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Bile duct papillary neoplasm

MedGen UID:
360303
•Concept ID:
C1879344
•
Neoplastic Process
Synonyms: Bile Duct Intraductal Papillary Neoplasm; Bile Duct IPN; bile duct papillary epithelial neoplasm; bile duct papillary neoplasm; Bile Duct Papillomatosis; bile duct papillomatosis; Biliary papillomatosis; Biliary Papillomatosis; biliary papillomatosis; intraductal papillary neoplasm; IPN
SNOMED CT: Biliary papillomatosis (128663007); Biliary papillomatosis (1187632006)
 
Monarch Initiative: MONDO:0003455

Definition

An intraductal papillary neoplasm that arises from the epithelium of the intrahepatic or extrahepatic bile ducts. [from NCI]

Professional guidelines

PubMed

The Diagnosis and Treatment of Ampullary Carcinoma.
Walter D, Schnitzbauer AA, Schulze F, Trojan J
Dtsch Arztebl Int 2023 Oct 27;120(43):729-735. doi: 10.3238/arztebl.m2023.0195. PMID: 37656482Free PMC Article
Cystic biliary tumors of the liver: diagnostic criteria and common pitfalls.
Shyu S, Singhi AD
Hum Pathol 2021 Jun;112:70-83. Epub 2020 Dec 28 doi: 10.1016/j.humpath.2020.12.010. PMID: 33383041Free PMC Article
Primary Liver Cancers-Part 1: Histopathology, Differential Diagnoses, and Risk Stratification.
Jiang K, Al-Diffhala S, Centeno BA
Cancer Control 2018 Jan-Mar;25(1):1073274817744625. doi: 10.1177/1073274817744625. PMID: 29350068Free PMC Article

Recent clinical studies

Etiology

Biliary papillomatosis.
Gelders F, Struyve M, van Malenstein H
Acta Gastroenterol Belg 2023 Jul-Sep;86(3):483-485. doi: 10.51821/86.3.11733. PMID: 37814564
The World Health Organization Reporting System for Pancreaticobiliary Cytopathology.
Pitman MB, Centeno BA, Reid MD, Siddiqui MT, Layfield LJ, Perez-Machado M, Weynand B, Stelow EB, Lozano MD, Fukushima N, Cree IA, Mehrotra R, Schmitt FC, Field AS
Acta Cytol 2023;67(3):304-320. Epub 2022 Dec 14 doi: 10.1159/000527912. PMID: 36516741
Intraductal papillary neoplasm of the bile duct: Radiologic findings in a new disease.
Rodríguez Vargas D, Parada Blázquez MJ, Vargas Serrano B
Radiologia (Engl Ed) 2020 Jan-Feb;62(1):28-37. Epub 2019 Oct 9 doi: 10.1016/j.rx.2019.07.003. PMID: 31606127
Anatomical, histomorphological and molecular classification of cholangiocarcinoma.
Kendall T, Verheij J, Gaudio E, Evert M, Guido M, Goeppert B, Carpino G
Liver Int 2019 May;39 Suppl 1:7-18. doi: 10.1111/liv.14093. PMID: 30882996
Premalignant Lesions of the Biliary Tract.
Kanji ZS, Rocha FG
Surg Clin North Am 2019 Apr;99(2):301-314. Epub 2019 Feb 10 doi: 10.1016/j.suc.2018.11.007. PMID: 30846036

Diagnosis

Intraductal papillary neoplasm of the bile duct: The new frontier of biliary pathology.
Mocchegiani F, Vincenzi P, Conte G, Nicolini D, Rossi R, Cacciaguerra AB, Vivarelli M
World J Gastroenterol 2023 Oct 14;29(38):5361-5373. doi: 10.3748/wjg.v29.i38.5361. PMID: 37900587Free PMC Article
The Diagnosis and Treatment of Ampullary Carcinoma.
Walter D, Schnitzbauer AA, Schulze F, Trojan J
Dtsch Arztebl Int 2023 Oct 27;120(43):729-735. doi: 10.3238/arztebl.m2023.0195. PMID: 37656482Free PMC Article
Intraductal papillary neoplasm of the bile duct: Radiologic findings in a new disease.
Rodríguez Vargas D, Parada Blázquez MJ, Vargas Serrano B
Radiologia (Engl Ed) 2020 Jan-Feb;62(1):28-37. Epub 2019 Oct 9 doi: 10.1016/j.rx.2019.07.003. PMID: 31606127
Anatomical, histomorphological and molecular classification of cholangiocarcinoma.
Kendall T, Verheij J, Gaudio E, Evert M, Guido M, Goeppert B, Carpino G
Liver Int 2019 May;39 Suppl 1:7-18. doi: 10.1111/liv.14093. PMID: 30882996
Intraductal Papillary Neoplasm of the Bile Duct: Clinical, Imaging, and Pathologic Features.
Park HJ, Kim SY, Kim HJ, Lee SS, Hong GS, Byun JH, Hong SM, Lee MG
AJR Am J Roentgenol 2018 Jul;211(1):67-75. Epub 2018 Apr 9 doi: 10.2214/AJR.17.19261. PMID: 29629808

Therapy

Intraductal papillary neoplasm of the bile duct : case report and review of the literature.
Apostolopoulos P, Ekmektzoglou KA, Paraskeva K, Dimopoulos K, Paparaskeva K, Alexandrakis G
Acta Gastroenterol Belg 2018 Jan-Mar;81(1):97-99. PMID: 29562383
Peroral cholangiopancreatoscopy with the SpyGlass® system: what do we know 10 years later.
Pereira P, Peixoto A, Andrade P, Macedo G
J Gastrointestin Liver Dis 2017 Jun;26(2):165-170. doi: 10.15403/jgld.2014.1121.262.cho. PMID: 28617887
Endoscopic ampullectomy: a technical review.
Espinel J, Pinedo E, Ojeda V, Guerra Del Río M
Rev Esp Enferm Dig 2016 May;108(5):271-8. doi: 10.17235/reed.2016.3867/2015. PMID: 27187501
Endoscopic papillectomy: indications, techniques, and results.
De Palma GD
World J Gastroenterol 2014 Feb 14;20(6):1537-43. doi: 10.3748/wjg.v20.i6.1537. PMID: 24587629Free PMC Article
ERCP.
Cotton PB
Gut 1977 Apr;18(4):316-41. doi: 10.1136/gut.18.4.316. PMID: 324875Free PMC Article

Prognosis

Intraductal papillary neoplasm of the bile duct: The new frontier of biliary pathology.
Mocchegiani F, Vincenzi P, Conte G, Nicolini D, Rossi R, Cacciaguerra AB, Vivarelli M
World J Gastroenterol 2023 Oct 14;29(38):5361-5373. doi: 10.3748/wjg.v29.i38.5361. PMID: 37900587Free PMC Article
The Diagnosis and Treatment of Ampullary Carcinoma.
Walter D, Schnitzbauer AA, Schulze F, Trojan J
Dtsch Arztebl Int 2023 Oct 27;120(43):729-735. doi: 10.3238/arztebl.m2023.0195. PMID: 37656482Free PMC Article
The World Health Organization Reporting System for Pancreaticobiliary Cytopathology.
Pitman MB, Centeno BA, Reid MD, Siddiqui MT, Layfield LJ, Perez-Machado M, Weynand B, Stelow EB, Lozano MD, Fukushima N, Cree IA, Mehrotra R, Schmitt FC, Field AS
Acta Cytol 2023;67(3):304-320. Epub 2022 Dec 14 doi: 10.1159/000527912. PMID: 36516741
Intraductal papillary neoplasm of the bile duct - A comprehensive review.
Krawczyk M, Ziarkiewicz-Wróblewska B, Podgórska J, Grzybowski J, Gierej B, Krawczyk P, Grąt M, Kornasiewicz O, Skalski M, Wróblewski T
Adv Med Sci 2021 Mar;66(1):138-147. Epub 2021 Feb 6 doi: 10.1016/j.advms.2021.01.005. PMID: 33556909
Intraductal papillary neoplasm of the bile duct: Radiologic findings in a new disease.
Rodríguez Vargas D, Parada Blázquez MJ, Vargas Serrano B
Radiologia (Engl Ed) 2020 Jan-Feb;62(1):28-37. Epub 2019 Oct 9 doi: 10.1016/j.rx.2019.07.003. PMID: 31606127

Clinical prediction guides

Intrahepatic cholangiocarcinoma: typical features, uncommon variants, and controversial related entities.
Zen Y
Hum Pathol 2023 Feb;132:197-207. Epub 2022 Jun 11 doi: 10.1016/j.humpath.2022.06.001. PMID: 35697170
Intraductal papillary neoplasm of the bile duct (IPNB): CT and MRI appearance with radiology-pathology correlation.
Aslam A, Wasnik AP, Shi J, Sahai V, Mendiratta-Lala M
Clin Imaging 2020 Oct;66:10-17. Epub 2020 May 3 doi: 10.1016/j.clinimag.2020.04.036. PMID: 32438236Free PMC Article
"Biliary Diseases with Pancreatic Counterparts": Cross-sectional Imaging Findings.
Katabathina VS, Flaherty EM, Dasyam AK, Menias CO, Riddle ND, Lath N, Kozaka K, Matsui O, Nakanuma Y, Prasad SR
Radiographics 2016 Mar-Apr;36(2):374-92. Epub 2016 Feb 1 doi: 10.1148/rg.2016150071. PMID: 26824512
Intraductal papillary neoplasm of the bile duct.
Wan XS, Xu YY, Qian JY, Yang XB, Wang AQ, He L, Zhao HT, Sang XT
World J Gastroenterol 2013 Dec 14;19(46):8595-604. doi: 10.3748/wjg.v19.i46.8595. PMID: 24379576Free PMC Article
Imaging bile duct tumors: pathologic concepts, classification, and early tumor detection.
Joo I, Lee JM
Abdom Imaging 2013 Dec;38(6):1334-50. doi: 10.1007/s00261-013-0027-3. PMID: 23925840

Recent systematic reviews

Pancreatic ductal adenocarcinomas associated with intraductal papillary mucinous neoplasms (IPMNs) versus pseudo-IPMNs: relative frequency, clinicopathologic characteristics and differential diagnosis.
Muraki T, Jang KT, Reid MD, Pehlivanoglu B, Memis B, Basturk O, Mittal P, Kooby D, Maithel SK, Sarmiento JM, Christians K, Tsai S, Evans D, Adsay V
Mod Pathol 2022 Jan;35(1):96-105. Epub 2021 Sep 13 doi: 10.1038/s41379-021-00902-x. PMID: 34518632
Pathological aspects of mucinous cholangiocarcinoma: A single-center experience and systematic review.
Laohawetwanit T, Klaikaew N
Pathol Int 2020 Sep;70(9):661-670. Epub 2020 Jul 7 doi: 10.1111/pin.12983. PMID: 32638458
Systematic Review and Meta-analysis of Current Experience in Treating IPNB: Clinical and Pathological Correlates.
Gordon-Weeks AN, Jones K, Harriss E, Smith A, Silva M
Ann Surg 2016 Apr;263(4):656-63. doi: 10.1097/SLA.0000000000001426. PMID: 26501712
Current therapy of hilar cholangiocarcinoma.
Lau SH, Lau WY
Hepatobiliary Pancreat Dis Int 2012 Feb;11(1):12-7. doi: 10.1016/s1499-3872(11)60119-7. PMID: 22251465
Intraductal oncocytic papillary neoplasms of the pancreas and bile ducts: a description of five new cases and review based on a systematic survey of the literature.
Liszka L, Pajak J, Zielińska-Pajak E, Krzych L, Gołka D, Mrowiec S, Lampe P
J Hepatobiliary Pancreat Sci 2010 May;17(3):246-61. Epub 2010 Mar 4 doi: 10.1007/s00534-010-0268-2. PMID: 20464560

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