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Undifferentiated Carcinoma with Osteoclast-Like Giant Cells

MedGen UID:
362921
•Concept ID:
C1883424
•
Neoplastic Process

Definition

A usually aggressive malignant epithelial neoplasm composed of atypical cells which do not display evidence of glandular or squamous differentiation and giant cells resembling osteoclasts. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUndifferentiated Carcinoma with Osteoclast-Like Giant Cells

Professional guidelines

PubMed

Comprehensive review of undifferentiated carcinoma of the pancreas: from epidemiology to treatment.
Imaoka H, Ikeda M, Umemoto K, Sunakawa Y, Ueno M, Ueno H, Ozaka M, Kuwahara T, Okano N, Kanai M, Hisano T, Suzuki Y, Asagi A, Shioji K, Todaka A, Tsuji K, Ikezawa K, Miki I, Komatsu Y, Akutsu N, Yamashita T, Okuyama H, Furuse J, Nagano H
Jpn J Clin Oncol 2023 Aug 30;53(9):764-773. doi: 10.1093/jjco/hyad062. PMID: 37325968Free PMC Article
Clear cell renal cell carcinoma with a syncytial-type multinucleated giant tumor cell component: implications for differential diagnosis.
Williamson SR, Kum JB, Goheen MP, Cheng L, Grignon DJ, Idrees MT
Hum Pathol 2014 Apr;45(4):735-44. Epub 2013 Nov 15 doi: 10.1016/j.humpath.2013.10.033. PMID: 24499686

Recent clinical studies

Etiology

Case report: Pathological and genetic features of pancreatic undifferentiated carcinoma with osteoclast-like giant cells.
Zhao N, Mei N, Yi Y, Wang H, Wang Y, Yao Y, Li C
Pathol Oncol Res 2023;29:1610983. Epub 2023 Mar 3 doi: 10.3389/pore.2023.1610983. PMID: 36938358Free PMC Article
Epithelial-mesenchymal transition in undifferentiated carcinoma of the pancreas with and without osteoclast-like giant cells.
Mattiolo P, Fiadone G, Paolino G, Chatterjee D, Bernasconi R, Piccoli P, Parolini C, El Aidi M, Sperandio N, Malleo G, Salvia R, Brosens LA, Wood LD, Scarpa A, Lawlor RT, Luchini C
Virchows Arch 2021 Feb;478(2):319-326. Epub 2020 Jul 13 doi: 10.1007/s00428-020-02889-3. PMID: 32661742Free PMC Article
Negative prognostic impact of PD-L1 expression in tumor cells of undifferentiated (anaplastic) carcinoma with osteoclast-like giant cells of the pancreas: study of 13 cases comparing ductal pancreatic carcinoma and review of the literature.
Hrudka J, Lawrie K, Waldauf P, Ciprová V, Moravcová J, Matěj R
Virchows Arch 2020 Nov;477(5):687-696. Epub 2020 May 18 doi: 10.1007/s00428-020-02830-8. PMID: 32424767
PD-1, PD-L1, and CD163 in pancreatic undifferentiated carcinoma with osteoclast-like giant cells: expression patterns and clinical implications.
Luchini C, Cros J, Pea A, Pilati C, Veronese N, Rusev B, Capelli P, Mafficini A, Nottegar A, Brosens LAA, Noë M, Offerhaus GJA, Chianchiano P, Riva G, Piccoli P, Parolini C, Malleo G, Lawlor RT, Corbo V, Sperandio N, Barbareschi M, Fassan M, Cheng L, Wood LD, Scarpa A
Hum Pathol 2018 Nov;81:157-165. Epub 2018 Jul 18 doi: 10.1016/j.humpath.2018.07.006. PMID: 30031096
A male case of an undifferentiated carcinoma with osteoclast-like giant cells originating in an indeterminate mucin-producing cystic neoplasm of the pancreas. A case report and review of the literature.
Wada T, Itano O, Oshima G, Chiba N, Ishikawa H, Koyama Y, Du W, Kitagawa Y
World J Surg Oncol 2011 Sep 8;9:100. doi: 10.1186/1477-7819-9-100. PMID: 21902830Free PMC Article

Diagnosis

Case report: Pathological and genetic features of pancreatic undifferentiated carcinoma with osteoclast-like giant cells.
Zhao N, Mei N, Yi Y, Wang H, Wang Y, Yao Y, Li C
Pathol Oncol Res 2023;29:1610983. Epub 2023 Mar 3 doi: 10.3389/pore.2023.1610983. PMID: 36938358Free PMC Article
Malignant epithelial/exocrine tumors of the pancreas.
Luchini C, Grillo F, Fassan M, Vanoli A, Capelli P, Paolino G, Ingravallo G, Renzulli G, Doglioni C, D'Amuri A, Mattiolo P, Pecori S, Parente P, Florena AM, Zamboni G, Scarpa A
Pathologica 2020 Sep;112(3):210-226. doi: 10.32074/1591-951X-167. PMID: 33179623Free PMC Article
Pancreatic Ductal Adenocarcinoma and Its Variants: Pearls and Perils.
Schawkat K, Manning MA, Glickman JN, Mortele KJ
Radiographics 2020 Sep-Oct;40(5):1219-1239. Epub 2020 Jul 17 doi: 10.1148/rg.2020190184. PMID: 32678699
Negative prognostic impact of PD-L1 expression in tumor cells of undifferentiated (anaplastic) carcinoma with osteoclast-like giant cells of the pancreas: study of 13 cases comparing ductal pancreatic carcinoma and review of the literature.
Hrudka J, Lawrie K, Waldauf P, Ciprová V, Moravcová J, Matěj R
Virchows Arch 2020 Nov;477(5):687-696. Epub 2020 May 18 doi: 10.1007/s00428-020-02830-8. PMID: 32424767
Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas and periampullary region.
Molberg KH, Heffess C, Delgado R, Albores-Saavedra J
Cancer 1998 Apr 1;82(7):1279-87. doi: 10.1002/(sici)1097-0142(19980401)82:7<1279::aid-cncr10>3.0.co;2-3. PMID: 9529019

Therapy

Negative prognostic impact of PD-L1 expression in tumor cells of undifferentiated (anaplastic) carcinoma with osteoclast-like giant cells of the pancreas: study of 13 cases comparing ductal pancreatic carcinoma and review of the literature.
Hrudka J, Lawrie K, Waldauf P, Ciprová V, Moravcová J, Matěj R
Virchows Arch 2020 Nov;477(5):687-696. Epub 2020 May 18 doi: 10.1007/s00428-020-02830-8. PMID: 32424767
An indeterminate mucin-producing cystic neoplasm containing an undifferentiated carcinoma with osteoclast-like giant cells: a case report of a rare association of pancreatic tumors.
Chiarelli M, Guttadauro A, Gerosa M, Marando A, Gabrielli F, De Simone M, Cioffi U
BMC Gastroenterol 2015 Nov 18;15:161. doi: 10.1186/s12876-015-0391-2. PMID: 26581412Free PMC Article
Locally advanced undifferentiated carcinoma with osteoclast-like giant cells of the pancreas.
Gao HQ, Yang YM, Zhuang Y, Liu P
World J Gastroenterol 2015 Jan 14;21(2):694-8. doi: 10.3748/wjg.v21.i2.694. PMID: 25593500Free PMC Article
Effective use of gemcitabine in the treatment of undifferentiated carcinoma with osteoclast-like giant cells of the pancreas with portal vein tumor thrombus.
Yoshioka M, Uchinami H, Watanabe G, Takahashi T, Nakagawa Y, Andoh H, Yoshioka T, Nanjo H, Yamamoto Y
Intern Med 2012;51(16):2145-50. Epub 2012 Aug 15 doi: 10.2169/internalmedicine.51.7670. PMID: 22892493

Prognosis

Case report: Pathological and genetic features of pancreatic undifferentiated carcinoma with osteoclast-like giant cells.
Zhao N, Mei N, Yi Y, Wang H, Wang Y, Yao Y, Li C
Pathol Oncol Res 2023;29:1610983. Epub 2023 Mar 3 doi: 10.3389/pore.2023.1610983. PMID: 36938358Free PMC Article
Single-cell RNA-seq reveals the genesis and heterogeneity of tumor microenvironment in pancreatic undifferentiated carcinoma with osteoclast-like giant-cells.
Wang X, Miao J, Wang S, Shen R, Zhang S, Tian Y, Li M, Zhu D, Yao A, Bao W, Zhang Q, Tang X, Wang X, Li J
Mol Cancer 2022 Jun 22;21(1):133. doi: 10.1186/s12943-022-01596-8. PMID: 35733218Free PMC Article
Epithelial-mesenchymal transition in undifferentiated carcinoma of the pancreas with and without osteoclast-like giant cells.
Mattiolo P, Fiadone G, Paolino G, Chatterjee D, Bernasconi R, Piccoli P, Parolini C, El Aidi M, Sperandio N, Malleo G, Salvia R, Brosens LA, Wood LD, Scarpa A, Lawlor RT, Luchini C
Virchows Arch 2021 Feb;478(2):319-326. Epub 2020 Jul 13 doi: 10.1007/s00428-020-02889-3. PMID: 32661742Free PMC Article
PD-1, PD-L1, and CD163 in pancreatic undifferentiated carcinoma with osteoclast-like giant cells: expression patterns and clinical implications.
Luchini C, Cros J, Pea A, Pilati C, Veronese N, Rusev B, Capelli P, Mafficini A, Nottegar A, Brosens LAA, Noë M, Offerhaus GJA, Chianchiano P, Riva G, Piccoli P, Parolini C, Malleo G, Lawlor RT, Corbo V, Sperandio N, Barbareschi M, Fassan M, Cheng L, Wood LD, Scarpa A
Hum Pathol 2018 Nov;81:157-165. Epub 2018 Jul 18 doi: 10.1016/j.humpath.2018.07.006. PMID: 30031096
Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas and periampullary region.
Molberg KH, Heffess C, Delgado R, Albores-Saavedra J
Cancer 1998 Apr 1;82(7):1279-87. doi: 10.1002/(sici)1097-0142(19980401)82:7<1279::aid-cncr10>3.0.co;2-3. PMID: 9529019

Clinical prediction guides

Undifferentiated Carcinoma with Osteoclast-like Giant Cells of the Pancreas: Molecular Genetic Analysis of 13 Cases.
Hrudka J, Kalinová M, Ciprová V, Moravcová J, Dvořák R, Matěj R
Int J Mol Sci 2024 Mar 14;25(6) doi: 10.3390/ijms25063285. PMID: 38542259Free PMC Article
Assessment and management of undifferentiated carcinoma with osteoclastic like giant cells of the pancreas: a case report and revision of literature.
Cavalcanti E, Schena N, Serino G, Lantone G, Armentano R
BMC Gastroenterol 2021 Jun 2;21(1):247. doi: 10.1186/s12876-021-01779-5. PMID: 34078293Free PMC Article
Epithelial-mesenchymal transition in undifferentiated carcinoma of the pancreas with and without osteoclast-like giant cells.
Mattiolo P, Fiadone G, Paolino G, Chatterjee D, Bernasconi R, Piccoli P, Parolini C, El Aidi M, Sperandio N, Malleo G, Salvia R, Brosens LA, Wood LD, Scarpa A, Lawlor RT, Luchini C
Virchows Arch 2021 Feb;478(2):319-326. Epub 2020 Jul 13 doi: 10.1007/s00428-020-02889-3. PMID: 32661742Free PMC Article
Pancreatic undifferentiated carcinoma with osteoclast-like giant cells is genetically similar to, but clinically distinct from, conventional ductal adenocarcinoma.
Luchini C, Pea A, Lionheart G, Mafficini A, Nottegar A, Veronese N, Chianchiano P, Brosens LA, Noë M, Offerhaus GJA, Yonescu R, Ning Y, Malleo G, Riva G, Piccoli P, Cataldo I, Capelli P, Zamboni G, Scarpa A, Wood LD
J Pathol 2017 Oct;243(2):148-154. Epub 2017 Sep 5 doi: 10.1002/path.4941. PMID: 28722124Free PMC Article
Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas and periampullary region.
Molberg KH, Heffess C, Delgado R, Albores-Saavedra J
Cancer 1998 Apr 1;82(7):1279-87. doi: 10.1002/(sici)1097-0142(19980401)82:7<1279::aid-cncr10>3.0.co;2-3. PMID: 9529019

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