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Spindle Cell Metaplasia

MedGen UID:
364361
•Concept ID:
C1883077
•
Finding

Definition

A morphologic finding indicating the transformation of non-spindle cells to spindle-shaped cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSpindle Cell Metaplasia

Professional guidelines

PubMed

AAV-P125A-endostatin and paclitaxel treatment increases endoreduplication in endothelial cells and inhibits metastasis of breast cancer.
Subramanian IV, Devineni S, Ghebre R, Ghosh G, Joshi HP, Jing Y, Truskinovsky AM, Ramakrishnan S
Gene Ther 2011 Feb;18(2):145-54. Epub 2010 Sep 16 doi: 10.1038/gt.2010.118. PMID: 20844568
Tumor cell plasticity in uveal melanoma: microenvironment directed dampening of the invasive and metastatic genotype and phenotype accompanies the generation of vasculogenic mimicry patterns.
Folberg R, Arbieva Z, Moses J, Hayee A, Sandal T, Kadkol S, Lin AY, Valyi-Nagy K, Setty S, Leach L, Chévez-Barrios P, Larsen P, Majumdar D, Pe'er J, Maniotis AJ
Am J Pathol 2006 Oct;169(4):1376-89. doi: 10.2353/ajpath.2006.060223. PMID: 17003493Free PMC Article
Keratin subsets and monoclonal antibody HBME-1 in chordoma: immunohistochemical differential diagnosis between tumors simulating chordoma.
O'Hara BJ, Paetau A, Miettinen M
Hum Pathol 1998 Feb;29(2):119-26. doi: 10.1016/s0046-8177(98)90220-9. PMID: 9490269

Recent clinical studies

Etiology

Follicular thyroid adenoma dominated by spindle cells: report of two unusual cases and literature review.
Agaimy A, Hahn T, Schroeder J, Elhag A
Int J Clin Exp Pathol 2012;5(2):143-51. Epub 2012 Feb 12 PMID: 22400075Free PMC Article
Metaplastic carcinoma of the breast: analysis of eight Asian patients with special emphasis on two unusual cases presenting with inflammatory-type breast cancer.
Kuo SH, Chen CL, Huang CS, Cheng AL
Anticancer Res 2000 May-Jun;20(3B):2219-22. PMID: 10928181
Squamous cell carcinoma of the breast: a clinicopathologic analysis of eight cases and review of the literature.
Eggers JW, Chesney TM
Hum Pathol 1984 Jun;15(6):526-31. doi: 10.1016/s0046-8177(84)80005-2. PMID: 6724572

Diagnosis

"Noninvasive Follicular Thyroid Neoplasm With Papillary-Like Nuclear Features" With Focal Spindle Cell Metaplasia.
Arnoux G, Pusztaszeri M
Int J Surg Pathol 2018 May;26(3):261-265. Epub 2017 Dec 6 doi: 10.1177/1066896917741548. PMID: 29212393
Not All Post-FNA Spindle Cell Proliferations in the Thyroid Are of Myofibroblastic Origin: Follicular Adenoma with Spindle Cell Metaplasia.
Yegen G, Büyük M, Solmaz İC, Önder S, Öztürk Ş, Mete Ö
Endocr Pathol 2015 Dec;26(4):374-6. doi: 10.1007/s12022-015-9399-y. PMID: 26490689
Papillary thyroid carcinoma with predominant spindle cell component: report of two rare cases and discussion on the differential diagnosis with other spindled thyroid neoplasm.
Corrado S, Corsello SM, Maiorana A, Rossi ED, Pontecorvi A, Fadda G, Papi G
Endocr Pathol 2014 Sep;25(3):307-14. doi: 10.1007/s12022-013-9290-7. PMID: 24356783
Spindle cell metaplasia arising in thyroid adenoma: characterization of its pathology and differential diagnosis.
Shikama Y, Mizukami H, Sakai T, Yagihashi N, Okamoto K, Yagihashi S
J Endocrinol Invest 2006 Feb;29(2):168-71. doi: 10.1007/BF03344092. PMID: 16610245
Pyloric gland type adenoma of the gallbladder with squamoid spindle cell metaplasia.
Kushima R, Remmele W, Stolte M, Borchard F
Pathol Res Pract 1996 Sep;192(9):963-9; discussion 970-1. doi: 10.1016/S0344-0338(96)80081-1. PMID: 8950764

Therapy

A case of hepatoblastoma misdiagnosed as combined hepatocellular carcinoma and cholangiocarcinoma in an adult.
Park KW, Seo CJ, Yun DY, Kim MK, Kim BS, Han YS, Oh HK, Lee CH
Clin Mol Hepatol 2015 Sep;21(3):300-8. Epub 2015 Sep 30 doi: 10.3350/cmh.2015.21.3.300. PMID: 26523273Free PMC Article
Malignant fibrous histiocytoma of the chest wall masquerading as medullary breast carcinoma: a case report.
Sharma P, Jain S, Nigam S, Bahadur AK, Ouseph MM
Acta Cytol 2006 Sep-Oct;50(5):577-80. doi: 10.1159/000326020. PMID: 17017451
Metaplastic carcinoma of the breast: analysis of eight Asian patients with special emphasis on two unusual cases presenting with inflammatory-type breast cancer.
Kuo SH, Chen CL, Huang CS, Cheng AL
Anticancer Res 2000 May-Jun;20(3B):2219-22. PMID: 10928181

Prognosis

Follicular thyroid adenoma dominated by spindle cells: report of two unusual cases and literature review.
Agaimy A, Hahn T, Schroeder J, Elhag A
Int J Clin Exp Pathol 2012;5(2):143-51. Epub 2012 Feb 12 PMID: 22400075Free PMC Article
Metaplastic carcinoma of the breast: analysis of eight Asian patients with special emphasis on two unusual cases presenting with inflammatory-type breast cancer.
Kuo SH, Chen CL, Huang CS, Cheng AL
Anticancer Res 2000 May-Jun;20(3B):2219-22. PMID: 10928181
Immunohistochemical expression of metallothionein in invasive breast cancer in relation to proliferative activity, histology and prognosis.
Oyama T, Take H, Hikino T, Iino Y, Nakajima T
Oncology 1996 Mar-Apr;53(2):112-7. doi: 10.1159/000227546. PMID: 8604236
Squamous cell carcinoma of the breast: a clinicopathologic analysis of eight cases and review of the literature.
Eggers JW, Chesney TM
Hum Pathol 1984 Jun;15(6):526-31. doi: 10.1016/s0046-8177(84)80005-2. PMID: 6724572

Clinical prediction guides

Metaplastic breast carcinomas display genomic and transcriptomic heterogeneity [corrected].
Weigelt B, Ng CK, Shen R, Popova T, Schizas M, Natrajan R, Mariani O, Stern MH, Norton L, Vincent-Salomon A, Reis-Filho JS
Mod Pathol 2015 Mar;28(3):340-51. Epub 2014 Nov 21 doi: 10.1038/modpathol.2014.142. PMID: 25412848Free PMC Article
Immunohistochemical expression of metallothionein in invasive breast cancer in relation to proliferative activity, histology and prognosis.
Oyama T, Take H, Hikino T, Iino Y, Nakajima T
Oncology 1996 Mar-Apr;53(2):112-7. doi: 10.1159/000227546. PMID: 8604236

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