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Parotid Gland Warthin Tumor

MedGen UID:
365325
•Concept ID:
C1883714
•
Neoplastic Process
Synonyms: Adenolymphoma of parotid gland; Parotid Gland Adenolymphoma; Parotid Gland Papillary Cystadenoma Lymphomatosum; Parotid Gland Warthin's Tumor; Warthin's tumor of parotid gland
SNOMED CT: Adenolymphoma of parotid gland (448211002); Warthin's tumor of parotid gland (448211002)

Definition

An adenoma that arises from the parotid gland. It is characterized by an oncocytic, often papillary, epithelial component, dense lymphoid stroma, and cystic spaces. A strong association with smoking has been reported. It typically presents as a painless swelling in the lower portion of the parotid gland. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVParotid Gland Warthin Tumor

Professional guidelines

PubMed

Differential diagnosis of parotid gland tumors using apparent diffusion coefficient, texture features, and their combination.
Muraoka H, Kaneda T, Kondo T, Okada S, Tokunaga S
Dentomaxillofac Radiol 2023 Apr;52(4):20220404. Epub 2023 Apr 4 doi: 10.1259/dmfr.20220404. PMID: 37015250Free PMC Article
Deep learning model developed by multiparametric MRI in differential diagnosis of parotid gland tumors.
Gunduz E, Alçin OF, Kizilay A, Yildirim IO
Eur Arch Otorhinolaryngol 2022 Nov;279(11):5389-5399. Epub 2022 May 21 doi: 10.1007/s00405-022-07455-y. PMID: 35596805
Current controversies in the management of Warthin tumour.
Thangarajah T, Reddy VM, Castellanos-Arango F, Panarese A
Postgrad Med J 2009 Jan;85(999):3-8. doi: 10.1136/pgmj.2008.071282. PMID: 19240281

Recent clinical studies

Etiology

Warthin Tumor of the Parotid Gland: The History of an Eponym.
Ide F, Sakamoto S, Miyazaki Y, Nishimura M, Ito Y, Muramatsu T, Kikuchi K
Head Neck Pathol 2023 Sep;17(3):775-781. Epub 2023 May 25 doi: 10.1007/s12105-023-01559-5. PMID: 37227678Free PMC Article
Diffusion-weighted and gadolinium-enhanced dynamic MRI in parotid gland tumors.
Pâris P, Fath L, Schultz P, Veillon F, Riehm S, Severac F, Venkatasamy A
Eur Arch Otorhinolaryngol 2023 Jan;280(1):391-398. Epub 2022 Aug 11 doi: 10.1007/s00405-022-07590-6. PMID: 35951107
Cytologic diagnosis of parotid gland Warthin tumor: Systematic review and meta-analysis.
Fisher R, Ronen O
Head Neck 2022 Oct;44(10):2277-2287. Epub 2022 May 18 doi: 10.1002/hed.27099. PMID: 35586869Free PMC Article
Parotid Warthin's tumor: novel MR imaging score as diagnostic indicator.
Luna LP, Coffey W 3rd, Alvin MD, Shanechi AM, Sankaran N, Rodriguez EF, Naeem Z, Aygun N, Khan M
Clin Imaging 2022 Jan;81:9-14. Epub 2021 Sep 22 doi: 10.1016/j.clinimag.2021.09.005. PMID: 34598007
Benign Parotid Tumors.
Zhan KY, Khaja SF, Flack AB, Day TA
Otolaryngol Clin North Am 2016 Apr;49(2):327-42. doi: 10.1016/j.otc.2015.10.005. PMID: 27040584

Diagnosis

Cytologic diagnosis of parotid gland Warthin tumor: Systematic review and meta-analysis.
Fisher R, Ronen O
Head Neck 2022 Oct;44(10):2277-2287. Epub 2022 May 18 doi: 10.1002/hed.27099. PMID: 35586869Free PMC Article
Benign Parotid Tumors.
Zhan KY, Khaja SF, Flack AB, Day TA
Otolaryngol Clin North Am 2016 Apr;49(2):327-42. doi: 10.1016/j.otc.2015.10.005. PMID: 27040584
Intraparotid schwannoma.
McCarthy WA, Cox BL
Arch Pathol Lab Med 2014 Jul;138(7):982-5. doi: 10.5858/arpa.2013-0014-RS. PMID: 24978928
Warthin's tumor.
Batsakis JG, el-Naggar AK
Ann Otol Rhinol Laryngol 1990 Jul;99(7 Pt 1):588-91. doi: 10.1177/000348949009900719. PMID: 2195965
Salivary glands.
Saunders JR Jr, Hirata RM, Jaques DA
Surg Clin North Am 1986 Feb;66(1):59-81. doi: 10.1016/s0039-6109(16)43829-6. PMID: 3003940

Therapy

Distinguishing Parotid Polymorphic Adenoma and Warthin Tumor Based on the CT Radiomics Nomogram: A Multicenter Study.
Feng B, Wang Z, Cui J, Li J, Xu H, Yu D, Zeng Q, Xiu J
Acad Radiol 2023 Apr;30(4):717-726. Epub 2022 Aug 8 doi: 10.1016/j.acra.2022.06.017. PMID: 35953356
Cytologic diagnosis of parotid gland Warthin tumor: Systematic review and meta-analysis.
Fisher R, Ronen O
Head Neck 2022 Oct;44(10):2277-2287. Epub 2022 May 18 doi: 10.1002/hed.27099. PMID: 35586869Free PMC Article
Surgical treatment strategy in Warthin tumor of the parotid gland.
Lee DH, Yoon TM, Lee JK, Lim SC
Braz J Otorhinolaryngol 2019 Sep-Oct;85(5):546-550. Epub 2018 May 16 doi: 10.1016/j.bjorl.2018.04.004. PMID: 29807810Free PMC Article
RANK and RANK Ligand Expression in Parotid Gland Carcinomas.
Franchi A, Taverna C, Simoni A, Pepi M, Mannelli G, Fasolati M, Gallo O
Appl Immunohistochem Mol Morphol 2018 Aug;26(7):478-482. doi: 10.1097/PAI.0000000000000465. PMID: 29494398
Functional superficial parotidectomy.
Zhao K, Qi DY, Wang LM
J Oral Maxillofac Surg 1994 Oct;52(10):1038-41. PMID: 8089788

Prognosis

Distinguishing Parotid Polymorphic Adenoma and Warthin Tumor Based on the CT Radiomics Nomogram: A Multicenter Study.
Feng B, Wang Z, Cui J, Li J, Xu H, Yu D, Zeng Q, Xiu J
Acad Radiol 2023 Apr;30(4):717-726. Epub 2022 Aug 8 doi: 10.1016/j.acra.2022.06.017. PMID: 35953356
Diffusion-weighted and gadolinium-enhanced dynamic MRI in parotid gland tumors.
Pâris P, Fath L, Schultz P, Veillon F, Riehm S, Severac F, Venkatasamy A
Eur Arch Otorhinolaryngol 2023 Jan;280(1):391-398. Epub 2022 Aug 11 doi: 10.1007/s00405-022-07590-6. PMID: 35951107
Parotid Warthin's tumor: novel MR imaging score as diagnostic indicator.
Luna LP, Coffey W 3rd, Alvin MD, Shanechi AM, Sankaran N, Rodriguez EF, Naeem Z, Aygun N, Khan M
Clin Imaging 2022 Jan;81:9-14. Epub 2021 Sep 22 doi: 10.1016/j.clinimag.2021.09.005. PMID: 34598007
Classification of parotid gland tumors by using multimodal MRI and deep learning.
Chang YJ, Huang TY, Liu YJ, Chung HW, Juan CJ
NMR Biomed 2021 Jan;34(1):e4408. Epub 2020 Sep 4 doi: 10.1002/nbm.4408. PMID: 32886955Free PMC Article
Intraparotid schwannoma.
McCarthy WA, Cox BL
Arch Pathol Lab Med 2014 Jul;138(7):982-5. doi: 10.5858/arpa.2013-0014-RS. PMID: 24978928

Clinical prediction guides

Value of T2-weighted-based radiomics model in distinguishing Warthin tumor from pleomorphic adenoma of the parotid.
Hu Z, Guo J, Feng J, Huang Y, Xu H, Zhou Q
Eur Radiol 2023 Jun;33(6):4453-4463. Epub 2022 Dec 11 doi: 10.1007/s00330-022-09295-0. PMID: 36502461
Diffusion-weighted and gadolinium-enhanced dynamic MRI in parotid gland tumors.
Pâris P, Fath L, Schultz P, Veillon F, Riehm S, Severac F, Venkatasamy A
Eur Arch Otorhinolaryngol 2023 Jan;280(1):391-398. Epub 2022 Aug 11 doi: 10.1007/s00405-022-07590-6. PMID: 35951107
Parotid Warthin's tumor: novel MR imaging score as diagnostic indicator.
Luna LP, Coffey W 3rd, Alvin MD, Shanechi AM, Sankaran N, Rodriguez EF, Naeem Z, Aygun N, Khan M
Clin Imaging 2022 Jan;81:9-14. Epub 2021 Sep 22 doi: 10.1016/j.clinimag.2021.09.005. PMID: 34598007
Classification of parotid gland tumors by using multimodal MRI and deep learning.
Chang YJ, Huang TY, Liu YJ, Chung HW, Juan CJ
NMR Biomed 2021 Jan;34(1):e4408. Epub 2020 Sep 4 doi: 10.1002/nbm.4408. PMID: 32886955Free PMC Article
Intraparotid schwannoma.
McCarthy WA, Cox BL
Arch Pathol Lab Med 2014 Jul;138(7):982-5. doi: 10.5858/arpa.2013-0014-RS. PMID: 24978928

Recent systematic reviews

Cytologic diagnosis of parotid gland Warthin tumor: Systematic review and meta-analysis.
Fisher R, Ronen O
Head Neck 2022 Oct;44(10):2277-2287. Epub 2022 May 18 doi: 10.1002/hed.27099. PMID: 35586869Free PMC Article
Multiparametric magnetic resonance imaging of parotid tumors: A systematic review.
Coudert H, Mirafzal S, Dissard A, Boyer L, Montoriol PF
Diagn Interv Imaging 2021 Mar;102(3):121-130. Epub 2020 Sep 14 doi: 10.1016/j.diii.2020.08.002. PMID: 32943368
Warthin's tumor of the larynx: a very rare case and systematic review of the literature.
Nisa L, Landis BN, Salmina C, Ailianou A, Karamitopoulou E, Giger R
J Otolaryngol Head Neck Surg 2015 May 12;44(1):16. doi: 10.1186/s40463-015-0067-5. PMID: 25964051Free PMC Article

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