoplasm of the bile duct in patients with occupational cholangiocarcinoma.

Kubo S, Tanaka S, Kinoshita M, Shinkawa H, Ishizawa T, Sato Y
Virchows Arch 2023 Apr;482(4):745-753. Epub 2023 Jan 30 doi: 10.1007/s00428-023-03499-5. PMID: 36715769

Intrahepatic cholangiocarcinoma: typical features, uncommon variants, and controversial related entities.

Zen Y
Hum Pathol 2023 Feb;132:197-207. Epub 2022 Jun 11 doi: 10.1016/j.humpath.2022.06.001. PMID: 35697170

Intraductal papillary neoplasm of the bile duct.

Wan XS, Xu YY, Qian JY, Yang XB, Wang AQ, He L, Zhao HT, Sang XT
World J Gastroenterol 2013 Dec 14;19(46):8595-604. doi: 10.3748/wjg.v19.i46.8595. PMID: 24379576 Free PMC Article

Imaging bile duct tumors: pathologic concepts, classification, and early tumor detection.

Joo I, Lee JM
Abdom Imaging 2013 Dec;38(6):1334-50. doi: 10.1007/s00261-013-0027-3. PMID: 23925840

See all (265)

Recent systematic reviews

Pancreatic ductal adenocarcinomas associated with intraductal papillary mucinous neoplasms (IPMNs) versus pseudo-IPMNs: relative frequency, clinicopathologic characteristics and differential diagnosis.

Muraki T, Jang KT, Reid MD, Pehlivanoglu B, Memis B, Basturk O, Mittal P, Kooby D, Maithel SK, Sarmiento JM, Christians K, Tsai S, Evans D, Adsay V
Mod Pathol 2022 Jan;35(1):96-105. Epub 2021 Sep 13 doi: 10.1038/s41379-021-00902-x. PMID: 34518632

Pathological aspects of mucinous cholangiocarcinoma: A single-center experience and systematic review.

Laohawetwanit T, Klaikaew N
Pathol Int 2020 Sep;70(9):661-670. Epub 2020 Jul 7 doi: 10.1111/pin.12983. PMID: 32638458

Systematic Review and Meta-analysis of Current Experience in Treating IPNB: Clinical and Pathological Correlates.

Gordon-Weeks AN, Jones K, Harriss E, Smith A, Silva M
Ann Surg 2016 Apr;263(4):656-63. doi: 10.1097/SLA.0000000000001426. PMID: 26501712

Current therapy of hilar cholangiocarcinoma.

Lau SH, Lau WY
Hepatobiliary Pancreat Dis Int 2012 Feb;11(1):12-7. doi: 10.1016/s1499-3872(11)60119-7. PMID: 22251465

Intraductal oncocytic papillary neoplasms of the pancreas and bile ducts: a description of five new cases and review based on a systematic survey of the literature.

Liszka L, Pajak J, Zielińska-Pajak E, Krzych L, Gołka D, Mrowiec S, Lampe P
J Hepatobiliary Pancreat Sci 2010 May;17(3):246-61. Epub 2010 Mar 4 doi: 10.1007/s00534-010-0268-2. PMID: 20464560

See all (5)

MedGen

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Bile duct papillary neoplasm

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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