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Polyarticular Still Disease

MedGen UID:
362250
Concept ID:
C1882414
Disease or Syndrome
Synonym: Polyarticular Still's Disease

Definition

Juvenile rheumatoid arthritis affecting multiple joints, usually symmetrically. It may be associated with low grade fever, anemia, and weight loss. Patients usually test negative for rheumatoid factor. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPolyarticular Still Disease

Professional guidelines

PubMed

Aletaha D, Kerschbaumer A, Kastrati K, Dejaco C, Dougados M, McInnes IB, Sattar N, Stamm TA, Takeuchi T, Trauner M, van der Heijde D, Voshaar M, Winthrop KL, Ravelli A, Betteridge N, Burmester GR, Bijlsma JW, Bykerk V, Caporali R, Choy EH, Codreanu C, Combe B, Crow MK, de Wit M, Emery P, Fleischmann RM, Gabay C, Hetland ML, Hyrich KL, Iagnocco A, Isaacs JD, Kremer JM, Mariette X, Merkel PA, Mysler EF, Nash P, Nurmohamed MT, Pavelka K, Poor G, Rubbert-Roth A, Schulze-Koops H, Strangfeld A, Tanaka Y, Smolen JS
Ann Rheum Dis 2023 Jun;82(6):773-787. Epub 2022 Aug 11 doi: 10.1136/ard-2022-222784. PMID: 35953263
Huang J, Fu X, Chen X, Li Z, Huang Y, Liang C
Front Immunol 2021;12:686155. Epub 2021 Jul 9 doi: 10.3389/fimmu.2021.686155. PMID: 34305919Free PMC Article
Castañeda S, Martínez-Quintanilla D, Martín-Varillas JL, García-Castañeda N, Atienza-Mateo B, González-Gay MA
Expert Opin Biol Ther 2019 Apr;19(4):273-286. doi: 10.1080/14712598.2019.1590334. PMID: 30827128

Recent clinical studies

Etiology

Ramanan AV, Quartier P, Okamoto N, Foeldvari I, Spindler A, Fingerhutová Š, Antón J, Wang Z, Meszaros G, Araújo J, Liao R, Keller S, Brunner HI, Ruperto N; JUVE-BASIS investigators; Paediatric Rheumatology International Trials Organisation
Lancet 2023 Aug 12;402(10401):555-570. Epub 2023 Jul 6 doi: 10.1016/S0140-6736(23)00921-2. PMID: 37423231
Azab AR, Kamel FH, Basha MA, Alrawaili SM, Aloraini GS, Hassan SM, Ewais NF, Elnaggar RK
Int J Environ Res Public Health 2022 Jun 25;19(13) doi: 10.3390/ijerph19137793. PMID: 35805451Free PMC Article
Ruperto N, Brunner HI, Synoverska O, Ting TV, Mendoza CA, Spindler A, Vyzhga Y, Marzan K, Grebenkina L, Tirosh I, Imundo L, Jerath R, Kingsbury DJ, Sozeri B, Vora SS, Prahalad S, Zholobova E, Butbul Aviel Y, Chasnyk V, Lerman M, Nanda K, Schmeling H, Tory H, Uziel Y, Viola DO, Posner HB, Kanik KS, Wouters A, Chang C, Zhang R, Lazariciu I, Hsu MA, Suehiro RM, Martini A, Lovell DJ; Paediatric Rheumatology International Trials Organisation (PRINTO) and Pediatric Rheumatology Collaborative Study Group (PRCSG)
Lancet 2021 Nov 27;398(10315):1984-1996. Epub 2021 Nov 9 doi: 10.1016/S0140-6736(21)01255-1. PMID: 34767764
Zaripova LN, Midgley A, Christmas SE, Beresford MW, Baildam EM, Oldershaw RA
Pediatr Rheumatol Online J 2021 Aug 23;19(1):135. doi: 10.1186/s12969-021-00629-8. PMID: 34425842Free PMC Article
Aggarwal A, Misra DP
Clin Rheumatol 2015 Nov;34(11):1839-46. Epub 2015 Aug 2 doi: 10.1007/s10067-015-3029-4. PMID: 26233720

Diagnosis

Martins D, Tonon CR, Pacca RL, Matchil NL, Junior LAJ, Queiroz DS, Pereira FWL, Silva AM, Padovese V, Padovani de Toledo Moraes M, Luiz da Silva D, Cardoso Nóbrega V, Curcelli EC, Okoshi MP
Am J Case Rep 2021 Sep 20;22:e932683. doi: 10.12659/AJCR.932683. PMID: 34855717Free PMC Article
Llopis E, Kroon HM, Acosta J, Bloem JL
Radiol Clin North Am 2017 Sep;55(5):917-941. Epub 2017 Jun 20 doi: 10.1016/j.rcl.2017.04.002. PMID: 28774455
Shoop-Worrall SJW, Kearsley-Fleet L, Thomson W, Verstappen SMM, Hyrich KL
Semin Arthritis Rheum 2017 Dec;47(3):331-337. Epub 2017 May 20 doi: 10.1016/j.semarthrit.2017.05.007. PMID: 28625712Free PMC Article
Barut K, Adrovic A, Şahin S, Kasapçopur Ö
Balkan Med J 2017 Apr 5;34(2):90-101. doi: 10.4274/balkanmedj.2017.0111. PMID: 28418334Free PMC Article
Aggarwal A, Misra DP
Clin Rheumatol 2015 Nov;34(11):1839-46. Epub 2015 Aug 2 doi: 10.1007/s10067-015-3029-4. PMID: 26233720

Therapy

Martins D, Tonon CR, Pacca RL, Matchil NL, Junior LAJ, Queiroz DS, Pereira FWL, Silva AM, Padovese V, Padovani de Toledo Moraes M, Luiz da Silva D, Cardoso Nóbrega V, Curcelli EC, Okoshi MP
Am J Case Rep 2021 Sep 20;22:e932683. doi: 10.12659/AJCR.932683. PMID: 34855717Free PMC Article
Ruperto N, Brunner HI, Synoverska O, Ting TV, Mendoza CA, Spindler A, Vyzhga Y, Marzan K, Grebenkina L, Tirosh I, Imundo L, Jerath R, Kingsbury DJ, Sozeri B, Vora SS, Prahalad S, Zholobova E, Butbul Aviel Y, Chasnyk V, Lerman M, Nanda K, Schmeling H, Tory H, Uziel Y, Viola DO, Posner HB, Kanik KS, Wouters A, Chang C, Zhang R, Lazariciu I, Hsu MA, Suehiro RM, Martini A, Lovell DJ; Paediatric Rheumatology International Trials Organisation (PRINTO) and Pediatric Rheumatology Collaborative Study Group (PRCSG)
Lancet 2021 Nov 27;398(10315):1984-1996. Epub 2021 Nov 9 doi: 10.1016/S0140-6736(21)01255-1. PMID: 34767764
Huang J, Fu X, Chen X, Li Z, Huang Y, Liang C
Front Immunol 2021;12:686155. Epub 2021 Jul 9 doi: 10.3389/fimmu.2021.686155. PMID: 34305919Free PMC Article
Barut K, Adrovic A, Şahin S, Kasapçopur Ö
Balkan Med J 2017 Apr 5;34(2):90-101. doi: 10.4274/balkanmedj.2017.0111. PMID: 28418334Free PMC Article
Aggarwal A, Misra DP
Clin Rheumatol 2015 Nov;34(11):1839-46. Epub 2015 Aug 2 doi: 10.1007/s10067-015-3029-4. PMID: 26233720

Prognosis

Ruperto N, Brunner HI, Synoverska O, Ting TV, Mendoza CA, Spindler A, Vyzhga Y, Marzan K, Grebenkina L, Tirosh I, Imundo L, Jerath R, Kingsbury DJ, Sozeri B, Vora SS, Prahalad S, Zholobova E, Butbul Aviel Y, Chasnyk V, Lerman M, Nanda K, Schmeling H, Tory H, Uziel Y, Viola DO, Posner HB, Kanik KS, Wouters A, Chang C, Zhang R, Lazariciu I, Hsu MA, Suehiro RM, Martini A, Lovell DJ; Paediatric Rheumatology International Trials Organisation (PRINTO) and Pediatric Rheumatology Collaborative Study Group (PRCSG)
Lancet 2021 Nov 27;398(10315):1984-1996. Epub 2021 Nov 9 doi: 10.1016/S0140-6736(21)01255-1. PMID: 34767764
Castañeda S, Martínez-Quintanilla D, Martín-Varillas JL, García-Castañeda N, Atienza-Mateo B, González-Gay MA
Expert Opin Biol Ther 2019 Apr;19(4):273-286. doi: 10.1080/14712598.2019.1590334. PMID: 30827128
Barut K, Adrovic A, Şahin S, Kasapçopur Ö
Balkan Med J 2017 Apr 5;34(2):90-101. doi: 10.4274/balkanmedj.2017.0111. PMID: 28418334Free PMC Article
Aggarwal A, Misra DP
Clin Rheumatol 2015 Nov;34(11):1839-46. Epub 2015 Aug 2 doi: 10.1007/s10067-015-3029-4. PMID: 26233720
Gerfaud-Valentin M, Jamilloux Y, Iwaz J, Sève P
Autoimmun Rev 2014 Jul;13(7):708-22. Epub 2014 Mar 19 doi: 10.1016/j.autrev.2014.01.058. PMID: 24657513

Clinical prediction guides

Zeller L, Tyrrell PN, Wang S, Fischer N, Haas JP, Hügle B
Pediatr Rheumatol Online J 2022 Aug 13;20(1):66. doi: 10.1186/s12969-022-00721-7. PMID: 35964131Free PMC Article
Liebling EJ, Faig W, Chang JC, Mendoza E, Moore N, Vicioso NL, Lerman MA
Arthritis Care Res (Hoboken) 2022 Mar;74(3):349-354. Epub 2022 Jan 28 doi: 10.1002/acr.24483. PMID: 33044800
Buckley L, Ware E, Kreher G, Wiater L, Mehta J, Burnham JM
J Rheumatol 2020 Feb;47(2):273-281. Epub 2019 Jul 15 doi: 10.3899/jrheum.190268. PMID: 31308202
Frampton JE
BioDrugs 2017 Jun;31(3):263-274. doi: 10.1007/s40259-017-0217-6. PMID: 28530020
Webb K, Wedderburn LR
Curr Opin Rheumatol 2015 Sep;27(5):505-10. doi: 10.1097/BOR.0000000000000206. PMID: 26147756Free PMC Article

Recent systematic reviews

Badin D, Leland CR, Bronheim RS, Balmuri N, Lee RJ
Medicine (Baltimore) 2022 Dec 9;101(49):e32278. doi: 10.1097/MD.0000000000032278. PMID: 36626489Free PMC Article
Chaplin H, Carpenter L, Raz A, Nikiphorou E, Lempp H, Norton S
Rheumatology (Oxford) 2021 Aug 2;60(8):3540-3552. doi: 10.1093/rheumatology/keab237. PMID: 33710321Free PMC Article
Shoop-Worrall SJW, Kearsley-Fleet L, Thomson W, Verstappen SMM, Hyrich KL
Semin Arthritis Rheum 2017 Dec;47(3):331-337. Epub 2017 May 20 doi: 10.1016/j.semarthrit.2017.05.007. PMID: 28625712Free PMC Article
Shepherd J, Cooper K, Harris P, Picot J, Rose M
Health Technol Assess 2016 Apr;20(34):1-222. doi: 10.3310/hta20340. PMID: 27135404Free PMC Article
van Dijkhuizen EH, Wulffraat NM
Ann Rheum Dis 2015 Nov;74(11):1996-2005. Epub 2014 Jun 24 doi: 10.1136/annrheumdis-2014-205265. PMID: 24962873

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