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Benign Myoepithelioma

MedGen UID:
365336
•Concept ID:
C1947949
•
Neoplastic Process
Synonym: Benign myoepithelioma
SNOMED CT: Benign myoepithelioma (69291002)

Definition

A tumor with myoepithelial differentiation that lacks an infiltrative growth pattern and does not metastasize. [from NCI]

Professional guidelines

PubMed

CD10 and HHF35 actin in the differential diagnosis between Collagenous spherulosis and adenoid-cystic carcinoma of the breast.
Cabibi D, Giannone AG, Belmonte B, Aragona F, Aragona F
Pathol Res Pract 2012 Jul 15;208(7):405-9. Epub 2012 May 31 doi: 10.1016/j.prp.2012.05.002. PMID: 22658481
Primary tumors of the submandibular glands: a retrospective study based on 41 cases.
Ziglinas P, Arnold A, Arnold M, Zbären P
Oral Oncol 2010 Apr;46(4):287-91. Epub 2010 Feb 26 doi: 10.1016/j.oraloncology.2010.01.011. PMID: 20189445
Myoepithelioma: definitions and diagnostic criteria.
Dardick I
Ultrastruct Pathol 1995 Sep-Oct;19(5):335-45. doi: 10.3109/01913129509021906. PMID: 7483010

Recent clinical studies

Etiology

Benign myoepithelioma in the intrathoracic trachea.
Sekine A, Morishita Y, Okudela K, Tsunoda Y, Sumazaki Y, Tanaka T, Takoi H, Lin SY, Yatagai Y, Shimanouchi M, Hashizume T, Hayashihara K, Saito T
Intern Med 2014;53(14):1535-8. Epub 2014 Jul 15 doi: 10.2169/internalmedicine.53.1697. PMID: 25030568
Salivary gland-like tumours of the breast: surgical and molecular pathology.
Pia-Foschini M, Reis-Filho JS, Eusebi V, Lakhani SR
J Clin Pathol 2003 Jul;56(7):497-506. doi: 10.1136/jcp.56.7.497. PMID: 12835294Free PMC Article

Diagnosis

Top Ten Differentials to Mull Over for Head and Neck Myoepithelial Neoplasms.
Thompson LDR, Xu B
Head Neck Pathol 2023 Mar;17(1):1-15. Epub 2023 Mar 16 doi: 10.1007/s12105-022-01502-0. PMID: 36928733Free PMC Article
Benign myoepithelioma of the breast: origin and development.
Hikino H, Nagaoka S, Miura H, Kurosumi M
Pathol Int 2009 Jun;59(6):422-6. doi: 10.1111/j.1440-1827.2009.02388.x. PMID: 19490475
Submandibular gland myoepithelioma.
Testa D, Galera F, Insabato L, Vassallo A, Mesolella M, Galli V
Acta Otolaryngol 2005 Jun;125(6):664-6. doi: 10.1080/00016480510026926. PMID: 16076718
Benign myoepithelioma of the lung: a case report and review of the literature.
Veeramachaneni R, Gulick J, Halldorsson AO, Van TT, Zhang PL, Herrera GA
Arch Pathol Lab Med 2001 Nov;125(11):1494-6. doi: 10.5858/2001-125-1494-BMOTL. PMID: 11698012
Myoepithelial carcinoma arising in a benign myoepithelioma: immunohistochemical, ultrastructural, and flow-cytometrical study.
Bombí JA, Alós L, Rey MJ, Mallofré C, Cuchi A, Trasserra J, Cardesa A
Ultrastruct Pathol 1996 Mar-Apr;20(2):145-54. doi: 10.3109/01913129609016309. PMID: 8882360

Therapy

Small cell carcinoma of the lung in a treated case of Myoepithelial carcinoma of the tongue--report of a rare case with illustrated review of the literature.
Venkatesulu B, Mallick S, George A, Bhasker S
J Egypt Natl Canc Inst 2016 Mar;28(1):45-8. Epub 2015 Jun 24 doi: 10.1016/j.jnci.2015.06.002. PMID: 26117146

Prognosis

Benign myoepithelioma of the soft palate: an unusual clinical entity.
Mireles MG, Julián A, Salgado-Chavarría F, González GM
BMJ Case Rep 2021 Jun 29;14(6) doi: 10.1136/bcr-2020-240384. PMID: 34187791Free PMC Article
Clear cell myoepithelial carcinoma of salivary glands showing EWSR1 rearrangement: molecular analysis of 94 salivary gland carcinomas with prominent clear cell component.
Skálová A, Weinreb I, Hyrcza M, Simpson RH, Laco J, Agaimy A, Vazmitel M, Majewska H, Vanecek T, Talarčik P, Manajlovic S, Losito SN, Šteiner P, Klimkova A, Michal M
Am J Surg Pathol 2015 Mar;39(3):338-48. doi: 10.1097/PAS.0000000000000364. PMID: 25581728
Benign myoepithelioma in the intrathoracic trachea.
Sekine A, Morishita Y, Okudela K, Tsunoda Y, Sumazaki Y, Tanaka T, Takoi H, Lin SY, Yatagai Y, Shimanouchi M, Hashizume T, Hayashihara K, Saito T
Intern Med 2014;53(14):1535-8. Epub 2014 Jul 15 doi: 10.2169/internalmedicine.53.1697. PMID: 25030568
Giant myoepithelioma of the upper lip.
Shiomori T, Udaka T, Tokui N, Morio T, Ohbuchi T, Suzuki H
Acta Otolaryngol 2005 Aug;125(8):894-8. doi: 10.1080/00016480510035458. PMID: 16099771
Salivary gland malignant myoepithelioma: a clinicopathologic and immunohistochemical study of ten cases.
Nagao T, Sugano I, Ishida Y, Tajima Y, Matsuzaki O, Konno A, Kondo Y, Nagao K
Cancer 1998 Oct 1;83(7):1292-9. doi: 10.1002/(sici)1097-0142(19981001)83:7<1292::aid-cncr4>3.0.co;2-l. PMID: 9762928

Clinical prediction guides

Clear cell myoepithelial carcinoma of salivary glands showing EWSR1 rearrangement: molecular analysis of 94 salivary gland carcinomas with prominent clear cell component.
Skálová A, Weinreb I, Hyrcza M, Simpson RH, Laco J, Agaimy A, Vazmitel M, Majewska H, Vanecek T, Talarčik P, Manajlovic S, Losito SN, Šteiner P, Klimkova A, Michal M
Am J Surg Pathol 2015 Mar;39(3):338-48. doi: 10.1097/PAS.0000000000000364. PMID: 25581728
Benign myoepithelioma in the intrathoracic trachea.
Sekine A, Morishita Y, Okudela K, Tsunoda Y, Sumazaki Y, Tanaka T, Takoi H, Lin SY, Yatagai Y, Shimanouchi M, Hashizume T, Hayashihara K, Saito T
Intern Med 2014;53(14):1535-8. Epub 2014 Jul 15 doi: 10.2169/internalmedicine.53.1697. PMID: 25030568
Salivary gland malignant myoepithelioma: a clinicopathologic and immunohistochemical study of ten cases.
Nagao T, Sugano I, Ishida Y, Tajima Y, Matsuzaki O, Konno A, Kondo Y, Nagao K
Cancer 1998 Oct 1;83(7):1292-9. doi: 10.1002/(sici)1097-0142(19981001)83:7<1292::aid-cncr4>3.0.co;2-l. PMID: 9762928
Benign myoepithelioma of the skin.
Fernández-Figueras MT, Puig L, Trias I, Lorenzo JC, Navas-Palacios JJ
Am J Dermatopathol 1998 Apr;20(2):208-12. doi: 10.1097/00000372-199804000-00020. PMID: 9557794

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