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Parotid Gland Warthin Tumor

MedGen UID:
365325
•Concept ID:
C1883714
•
Neoplastic Process
Synonyms: Adenolymphoma of parotid gland; Parotid Gland Adenolymphoma; Parotid Gland Papillary Cystadenoma Lymphomatosum; Parotid Gland Warthin's Tumor; Warthin's tumor of parotid gland
SNOMED CT: Adenolymphoma of parotid gland (448211002); Warthin's tumor of parotid gland (448211002)

Definition

An adenoma that arises from the parotid gland. It is characterized by an oncocytic, often papillary, epithelial component, dense lymphoid stroma, and cystic spaces. A strong association with smoking has been reported. It typically presents as a painless swelling in the lower portion of the parotid gland. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVParotid Gland Warthin Tumor

Professional guidelines

PubMed

Differential diagnosis of parotid gland tumors using apparent diffusion coefficient, texture features, and their combination.
Muraoka H, Kaneda T, Kondo T, Okada S, Tokunaga S
Dentomaxillofac Radiol 2023 Apr;52(4):20220404. Epub 2023 Apr 4 doi: 10.1259/dmfr.20220404. PMID: 37015250Free PMC Article
MRI criteria for the diagnosis of pleomorphic adenoma: a validation study.
Zaghi S, Hendizadeh L, Hung T, Farahvar S, Abemayor E, Sepahdari AR
Am J Otolaryngol 2014 Nov-Dec;35(6):713-8. Epub 2014 Jul 22 doi: 10.1016/j.amjoto.2014.07.013. PMID: 25128908
Practical management of parotid salivary gland tumors.
Karlan MS
Med Times 1970 Nov;98(11):193-205. PMID: 4319254

Recent clinical studies

Etiology

Warthin Tumor of the Parotid Gland: The History of an Eponym.
Ide F, Sakamoto S, Miyazaki Y, Nishimura M, Ito Y, Muramatsu T, Kikuchi K
Head Neck Pathol 2023 Sep;17(3):775-781. Epub 2023 May 25 doi: 10.1007/s12105-023-01559-5. PMID: 37227678Free PMC Article
Cytologic diagnosis of parotid gland Warthin tumor: Systematic review and meta-analysis.
Fisher R, Ronen O
Head Neck 2022 Oct;44(10):2277-2287. Epub 2022 May 18 doi: 10.1002/hed.27099. PMID: 35586869Free PMC Article
Change in Warthin's tumor incidence: a 20-year joinpoint trend analysis.
Tunç O, Gönüldaş B, Arslanhan Y, Kanlıkama M
Eur Arch Otorhinolaryngol 2020 Dec;277(12):3431-3434. Epub 2020 May 29 doi: 10.1007/s00405-020-06081-w. PMID: 32472159
The incidence of Warthin tumours and pleomorphic adenomas in the parotid gland over a 25-year period.
Luers JC, Guntinas-Lichius O, Klussmann JP, Küsgen C, Beutner D, Grosheva M
Clin Otolaryngol 2016 Dec;41(6):793-797. Epub 2016 Jul 18 doi: 10.1111/coa.12694. PMID: 27343470
Benign Parotid Tumors.
Zhan KY, Khaja SF, Flack AB, Day TA
Otolaryngol Clin North Am 2016 Apr;49(2):327-42. doi: 10.1016/j.otc.2015.10.005. PMID: 27040584

Diagnosis

Cytologic diagnosis of parotid gland Warthin tumor: Systematic review and meta-analysis.
Fisher R, Ronen O
Head Neck 2022 Oct;44(10):2277-2287. Epub 2022 May 18 doi: 10.1002/hed.27099. PMID: 35586869Free PMC Article
Benign Parotid Tumors.
Zhan KY, Khaja SF, Flack AB, Day TA
Otolaryngol Clin North Am 2016 Apr;49(2):327-42. doi: 10.1016/j.otc.2015.10.005. PMID: 27040584
Intraparotid schwannoma.
McCarthy WA, Cox BL
Arch Pathol Lab Med 2014 Jul;138(7):982-5. doi: 10.5858/arpa.2013-0014-RS. PMID: 24978928
Parotid space: anatomic imaging.
Kanekar SG, Mannion K, Zacharia T, Showalter M
Otolaryngol Clin North Am 2012 Dec;45(6):1253-72. doi: 10.1016/j.otc.2012.08.011. PMID: 23153748
Salivary glands.
Saunders JR Jr, Hirata RM, Jaques DA
Surg Clin North Am 1986 Feb;66(1):59-81. doi: 10.1016/s0039-6109(16)43829-6. PMID: 3003940

Therapy

Cytologic diagnosis of parotid gland Warthin tumor: Systematic review and meta-analysis.
Fisher R, Ronen O
Head Neck 2022 Oct;44(10):2277-2287. Epub 2022 May 18 doi: 10.1002/hed.27099. PMID: 35586869Free PMC Article
Percutaneous sclerotherapy of sialoceles after parotidectomy with fibrin glue, OK-432, and bleomycin.
Chen WL, Zhang LP, Huang ZQ, Zhou B
Br J Oral Maxillofac Surg 2013 Dec;51(8):786-8. Epub 2013 Apr 29 doi: 10.1016/j.bjoms.2013.04.003. PMID: 23639412
False positive findings in F-18 FDG PET and whole body scans with I-131 in Warthin tumor of the parotid gland.
Gekeler J, Luers JC, Krohn T, Beutner D
Clin Nucl Med 2010 Feb;35(2):105-6. doi: 10.1097/RLU.0b013e3181c7bf39. PMID: 20090459
Bilateral parotid swelling: a review.
Mandel L, Surattanont F
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002 Mar;93(3):221-37. doi: 10.1067/moe.2002.121163. PMID: 11925529
Functional superficial parotidectomy.
Zhao K, Qi DY, Wang LM
J Oral Maxillofac Surg 1994 Oct;52(10):1038-41. PMID: 8089788

Prognosis

Change in Warthin's tumor incidence: a 20-year joinpoint trend analysis.
Tunç O, Gönüldaş B, Arslanhan Y, Kanlıkama M
Eur Arch Otorhinolaryngol 2020 Dec;277(12):3431-3434. Epub 2020 May 29 doi: 10.1007/s00405-020-06081-w. PMID: 32472159
The incidence of Warthin tumours and pleomorphic adenomas in the parotid gland over a 25-year period.
Luers JC, Guntinas-Lichius O, Klussmann JP, Küsgen C, Beutner D, Grosheva M
Clin Otolaryngol 2016 Dec;41(6):793-797. Epub 2016 Jul 18 doi: 10.1111/coa.12694. PMID: 27343470
Intraparotid schwannoma.
McCarthy WA, Cox BL
Arch Pathol Lab Med 2014 Jul;138(7):982-5. doi: 10.5858/arpa.2013-0014-RS. PMID: 24978928
Incidence of salivary gland neoplasms in a defined UK population.
Bradley PJ, McGurk M
Br J Oral Maxillofac Surg 2013 Jul;51(5):399-403. Epub 2012 Oct 24 doi: 10.1016/j.bjoms.2012.10.002. PMID: 23103239
Ulcerating Warthin's tumour.
Stárek I, Tichý T, Skýpalová P, Skálová A
Acta Otolaryngol 2004 Aug;124(6):744-6. doi: 10.1080/00016480410016991. PMID: 15515501

Clinical prediction guides

Diffusion-weighted and gadolinium-enhanced dynamic MRI in parotid gland tumors.
Pâris P, Fath L, Schultz P, Veillon F, Riehm S, Severac F, Venkatasamy A
Eur Arch Otorhinolaryngol 2023 Jan;280(1):391-398. Epub 2022 Aug 11 doi: 10.1007/s00405-022-07590-6. PMID: 35951107
Parotid Warthin's tumor: novel MR imaging score as diagnostic indicator.
Luna LP, Coffey W 3rd, Alvin MD, Shanechi AM, Sankaran N, Rodriguez EF, Naeem Z, Aygun N, Khan M
Clin Imaging 2022 Jan;81:9-14. Epub 2021 Sep 22 doi: 10.1016/j.clinimag.2021.09.005. PMID: 34598007
Classification of parotid gland tumors by using multimodal MRI and deep learning.
Chang YJ, Huang TY, Liu YJ, Chung HW, Juan CJ
NMR Biomed 2021 Jan;34(1):e4408. Epub 2020 Sep 4 doi: 10.1002/nbm.4408. PMID: 32886955Free PMC Article
Change in Warthin's tumor incidence: a 20-year joinpoint trend analysis.
Tunç O, Gönüldaş B, Arslanhan Y, Kanlıkama M
Eur Arch Otorhinolaryngol 2020 Dec;277(12):3431-3434. Epub 2020 May 29 doi: 10.1007/s00405-020-06081-w. PMID: 32472159
Intraparotid schwannoma.
McCarthy WA, Cox BL
Arch Pathol Lab Med 2014 Jul;138(7):982-5. doi: 10.5858/arpa.2013-0014-RS. PMID: 24978928

Recent systematic reviews

Bilateral Warthin's tumour of the parotid gland: a 16-year retrospective analysis and systematic review.
Siddiqui Z, Gupta A, Nam RHK, Huynh RCT, Jan M, Dusu K, Dhar V
J Laryngol Otol 2024 May;138(5):559-564. Epub 2023 Nov 3 doi: 10.1017/S0022215123001834. PMID: 37920099
Cytologic diagnosis of parotid gland Warthin tumor: Systematic review and meta-analysis.
Fisher R, Ronen O
Head Neck 2022 Oct;44(10):2277-2287. Epub 2022 May 18 doi: 10.1002/hed.27099. PMID: 35586869Free PMC Article
Multiparametric magnetic resonance imaging of parotid tumors: A systematic review.
Coudert H, Mirafzal S, Dissard A, Boyer L, Montoriol PF
Diagn Interv Imaging 2021 Mar;102(3):121-130. Epub 2020 Sep 14 doi: 10.1016/j.diii.2020.08.002. PMID: 32943368
Warthin's tumor of the larynx: a very rare case and systematic review of the literature.
Nisa L, Landis BN, Salmina C, Ailianou A, Karamitopoulou E, Giger R
J Otolaryngol Head Neck Surg 2015 May 12;44(1):16. doi: 10.1186/s40463-015-0067-5. PMID: 25964051Free PMC Article

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