U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Neutrophil Engraftment

MedGen UID:
362151
Concept ID:
C1882078
Finding

Definition

An absolute neutrophil count (ANC) of 500 or more (500 or more neutrophils in a cubic millimeter of blood) for 3 days in a row is a sign of engraftment. Neutrophil engraftment can occur as early as 10 days after transplant. About 20 days is more common for patients who receive marrow or peripheral (circulating) blood cells. For patients who receive cord blood, the average time to neutrophil engraftment is between 21 and 35 days. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeutrophil Engraftment

Professional guidelines

PubMed

Yao JM, Otoukesh S, Kim H, Yang D, Mokhtari S, Samara Y, Blackmon A, Arslan S, Agrawal V, Pourhassan H, Amanam I, Ball B, Koller P, Salhotra A, Becker P, Curtin P, Artz A, Aldoss I, Ali H, Stewart F, Smith E, Stein A, Marcucci G, Forman SJ, Nakamura R, Al Malki MM
Transplant Cell Ther 2023 Aug;29(8):515.e1-515.e7. Epub 2023 May 12 doi: 10.1016/j.jtct.2023.05.008. PMID: 37182736Free PMC Article
Shen Y, Zhang L, Zhang X, Zhang T, Jiang E, Feng S, He Y, Zhang R
Transplant Cell Ther 2023 Aug;29(8):514.e1-514.e6. Epub 2023 May 11 doi: 10.1016/j.jtct.2023.05.005. PMID: 37178922
Schoettler ML, Carreras E, Cho B, Dandoy CE, Ho VT, Jodele S, Moissev I, Sanchez-Ortega I, Srivastava A, Atsuta Y, Carpenter P, Koreth J, Kroger N, Ljungman P, Page K, Popat U, Shaw BE, Sureda A, Soiffer R, Vasu S
Transplant Cell Ther 2023 Mar;29(3):151-163. Epub 2022 Nov 25 doi: 10.1016/j.jtct.2022.11.015. PMID: 36442770Free PMC Article

Recent clinical studies

Etiology

Portuguese AJ, Holmberg L, Hill GR, Lee SJ, Green DJ, Mielcarek M, Gooley T, Yeh AC
Transplant Cell Ther 2023 Nov;29(11):696.e1-696.e7. Epub 2023 Aug 25 doi: 10.1016/j.jtct.2023.08.021. PMID: 37634844Free PMC Article
Shuman K, Palmer S, Anders B, Moore D, Ptachcinski J, Grgic T, Alexander M, Hill L, Sung AD, Armistead PM, Kennedy L, Shaw JR
Transplant Cell Ther 2023 Jan;29(1):36.e1-36.e5. Epub 2022 Oct 28 doi: 10.1016/j.jtct.2022.10.017. PMID: 36404519
Johnson AK, Lorimer EL, Szabo A, Wu R, Shah NN, D'Souza A, Chhabra S, Hamadani M, Dhakal B, Hari P, Rao S, Carlson K, Williams CL, Knight JM
Yale J Biol Med 2022 Mar;95(1):45-56. Epub 2022 Mar 31 PMID: 35370486Free PMC Article
Kume T, Shimizu R, Akiyama K, Tsuchiya T, Shino M, Ikeda T, Iwai S
Support Care Cancer 2022 Feb;30(2):1539-1546. Epub 2021 Sep 18 doi: 10.1007/s00520-021-06573-3. PMID: 34536133
Yuasa M, Yamamoto H, Kageyama K, Kaji D, Taya Y, Takagi S, Yamamoto G, Asano-Mori Y, Wake A, Yoneyama A, Makino S, Uchida N, Taniguchi S
Biol Blood Marrow Transplant 2020 Sep;26(9):1689-1696. Epub 2020 Jun 4 doi: 10.1016/j.bbmt.2020.05.018. PMID: 32505808

Diagnosis

Schoettler ML, Carreras E, Cho B, Dandoy CE, Ho VT, Jodele S, Moissev I, Sanchez-Ortega I, Srivastava A, Atsuta Y, Carpenter P, Koreth J, Kroger N, Ljungman P, Page K, Popat U, Shaw BE, Sureda A, Soiffer R, Vasu S
Transplant Cell Ther 2023 Mar;29(3):151-163. Epub 2022 Nov 25 doi: 10.1016/j.jtct.2022.11.015. PMID: 36442770Free PMC Article
Gunes AK, Serin I, Demir I, Sarifakiogullari S, Durusoy SS, Akkurt DM, Ince I, Ozkan G, Cinli TA, Pehlivan M
Hematol Oncol Stem Cell Ther 2022 Dec 23;15(4):201-207. doi: 10.1016/j.hemonc.2021.03.005. PMID: 33933474
Noorazar L, Bonakchi H, Sankanian G, Parkhideh S, Salimi M, Hajifathali A, Mirfakhraie R, Roshandel E
J Clin Lab Anal 2021 Dec;35(12):e24060. Epub 2021 Oct 21 doi: 10.1002/jcla.24060. PMID: 34674310Free PMC Article
Ataca Atilla P, Akkus E, Atilla E, Gokmen N, Civriz Bozdag S, Kocak Toprak S, Kurt Yuksel M, Ozcan M, Demirer T, Ilhan O, Beksac M, Akan H, Arslan O, Topcuoglu P, Gurman G
Transfus Clin Biol 2020 Aug;27(3):115-121. Epub 2020 Jul 10 doi: 10.1016/j.tracli.2020.06.008. PMID: 32659269
Hong KT, Kang HJ, Kim NH, Kim MS, Lee JW, Kim H, Park KD, Shin HY, Ahn HS
Bone Marrow Transplant 2013 Apr;48(4):523-8. Epub 2012 Sep 24 doi: 10.1038/bmt.2012.171. PMID: 23000648

Therapy

Schoettler ML, Carreras E, Cho B, Dandoy CE, Ho VT, Jodele S, Moissev I, Sanchez-Ortega I, Srivastava A, Atsuta Y, Carpenter P, Koreth J, Kroger N, Ljungman P, Page K, Popat U, Shaw BE, Sureda A, Soiffer R, Vasu S
Transplant Cell Ther 2023 Mar;29(3):151-163. Epub 2022 Nov 25 doi: 10.1016/j.jtct.2022.11.015. PMID: 36442770Free PMC Article
Johnson AK, Lorimer EL, Szabo A, Wu R, Shah NN, D'Souza A, Chhabra S, Hamadani M, Dhakal B, Hari P, Rao S, Carlson K, Williams CL, Knight JM
Yale J Biol Med 2022 Mar;95(1):45-56. Epub 2022 Mar 31 PMID: 35370486Free PMC Article
Kume T, Shimizu R, Akiyama K, Tsuchiya T, Shino M, Ikeda T, Iwai S
Support Care Cancer 2022 Feb;30(2):1539-1546. Epub 2021 Sep 18 doi: 10.1007/s00520-021-06573-3. PMID: 34536133
Horwitz ME, Stiff PJ, Cutler C, Brunstein C, Hanna R, Maziarz RT, Rezvani AR, Karris NA, McGuirk J, Valcarcel D, Schiller GJ, Lindemans CA, Hwang WYK, Koh LP, Keating A, Khaled Y, Hamerschlak N, Frankfurt O, Peled T, Segalovich I, Blackwell B, Wease S, Freedman LS, Galamidi-Cohen E, Sanz G
Blood 2021 Oct 21;138(16):1429-1440. doi: 10.1182/blood.2021011719. PMID: 34157093Free PMC Article
Pusic I, DiPersio JF
Curr Pharm Des 2008;14(20):1950-61. doi: 10.2174/138161208785061427. PMID: 18691106

Prognosis

Masetti R, Leardini D, Muratore E, Fabbrini M, D'Amico F, Zama D, Baccelli F, Gottardi F, Belotti T, Ussowicz M, Fraczkiewicz J, Cesaro S, Zecca M, Merli P, Candela M, Pession A, Locatelli F, Prete A, Brigidi P, Turroni S
Blood 2023 Oct 19;142(16):1387-1398. doi: 10.1182/blood.2023020026. PMID: 37856089Free PMC Article
Schoettler ML, Carreras E, Cho B, Dandoy CE, Ho VT, Jodele S, Moissev I, Sanchez-Ortega I, Srivastava A, Atsuta Y, Carpenter P, Koreth J, Kroger N, Ljungman P, Page K, Popat U, Shaw BE, Sureda A, Soiffer R, Vasu S
Transplant Cell Ther 2023 Mar;29(3):151-163. Epub 2022 Nov 25 doi: 10.1016/j.jtct.2022.11.015. PMID: 36442770Free PMC Article
Otegbeye F, Vina MAF, Wang T, Bolon YT, Lazaryan A, Beitinjaneh A, Bhatt VR, Castillo P, Marsh SGE, Hildebrandt GC, Assal A, Brown VI, Hsu J, Spellman S, de Lima M, Lee SJ
Transplant Cell Ther 2022 Aug;28(8):483.e1-483.e7. Epub 2022 May 26 doi: 10.1016/j.jtct.2022.05.034. PMID: 35643351Free PMC Article
Okada Y, Nakasone H, Konuma T, Uchida N, Tanaka M, Sugio Y, Aotsuka N, Nishijima A, Katsuoka Y, Ara T, Ota S, Onizuka M, Sawa M, Kimura T, Fukuda T, Atsuta Y, Kanda J, Kimura F
Transplant Cell Ther 2022 Aug;28(8):504.e1-504.e7. Epub 2022 May 13 doi: 10.1016/j.jtct.2022.05.006. PMID: 35577325
Peled JU, Gomes ALC, Devlin SM, Littmann ER, Taur Y, Sung AD, Weber D, Hashimoto D, Slingerland AE, Slingerland JB, Maloy M, Clurman AG, Stein-Thoeringer CK, Markey KA, Docampo MD, Burgos da Silva M, Khan N, Gessner A, Messina JA, Romero K, Lew MV, Bush A, Bohannon L, Brereton DG, Fontana E, Amoretti LA, Wright RJ, Armijo GK, Shono Y, Sanchez-Escamilla M, Castillo Flores N, Alarcon Tomas A, Lin RJ, Yáñez San Segundo L, Shah GL, Cho C, Scordo M, Politikos I, Hayasaka K, Hasegawa Y, Gyurkocza B, Ponce DM, Barker JN, Perales MA, Giralt SA, Jenq RR, Teshima T, Chao NJ, Holler E, Xavier JB, Pamer EG, van den Brink MRM
N Engl J Med 2020 Feb 27;382(9):822-834. doi: 10.1056/NEJMoa1900623. PMID: 32101664Free PMC Article

Clinical prediction guides

Masetti R, Leardini D, Muratore E, Fabbrini M, D'Amico F, Zama D, Baccelli F, Gottardi F, Belotti T, Ussowicz M, Fraczkiewicz J, Cesaro S, Zecca M, Merli P, Candela M, Pession A, Locatelli F, Prete A, Brigidi P, Turroni S
Blood 2023 Oct 19;142(16):1387-1398. doi: 10.1182/blood.2023020026. PMID: 37856089Free PMC Article
Mussetti A, Kanate AS, Wang T, He M, Hamadani M, Finel H Sr, Boumendil A Sr, Glass B, Castagna L, Dominietto A, McGuirk J, Blaise D, Gülbas Z, Diez-Martin J, Marsh SGE, Paczesny S, Gadalla SM, Dreger P, Zhang MJ, Spellman SR, Lee SJ, Bolon YT, Sureda A
Transplant Cell Ther 2023 Mar;29(3):184.e1-184.e9. Epub 2022 Dec 25 doi: 10.1016/j.jtct.2022.11.028. PMID: 36577482Free PMC Article
Johnson AK, Lorimer EL, Szabo A, Wu R, Shah NN, D'Souza A, Chhabra S, Hamadani M, Dhakal B, Hari P, Rao S, Carlson K, Williams CL, Knight JM
Yale J Biol Med 2022 Mar;95(1):45-56. Epub 2022 Mar 31 PMID: 35370486Free PMC Article
Yuasa M, Yamamoto H, Kageyama K, Kaji D, Taya Y, Takagi S, Yamamoto G, Asano-Mori Y, Wake A, Yoneyama A, Makino S, Uchida N, Taniguchi S
Biol Blood Marrow Transplant 2020 Sep;26(9):1689-1696. Epub 2020 Jun 4 doi: 10.1016/j.bbmt.2020.05.018. PMID: 32505808
Peled JU, Gomes ALC, Devlin SM, Littmann ER, Taur Y, Sung AD, Weber D, Hashimoto D, Slingerland AE, Slingerland JB, Maloy M, Clurman AG, Stein-Thoeringer CK, Markey KA, Docampo MD, Burgos da Silva M, Khan N, Gessner A, Messina JA, Romero K, Lew MV, Bush A, Bohannon L, Brereton DG, Fontana E, Amoretti LA, Wright RJ, Armijo GK, Shono Y, Sanchez-Escamilla M, Castillo Flores N, Alarcon Tomas A, Lin RJ, Yáñez San Segundo L, Shah GL, Cho C, Scordo M, Politikos I, Hayasaka K, Hasegawa Y, Gyurkocza B, Ponce DM, Barker JN, Perales MA, Giralt SA, Jenq RR, Teshima T, Chao NJ, Holler E, Xavier JB, Pamer EG, van den Brink MRM
N Engl J Med 2020 Feb 27;382(9):822-834. doi: 10.1056/NEJMoa1900623. PMID: 32101664Free PMC Article

Recent systematic reviews

Huang Y, Luo C, Wu G, Huang X, Ding Y, Huang Z, Chen J, Li X, Xu S
Bone Marrow Transplant 2023 May;58(5):544-551. Epub 2023 Feb 13 doi: 10.1038/s41409-023-01932-6. PMID: 36782066
Li T, Luo C, Zhang J, Wei L, Sun W, Xie Q, Liu Y, Zhao Y, Xu S, Wang L
Stem Cell Res Ther 2021 Apr 20;12(1):246. doi: 10.1186/s13287-021-02304-x. PMID: 33879242Free PMC Article
Evans JC, Hirani SP, Needle JJ
Biol Blood Marrow Transplant 2019 Aug;25(8):e252-e259. Epub 2019 Mar 1 doi: 10.1016/j.bbmt.2019.02.023. PMID: 30826462
Kiernan J, Damien P, Monaghan M, Shorr R, McIntyre L, Fergusson D, Tinmouth A, Allan D
Transfus Med Rev 2017 Jul;31(3):173-182. Epub 2016 Dec 23 doi: 10.1016/j.tmrv.2016.12.004. PMID: 28087163
Arai Y, Jo T, Matsui H, Kondo T, Takaori-Kondo A
Leuk Lymphoma 2017 Aug;58(8):1840-1848. Epub 2016 Dec 12 doi: 10.1080/10428194.2016.1266624. PMID: 27951736

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...