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Lymphoma, Extranodal NK-T-Cell

MedGen UID:
364981
•Concept ID:
C1955906
•
Neoplastic Process
Synonyms: Extranodal NK T Cell Lymphoma; Extranodal NK-T-Cell Lymphoma; Extranodal NK-T-Cell Lymphomas; Lymphoma, Extranodal NK T Cell; Lymphomas, Extranodal NK-T-Cell; NK-T-Cell Lymphoma, Extranodal; NK-T-Cell Lymphomas, Extranodal

Definition

An extranodal neoplasm, usually possessing an NK-cell phenotype and associated with EPSTEIN-BARR VIRUS. These lymphomas exhibit a broad morphologic spectrum, frequent necrosis, angioinvasion, and most commonly present in the midfacial region, but also in other extranodal sites. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLymphoma, Extranodal NK-T-Cell

Professional guidelines

PubMed

Primary cutaneous T-cell lymphomas other than mycosis fungoides and Sézary syndrome. Part II: Prognosis and management.
Oh Y, Stoll JR, Moskowitz A, Pulitzer M, Horwitz S, Myskowski P, Noor SJ
J Am Acad Dermatol 2021 Nov;85(5):1093-1106. Epub 2021 May 1 doi: 10.1016/j.jaad.2021.04.081. PMID: 33945836
Advances in the treatment of extranodal NK/T-cell lymphoma, nasal type.
Yamaguchi M, Suzuki R, Oguchi M
Blood 2018 Jun 7;131(23):2528-2540. Epub 2018 Mar 30 doi: 10.1182/blood-2017-12-791418. PMID: 29602763
The diagnosis and management of NK/T-cell lymphomas.
Tse E, Kwong YL
J Hematol Oncol 2017 Apr 14;10(1):85. doi: 10.1186/s13045-017-0452-9. PMID: 28410601Free PMC Article

Recent clinical studies

Etiology

Extranodal T- and NK-cell lymphomas.
de Leval L, Feldman AL, Pileri S, Nakamura S, Gaulard P
Virchows Arch 2023 Jan;482(1):245-264. Epub 2022 Nov 7 doi: 10.1007/s00428-022-03434-0. PMID: 36336765Free PMC Article
EBV-associated NK and T-cell lymphoid neoplasms.
Kimura H, de Leval L, Cai Q, Kim WS
Curr Opin Oncol 2022 Sep 1;34(5):422-431. Epub 2022 Jul 27 doi: 10.1097/CCO.0000000000000889. PMID: 35900729Free PMC Article
T- and NK-cell lymphoproliferative disorders of the gastrointestinal tract: review and update.
van Vliet C, Spagnolo DV
Pathology 2020 Jan;52(1):128-141. Epub 2019 Nov 11 doi: 10.1016/j.pathol.2019.10.001. PMID: 31727264
Oncogenic activation of the STAT3 pathway drives PD-L1 expression in natural killer/T-cell lymphoma.
Song TL, Nairismägi ML, Laurensia Y, Lim JQ, Tan J, Li ZM, Pang WL, Kizhakeyil A, Wijaya GC, Huang DC, Nagarajan S, Chia BK, Cheah D, Liu YH, Zhang F, Rao HL, Tang T, Wong EK, Bei JX, Iqbal J, Grigoropoulos NF, Ng SB, Chng WJ, Teh BT, Tan SY, Verma NK, Fan H, Lim ST, Ong CK
Blood 2018 Sep 13;132(11):1146-1158. Epub 2018 Jul 27 doi: 10.1182/blood-2018-01-829424. PMID: 30054295Free PMC Article
The diagnosis and management of NK/T-cell lymphomas.
Tse E, Kwong YL
J Hematol Oncol 2017 Apr 14;10(1):85. doi: 10.1186/s13045-017-0452-9. PMID: 28410601Free PMC Article

Diagnosis

Extranodal T- and NK-cell lymphomas.
de Leval L, Feldman AL, Pileri S, Nakamura S, Gaulard P
Virchows Arch 2023 Jan;482(1):245-264. Epub 2022 Nov 7 doi: 10.1007/s00428-022-03434-0. PMID: 36336765Free PMC Article
How we treat NK/T-cell lymphomas.
Tse E, Zhao WL, Xiong J, Kwong YL
J Hematol Oncol 2022 Jun 3;15(1):74. doi: 10.1186/s13045-022-01293-5. PMID: 35659326Free PMC Article
NK-/T-cell lymphomas.
Wang H, Fu BB, Gale RP, Liang Y
Leukemia 2021 Sep;35(9):2460-2468. Epub 2021 Jun 11 doi: 10.1038/s41375-021-01313-2. PMID: 34117356Free PMC Article
Extranodal NK/T cell lymphoma, nasal type: An updated overview.
Sánchez-Romero C, Bologna-Molina R, Paes de Almeida O, Santos-Silva AR, Prado-Ribeiro AC, Brandão TB, Carlos R
Crit Rev Oncol Hematol 2021 Mar;159:103237. Epub 2021 Jan 22 doi: 10.1016/j.critrevonc.2021.103237. PMID: 33493634
The diagnosis and management of NK/T-cell lymphomas.
Tse E, Kwong YL
J Hematol Oncol 2017 Apr 14;10(1):85. doi: 10.1186/s13045-017-0452-9. PMID: 28410601Free PMC Article

Therapy

How we treat NK/T-cell lymphomas.
Tse E, Zhao WL, Xiong J, Kwong YL
J Hematol Oncol 2022 Jun 3;15(1):74. doi: 10.1186/s13045-022-01293-5. PMID: 35659326Free PMC Article
NK-/T-cell lymphomas.
Wang H, Fu BB, Gale RP, Liang Y
Leukemia 2021 Sep;35(9):2460-2468. Epub 2021 Jun 11 doi: 10.1038/s41375-021-01313-2. PMID: 34117356Free PMC Article
NK/T-cell lymphomas.
Tse E, Kwong YL
Best Pract Res Clin Haematol 2019 Sep;32(3):253-261. Epub 2019 Jun 12 doi: 10.1016/j.beha.2019.06.005. PMID: 31585625
Advances in the treatment of extranodal NK/T-cell lymphoma, nasal type.
Yamaguchi M, Suzuki R, Oguchi M
Blood 2018 Jun 7;131(23):2528-2540. Epub 2018 Mar 30 doi: 10.1182/blood-2017-12-791418. PMID: 29602763
The diagnosis and management of NK/T-cell lymphomas.
Tse E, Kwong YL
J Hematol Oncol 2017 Apr 14;10(1):85. doi: 10.1186/s13045-017-0452-9. PMID: 28410601Free PMC Article

Prognosis

Review on natural killer/T-cell lymphoma.
He X, Gao Y, Li Z, Huang H
Hematol Oncol 2023 Apr;41(2):221-229. Epub 2021 Dec 9 doi: 10.1002/hon.2944. PMID: 34731509
How we treat NK/T-cell lymphomas.
Tse E, Zhao WL, Xiong J, Kwong YL
J Hematol Oncol 2022 Jun 3;15(1):74. doi: 10.1186/s13045-022-01293-5. PMID: 35659326Free PMC Article
NK-/T-cell lymphomas.
Wang H, Fu BB, Gale RP, Liang Y
Leukemia 2021 Sep;35(9):2460-2468. Epub 2021 Jun 11 doi: 10.1038/s41375-021-01313-2. PMID: 34117356Free PMC Article
Extranodal NK/T cell lymphoma, nasal type: An updated overview.
Sánchez-Romero C, Bologna-Molina R, Paes de Almeida O, Santos-Silva AR, Prado-Ribeiro AC, Brandão TB, Carlos R
Crit Rev Oncol Hematol 2021 Mar;159:103237. Epub 2021 Jan 22 doi: 10.1016/j.critrevonc.2021.103237. PMID: 33493634
The diagnosis and management of NK/T-cell lymphomas.
Tse E, Kwong YL
J Hematol Oncol 2017 Apr 14;10(1):85. doi: 10.1186/s13045-017-0452-9. PMID: 28410601Free PMC Article

Clinical prediction guides

How we treat NK/T-cell lymphomas.
Tse E, Zhao WL, Xiong J, Kwong YL
J Hematol Oncol 2022 Jun 3;15(1):74. doi: 10.1186/s13045-022-01293-5. PMID: 35659326Free PMC Article
Estimating the global burden of Epstein-Barr virus-related cancers.
Wong Y, Meehan MT, Burrows SR, Doolan DL, Miles JJ
J Cancer Res Clin Oncol 2022 Jan;148(1):31-46. Epub 2021 Oct 27 doi: 10.1007/s00432-021-03824-y. PMID: 34705104Free PMC Article
NK-/T-cell lymphomas.
Wang H, Fu BB, Gale RP, Liang Y
Leukemia 2021 Sep;35(9):2460-2468. Epub 2021 Jun 11 doi: 10.1038/s41375-021-01313-2. PMID: 34117356Free PMC Article
A composite single-nucleotide polymorphism prediction signature for extranodal natural killer/T-cell lymphoma.
Tian XP, Ma SY, Young KH, Ong CK, Liu YH, Li ZH, Zhai QL, Huang HQ, Lin TY, Li ZM, Xia ZJ, Zhong LY, Rao HL, Li M, Cai J, Zhang YC, Zhang F, Su N, Li PF, Zhu F, Xu-Monette ZY, Wong EKY, Ha JCH, Khoo LP, Ai L, Cheng RF, Lim JQ, de Mel S, Ng SB, Lim ST, Cai QQ
Blood 2021 Aug 12;138(6):452-463. doi: 10.1182/blood.2020010637. PMID: 33728448
Oncogenic activation of the STAT3 pathway drives PD-L1 expression in natural killer/T-cell lymphoma.
Song TL, Nairismägi ML, Laurensia Y, Lim JQ, Tan J, Li ZM, Pang WL, Kizhakeyil A, Wijaya GC, Huang DC, Nagarajan S, Chia BK, Cheah D, Liu YH, Zhang F, Rao HL, Tang T, Wong EK, Bei JX, Iqbal J, Grigoropoulos NF, Ng SB, Chng WJ, Teh BT, Tan SY, Verma NK, Fan H, Lim ST, Ong CK
Blood 2018 Sep 13;132(11):1146-1158. Epub 2018 Jul 27 doi: 10.1182/blood-2018-01-829424. PMID: 30054295Free PMC Article

Recent systematic reviews

Allogeneic Hematopoietic Stem Cell Transplantation in Extranodal Natural Killer/T-cell Lymphoma.
Peng YY, Xiong YY, Zhang LX, Wang J, Zhang HB, Xiao Q, Guo SL
Turk J Haematol 2021 Jun 1;38(2):126-137. Epub 2021 Feb 4 doi: 10.4274/tjh.galenos.2021.2020.0438. PMID: 33535731Free PMC Article
Defining the toxicity of current regimens for extranodal NK/T cell lymphoma: a systematic review and metaproportion.
Pokrovsky VS, Vinnikov D
Expert Rev Anticancer Ther 2019 Jan;19(1):93-104. Epub 2018 Nov 23 doi: 10.1080/14737140.2019.1549992. PMID: 30449214
Treatment of localized extranodal NK/T cell lymphoma, nasal type: a systematic review.
Kim SJ, Yoon SE, Kim WS
J Hematol Oncol 2018 Dec 20;11(1):140. doi: 10.1186/s13045-018-0687-0. PMID: 30567593Free PMC Article
The optimal timing of radiotherapy in the combined modality therapy for limited-stage extranodal NK/T cell lymphoma (ENKTL): a systematic review and meta-analysis.
Hu S, Zhou D, Zhang W
Ann Hematol 2018 Dec;97(12):2279-2287. Epub 2018 Aug 20 doi: 10.1007/s00277-018-3479-2. PMID: 30128904
L-Asparaginase for newly diagnosed extra-nodal NK/T-cell lymphoma: systematic review and meta-analysis.
Pokrovsky VS, Vinnikov D
Expert Rev Anticancer Ther 2017 Aug;17(8):759-768. Epub 2017 Jun 21 doi: 10.1080/14737140.2017.1344100. PMID: 28621166

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