U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tumor Replacement

MedGen UID:
365246
•Concept ID:
C1883411
•
Neoplastic Process

Definition

The process whereby normal tissue cells and structures are replaced by tumor cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTumor Replacement

Professional guidelines

PubMed

The intermediate hepatocellular carcinoma stage: Should treatment be expanded?
Piscaglia F, Bolondi L
Dig Liver Dis 2010 Jul;42 Suppl 3:S258-63. doi: 10.1016/S1590-8658(10)60514-2. PMID: 20547312
Yttrium-90 microspheres for the treatment of hepatocellular carcinoma.
Geschwind JF, Salem R, Carr BI, Soulen MC, Thurston KG, Goin KA, Van Buskirk M, Roberts CA, Goin JE
Gastroenterology 2004 Nov;127(5 Suppl 1):S194-205. doi: 10.1053/j.gastro.2004.09.034. PMID: 15508085
Vincristine sulfate in management of Wilms' tumor. Replacement of preoperative irradiation by chemotherapy.
Sullivan MP, Sutow WW, Cangir A, Taylor G
JAMA 1967 Oct 30;202(5):381-4. PMID: 4293363

Recent clinical studies

Etiology

Sentinel lymph node melanoma metastases: Assessment of tumor burden for clinical prediction of outcome in the first Multicenter Selective Lymphadenectomy Trial (MSLT-I).
Cochran AJ, Wen DR, Huang RR, Abrishami P, Smart C, Binder S, Scolyer RA, Thompson JF, Stern S, Van Kreuningen L, Elashoff DE, Sim MS, Wang HJ, Faries MB; MSLT-I Study Group
Eur J Surg Oncol 2022 Jun;48(6):1280-1287. Epub 2022 Feb 12 doi: 10.1016/j.ejso.2022.01.021. PMID: 35246348
Characteristics of breast carcinoma cases with false-negative sentinel lymph nodes.
Wei S, Bleiweiss IJ, Nagi C, Jaffer S
Clin Breast Cancer 2014 Aug;14(4):280-4. Epub 2014 Jan 3 doi: 10.1016/j.clbc.2013.12.009. PMID: 24581736
Radioembolization of colorectal hepatic metastases using yttrium-90 microspheres.
Mulcahy MF, Lewandowski RJ, Ibrahim SM, Sato KT, Ryu RK, Atassi B, Newman S, Talamonti M, Omary RA, Benson A 3rd, Salem R
Cancer 2009 May 1;115(9):1849-58. doi: 10.1002/cncr.24224. PMID: 19267416
Genomic instability and the development of metastatic lymph node tumors.
Callaghan KA, Becker TE, Ellsworth DL, Hooke JA, Ellsworth RE, Shriver CD
Ann Surg Oncol 2007 Nov;14(11):3125-32. Epub 2007 Jul 25 doi: 10.1245/s10434-007-9504-7. PMID: 17653592
Lymphatic mapping and sentinel lymphadenectomy for 106 head and neck lesions: contrasts between oral cavity and cutaneous malignancy.
Civantos FJ, Moffat FL, Goodwin WJ
Laryngoscope 2006 Mar;112(3 Pt 2 Suppl 109):1-15. doi: 10.1097/01.mlg.0000200750.74249.79. PMID: 16540925

Diagnosis

Axillary lymph node metastasis: Fine-needle aspiration biopsy sensitivity as a function of node size, percent replacement of lymph node by tumor and tumor deposit size.
Layfield LJ, Zhang T, Esebua M, Schmidt R
Diagn Cytopathol 2021 Feb;49(2):181-186. Epub 2020 Sep 17 doi: 10.1002/dc.24617. PMID: 32945140
Radioembolization of colorectal hepatic metastases using yttrium-90 microspheres.
Mulcahy MF, Lewandowski RJ, Ibrahim SM, Sato KT, Ryu RK, Atassi B, Newman S, Talamonti M, Omary RA, Benson A 3rd, Salem R
Cancer 2009 May 1;115(9):1849-58. doi: 10.1002/cncr.24224. PMID: 19267416
Radioembolization for unresectable neuroendocrine hepatic metastases using resin 90Y-microspheres: early results in 148 patients.
Kennedy AS, Dezarn WA, McNeillie P, Coldwell D, Nutting C, Carter D, Murthy R, Rose S, Warner RR, Liu D, Palmedo H, Overton C, Jones B, Salem R
Am J Clin Oncol 2008 Jun;31(3):271-9. doi: 10.1097/COC.0b013e31815e4557. PMID: 18525307
Usefulness of bone marrow imaging in childhood malignancies.
Oseas RS, Siddiqui AR, Wellman HN, Baehner RL
J Pediatr 1982 Aug;101(2):206-9. doi: 10.1016/s0022-3476(82)80118-2. PMID: 6284900
Evaluation of bone-marrow scanning with technetium-99m sulfur colloid in pediatric oncology.
Siddiqui AR, Oseas RS, Wellman HN, Doerr DR, Baehner RL
J Nucl Med 1979 May;20(5):379-86. PMID: 232146

Therapy

Sentinel lymph node melanoma metastases: Assessment of tumor burden for clinical prediction of outcome in the first Multicenter Selective Lymphadenectomy Trial (MSLT-I).
Cochran AJ, Wen DR, Huang RR, Abrishami P, Smart C, Binder S, Scolyer RA, Thompson JF, Stern S, Van Kreuningen L, Elashoff DE, Sim MS, Wang HJ, Faries MB; MSLT-I Study Group
Eur J Surg Oncol 2022 Jun;48(6):1280-1287. Epub 2022 Feb 12 doi: 10.1016/j.ejso.2022.01.021. PMID: 35246348
Infarct-like necrosis: a distinct form of necrosis seen in colorectal carcinoma liver metastases treated with perioperative chemotherapy.
Chang HH, Leeper WR, Chan G, Quan D, Driman DK
Am J Surg Pathol 2012 Apr;36(4):570-6. doi: 10.1097/PAS.0b013e31824057e7. PMID: 22301494
Radioembolization of colorectal hepatic metastases using yttrium-90 microspheres.
Mulcahy MF, Lewandowski RJ, Ibrahim SM, Sato KT, Ryu RK, Atassi B, Newman S, Talamonti M, Omary RA, Benson A 3rd, Salem R
Cancer 2009 May 1;115(9):1849-58. doi: 10.1002/cncr.24224. PMID: 19267416
Radioembolization for unresectable neuroendocrine hepatic metastases using resin 90Y-microspheres: early results in 148 patients.
Kennedy AS, Dezarn WA, McNeillie P, Coldwell D, Nutting C, Carter D, Murthy R, Rose S, Warner RR, Liu D, Palmedo H, Overton C, Jones B, Salem R
Am J Clin Oncol 2008 Jun;31(3):271-9. doi: 10.1097/COC.0b013e31815e4557. PMID: 18525307
Evaluation of bone-marrow scanning with technetium-99m sulfur colloid in pediatric oncology.
Siddiqui AR, Oseas RS, Wellman HN, Doerr DR, Baehner RL
J Nucl Med 1979 May;20(5):379-86. PMID: 232146

Prognosis

Sentinel lymph node melanoma metastases: Assessment of tumor burden for clinical prediction of outcome in the first Multicenter Selective Lymphadenectomy Trial (MSLT-I).
Cochran AJ, Wen DR, Huang RR, Abrishami P, Smart C, Binder S, Scolyer RA, Thompson JF, Stern S, Van Kreuningen L, Elashoff DE, Sim MS, Wang HJ, Faries MB; MSLT-I Study Group
Eur J Surg Oncol 2022 Jun;48(6):1280-1287. Epub 2022 Feb 12 doi: 10.1016/j.ejso.2022.01.021. PMID: 35246348
Characteristics of breast carcinoma cases with false-negative sentinel lymph nodes.
Wei S, Bleiweiss IJ, Nagi C, Jaffer S
Clin Breast Cancer 2014 Aug;14(4):280-4. Epub 2014 Jan 3 doi: 10.1016/j.clbc.2013.12.009. PMID: 24581736
The intermediate hepatocellular carcinoma stage: Should treatment be expanded?
Piscaglia F, Bolondi L
Dig Liver Dis 2010 Jul;42 Suppl 3:S258-63. doi: 10.1016/S1590-8658(10)60514-2. PMID: 20547312
Lymphatic mapping and sentinel lymphadenectomy for 106 head and neck lesions: contrasts between oral cavity and cutaneous malignancy.
Civantos FJ, Moffat FL, Goodwin WJ
Laryngoscope 2006 Mar;112(3 Pt 2 Suppl 109):1-15. doi: 10.1097/01.mlg.0000200750.74249.79. PMID: 16540925
Evaluation of bone-marrow scanning with technetium-99m sulfur colloid in pediatric oncology.
Siddiqui AR, Oseas RS, Wellman HN, Doerr DR, Baehner RL
J Nucl Med 1979 May;20(5):379-86. PMID: 232146

Clinical prediction guides

Sentinel lymph node melanoma metastases: Assessment of tumor burden for clinical prediction of outcome in the first Multicenter Selective Lymphadenectomy Trial (MSLT-I).
Cochran AJ, Wen DR, Huang RR, Abrishami P, Smart C, Binder S, Scolyer RA, Thompson JF, Stern S, Van Kreuningen L, Elashoff DE, Sim MS, Wang HJ, Faries MB; MSLT-I Study Group
Eur J Surg Oncol 2022 Jun;48(6):1280-1287. Epub 2022 Feb 12 doi: 10.1016/j.ejso.2022.01.021. PMID: 35246348
Infarct-like necrosis: a distinct form of necrosis seen in colorectal carcinoma liver metastases treated with perioperative chemotherapy.
Chang HH, Leeper WR, Chan G, Quan D, Driman DK
Am J Surg Pathol 2012 Apr;36(4):570-6. doi: 10.1097/PAS.0b013e31824057e7. PMID: 22301494
The histopathologic spectrum of regression in atypical fibroxanthoma.
Stefanato CM, Robson A, Calonje JE
J Cutan Pathol 2010 Mar;37(3):310-5. Epub 2009 Sep 17 doi: 10.1111/j.1600-0560.2009.01421.x. PMID: 19765173
Radioembolization of colorectal hepatic metastases using yttrium-90 microspheres.
Mulcahy MF, Lewandowski RJ, Ibrahim SM, Sato KT, Ryu RK, Atassi B, Newman S, Talamonti M, Omary RA, Benson A 3rd, Salem R
Cancer 2009 May 1;115(9):1849-58. doi: 10.1002/cncr.24224. PMID: 19267416
Lymphatic mapping and sentinel lymphadenectomy for 106 head and neck lesions: contrasts between oral cavity and cutaneous malignancy.
Civantos FJ, Moffat FL, Goodwin WJ
Laryngoscope 2006 Mar;112(3 Pt 2 Suppl 109):1-15. doi: 10.1097/01.mlg.0000200750.74249.79. PMID: 16540925

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...