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Aberrant Crypt Focus

MedGen UID:
361841
•Concept ID:
C1879526
•
Finding
Synonyms: Aberrant Crypt Foci; Crypt Foci, Aberrant; Foci, Aberrant Crypt

Definition

A larger than normal, microscopically elevated colonic crypt that may contain dysplastic epithelium. It is considered as a possible precursor of colonic adenoma and carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAberrant Crypt Focus

Professional guidelines

PubMed

Chemopreventive and Therapeutic Effects of Edible Berries: A Focus on Colon Cancer Prevention and Treatment.
Afrin S, Giampieri F, Gasparrini M, Forbes-Hernandez TY, Varela-López A, Quiles JL, Mezzetti B, Battino M
Molecules 2016 Jan 30;21(2):169. doi: 10.3390/molecules21020169. PMID: 26840292Free PMC Article
The significance of ectopic crypt formation in the differential diagnosis of colorectal polyps.
Kim MJ, Lee EJ, Chun SM, Jang SJ, Kim DS, Lee DH, Youk EG
Diagn Pathol 2014 Nov 25;9:212. doi: 10.1186/s13000-014-0212-x. PMID: 25421018Free PMC Article
Metformin as an antitumor agent in cancer prevention and treatment.
Li D
J Diabetes 2011 Dec;3(4):320-7. doi: 10.1111/j.1753-0407.2011.00119.x. PMID: 21631893

Recent clinical studies

Etiology

Hyperplastic and serrated polyps of the colorectum.
O'Brien MJ
Gastroenterol Clin North Am 2007 Dec;36(4):947-68, viii. doi: 10.1016/j.gtc.2007.08.007. PMID: 17996799
Early detection and prevention of colorectal cancer (review).
Dashwood RH
Oncol Rep 1999 Mar-Apr;6(2):277-81. PMID: 10022989
Genetic determinant and environmental carcinogens.
Nagao M, Ochiai M, Ushijima T, Watanabe M, Sugimura T, Nakagama H
Mutat Res 1998 Jun 18;402(1-2):85-91. doi: 10.1016/s0027-5107(97)00285-6. PMID: 9675250
Phenotypic and genotypic characteristics of aberrant crypt foci in human colorectal mucosa.
Nucci MR, Robinson CR, Longo P, Campbell P, Hamilton SR
Hum Pathol 1997 Dec;28(12):1396-407. doi: 10.1016/s0046-8177(97)90230-6. PMID: 9416697
Diet, aberrant crypt foci and colorectal cancer.
Bruce WR, Archer MC, Corpet DE, Medline A, Minkin S, Stamp D, Yin Y, Zhang XM
Mutat Res 1993 Nov;290(1):111-8. doi: 10.1016/0027-5107(93)90038-h. PMID: 7694090

Diagnosis

Predictive Value Tools as an Aid in Chemopreventive Agent Development.
Dunn BK, Steele VE, Fagerstrom RM, Topp CF, Ransohoff D, Cunningham C, Lubet R, Ford LG, Kramer BS
J Natl Cancer Inst 2015 Dec;107(12):djv259. Epub 2015 Sep 28 doi: 10.1093/jnci/djv259. PMID: 26420882Free PMC Article
Role of aberrant crypt foci detected using high-magnification-chromoscopic colonoscopy in human colorectal carcinogenesis.
Hurlstone DP, Cross SS
J Gastroenterol Hepatol 2005 Feb;20(2):173-81. doi: 10.1111/j.1440-1746.2004.03433.x. PMID: 15683417
Early detection and prevention of colorectal cancer (review).
Dashwood RH
Oncol Rep 1999 Mar-Apr;6(2):277-81. PMID: 10022989
Genetic determinant and environmental carcinogens.
Nagao M, Ochiai M, Ushijima T, Watanabe M, Sugimura T, Nakagama H
Mutat Res 1998 Jun 18;402(1-2):85-91. doi: 10.1016/s0027-5107(97)00285-6. PMID: 9675250
Frequent and characteristic K-ras activation in aberrant crypt foci of colon. Is there preference among K-ras mutants for malignant progression?
Yamashita N, Minamoto T, Ochiai A, Onda M, Esumi H
Cancer 1995 Mar 15;75(6 Suppl):1527-33. doi: 10.1002/1097-0142(19950315)75:6+<1527::aid-cncr2820751524>3.0.co;2-y. PMID: 7889486

Therapy

Diet, aberrant crypt foci and colorectal cancer.
Bruce WR, Archer MC, Corpet DE, Medline A, Minkin S, Stamp D, Yin Y, Zhang XM
Mutat Res 1993 Nov;290(1):111-8. doi: 10.1016/0027-5107(93)90038-h. PMID: 7694090

Prognosis

Predictive Value Tools as an Aid in Chemopreventive Agent Development.
Dunn BK, Steele VE, Fagerstrom RM, Topp CF, Ransohoff D, Cunningham C, Lubet R, Ford LG, Kramer BS
J Natl Cancer Inst 2015 Dec;107(12):djv259. Epub 2015 Sep 28 doi: 10.1093/jnci/djv259. PMID: 26420882Free PMC Article
Aberrant crypt focus size predicts distal polyp histopathology.
Kim J, Ng J, Arozulllah A, Ewing R, Llor X, Carroll RE, Benya RV
Cancer Epidemiol Biomarkers Prev 2008 May;17(5):1155-62. doi: 10.1158/1055-9965.EPI-07-2731. PMID: 18483337
Pathology of the adenoma-carcinoma sequence: from aberrant crypt focus to invasive carcinoma.
Cummings OW
Semin Gastrointest Dis 2000 Oct;11(4):229-37. PMID: 11057950
Early detection and prevention of colorectal cancer (review).
Dashwood RH
Oncol Rep 1999 Mar-Apr;6(2):277-81. PMID: 10022989

Clinical prediction guides

Predictive Value Tools as an Aid in Chemopreventive Agent Development.
Dunn BK, Steele VE, Fagerstrom RM, Topp CF, Ransohoff D, Cunningham C, Lubet R, Ford LG, Kramer BS
J Natl Cancer Inst 2015 Dec;107(12):djv259. Epub 2015 Sep 28 doi: 10.1093/jnci/djv259. PMID: 26420882Free PMC Article
Reduced type II interleukin-4 receptor signalling drives initiation, but not progression, of colorectal carcinogenesis: evidence from transgenic mouse models and human case-control epidemiological observations.
Ingram N, Northwood EL, Perry SL, Marston G, Snowden H, Taylor JC, Scott N, Bishop DT, Coletta PL, Hull MA
Carcinogenesis 2013 Oct;34(10):2341-9. Epub 2013 Jun 19 doi: 10.1093/carcin/bgt222. PMID: 23784081Free PMC Article
Aberrant crypt focus size predicts distal polyp histopathology.
Kim J, Ng J, Arozulllah A, Ewing R, Llor X, Carroll RE, Benya RV
Cancer Epidemiol Biomarkers Prev 2008 May;17(5):1155-62. doi: 10.1158/1055-9965.EPI-07-2731. PMID: 18483337
Early detection and prevention of colorectal cancer (review).
Dashwood RH
Oncol Rep 1999 Mar-Apr;6(2):277-81. PMID: 10022989
Frequent and characteristic K-ras activation in aberrant crypt foci of colon. Is there preference among K-ras mutants for malignant progression?
Yamashita N, Minamoto T, Ochiai A, Onda M, Esumi H
Cancer 1995 Mar 15;75(6 Suppl):1527-33. doi: 10.1002/1097-0142(19950315)75:6+<1527::aid-cncr2820751524>3.0.co;2-y. PMID: 7889486

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