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Skin Basal Cell Carcinoma with Adnexal Differentiation

MedGen UID:
361906
•Concept ID:
C1879790
•
Neoplastic Process

Definition

A basal cell carcinoma of the skin that is characterized by adnexal differentiation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSkin Basal Cell Carcinoma with Adnexal Differentiation

Professional guidelines

PubMed

The immunohistochemical differential diagnosis of microcystic adnexal carcinoma, desmoplastic trichoepithelioma and morpheaform basal cell carcinoma using BerEP4 and stem cell markers.
Sellheyer K, Nelson P, Kutzner H, Patel RM
J Cutan Pathol 2013 Apr;40(4):363-70. Epub 2013 Feb 11 doi: 10.1111/cup.12085. PMID: 23398472
Differential diagnosis of pediatric tumors of the nasal cavity and paranasal sinuses: a 45-year multi-institutional review.
Holsinger FC, Hafemeister AC, Hicks MJ, Sulek M, Huh WW, Friedman EM
Ear Nose Throat J 2010 Nov;89(11):534-40. PMID: 21086277
The management of lid and conjunctival malignancies.
Char DH
Surv Ophthalmol 1980 May-Jun;24(6):679-89. doi: 10.1016/0039-6257(80)90127-7. PMID: 7414509

Recent clinical studies

Etiology

Dermoscopy of cutaneous adnexal tumours: a systematic review of the literature.
Lai M, Muscianese M, Piana S, Chester J, Borsari S, Paolino G, Pellacani G, Longo C, Pampena R
J Eur Acad Dermatol Venereol 2022 Sep;36(9):1524-1540. Epub 2022 May 25 doi: 10.1111/jdv.18210. PMID: 35536546Free PMC Article
The limitations of dermoscopy: false-positive and false-negative tumours.
Papageorgiou V, Apalla Z, Sotiriou E, Papageorgiou C, Lazaridou E, Vakirlis S, Ioannides D, Lallas A
J Eur Acad Dermatol Venereol 2018 Jun;32(6):879-888. Epub 2018 Jan 24 doi: 10.1111/jdv.14782. PMID: 29314288
Microcystic Adnexal Carcinoma and a Summary of Other Rare Malignant Adnexal Tumours.
Aslam A
Curr Treat Options Oncol 2017 Aug;18(8):49. doi: 10.1007/s11864-017-0491-z. PMID: 28681209
Evidence-Based Medicine: Cutaneous Facial Malignancies: Nonmelanoma Skin Cancer.
Connolly KL, Nehal KS, Disa JJ
Plast Reconstr Surg 2017 Jan;139(1):181e-190e. doi: 10.1097/PRS.0000000000002853. PMID: 28027254
Unusual cutaneous malignancies.
Cook TF, Fosko SW
Semin Cutan Med Surg 1998 Jun;17(2):114-32. doi: 10.1016/s1085-5629(98)80005-9. PMID: 9669605

Diagnosis

Dermoscopy of Adnexal Tumors.
Zaballos P, Gómez-Martín I, Martin JM, Bañuls J
Dermatol Clin 2018 Oct;36(4):397-412. Epub 2018 Aug 16 doi: 10.1016/j.det.2018.05.007. PMID: 30201149
Primary Cutaneous Osteosarcoma.
Fiegen AP, Tjarks BJ, Jassim AD
S D Med 2018 Apr;71(4):164-166. PMID: 29996033
Microcystic Adnexal Carcinoma and a Summary of Other Rare Malignant Adnexal Tumours.
Aslam A
Curr Treat Options Oncol 2017 Aug;18(8):49. doi: 10.1007/s11864-017-0491-z. PMID: 28681209
GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumors.
Miettinen M, McCue PA, Sarlomo-Rikala M, Rys J, Czapiewski P, Wazny K, Langfort R, Waloszczyk P, Biernat W, Lasota J, Wang Z
Am J Surg Pathol 2014 Jan;38(1):13-22. doi: 10.1097/PAS.0b013e3182a0218f. PMID: 24145643Free PMC Article
Trichogerminoma.
Tellechea O, Reis JP
Am J Dermatopathol 2009 Jul;31(5):480-3. doi: 10.1097/DAD.0b013e31818ffcc3. PMID: 19542926

Therapy

Sebaceous Carcinoma: A Review of the Scientific Literature.
Knackstedt T, Samie FH
Curr Treat Options Oncol 2017 Aug;18(8):47. doi: 10.1007/s11864-017-0490-0. PMID: 28681210
Vismodegib induces significant clinical response in locally advanced trichoblastic carcinoma.
Lepesant P, Crinquette M, Alkeraye S, Mirabel X, Dziwniel V, Cribier B, Mortier L
Br J Dermatol 2015 Oct;173(4):1059-62. Epub 2015 Aug 27 doi: 10.1111/bjd.13919. PMID: 25998864
Skin cancer in organ transplant recipients.
Kempf W, Mertz KD, Hofbauer GF, Tinguely M
Pathobiology 2013;80(6):302-9. Epub 2013 Aug 30 doi: 10.1159/000350757. PMID: 24013135
Lipid synthesis and processing proteins ABHD5, PGRMC1 and squalene synthase can serve as novel immunohistochemical markers for sebaceous neoplasms and differentiate sebaceous carcinoma from sebaceoma and basal cell carcinoma with clear cell features.
Chen WS, Chen PL, Li J, Lind AC, Lu D
J Cutan Pathol 2013 Jul;40(7):631-8. Epub 2013 Apr 5 doi: 10.1111/cup.12147. PMID: 23557589
Microcystic adnexal carcinoma arising in the setting of previous radiation therapy.
Antley CA, Carney M, Smoller BR
J Cutan Pathol 1999 Jan;26(1):48-50. doi: 10.1111/j.1600-0560.1999.tb01790.x. PMID: 10189245

Prognosis

Sebaceous Carcinoma: A Review of the Scientific Literature.
Knackstedt T, Samie FH
Curr Treat Options Oncol 2017 Aug;18(8):47. doi: 10.1007/s11864-017-0490-0. PMID: 28681210
Microcystic Adnexal Carcinoma and a Summary of Other Rare Malignant Adnexal Tumours.
Aslam A
Curr Treat Options Oncol 2017 Aug;18(8):49. doi: 10.1007/s11864-017-0491-z. PMID: 28681209
Microcystic Adnexal Carcinoma: A Review of the Literature.
Gordon S, Fischer C, Martin A, Rosman IS, Council ML
Dermatol Surg 2017 Aug;43(8):1012-1016. doi: 10.1097/DSS.0000000000001142. PMID: 28654578
GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumors.
Miettinen M, McCue PA, Sarlomo-Rikala M, Rys J, Czapiewski P, Wazny K, Langfort R, Waloszczyk P, Biernat W, Lasota J, Wang Z
Am J Surg Pathol 2014 Jan;38(1):13-22. doi: 10.1097/PAS.0b013e3182a0218f. PMID: 24145643Free PMC Article
Unusual cutaneous malignancies.
Cook TF, Fosko SW
Semin Cutan Med Surg 1998 Jun;17(2):114-32. doi: 10.1016/s1085-5629(98)80005-9. PMID: 9669605

Clinical prediction guides

Use of Cytokeratin 17 in the Differentiation Between Desmoplastic Trichilemmoma and Cutaneous Basal Cell Carcinoma.
Chaudet KM, Stagner AM, Nazarian RM
Am J Dermatopathol 2022 Dec 1;44(12):886-890. Epub 2022 Sep 27 doi: 10.1097/DAD.0000000000002302. PMID: 36197047
Molecular pathology of skin adnexal tumours.
Plotzke JM, Adams DJ, Harms PW
Histopathology 2022 Jan;80(1):166-183. doi: 10.1111/his.14441. PMID: 34197659
Skin tumors in xeroderma pigmentosum: Evaluation of a large series and a literature review.
Baykal C, Atcı T, Yılmaz Z, Büyükbabani N
J Cutan Pathol 2021 Jul;48(7):884-895. Epub 2021 Mar 9 doi: 10.1111/cup.13979. PMID: 33569789
Dermoscopy of Adnexal Tumors.
Zaballos P, Gómez-Martín I, Martin JM, Bañuls J
Dermatol Clin 2018 Oct;36(4):397-412. Epub 2018 Aug 16 doi: 10.1016/j.det.2018.05.007. PMID: 30201149
GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumors.
Miettinen M, McCue PA, Sarlomo-Rikala M, Rys J, Czapiewski P, Wazny K, Langfort R, Waloszczyk P, Biernat W, Lasota J, Wang Z
Am J Surg Pathol 2014 Jan;38(1):13-22. doi: 10.1097/PAS.0b013e3182a0218f. PMID: 24145643Free PMC Article

Recent systematic reviews

Dermoscopy of cutaneous adnexal tumours: a systematic review of the literature.
Lai M, Muscianese M, Piana S, Chester J, Borsari S, Paolino G, Pellacani G, Longo C, Pampena R
J Eur Acad Dermatol Venereol 2022 Sep;36(9):1524-1540. Epub 2022 May 25 doi: 10.1111/jdv.18210. PMID: 35536546Free PMC Article

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