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Platelet Engraftment

MedGen UID:
364198
•Concept ID:
C1882407
•
Finding

Definition

A platelet count of 20,000 to 50,000 (platelets per microliter of blood) is a sign of platelet engraftment. For patients who receive marrow or peripheral blood cells, platelet engraftment often happens at the same time or a little bit after neutrophil engraftment. For patients who receive cord blood, it may be 8 weeks or longer after transplant before platelet engraftment occurs. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPlatelet Engraftment

Professional guidelines

PubMed

Harmonizing Definitions for Diagnostic Criteria and Prognostic Assessment of Transplantation-Associated Thrombotic Microangiopathy: A Report on Behalf of the European Society for Blood and Marrow Transplantation, American Society for Transplantation and Cellular Therapy, Asia-Pacific Blood and Marrow Transplantation Group, and Center for International Blood and Marrow Transplant Research.
Schoettler ML, Carreras E, Cho B, Dandoy CE, Ho VT, Jodele S, Moissev I, Sanchez-Ortega I, Srivastava A, Atsuta Y, Carpenter P, Koreth J, Kroger N, Ljungman P, Page K, Popat U, Shaw BE, Sureda A, Soiffer R, Vasu S
Transplant Cell Ther 2023 Mar;29(3):151-163. Epub 2022 Nov 25 doi: 10.1016/j.jtct.2022.11.015. PMID: 36442770Free PMC Article
Eltrombopag as first-line treatment for thrombocytopenia among paediatric patients after allogeneic haematopoietic stem cell transplantation.
Qiu KY, Liao XY, Huang K, Wu RH, Xu HG, Xu LH, Li Y, Weng WJ, Zhou DH, Fang JP
Br J Clin Pharmacol 2021 Apr;87(4):2023-2031. Epub 2020 Dec 7 doi: 10.1111/bcp.14607. PMID: 33080064
A study of human leukocyte antigen-haploidentical hematopoietic stem cells transplantation combined with allogenic mesenchymal stem cell infusion for treatment of severe aplastic anemia in pediatric and adolescent patients.
Ding L, Han DM, Zheng XL, Yan HM, Xue M, Liu J, Zhu L, Li S, Mao N, Guo ZK, Ning HM, Wang HX, Zhu H
Stem Cells Transl Med 2021 Feb;10(2):291-302. Epub 2020 Sep 25 doi: 10.1002/sctm.20-0345. PMID: 32978903Free PMC Article

Recent clinical studies

Etiology

Harmonizing Definitions for Diagnostic Criteria and Prognostic Assessment of Transplantation-Associated Thrombotic Microangiopathy: A Report on Behalf of the European Society for Blood and Marrow Transplantation, American Society for Transplantation and Cellular Therapy, Asia-Pacific Blood and Marrow Transplantation Group, and Center for International Blood and Marrow Transplant Research.
Schoettler ML, Carreras E, Cho B, Dandoy CE, Ho VT, Jodele S, Moissev I, Sanchez-Ortega I, Srivastava A, Atsuta Y, Carpenter P, Koreth J, Kroger N, Ljungman P, Page K, Popat U, Shaw BE, Sureda A, Soiffer R, Vasu S
Transplant Cell Ther 2023 Mar;29(3):151-163. Epub 2022 Nov 25 doi: 10.1016/j.jtct.2022.11.015. PMID: 36442770Free PMC Article
Recombinant human thrombopoietin promotes platelet engraftment after umbilical cord blood transplantation.
Tang B, Huang L, Liu H, Cheng S, Song K, Zhang X, Yao W, Ning L, Wan X, Sun G, Wu Y, Cheng J, Long Q, Sun Z, Zhu X
Blood Adv 2020 Aug 25;4(16):3829-3839. doi: 10.1182/bloodadvances.2020002257. PMID: 32790845Free PMC Article
Transfusion support issues in hematopoietic stem cell transplantation.
Cohn CS
Cancer Control 2015 Jan;22(1):52-9. doi: 10.1177/107327481502200108. PMID: 25504279
Neonatal and adult megakaryopoiesis.
Liu ZJ, Sola-Visner M
Curr Opin Hematol 2011 Sep;18(5):330-7. doi: 10.1097/MOH.0b013e3283497ed5. PMID: 21738028
Peripheral blood stem cell mobilization tactics.
Rosenbeck LL, Srivastava S, Kiel PJ
Ann Pharmacother 2010 Jan;44(1):107-16. Epub 2009 Dec 8 doi: 10.1345/aph.1M289. PMID: 19996324

Diagnosis

Once-Daily Foscarnet Is Effective for Human Herpesvirus 6 Reactivation after Hematopoietic Stem Cell Transplantation.
Vittayawacharin P, E'Leimat G, Lee BJ, Griffin S, Doh J, Nam H, Blodget E, Jeyakumar D, Kongtim P, Ciurea SO
Transplant Cell Ther 2023 Jun;29(6):397.e1-397.e6. Epub 2023 Mar 4 doi: 10.1016/j.jtct.2023.02.022. PMID: 36878429
Stem Cell Mobilization Yields with Daratumumab- and Lenalidomide-Containing Quadruplet Induction Therapy in Newly Diagnosed Multiple Myeloma: Findings from the MASTER and GRIFFIN Trials.
Chhabra S, Callander N, Watts NL, Costa LJ, Thapa B, Kaufman JL, Laubach J, Sborov DW, Reeves B, Rodriguez C, Chari A, Silbermann R, Anderson LD Jr, Bal S, Dhakal B, Nathwani N, Shah N, Medvedova E, Bumma N, Holstein SA, Costello C, Jakubowiak A, Wildes TM, Schmidt T, Orlowski RZ, Shain KH, Cowan AJ, Dholaria B, Cornell RF, Jerkins JH, Pei H, Cortoos A, Patel S, Lin TS, Usmani SZ, Richardson PG, Voorhees PM
Transplant Cell Ther 2023 Mar;29(3):174.e1-174.e10. Epub 2022 Dec 6 doi: 10.1016/j.jtct.2022.11.029. PMID: 36494017
Harmonizing Definitions for Diagnostic Criteria and Prognostic Assessment of Transplantation-Associated Thrombotic Microangiopathy: A Report on Behalf of the European Society for Blood and Marrow Transplantation, American Society for Transplantation and Cellular Therapy, Asia-Pacific Blood and Marrow Transplantation Group, and Center for International Blood and Marrow Transplant Research.
Schoettler ML, Carreras E, Cho B, Dandoy CE, Ho VT, Jodele S, Moissev I, Sanchez-Ortega I, Srivastava A, Atsuta Y, Carpenter P, Koreth J, Kroger N, Ljungman P, Page K, Popat U, Shaw BE, Sureda A, Soiffer R, Vasu S
Transplant Cell Ther 2023 Mar;29(3):151-163. Epub 2022 Nov 25 doi: 10.1016/j.jtct.2022.11.015. PMID: 36442770Free PMC Article
Daratumumab, lenalidomide, bortezomib, and dexamethasone for transplant-eligible newly diagnosed multiple myeloma: the GRIFFIN trial.
Voorhees PM, Kaufman JL, Laubach J, Sborov DW, Reeves B, Rodriguez C, Chari A, Silbermann R, Costa LJ, Anderson LD Jr, Nathwani N, Shah N, Efebera YA, Holstein SA, Costello C, Jakubowiak A, Wildes TM, Orlowski RZ, Shain KH, Cowan AJ, Murphy S, Lutska Y, Pei H, Ukropec J, Vermeulen J, de Boer C, Hoehn D, Lin TS, Richardson PG
Blood 2020 Aug 20;136(8):936-945. doi: 10.1182/blood.2020005288. PMID: 32325490Free PMC Article
Unrelated cord blood transplantation for central nervous system relapse in high-risk childhood acute lymphoblastic leukemia.
Zheng C, Tang B, Tong J, Liu H, Geng L, Wang X, Ding K, Sun Z
Ann Hematol 2013 Dec;92(12):1665-73. Epub 2013 Jun 22 doi: 10.1007/s00277-013-1820-3. PMID: 23793915

Therapy

Stem Cell Mobilization Yields with Daratumumab- and Lenalidomide-Containing Quadruplet Induction Therapy in Newly Diagnosed Multiple Myeloma: Findings from the MASTER and GRIFFIN Trials.
Chhabra S, Callander N, Watts NL, Costa LJ, Thapa B, Kaufman JL, Laubach J, Sborov DW, Reeves B, Rodriguez C, Chari A, Silbermann R, Anderson LD Jr, Bal S, Dhakal B, Nathwani N, Shah N, Medvedova E, Bumma N, Holstein SA, Costello C, Jakubowiak A, Wildes TM, Schmidt T, Orlowski RZ, Shain KH, Cowan AJ, Dholaria B, Cornell RF, Jerkins JH, Pei H, Cortoos A, Patel S, Lin TS, Usmani SZ, Richardson PG, Voorhees PM
Transplant Cell Ther 2023 Mar;29(3):174.e1-174.e10. Epub 2022 Dec 6 doi: 10.1016/j.jtct.2022.11.029. PMID: 36494017
Harmonizing Definitions for Diagnostic Criteria and Prognostic Assessment of Transplantation-Associated Thrombotic Microangiopathy: A Report on Behalf of the European Society for Blood and Marrow Transplantation, American Society for Transplantation and Cellular Therapy, Asia-Pacific Blood and Marrow Transplantation Group, and Center for International Blood and Marrow Transplant Research.
Schoettler ML, Carreras E, Cho B, Dandoy CE, Ho VT, Jodele S, Moissev I, Sanchez-Ortega I, Srivastava A, Atsuta Y, Carpenter P, Koreth J, Kroger N, Ljungman P, Page K, Popat U, Shaw BE, Sureda A, Soiffer R, Vasu S
Transplant Cell Ther 2023 Mar;29(3):151-163. Epub 2022 Nov 25 doi: 10.1016/j.jtct.2022.11.015. PMID: 36442770Free PMC Article
Recombinant human thrombopoietin promotes platelet engraftment after umbilical cord blood transplantation.
Tang B, Huang L, Liu H, Cheng S, Song K, Zhang X, Yao W, Ning L, Wan X, Sun G, Wu Y, Cheng J, Long Q, Sun Z, Zhu X
Blood Adv 2020 Aug 25;4(16):3829-3839. doi: 10.1182/bloodadvances.2020002257. PMID: 32790845Free PMC Article
Daratumumab, lenalidomide, bortezomib, and dexamethasone for transplant-eligible newly diagnosed multiple myeloma: the GRIFFIN trial.
Voorhees PM, Kaufman JL, Laubach J, Sborov DW, Reeves B, Rodriguez C, Chari A, Silbermann R, Costa LJ, Anderson LD Jr, Nathwani N, Shah N, Efebera YA, Holstein SA, Costello C, Jakubowiak A, Wildes TM, Orlowski RZ, Shain KH, Cowan AJ, Murphy S, Lutska Y, Pei H, Ukropec J, Vermeulen J, de Boer C, Hoehn D, Lin TS, Richardson PG
Blood 2020 Aug 20;136(8):936-945. doi: 10.1182/blood.2020005288. PMID: 32325490Free PMC Article
Transfusion support issues in hematopoietic stem cell transplantation.
Cohn CS
Cancer Control 2015 Jan;22(1):52-9. doi: 10.1177/107327481502200108. PMID: 25504279

Prognosis

Stem Cell Mobilization Yields with Daratumumab- and Lenalidomide-Containing Quadruplet Induction Therapy in Newly Diagnosed Multiple Myeloma: Findings from the MASTER and GRIFFIN Trials.
Chhabra S, Callander N, Watts NL, Costa LJ, Thapa B, Kaufman JL, Laubach J, Sborov DW, Reeves B, Rodriguez C, Chari A, Silbermann R, Anderson LD Jr, Bal S, Dhakal B, Nathwani N, Shah N, Medvedova E, Bumma N, Holstein SA, Costello C, Jakubowiak A, Wildes TM, Schmidt T, Orlowski RZ, Shain KH, Cowan AJ, Dholaria B, Cornell RF, Jerkins JH, Pei H, Cortoos A, Patel S, Lin TS, Usmani SZ, Richardson PG, Voorhees PM
Transplant Cell Ther 2023 Mar;29(3):174.e1-174.e10. Epub 2022 Dec 6 doi: 10.1016/j.jtct.2022.11.029. PMID: 36494017
Harmonizing Definitions for Diagnostic Criteria and Prognostic Assessment of Transplantation-Associated Thrombotic Microangiopathy: A Report on Behalf of the European Society for Blood and Marrow Transplantation, American Society for Transplantation and Cellular Therapy, Asia-Pacific Blood and Marrow Transplantation Group, and Center for International Blood and Marrow Transplant Research.
Schoettler ML, Carreras E, Cho B, Dandoy CE, Ho VT, Jodele S, Moissev I, Sanchez-Ortega I, Srivastava A, Atsuta Y, Carpenter P, Koreth J, Kroger N, Ljungman P, Page K, Popat U, Shaw BE, Sureda A, Soiffer R, Vasu S
Transplant Cell Ther 2023 Mar;29(3):151-163. Epub 2022 Nov 25 doi: 10.1016/j.jtct.2022.11.015. PMID: 36442770Free PMC Article
Reduced platelet transfusions and earlier platelet engraftment using alemtuzumab-based conditioning regimen in allogeneic stem cell transplantation.
Neumann T, Schneidewind L, Thiele T, Schulze M, Klenner AF, Busemann C, Pink D, Greinacher A, Dölken G, Krüger WH
J Cancer Res Clin Oncol 2016 May;142(5):1091-7. Epub 2016 Jan 16 doi: 10.1007/s00432-016-2114-7. PMID: 26779644
Transfusion support issues in hematopoietic stem cell transplantation.
Cohn CS
Cancer Control 2015 Jan;22(1):52-9. doi: 10.1177/107327481502200108. PMID: 25504279
Peripheral blood stem cell mobilization tactics.
Rosenbeck LL, Srivastava S, Kiel PJ
Ann Pharmacother 2010 Jan;44(1):107-16. Epub 2009 Dec 8 doi: 10.1345/aph.1M289. PMID: 19996324

Clinical prediction guides

Stem Cell Mobilization Yields with Daratumumab- and Lenalidomide-Containing Quadruplet Induction Therapy in Newly Diagnosed Multiple Myeloma: Findings from the MASTER and GRIFFIN Trials.
Chhabra S, Callander N, Watts NL, Costa LJ, Thapa B, Kaufman JL, Laubach J, Sborov DW, Reeves B, Rodriguez C, Chari A, Silbermann R, Anderson LD Jr, Bal S, Dhakal B, Nathwani N, Shah N, Medvedova E, Bumma N, Holstein SA, Costello C, Jakubowiak A, Wildes TM, Schmidt T, Orlowski RZ, Shain KH, Cowan AJ, Dholaria B, Cornell RF, Jerkins JH, Pei H, Cortoos A, Patel S, Lin TS, Usmani SZ, Richardson PG, Voorhees PM
Transplant Cell Ther 2023 Mar;29(3):174.e1-174.e10. Epub 2022 Dec 6 doi: 10.1016/j.jtct.2022.11.029. PMID: 36494017
Recombinant human thrombopoietin promotes platelet engraftment after umbilical cord blood transplantation.
Tang B, Huang L, Liu H, Cheng S, Song K, Zhang X, Yao W, Ning L, Wan X, Sun G, Wu Y, Cheng J, Long Q, Sun Z, Zhu X
Blood Adv 2020 Aug 25;4(16):3829-3839. doi: 10.1182/bloodadvances.2020002257. PMID: 32790845Free PMC Article
Prediction of delayed platelet engraftment after autologous stem cell transplantation for B-cell non-Hodgkin lymphoma.
Yamaguchi J, Chinen Y, Takimoto-Shimomura T, Nagata H, Muramatsu A, Kuriyama K, Ohshiro M, Hirakawa Y, Iwai T, Uchiyama H, Uoshima N, Kaneko H, Nakao M, Tsukamoto T, Shimura Y, Kobayashi T, Horiike S, Yokota I, Kuroda J; KOTOSG Investigators
Leuk Lymphoma 2019 Dec;60(14):3434-3441. Epub 2019 Jul 18 doi: 10.1080/10428194.2019.1636982. PMID: 31318305
Transfusion support issues in hematopoietic stem cell transplantation.
Cohn CS
Cancer Control 2015 Jan;22(1):52-9. doi: 10.1177/107327481502200108. PMID: 25504279
Placental/umbilical cord blood transplantation.
Sirchia G, Rebulla P
Haematologica 1999 Aug;84(8):738-47. PMID: 10457410

Recent systematic reviews

Efficacy and safety of mesenchymal stem cells co-infusion in allogeneic hematopoietic stem cell transplantation: a systematic review and meta-analysis.
Li T, Luo C, Zhang J, Wei L, Sun W, Xie Q, Liu Y, Zhao Y, Xu S, Wang L
Stem Cell Res Ther 2021 Apr 20;12(1):246. doi: 10.1186/s13287-021-02304-x. PMID: 33879242Free PMC Article
Pegylated granulocyte-colony stimulating factor versus non-pegylated granulocyte-colony stimulating factor for peripheral blood stem cell mobilization: A systematic review and meta-analysis.
Kuan JW, Su AT, Leong CF
J Clin Apher 2017 Dec;32(6):517-542. Epub 2017 May 9 doi: 10.1002/jca.21550. PMID: 28485020
Additional plerixafor to granulocyte colony-stimulating factors for haematopoietic stem cell mobilisation for autologous transplantation in people with malignant lymphoma or multiple myeloma.
Hartmann T, Hübel K, Monsef I, Engert A, Skoetz N
Cochrane Database Syst Rev 2015 Oct 20;2015(10):CD010615. doi: 10.1002/14651858.CD010615.pub2. PMID: 26484982Free PMC Article
Bone marrow versus peripheral blood allogeneic haematopoietic stem cell transplantation for haematological malignancies in adults.
Holtick U, Albrecht M, Chemnitz JM, Theurich S, Skoetz N, Scheid C, von Bergwelt-Baildon M
Cochrane Database Syst Rev 2014 Apr 20;2014(4):CD010189. doi: 10.1002/14651858.CD010189.pub2. PMID: 24748537Free PMC Article
Autologous stem cells derived from the peripheral blood compared to standard bone marrow transplant; time to engraftment: a systematic review.
Lewis A
Int J Nurs Stud 2005 Jul;42(5):589-96. doi: 10.1016/j.ijnurstu.2005.01.007. PMID: 15921990

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