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Colon medullary carcinoma

MedGen UID:: 363630
•Concept ID:: C1880119
•: Neoplastic Process

Synonyms:	Colon Medullary Carcinoma; colon medullary carcinoma; medullary carcinoma of the colon; medullary colon carcinoma

Monarch Initiative:	MONDO:0000892

Definition

A rare, invasive colon adenocarcinoma characterized by the presence of sheets of malignant epithelial cells with vesicular nuclei, prominent nucleoli, and abundant eosinophilic cytoplasm. It usually has a favorable prognosis. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVColon medullary carcinoma

Neoplasm
- Epithelial neoplasm
  - Carcinoma
    - Adenocarcinoma
      - Adenocarcinoma of the large intestine
        Colon adenocarcinoma
        Colon medullary carcinoma

Professional guidelines

PubMed

Novel Criteria for Intratumoral Budding with Prognostic Relevance for Colon Cancer and Its Histological Subtypes.

Pour Farid P, Eckstein M, Merkel S, Grützmann R, Hartmann A, Bruns V, Benz M, Schneider-Stock R, Geppert CI
Int J Mol Sci 2021 Dec 3;22(23) doi: 10.3390/ijms222313108. PMID: 34884913 Free PMC Article

Clinicopathologic profile, immunophenotype, and genotype of CD274 (PD-L1)-positive colorectal carcinomas.

Inaguma S, Lasota J, Wang Z, Felisiak-Golabek A, Ikeda H, Miettinen M
Mod Pathol 2017 Feb;30(2):278-285. Epub 2016 Nov 4 doi: 10.1038/modpathol.2016.185. PMID: 27813511 Free PMC Article

Tumor markers: value and limitations in the management of cancer patients.

Bates SE, Longo DL
Cancer Treat Rev 1985 Sep;12(3):163-207. doi: 10.1016/0305-7372(85)90037-4. PMID: 2416441

See all (4)

Recent clinical studies

Etiology

Histology of Colorectal Carcinoma: Proven and Purported Prognostic Factors.

Johncilla M, Yantiss RK
Surg Pathol Clin 2020 Sep;13(3):503-520. Epub 2020 Jul 9 doi: 10.1016/j.path.2020.05.008. PMID: 32773197

Medullary carcinoma in the colorectum: a systematic review and meta-analysis.

Pyo JS, Sohn JH, Kang G
Hum Pathol 2016 Jul;53:91-6. Epub 2016 Mar 19 doi: 10.1016/j.humpath.2016.02.018. PMID: 27001432

Medullary carcinoma of the colon: a distinct morphology reveals a distinctive immunoregulatory microenvironment.

Friedman K, Brodsky AS, Lu S, Wood S, Gill AJ, Lombardo K, Yang D, Resnick MB
Mod Pathol 2016 May;29(5):528-41. Epub 2016 Mar 11 doi: 10.1038/modpathol.2016.54. PMID: 26965581

Medullary colorectal carcinoma revisited: a clinical and pathological study of 102 cases.

Knox RD, Luey N, Sioson L, Kedziora A, Clarkson A, Watson N, Toon CW, Cussigh C, Pincott S, Pillinger S, Salama Y, Evans J, Percy J, Schnitzler M, Engel A, Gill AJ
Ann Surg Oncol 2015 Sep;22(9):2988-96. Epub 2015 Jan 9 doi: 10.1245/s10434-014-4355-5. PMID: 25572685

GLP1 and cancer: friend or foe?

Vangoitsenhoven R, Mathieu C, Van der Schueren B
Endocr Relat Cancer 2012 Oct;19(5):F77-88. Epub 2012 Sep 5 doi: 10.1530/ERC-12-0111. PMID: 22691625

See all (43)

Diagnosis

Medullary carcinoma in the colon.

Kelly ML
ANZ J Surg 2023 Mar;93(3):710-711. Epub 2022 Jul 4 doi: 10.1111/ans.17901. PMID: 35789052

Medullary carcinoma of the colon: A comprehensive analysis of the National Cancer Database.

Jabbal IS, Nagarajan A, Rivera C, Yaghi M, Liang H, Nahleh Z, Bejarano P, Berho M, Wexner S
Surg Oncol 2022 Dec;45:101856. Epub 2022 Sep 29 doi: 10.1016/j.suronc.2022.101856. PMID: 36446307

Chen X, Liu K, Xu W, Zhou G, Yuan C
Mini Rev Med Chem 2022;22(10):1374-1379. doi: 10.2174/1389557521666211202150646. PMID: 34856896

Medullary carcinoma of the colon: a case series and review of the literature.

Cunningham J, Kantekure K, Saif MW
In Vivo 2014 May-Jun;28(3):311-4. PMID: 24815832

Hereditary renal cancers.

Choyke PL, Glenn GM, Walther MM, Zbar B, Linehan WM
Radiology 2003 Jan;226(1):33-46. doi: 10.1148/radiol.2261011296. PMID: 12511666

See all (78)

Therapy

Gemcitabine plus platinum-based chemotherapy in combination with bevacizumab for kidney metastatic collecting duct and medullary carcinomas: Results of a prospective phase II trial (BEVABEL-GETUG/AFU24).

Thibault C, Fléchon A, Albiges L, Joly C, Barthelemy P, Gross-Goupil M, Chevreau C, Coquan E, Rolland F, Laguerre B, Gravis G, Pécuchet N, Elaidi RT, Timsit MO, Brihoum M, Auclin E, de Reyniès A, Allory Y, Oudard S
Eur J Cancer 2023 Jun;186:83-90. Epub 2023 Mar 23 doi: 10.1016/j.ejca.2023.03.018. PMID: 37054556

Novel Criteria for Intratumoral Budding with Prognostic Relevance for Colon Cancer and Its Histological Subtypes.

Properties of FDA-approved small molecule protein kinase inhibitors: A 2021 update.

Roskoski R Jr
Pharmacol Res 2021 Mar;165:105463. Epub 2021 Jan 26 doi: 10.1016/j.phrs.2021.105463. PMID: 33513356

Microsatellite instability and mismatch repair protein expressions in lymphocyte-predominant breast cancer.

Horimoto Y, Thinzar Hlaing M, Saeki H, Kitano S, Nakai K, Sasaki R, Kurisaki-Arakawa A, Arakawa A, Otsuji N, Matsuoka S, Tokuda E, Arai M, Saito M
Cancer Sci 2020 Jul;111(7):2647-2654. Epub 2020 Jun 13 doi: 10.1111/cas.14500. PMID: 32449246 Free PMC Article

Sunitinib: from rational design to clinical efficacy.

Chow LQ, Eckhardt SG
J Clin Oncol 2007 Mar 1;25(7):884-96. doi: 10.1200/JCO.2006.06.3602. PMID: 17327610

See all (20)

Prognosis

Medullary carcinoma of the colon: A comprehensive analysis of the National Cancer Database.

Jabbal IS, Nagarajan A, Rivera C, Yaghi M, Liang H, Nahleh Z, Bejarano P, Berho M, Wexner S
Surg Oncol 2022 Dec;45:101856. Epub 2022 Sep 29 doi: 10.1016/j.suronc.2022.101856. PMID: 36446307

Histology of Colorectal Carcinoma: Proven and Purported Prognostic Factors.

Johncilla M, Yantiss RK
Surg Pathol Clin 2020 Sep;13(3):503-520. Epub 2020 Jul 9 doi: 10.1016/j.path.2020.05.008. PMID: 32773197

Medullary carcinoma in the colorectum: a systematic review and meta-analysis.

Pyo JS, Sohn JH, Kang G
Hum Pathol 2016 Jul;53:91-6. Epub 2016 Mar 19 doi: 10.1016/j.humpath.2016.02.018. PMID: 27001432

Medullary carcinoma of the colon: can the undifferentiated be differentiated?

Fiehn AM, Grauslund M, Glenthøj A, Melchior LC, Vainer B, Willemoe GL
Virchows Arch 2015 Jan;466(1):13-20. Epub 2014 Oct 23 doi: 10.1007/s00428-014-1675-6. PMID: 25339302

Medullary carcinoma of the colon: a case series and review of the literature.

Cunningham J, Kantekure K, Saif MW
In Vivo 2014 May-Jun;28(3):311-4. PMID: 24815832

See all (50)

Clinical prediction guides

Histology of Colorectal Carcinoma: Proven and Purported Prognostic Factors.

Johncilla M, Yantiss RK
Surg Pathol Clin 2020 Sep;13(3):503-520. Epub 2020 Jul 9 doi: 10.1016/j.path.2020.05.008. PMID: 32773197

Medullary carcinoma of the colon: can the undifferentiated be differentiated?

Fiehn AM, Grauslund M, Glenthøj A, Melchior LC, Vainer B, Willemoe GL
Virchows Arch 2015 Jan;466(1):13-20. Epub 2014 Oct 23 doi: 10.1007/s00428-014-1675-6. PMID: 25339302

Poorly differentiated medullary carcinoma of the colon with an unusual phenotypic profile mimicking high grade large cell lymphoma - a unique case report and review of the literature.

Nguyen J, Coppola D, Shan Y, Zhang L
Int J Clin Exp Pathol 2014;7(2):828-34. Epub 2014 Jan 15 PMID: 24551312 Free PMC Article

GLP1 and cancer: friend or foe?

Vangoitsenhoven R, Mathieu C, Van der Schueren B
Endocr Relat Cancer 2012 Oct;19(5):F77-88. Epub 2012 Sep 5 doi: 10.1530/ERC-12-0111. PMID: 22691625

Tumor markers: value and limitations in the management of cancer patients.

Bates SE, Longo DL
Cancer Treat Rev 1985 Sep;12(3):163-207. doi: 10.1016/0305-7372(85)90037-4. PMID: 2416441

See all (38)