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Head and Neck Nevus

MedGen UID:
363447
•Concept ID:
C1881034
•
Neoplastic Process
Synonym: Nevus of Head and Neck

Definition

A benign nevus that arises from the skin in the head and neck region. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHead and Neck Nevus

Professional guidelines

PubMed

Clinical characteristics and treatment of 52 cases of phakomatosis pigmentovascularis.
Shin H, Kim YG, Kim YE, Park H
J Dermatol 2019 Oct;46(10):843-848. Epub 2019 Aug 6 doi: 10.1111/1346-8138.15035. PMID: 31389056
Management of visceral vascular anomalies.
Dasgupta R, Fishman SJ
Semin Pediatr Surg 2014 Aug;23(4):216-20. Epub 2014 Jul 15 doi: 10.1053/j.sempedsurg.2014.07.003. PMID: 25241101
Vitamin A derivatives in the prevention and treatment of human cancer.
Lippman SM, Meyskens FL Jr
J Am Coll Nutr 1988 Aug;7(4):269-84. doi: 10.1080/07315724.1988.10720244. PMID: 3062055

Recent clinical studies

Etiology

Neck Melanoma: Clinical, Dermoscopic and Confocal Features.
Borsari S, Pampena R, Raucci M, Mirra M, Piana S, Pellacani G, Longo C
Dermatology 2020;236(3):241-247. Epub 2019 Nov 8 doi: 10.1159/000503284. PMID: 31707398
Black and Brown Oro-facial Mucocutaneous Neoplasms.
Natarajan E
Head Neck Pathol 2019 Mar;13(1):56-70. Epub 2019 Jan 29 doi: 10.1007/s12105-019-01008-2. PMID: 30693458Free PMC Article
Molecular pathology of skin neoplasms of the head and neck.
Kraft S, Granter SR
Arch Pathol Lab Med 2014 Jun;138(6):759-87. doi: 10.5858/arpa.2013-0157-RA. PMID: 24878016
Cutaneous lesions: benign and malignant.
Padgett JK
Facial Plast Surg Clin North Am 2005 May;13(2):195-202, v. doi: 10.1016/j.fsc.2004.11.006. PMID: 15817400
Scalloped cell xanthogranuloma.
Zelger BG, Orchard G, Rudolph P, Zelger B
Histopathology 1998 Apr;32(4):368-74. doi: 10.1046/j.1365-2559.1998.00396.x. PMID: 9602335

Diagnosis

Pitfalls in the diagnosis of lentigo maligna and lentigo maligna melanoma, facts and an opinion.
Sina N, Saeed-Kamil Z, Ghazarian D
J Clin Pathol 2021 Jan;74(1):7-9. Epub 2020 Oct 13 doi: 10.1136/jclinpath-2020-207051. PMID: 33051287
Black and Brown Oro-facial Mucocutaneous Neoplasms.
Natarajan E
Head Neck Pathol 2019 Mar;13(1):56-70. Epub 2019 Jan 29 doi: 10.1007/s12105-019-01008-2. PMID: 30693458Free PMC Article
Molecular pathology of skin neoplasms of the head and neck.
Kraft S, Granter SR
Arch Pathol Lab Med 2014 Jun;138(6):759-87. doi: 10.5858/arpa.2013-0157-RA. PMID: 24878016
Syringocystadenoma.
Mundi JP, Rose AE, Boyd KP, Patel RR, Lipkin G
Dermatol Online J 2013 Dec 16;19(12):20722. PMID: 24365013
Desmoplastic melanoma.
Busam KJ
Clin Lab Med 2011 Jun;31(2):321-30. doi: 10.1016/j.cll.2011.03.009. PMID: 21549245

Therapy

Clinical characteristics and treatment of 52 cases of phakomatosis pigmentovascularis.
Shin H, Kim YG, Kim YE, Park H
J Dermatol 2019 Oct;46(10):843-848. Epub 2019 Aug 6 doi: 10.1111/1346-8138.15035. PMID: 31389056
Molecular pathology of skin neoplasms of the head and neck.
Kraft S, Granter SR
Arch Pathol Lab Med 2014 Jun;138(6):759-87. doi: 10.5858/arpa.2013-0157-RA. PMID: 24878016
Targeted therapy for orbital and periocular basal cell carcinoma and squamous cell carcinoma.
Yin VT, Pfeiffer ML, Esmaeli B
Ophthalmic Plast Reconstr Surg 2013 Mar-Apr;29(2):87-92. doi: 10.1097/IOP.0b013e3182831bf3. PMID: 23446297Free PMC Article
Cutaneous lesions: benign and malignant.
Padgett JK
Facial Plast Surg Clin North Am 2005 May;13(2):195-202, v. doi: 10.1016/j.fsc.2004.11.006. PMID: 15817400
Vitamin A derivatives in the prevention and treatment of human cancer.
Lippman SM, Meyskens FL Jr
J Am Coll Nutr 1988 Aug;7(4):269-84. doi: 10.1080/07315724.1988.10720244. PMID: 3062055

Prognosis

Pitfalls in the diagnosis of lentigo maligna and lentigo maligna melanoma, facts and an opinion.
Sina N, Saeed-Kamil Z, Ghazarian D
J Clin Pathol 2021 Jan;74(1):7-9. Epub 2020 Oct 13 doi: 10.1136/jclinpath-2020-207051. PMID: 33051287
Eruptive disseminated Spitz nevi.
Ricci F, Paradisi A, Annessi G, Paradisi M, Abeni D
Eur J Dermatol 2017 Feb 1;27(1):59-62. doi: 10.1684/ejd.2016.2917. PMID: 27758761
Melanoma arising in association with blue nevus: a clinical and pathologic study of 24 cases and comprehensive review of the literature.
Loghavi S, Curry JL, Torres-Cabala CA, Ivan D, Patel KP, Mehrotra M, Bassett R, Prieto VG, Tetzlaff MT
Mod Pathol 2014 Nov;27(11):1468-78. Epub 2014 Apr 18 doi: 10.1038/modpathol.2014.62. PMID: 24743221
Pathologic features of pediatric head and neck melanoma.
Tcheung WJ, Nelson K, Aldabagh B, Puja P
Pediatr Dermatol 2013 Sep-Oct;30(5):568-73. Epub 2013 Apr 29 doi: 10.1111/pde.12153. PMID: 23627731
Desmoplastic melanoma.
Busam KJ
Clin Lab Med 2011 Jun;31(2):321-30. doi: 10.1016/j.cll.2011.03.009. PMID: 21549245

Clinical prediction guides

Primary mucosal melanomas of the head and neck are characterised by overexpression of the DNA mutating enzyme APOBEC3B.
Argyris PP, Naumann J, Jarvis MC, Wilkinson PE, Ho DP, Islam MN, Bhattacharyya I, Gopalakrishnan R, Li F, Koutlas IG, Giubellino A, Harris RS
Histopathology 2023 Mar;82(4):608-621. Epub 2022 Dec 5 doi: 10.1111/his.14843. PMID: 36416305Free PMC Article
Clinical characteristics and treatment of 52 cases of phakomatosis pigmentovascularis.
Shin H, Kim YG, Kim YE, Park H
J Dermatol 2019 Oct;46(10):843-848. Epub 2019 Aug 6 doi: 10.1111/1346-8138.15035. PMID: 31389056
Melanoma arising in association with blue nevus: a clinical and pathologic study of 24 cases and comprehensive review of the literature.
Loghavi S, Curry JL, Torres-Cabala CA, Ivan D, Patel KP, Mehrotra M, Bassett R, Prieto VG, Tetzlaff MT
Mod Pathol 2014 Nov;27(11):1468-78. Epub 2014 Apr 18 doi: 10.1038/modpathol.2014.62. PMID: 24743221
Pathologic features of pediatric head and neck melanoma.
Tcheung WJ, Nelson K, Aldabagh B, Puja P
Pediatr Dermatol 2013 Sep-Oct;30(5):568-73. Epub 2013 Apr 29 doi: 10.1111/pde.12153. PMID: 23627731
Dermatopathology updates on melanocytic lesions.
Cheung WL, Smoller BR
Dermatol Clin 2012 Oct;30(4):617-22, vi. Epub 2012 Aug 3 doi: 10.1016/j.det.2012.06.014. PMID: 23021049

Recent systematic reviews

Atypical Spitz tumours and sentinel lymph node biopsy: a systematic review.
Lallas A, Kyrgidis A, Ferrara G, Kittler H, Apalla Z, Castagnetti F, Longo C, Moscarella E, Piana S, Zalaudek I, Argenziano G
Lancet Oncol 2014 Apr;15(4):e178-83. doi: 10.1016/S1470-2045(13)70608-9. PMID: 24694641
Divided nevus of the eyelid: review of embryology, pathology and treatment.
Desai SC, Walen S, Holds JB, Branham G
Am J Otolaryngol 2013 May-Jun;34(3):223-9. Epub 2013 Feb 4 doi: 10.1016/j.amjoto.2013.01.004. PMID: 23380310

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