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Colon medullary carcinoma

MedGen UID:
363630
Concept ID:
C1880119
Neoplastic Process
Synonyms: Colon Medullary Carcinoma; colon medullary carcinoma; medullary carcinoma of the colon; medullary colon carcinoma
 
Monarch Initiative: MONDO:0000892

Definition

A rare, invasive colon adenocarcinoma characterized by the presence of sheets of malignant epithelial cells with vesicular nuclei, prominent nucleoli, and abundant eosinophilic cytoplasm. It usually has a favorable prognosis. [from NCI]

Professional guidelines

PubMed

Pour Farid P, Eckstein M, Merkel S, Grützmann R, Hartmann A, Bruns V, Benz M, Schneider-Stock R, Geppert CI
Int J Mol Sci 2021 Dec 3;22(23) doi: 10.3390/ijms222313108. PMID: 34884913Free PMC Article
Inaguma S, Lasota J, Wang Z, Felisiak-Golabek A, Ikeda H, Miettinen M
Mod Pathol 2017 Feb;30(2):278-285. Epub 2016 Nov 4 doi: 10.1038/modpathol.2016.185. PMID: 27813511Free PMC Article
Bates SE, Longo DL
Cancer Treat Rev 1985 Sep;12(3):163-207. doi: 10.1016/0305-7372(85)90037-4. PMID: 2416441

Recent clinical studies

Etiology

Johncilla M, Yantiss RK
Surg Pathol Clin 2020 Sep;13(3):503-520. Epub 2020 Jul 9 doi: 10.1016/j.path.2020.05.008. PMID: 32773197
Pyo JS, Sohn JH, Kang G
Hum Pathol 2016 Jul;53:91-6. Epub 2016 Mar 19 doi: 10.1016/j.humpath.2016.02.018. PMID: 27001432
Friedman K, Brodsky AS, Lu S, Wood S, Gill AJ, Lombardo K, Yang D, Resnick MB
Mod Pathol 2016 May;29(5):528-41. Epub 2016 Mar 11 doi: 10.1038/modpathol.2016.54. PMID: 26965581
Knox RD, Luey N, Sioson L, Kedziora A, Clarkson A, Watson N, Toon CW, Cussigh C, Pincott S, Pillinger S, Salama Y, Evans J, Percy J, Schnitzler M, Engel A, Gill AJ
Ann Surg Oncol 2015 Sep;22(9):2988-96. Epub 2015 Jan 9 doi: 10.1245/s10434-014-4355-5. PMID: 25572685
Vangoitsenhoven R, Mathieu C, Van der Schueren B
Endocr Relat Cancer 2012 Oct;19(5):F77-88. Epub 2012 Sep 5 doi: 10.1530/ERC-12-0111. PMID: 22691625

Diagnosis

Kelly ML
ANZ J Surg 2023 Mar;93(3):710-711. Epub 2022 Jul 4 doi: 10.1111/ans.17901. PMID: 35789052
Jabbal IS, Nagarajan A, Rivera C, Yaghi M, Liang H, Nahleh Z, Bejarano P, Berho M, Wexner S
Surg Oncol 2022 Dec;45:101856. Epub 2022 Sep 29 doi: 10.1016/j.suronc.2022.101856. PMID: 36446307
Chen X, Liu K, Xu W, Zhou G, Yuan C
Mini Rev Med Chem 2022;22(10):1374-1379. doi: 10.2174/1389557521666211202150646. PMID: 34856896
Fiehn AM, Grauslund M, Glenthøj A, Melchior LC, Vainer B, Willemoe GL
Virchows Arch 2015 Jan;466(1):13-20. Epub 2014 Oct 23 doi: 10.1007/s00428-014-1675-6. PMID: 25339302
Choyke PL, Glenn GM, Walther MM, Zbar B, Linehan WM
Radiology 2003 Jan;226(1):33-46. doi: 10.1148/radiol.2261011296. PMID: 12511666

Therapy

Yang L, Yu L, Zhou Q, Liu L, Shen N, Li N
Sci Rep 2024 May 19;14(1):11426. doi: 10.1038/s41598-024-61354-2. PMID: 38763982Free PMC Article
Thibault C, Fléchon A, Albiges L, Joly C, Barthelemy P, Gross-Goupil M, Chevreau C, Coquan E, Rolland F, Laguerre B, Gravis G, Pécuchet N, Elaidi RT, Timsit MO, Brihoum M, Auclin E, de Reyniès A, Allory Y, Oudard S
Eur J Cancer 2023 Jun;186:83-90. Epub 2023 Mar 23 doi: 10.1016/j.ejca.2023.03.018. PMID: 37054556
Pour Farid P, Eckstein M, Merkel S, Grützmann R, Hartmann A, Bruns V, Benz M, Schneider-Stock R, Geppert CI
Int J Mol Sci 2021 Dec 3;22(23) doi: 10.3390/ijms222313108. PMID: 34884913Free PMC Article
Roskoski R Jr
Pharmacol Res 2021 Mar;165:105463. Epub 2021 Jan 26 doi: 10.1016/j.phrs.2021.105463. PMID: 33513356
Chow LQ, Eckhardt SG
J Clin Oncol 2007 Mar 1;25(7):884-96. doi: 10.1200/JCO.2006.06.3602. PMID: 17327610

Prognosis

Jabbal IS, Nagarajan A, Rivera C, Yaghi M, Liang H, Nahleh Z, Bejarano P, Berho M, Wexner S
Surg Oncol 2022 Dec;45:101856. Epub 2022 Sep 29 doi: 10.1016/j.suronc.2022.101856. PMID: 36446307
Johncilla M, Yantiss RK
Surg Pathol Clin 2020 Sep;13(3):503-520. Epub 2020 Jul 9 doi: 10.1016/j.path.2020.05.008. PMID: 32773197
Pyo JS, Sohn JH, Kang G
Hum Pathol 2016 Jul;53:91-6. Epub 2016 Mar 19 doi: 10.1016/j.humpath.2016.02.018. PMID: 27001432
Fiehn AM, Grauslund M, Glenthøj A, Melchior LC, Vainer B, Willemoe GL
Virchows Arch 2015 Jan;466(1):13-20. Epub 2014 Oct 23 doi: 10.1007/s00428-014-1675-6. PMID: 25339302
Cunningham J, Kantekure K, Saif MW
In Vivo 2014 May-Jun;28(3):311-4. PMID: 24815832

Clinical prediction guides

Yang L, Yu L, Zhou Q, Liu L, Shen N, Li N
Sci Rep 2024 May 19;14(1):11426. doi: 10.1038/s41598-024-61354-2. PMID: 38763982Free PMC Article
Johncilla M, Yantiss RK
Surg Pathol Clin 2020 Sep;13(3):503-520. Epub 2020 Jul 9 doi: 10.1016/j.path.2020.05.008. PMID: 32773197
Fiehn AM, Grauslund M, Glenthøj A, Melchior LC, Vainer B, Willemoe GL
Virchows Arch 2015 Jan;466(1):13-20. Epub 2014 Oct 23 doi: 10.1007/s00428-014-1675-6. PMID: 25339302
Vangoitsenhoven R, Mathieu C, Van der Schueren B
Endocr Relat Cancer 2012 Oct;19(5):F77-88. Epub 2012 Sep 5 doi: 10.1530/ERC-12-0111. PMID: 22691625
Bates SE, Longo DL
Cancer Treat Rev 1985 Sep;12(3):163-207. doi: 10.1016/0305-7372(85)90037-4. PMID: 2416441

Recent systematic reviews

Pyo JS, Sohn JH, Kang G
Hum Pathol 2016 Jul;53:91-6. Epub 2016 Mar 19 doi: 10.1016/j.humpath.2016.02.018. PMID: 27001432

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