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Colon medullary carcinoma

MedGen UID:
363630
•Concept ID:
C1880119
•
Neoplastic Process
Synonyms: Colon Medullary Carcinoma; colon medullary carcinoma; medullary carcinoma of the colon; medullary colon carcinoma
 
Monarch Initiative: MONDO:0000892

Definition

A rare, invasive colon adenocarcinoma characterized by the presence of sheets of malignant epithelial cells with vesicular nuclei, prominent nucleoli, and abundant eosinophilic cytoplasm. It usually has a favorable prognosis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVColon medullary carcinoma

Professional guidelines

PubMed

Novel Criteria for Intratumoral Budding with Prognostic Relevance for Colon Cancer and Its Histological Subtypes.
Pour Farid P, Eckstein M, Merkel S, Grützmann R, Hartmann A, Bruns V, Benz M, Schneider-Stock R, Geppert CI
Int J Mol Sci 2021 Dec 3;22(23) doi: 10.3390/ijms222313108. PMID: 34884913Free PMC Article
Clinicopathologic profile, immunophenotype, and genotype of CD274 (PD-L1)-positive colorectal carcinomas.
Inaguma S, Lasota J, Wang Z, Felisiak-Golabek A, Ikeda H, Miettinen M
Mod Pathol 2017 Feb;30(2):278-285. Epub 2016 Nov 4 doi: 10.1038/modpathol.2016.185. PMID: 27813511Free PMC Article
Tumor markers: value and limitations in the management of cancer patients.
Bates SE, Longo DL
Cancer Treat Rev 1985 Sep;12(3):163-207. doi: 10.1016/0305-7372(85)90037-4. PMID: 2416441

Recent clinical studies

Etiology

Histology of Colorectal Carcinoma: Proven and Purported Prognostic Factors.
Johncilla M, Yantiss RK
Surg Pathol Clin 2020 Sep;13(3):503-520. Epub 2020 Jul 9 doi: 10.1016/j.path.2020.05.008. PMID: 32773197
Medullary carcinoma in the colorectum: a systematic review and meta-analysis.
Pyo JS, Sohn JH, Kang G
Hum Pathol 2016 Jul;53:91-6. Epub 2016 Mar 19 doi: 10.1016/j.humpath.2016.02.018. PMID: 27001432
Medullary colorectal carcinoma revisited: a clinical and pathological study of 102 cases.
Knox RD, Luey N, Sioson L, Kedziora A, Clarkson A, Watson N, Toon CW, Cussigh C, Pincott S, Pillinger S, Salama Y, Evans J, Percy J, Schnitzler M, Engel A, Gill AJ
Ann Surg Oncol 2015 Sep;22(9):2988-96. Epub 2015 Jan 9 doi: 10.1245/s10434-014-4355-5. PMID: 25572685
GLP1 and cancer: friend or foe?
Vangoitsenhoven R, Mathieu C, Van der Schueren B
Endocr Relat Cancer 2012 Oct;19(5):F77-88. Epub 2012 Sep 5 doi: 10.1530/ERC-12-0111. PMID: 22691625
Apudomas.
Nakano PH, Bloom RR, Brown BC, Gray SW, Skandalakis JE, Kibbe JM
Am Surg 1987 Sep;53(9):505-9. PMID: 2820286

Diagnosis

Medullary carcinoma in the colon.
Kelly ML
ANZ J Surg 2023 Mar;93(3):710-711. Epub 2022 Jul 4 doi: 10.1111/ans.17901. PMID: 35789052
Medullary carcinoma of the colon: A comprehensive analysis of the National Cancer Database.
Jabbal IS, Nagarajan A, Rivera C, Yaghi M, Liang H, Nahleh Z, Bejarano P, Berho M, Wexner S
Surg Oncol 2022 Dec;45:101856. Epub 2022 Sep 29 doi: 10.1016/j.suronc.2022.101856. PMID: 36446307
Tumor-related Molecular Regulatory Mechanisms of Long Non-coding RNA RMST: Recent Evidence.
Chen X, Liu K, Xu W, Zhou G, Yuan C
Mini Rev Med Chem 2022;22(10):1374-1379. doi: 10.2174/1389557521666211202150646. PMID: 34856896
Medullary carcinoma of the colon: a case series and review of the literature.
Cunningham J, Kantekure K, Saif MW
In Vivo 2014 May-Jun;28(3):311-4. PMID: 24815832
Hereditary renal cancers.
Choyke PL, Glenn GM, Walther MM, Zbar B, Linehan WM
Radiology 2003 Jan;226(1):33-46. doi: 10.1148/radiol.2261011296. PMID: 12511666

Therapy

Properties of FDA-approved small molecule protein kinase inhibitors: A 2021 update.
Roskoski R Jr
Pharmacol Res 2021 Mar;165:105463. Epub 2021 Jan 26 doi: 10.1016/j.phrs.2021.105463. PMID: 33513356
Microsatellite instability and mismatch repair protein expressions in lymphocyte-predominant breast cancer.
Horimoto Y, Thinzar Hlaing M, Saeki H, Kitano S, Nakai K, Sasaki R, Kurisaki-Arakawa A, Arakawa A, Otsuji N, Matsuoka S, Tokuda E, Arai M, Saito M
Cancer Sci 2020 Jul;111(7):2647-2654. Epub 2020 Jun 13 doi: 10.1111/cas.14500. PMID: 32449246Free PMC Article
Long-term effects of crizotinib in ALK-positive tumors (excluding NSCLC): A phase 1b open-label study.
Gambacorti-Passerini C, Orlov S, Zhang L, Braiteh F, Huang H, Esaki T, Horibe K, Ahn JS, Beck JT, Edenfield WJ, Shi Y, Taylor M, Tamura K, Van Tine BA, Wu SJ, Paolini J, Selaru P, Kim TM
Am J Hematol 2018 May;93(5):607-614. Epub 2018 Feb 8 doi: 10.1002/ajh.25043. PMID: 29352732Free PMC Article
Sunitinib: from rational design to clinical efficacy.
Chow LQ, Eckhardt SG
J Clin Oncol 2007 Mar 1;25(7):884-96. doi: 10.1200/JCO.2006.06.3602. PMID: 17327610
Bispecific-antibody-mediated targeting of radiolabeled bivalent haptens: theoretical, experimental and clinical results.
Le Doussal JM, Barbet J, Delaage M
Int J Cancer Suppl 1992;7:58-62. PMID: 1428406

Prognosis

Medullary carcinoma of the colon: A comprehensive analysis of the National Cancer Database.
Jabbal IS, Nagarajan A, Rivera C, Yaghi M, Liang H, Nahleh Z, Bejarano P, Berho M, Wexner S
Surg Oncol 2022 Dec;45:101856. Epub 2022 Sep 29 doi: 10.1016/j.suronc.2022.101856. PMID: 36446307
Histology of Colorectal Carcinoma: Proven and Purported Prognostic Factors.
Johncilla M, Yantiss RK
Surg Pathol Clin 2020 Sep;13(3):503-520. Epub 2020 Jul 9 doi: 10.1016/j.path.2020.05.008. PMID: 32773197
Medullary carcinoma in the colorectum: a systematic review and meta-analysis.
Pyo JS, Sohn JH, Kang G
Hum Pathol 2016 Jul;53:91-6. Epub 2016 Mar 19 doi: 10.1016/j.humpath.2016.02.018. PMID: 27001432
Medullary carcinoma of the colon: a case series and review of the literature.
Cunningham J, Kantekure K, Saif MW
In Vivo 2014 May-Jun;28(3):311-4. PMID: 24815832
Pathology of colorectal cancer.
Ponz de Leon M, Di Gregorio C
Dig Liver Dis 2001 May;33(4):372-88. doi: 10.1016/s1590-8658(01)80095-5. PMID: 11432519

Clinical prediction guides

Histology of Colorectal Carcinoma: Proven and Purported Prognostic Factors.
Johncilla M, Yantiss RK
Surg Pathol Clin 2020 Sep;13(3):503-520. Epub 2020 Jul 9 doi: 10.1016/j.path.2020.05.008. PMID: 32773197
Medullary carcinoma of the colon: can the undifferentiated be differentiated?
Fiehn AM, Grauslund M, Glenthøj A, Melchior LC, Vainer B, Willemoe GL
Virchows Arch 2015 Jan;466(1):13-20. Epub 2014 Oct 23 doi: 10.1007/s00428-014-1675-6. PMID: 25339302
Poorly differentiated medullary carcinoma of the colon with an unusual phenotypic profile mimicking high grade large cell lymphoma - a unique case report and review of the literature.
Nguyen J, Coppola D, Shan Y, Zhang L
Int J Clin Exp Pathol 2014;7(2):828-34. Epub 2014 Jan 15 PMID: 24551312Free PMC Article
GLP1 and cancer: friend or foe?
Vangoitsenhoven R, Mathieu C, Van der Schueren B
Endocr Relat Cancer 2012 Oct;19(5):F77-88. Epub 2012 Sep 5 doi: 10.1530/ERC-12-0111. PMID: 22691625
Tumor markers: value and limitations in the management of cancer patients.
Bates SE, Longo DL
Cancer Treat Rev 1985 Sep;12(3):163-207. doi: 10.1016/0305-7372(85)90037-4. PMID: 2416441

Recent systematic reviews

Medullary carcinoma in the colorectum: a systematic review and meta-analysis.
Pyo JS, Sohn JH, Kang G
Hum Pathol 2016 Jul;53:91-6. Epub 2016 Mar 19 doi: 10.1016/j.humpath.2016.02.018. PMID: 27001432

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