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Neutrophil Engraftment

MedGen UID:
362151
Concept ID:
C1882078
Finding

Definition

An absolute neutrophil count (ANC) of 500 or more (500 or more neutrophils in a cubic millimeter of blood) for 3 days in a row is a sign of engraftment. Neutrophil engraftment can occur as early as 10 days after transplant. About 20 days is more common for patients who receive marrow or peripheral (circulating) blood cells. For patients who receive cord blood, the average time to neutrophil engraftment is between 21 and 35 days. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeutrophil Engraftment

Professional guidelines

PubMed

Kilic Gunes E, Yigit Kaya S, Yaman F, Yeniay MK, Vural K, Comert M, Sevindik OG, Andic N, Dagdas S, Nizam Ozen I, Kaynar L, Yavasoglu F, Ozet G, Karakus V, Ayli M
Leuk Res 2024 May;140:107484. Epub 2024 Mar 15 doi: 10.1016/j.leukres.2024.107484. PMID: 38520796
Shen Y, Zhang L, Zhang X, Zhang T, Jiang E, Feng S, He Y, Zhang R
Transplant Cell Ther 2023 Aug;29(8):514.e1-514.e6. Epub 2023 May 11 doi: 10.1016/j.jtct.2023.05.005. PMID: 37178922
Schoettler ML, Carreras E, Cho B, Dandoy CE, Ho VT, Jodele S, Moissev I, Sanchez-Ortega I, Srivastava A, Atsuta Y, Carpenter P, Koreth J, Kroger N, Ljungman P, Page K, Popat U, Shaw BE, Sureda A, Soiffer R, Vasu S
Transplant Cell Ther 2023 Mar;29(3):151-163. Epub 2022 Nov 25 doi: 10.1016/j.jtct.2022.11.015. PMID: 36442770Free PMC Article

Recent clinical studies

Etiology

Farhan S, Mazur I, Hartzell S, Xie P, Neme K, German A, Mikulandric N, Patel K, Wu M, Kortam N, Yaseen A, Sweidan A, Latack K, Emole J, Peres E, Abidi MH, Ramesh M
Int J Infect Dis 2024 Oct;147:107172. Epub 2024 Jul 15 doi: 10.1016/j.ijid.2024.107172. PMID: 39019103
Agholme MB, Dahllöf G, Törlén JK, Majorana A, Brennan MT, von Bültzingslöwen I, Tan PL, Hu S, Sim YF, Hong C
Support Care Cancer 2023 Nov 16;31(12):702. doi: 10.1007/s00520-023-08151-1. PMID: 37971651Free PMC Article
Kajimura Y, Nakamura Y, Tanaka Y, Tanaka M, Yamamoto K, Matsuguma M, Tokunaga Y, Yujiri T, Tanizawa Y
Transplant Proc 2021 Jan-Feb;53(1):379-385. Epub 2020 May 7 doi: 10.1016/j.transproceed.2020.03.027. PMID: 32389487
Gluckman E, Fuente J, Cappelli B, Scigliuolo GM, Volt F, Tozatto-Maio K, Rocha V, Tommaso M, O'Boyle F, Smiers F, Cunha-Riehm CBD, Calore E, Bonanomi S, Graphakos S, Paisiou A, Albert MH, Ruggeri A, Zecca M, Lankester AC, Corbacioglu S; Paediatric Diseases (PDWP) and Inborn Errors Working Parties (IEWP) of the EBMT
Bone Marrow Transplant 2020 Oct;55(10):1946-1954. Epub 2020 Mar 10 doi: 10.1038/s41409-020-0847-z. PMID: 32157246
Jeyaraman P, Borah P, Dayal N, Pathak S, Naithani R
Clin Lymphoma Myeloma Leuk 2020 Apr;20(4):260-263. Epub 2020 Jan 8 doi: 10.1016/j.clml.2019.12.018. PMID: 32019732

Diagnosis

Schoettler ML, Carreras E, Cho B, Dandoy CE, Ho VT, Jodele S, Moissev I, Sanchez-Ortega I, Srivastava A, Atsuta Y, Carpenter P, Koreth J, Kroger N, Ljungman P, Page K, Popat U, Shaw BE, Sureda A, Soiffer R, Vasu S
Transplant Cell Ther 2023 Mar;29(3):151-163. Epub 2022 Nov 25 doi: 10.1016/j.jtct.2022.11.015. PMID: 36442770Free PMC Article
Kliman D, Bilmon I, Kwan J, Blyth E, Micklethwaite K, Panicker S, Bhattacharyya A, Deren S, Antonenas V, Huang G, Gottlieb D
Intern Med J 2018 Aug;48(8):988-991. doi: 10.1111/imj.13979. PMID: 30133987
Onizuka M, Matsushita H, Machida S, Toyosaki M, Amaki J, Aoyama Y, Miyamoto M, Ando K
Intern Med 2016;55(2):179-83. Epub 2016 Jan 15 doi: 10.2169/internalmedicine.55.4724. PMID: 26781020
Daphne O'Hara VJ, Karr AH, Srivastava S, Kiel PJ
Pharmacotherapy 2014 Jan;34(1):85-8. Epub 2013 Jul 17 doi: 10.1002/phar.1332. PMID: 23864559
Boutolleau D, Fernandez C, André E, Imbert-Marcille BM, Milpied N, Agut H, Gautheret-Dejean A
J Infect Dis 2003 Jan 15;187(2):179-86. Epub 2003 Jan 6 doi: 10.1086/367677. PMID: 12552442

Therapy

Farhan S, Mazur I, Hartzell S, Xie P, Neme K, German A, Mikulandric N, Patel K, Wu M, Kortam N, Yaseen A, Sweidan A, Latack K, Emole J, Peres E, Abidi MH, Ramesh M
Int J Infect Dis 2024 Oct;147:107172. Epub 2024 Jul 15 doi: 10.1016/j.ijid.2024.107172. PMID: 39019103
Schoettler ML, Carreras E, Cho B, Dandoy CE, Ho VT, Jodele S, Moissev I, Sanchez-Ortega I, Srivastava A, Atsuta Y, Carpenter P, Koreth J, Kroger N, Ljungman P, Page K, Popat U, Shaw BE, Sureda A, Soiffer R, Vasu S
Transplant Cell Ther 2023 Mar;29(3):151-163. Epub 2022 Nov 25 doi: 10.1016/j.jtct.2022.11.015. PMID: 36442770Free PMC Article
Horwitz ME, Stiff PJ, Cutler C, Brunstein C, Hanna R, Maziarz RT, Rezvani AR, Karris NA, McGuirk J, Valcarcel D, Schiller GJ, Lindemans CA, Hwang WYK, Koh LP, Keating A, Khaled Y, Hamerschlak N, Frankfurt O, Peled T, Segalovich I, Blackwell B, Wease S, Freedman LS, Galamidi-Cohen E, Sanz G
Blood 2021 Oct 21;138(16):1429-1440. doi: 10.1182/blood.2021011719. PMID: 34157093Free PMC Article
Kajimura Y, Nakamura Y, Tanaka Y, Tanaka M, Yamamoto K, Matsuguma M, Tokunaga Y, Yujiri T, Tanizawa Y
Transplant Proc 2021 Jan-Feb;53(1):379-385. Epub 2020 May 7 doi: 10.1016/j.transproceed.2020.03.027. PMID: 32389487
Jeyaraman P, Borah P, Dayal N, Pathak S, Naithani R
Clin Lymphoma Myeloma Leuk 2020 Apr;20(4):260-263. Epub 2020 Jan 8 doi: 10.1016/j.clml.2019.12.018. PMID: 32019732

Prognosis

Masetti R, Leardini D, Muratore E, Fabbrini M, D'Amico F, Zama D, Baccelli F, Gottardi F, Belotti T, Ussowicz M, Fraczkiewicz J, Cesaro S, Zecca M, Merli P, Candela M, Pession A, Locatelli F, Prete A, Brigidi P, Turroni S
Blood 2023 Oct 19;142(16):1387-1398. doi: 10.1182/blood.2023020026. PMID: 37856089Free PMC Article
Schoettler ML, Carreras E, Cho B, Dandoy CE, Ho VT, Jodele S, Moissev I, Sanchez-Ortega I, Srivastava A, Atsuta Y, Carpenter P, Koreth J, Kroger N, Ljungman P, Page K, Popat U, Shaw BE, Sureda A, Soiffer R, Vasu S
Transplant Cell Ther 2023 Mar;29(3):151-163. Epub 2022 Nov 25 doi: 10.1016/j.jtct.2022.11.015. PMID: 36442770Free PMC Article
Kajimura Y, Nakamura Y, Tanaka Y, Tanaka M, Yamamoto K, Matsuguma M, Tokunaga Y, Yujiri T, Tanizawa Y
Transplant Proc 2021 Jan-Feb;53(1):379-385. Epub 2020 May 7 doi: 10.1016/j.transproceed.2020.03.027. PMID: 32389487
Peled JU, Gomes ALC, Devlin SM, Littmann ER, Taur Y, Sung AD, Weber D, Hashimoto D, Slingerland AE, Slingerland JB, Maloy M, Clurman AG, Stein-Thoeringer CK, Markey KA, Docampo MD, Burgos da Silva M, Khan N, Gessner A, Messina JA, Romero K, Lew MV, Bush A, Bohannon L, Brereton DG, Fontana E, Amoretti LA, Wright RJ, Armijo GK, Shono Y, Sanchez-Escamilla M, Castillo Flores N, Alarcon Tomas A, Lin RJ, Yáñez San Segundo L, Shah GL, Cho C, Scordo M, Politikos I, Hayasaka K, Hasegawa Y, Gyurkocza B, Ponce DM, Barker JN, Perales MA, Giralt SA, Jenq RR, Teshima T, Chao NJ, Holler E, Xavier JB, Pamer EG, van den Brink MRM
N Engl J Med 2020 Feb 27;382(9):822-834. doi: 10.1056/NEJMoa1900623. PMID: 32101664Free PMC Article
Seger RA, Gungor T, Belohradsky BH, Blanche S, Bordigoni P, Di Bartolomeo P, Flood T, Landais P, Müller S, Ozsahin H, Passwell JH, Porta F, Slavin S, Wulffraat N, Zintl F, Nagler A, Cant A, Fischer A
Blood 2002 Dec 15;100(13):4344-50. Epub 2002 Aug 8 doi: 10.1182/blood-2002-02-0583. PMID: 12393596

Clinical prediction guides

Masetti R, Leardini D, Muratore E, Fabbrini M, D'Amico F, Zama D, Baccelli F, Gottardi F, Belotti T, Ussowicz M, Fraczkiewicz J, Cesaro S, Zecca M, Merli P, Candela M, Pession A, Locatelli F, Prete A, Brigidi P, Turroni S
Blood 2023 Oct 19;142(16):1387-1398. doi: 10.1182/blood.2023020026. PMID: 37856089Free PMC Article
Kajimura Y, Nakamura Y, Tanaka Y, Tanaka M, Yamamoto K, Matsuguma M, Tokunaga Y, Yujiri T, Tanizawa Y
Transplant Proc 2021 Jan-Feb;53(1):379-385. Epub 2020 May 7 doi: 10.1016/j.transproceed.2020.03.027. PMID: 32389487
Peled JU, Gomes ALC, Devlin SM, Littmann ER, Taur Y, Sung AD, Weber D, Hashimoto D, Slingerland AE, Slingerland JB, Maloy M, Clurman AG, Stein-Thoeringer CK, Markey KA, Docampo MD, Burgos da Silva M, Khan N, Gessner A, Messina JA, Romero K, Lew MV, Bush A, Bohannon L, Brereton DG, Fontana E, Amoretti LA, Wright RJ, Armijo GK, Shono Y, Sanchez-Escamilla M, Castillo Flores N, Alarcon Tomas A, Lin RJ, Yáñez San Segundo L, Shah GL, Cho C, Scordo M, Politikos I, Hayasaka K, Hasegawa Y, Gyurkocza B, Ponce DM, Barker JN, Perales MA, Giralt SA, Jenq RR, Teshima T, Chao NJ, Holler E, Xavier JB, Pamer EG, van den Brink MRM
N Engl J Med 2020 Feb 27;382(9):822-834. doi: 10.1056/NEJMoa1900623. PMID: 32101664Free PMC Article
Narazaki T, Nakashima Y, Tsukamoto Y, Nishida R, Tsuda M, Muta H, Kimura D, Masuda T, Takamatsu A, Kohashi K, Murakami D, Shiratsuchi M, Ogawa Y
Transpl Infect Dis 2020 Feb;22(1):e13205. Epub 2019 Nov 13 doi: 10.1111/tid.13205. PMID: 31674700
Seger RA, Gungor T, Belohradsky BH, Blanche S, Bordigoni P, Di Bartolomeo P, Flood T, Landais P, Müller S, Ozsahin H, Passwell JH, Porta F, Slavin S, Wulffraat N, Zintl F, Nagler A, Cant A, Fischer A
Blood 2002 Dec 15;100(13):4344-50. Epub 2002 Aug 8 doi: 10.1182/blood-2002-02-0583. PMID: 12393596

Recent systematic reviews

Huang Y, Luo C, Wu G, Huang X, Ding Y, Huang Z, Chen J, Li X, Xu S
Bone Marrow Transplant 2023 May;58(5):544-551. Epub 2023 Feb 13 doi: 10.1038/s41409-023-01932-6. PMID: 36782066
Li T, Luo C, Zhang J, Wei L, Sun W, Xie Q, Liu Y, Zhao Y, Xu S, Wang L
Stem Cell Res Ther 2021 Apr 20;12(1):246. doi: 10.1186/s13287-021-02304-x. PMID: 33879242Free PMC Article
Evans JC, Hirani SP, Needle JJ
Biol Blood Marrow Transplant 2019 Aug;25(8):e252-e259. Epub 2019 Mar 1 doi: 10.1016/j.bbmt.2019.02.023. PMID: 30826462
Kiernan J, Damien P, Monaghan M, Shorr R, McIntyre L, Fergusson D, Tinmouth A, Allan D
Transfus Med Rev 2017 Jul;31(3):173-182. Epub 2016 Dec 23 doi: 10.1016/j.tmrv.2016.12.004. PMID: 28087163
Arai Y, Jo T, Matsui H, Kondo T, Takaori-Kondo A
Leuk Lymphoma 2017 Aug;58(8):1840-1848. Epub 2016 Dec 12 doi: 10.1080/10428194.2016.1266624. PMID: 27951736

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