U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Takotsubo cardiomyopathy

MedGen UID:
366029
•Concept ID:
C1739395
•
Disease or Syndrome
Synonyms: Acute stress cardiomyopathy; Apical ballooning syndrome; Left ventricular transient apical ballooning; Stress cardiomyopathy; Stress-induced cardiomyopathy; Tako tsubo syndrome; Tako-tsubo cardiomyopathy; Transient antero-apical dyskinesia
SNOMED CT: Left ventricular ballooning syndrome (441541008); Stress cardiomyopathy (441541008); Takotsubo cardiomyopathy (441541008); Takotsubo syndrome (441541008)
Modes of inheritance:
Unknown inheritance
MedGen UID:
989040
•Concept ID:
CN307042
•
Finding
Source: Orphanet
Hereditary clinical entity whose mode of inheritance is unknown.
See: This record
Unknown inheritance (Orphanet)
 
HPO: HP:0011665
Monarch Initiative: MONDO:0019018
Orphanet: ORPHA66529

Definition

Transient left ventricular apical ballooning syndrome or takotsubo cardiomyopathy is characterized by transient regional systolic dysfunction involving the left ventricular apex and/or mid-ventricle in the absence of obstructive coronary disease on coronary angiography. Patients present with an abrupt onset of angina-like chest pain, and have diffuse T-wave inversion, sometimes preceded by ST-segment elevation, and mild cardiac enzyme elevation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTakotsubo cardiomyopathy

Professional guidelines

PubMed

Reversible cerebral vasoconstriction syndrome: A review of pathogenesis, clinical presentation, and treatment.
Singhal AB
Int J Stroke 2023 Dec;18(10):1151-1160. Epub 2023 Jun 12 doi: 10.1177/17474930231181250. PMID: 37246916
Epidemiology, Pathophysiology, Diagnosis, and Principles of Management of Takotsubo Cardiomyopathy: A Review.
Matta AG, Carrié D
Med Sci Monit 2023 Mar 6;29:e939020. doi: 10.12659/MSM.939020. PMID: 36872594Free PMC Article
Myocardial infarction with nonobstructive coronary artery disease (MINOCA): a review of pathophysiology and management.
Cheema AN, Yanagawa B, Verma S, Bagai A, Liu S
Curr Opin Cardiol 2021 Sep 1;36(5):589-596. doi: 10.1097/HCO.0000000000000886. PMID: 34397465

Recent clinical studies

Etiology

Epidemiology, Pathophysiology, Diagnosis, and Principles of Management of Takotsubo Cardiomyopathy: A Review.
Matta AG, Carrié D
Med Sci Monit 2023 Mar 6;29:e939020. doi: 10.12659/MSM.939020. PMID: 36872594Free PMC Article
Stress Cardiomyopathy Diagnosis and Treatment: JACC State-of-the-Art Review.
Medina de Chazal H, Del Buono MG, Keyser-Marcus L, Ma L, Moeller FG, Berrocal D, Abbate A
J Am Coll Cardiol 2018 Oct 16;72(16):1955-1971. doi: 10.1016/j.jacc.2018.07.072. PMID: 30309474Free PMC Article
International Expert Consensus Document on Takotsubo Syndrome (Part I): Clinical Characteristics, Diagnostic Criteria, and Pathophysiology.
Ghadri JR, Wittstein IS, Prasad A, Sharkey S, Dote K, Akashi YJ, Cammann VL, Crea F, Galiuto L, Desmet W, Yoshida T, Manfredini R, Eitel I, Kosuge M, Nef HM, Deshmukh A, Lerman A, Bossone E, Citro R, Ueyama T, Corrado D, Kurisu S, Ruschitzka F, Winchester D, Lyon AR, Omerovic E, Bax JJ, Meimoun P, Tarantini G, Rihal C, Y-Hassan S, Migliore F, Horowitz JD, Shimokawa H, Lüscher TF, Templin C
Eur Heart J 2018 Jun 7;39(22):2032-2046. doi: 10.1093/eurheartj/ehy076. PMID: 29850871Free PMC Article
Acute stress-induced (takotsubo) cardiomyopathy.
Dawson DK
Heart 2018 Jan;104(2):96-102. Epub 2017 Aug 20 doi: 10.1136/heartjnl-2017-311579. PMID: 28824005
Clinical Features and Outcomes of Takotsubo (Stress) Cardiomyopathy.
Templin C, Ghadri JR, Diekmann J, Napp LC, Bataiosu DR, Jaguszewski M, Cammann VL, Sarcon A, Geyer V, Neumann CA, Seifert B, Hellermann J, Schwyzer M, Eisenhardt K, Jenewein J, Franke J, Katus HA, Burgdorf C, Schunkert H, Moeller C, Thiele H, Bauersachs J, Tschöpe C, Schultheiss HP, Laney CA, Rajan L, Michels G, Pfister R, Ukena C, Böhm M, Erbel R, Cuneo A, Kuck KH, Jacobshagen C, Hasenfuss G, Karakas M, Koenig W, Rottbauer W, Said SM, Braun-Dullaeus RC, Cuculi F, Banning A, Fischer TA, Vasankari T, Airaksinen KE, Fijalkowski M, Rynkiewicz A, Pawlak M, Opolski G, Dworakowski R, MacCarthy P, Kaiser C, Osswald S, Galiuto L, Crea F, Dichtl W, Franz WM, Empen K, Felix SB, Delmas C, Lairez O, Erne P, Bax JJ, Ford I, Ruschitzka F, Prasad A, Lüscher TF
N Engl J Med 2015 Sep 3;373(10):929-38. doi: 10.1056/NEJMoa1406761. PMID: 26332547

Diagnosis

Epidemiology, Pathophysiology, Diagnosis, and Principles of Management of Takotsubo Cardiomyopathy: A Review.
Matta AG, Carrié D
Med Sci Monit 2023 Mar 6;29:e939020. doi: 10.12659/MSM.939020. PMID: 36872594Free PMC Article
Takotsubo Cardiomyopathy: A Brief Review.
Amin HZ, Amin LZ, Pradipta A
J Med Life 2020 Jan-Mar;13(1):3-7. doi: 10.25122/jml-2018-0067. PMID: 32341693Free PMC Article
Takotsubo cardiomyopathy: Review of broken heart syndrome.
Boyd B, Solh T
JAAPA 2020 Mar;33(3):24-29. doi: 10.1097/01.JAA.0000654368.35241.fc. PMID: 32039951
Acute stress-induced (takotsubo) cardiomyopathy.
Dawson DK
Heart 2018 Jan;104(2):96-102. Epub 2017 Aug 20 doi: 10.1136/heartjnl-2017-311579. PMID: 28824005
Takotsubo syndrome: aetiology, presentation and treatment.
Kato K, Lyon AR, Ghadri JR, Templin C
Heart 2017 Sep;103(18):1461-1469. doi: 10.1136/heartjnl-2016-309783. PMID: 28839096

Therapy

Takotsubo Syndrome: Pathophysiology, Emerging Concepts, and Clinical Implications.
Singh T, Khan H, Gamble DT, Scally C, Newby DE, Dawson D
Circulation 2022 Mar 29;145(13):1002-1019. Epub 2022 Mar 28 doi: 10.1161/CIRCULATIONAHA.121.055854. PMID: 35344411Free PMC Article
Takotsubo cardiomyopathy.
Matta A, Delmas C, Campelo-Parada F, Lhermusier T, Bouisset F, Elbaz M, Nader V, Blanco S, Roncalli J, Carrié D
Rev Cardiovasc Med 2022 Jan 20;23(1):38. doi: 10.31083/j.rcm2301038. PMID: 35092230
Takotsubo cardiomyopathy: Review of broken heart syndrome.
Boyd B, Solh T
JAAPA 2020 Mar;33(3):24-29. doi: 10.1097/01.JAA.0000654368.35241.fc. PMID: 32039951
International Expert Consensus Document on Takotsubo Syndrome (Part II): Diagnostic Workup, Outcome, and Management.
Ghadri JR, Wittstein IS, Prasad A, Sharkey S, Dote K, Akashi YJ, Cammann VL, Crea F, Galiuto L, Desmet W, Yoshida T, Manfredini R, Eitel I, Kosuge M, Nef HM, Deshmukh A, Lerman A, Bossone E, Citro R, Ueyama T, Corrado D, Kurisu S, Ruschitzka F, Winchester D, Lyon AR, Omerovic E, Bax JJ, Meimoun P, Tarantini G, Rihal C, Y-Hassan S, Migliore F, Horowitz JD, Shimokawa H, Lüscher TF, Templin C
Eur Heart J 2018 Jun 7;39(22):2047-2062. doi: 10.1093/eurheartj/ehy077. PMID: 29850820Free PMC Article
Takotsubo syndrome: aetiology, presentation and treatment.
Kato K, Lyon AR, Ghadri JR, Templin C
Heart 2017 Sep;103(18):1461-1469. doi: 10.1136/heartjnl-2016-309783. PMID: 28839096

Prognosis

Takotsubo Cardiomyopathy: A Brief Review.
Amin HZ, Amin LZ, Pradipta A
J Med Life 2020 Jan-Mar;13(1):3-7. doi: 10.25122/jml-2018-0067. PMID: 32341693Free PMC Article
Sex differences in heart failure.
Lam CSP, Arnott C, Beale AL, Chandramouli C, Hilfiker-Kleiner D, Kaye DM, Ky B, Santema BT, Sliwa K, Voors AA
Eur Heart J 2019 Dec 14;40(47):3859-3868c. doi: 10.1093/eurheartj/ehz835. PMID: 31800034
Fluoropyrimidine-Associated Cardiotoxicity.
Kanduri J, More LA, Godishala A, Asnani A
Cardiol Clin 2019 Nov;37(4):399-405. Epub 2019 Aug 26 doi: 10.1016/j.ccl.2019.07.004. PMID: 31587781
Stress Cardiomyopathy Diagnosis and Treatment: JACC State-of-the-Art Review.
Medina de Chazal H, Del Buono MG, Keyser-Marcus L, Ma L, Moeller FG, Berrocal D, Abbate A
J Am Coll Cardiol 2018 Oct 16;72(16):1955-1971. doi: 10.1016/j.jacc.2018.07.072. PMID: 30309474Free PMC Article
Clinical Features and Outcomes of Takotsubo (Stress) Cardiomyopathy.
Templin C, Ghadri JR, Diekmann J, Napp LC, Bataiosu DR, Jaguszewski M, Cammann VL, Sarcon A, Geyer V, Neumann CA, Seifert B, Hellermann J, Schwyzer M, Eisenhardt K, Jenewein J, Franke J, Katus HA, Burgdorf C, Schunkert H, Moeller C, Thiele H, Bauersachs J, Tschöpe C, Schultheiss HP, Laney CA, Rajan L, Michels G, Pfister R, Ukena C, Böhm M, Erbel R, Cuneo A, Kuck KH, Jacobshagen C, Hasenfuss G, Karakas M, Koenig W, Rottbauer W, Said SM, Braun-Dullaeus RC, Cuculi F, Banning A, Fischer TA, Vasankari T, Airaksinen KE, Fijalkowski M, Rynkiewicz A, Pawlak M, Opolski G, Dworakowski R, MacCarthy P, Kaiser C, Osswald S, Galiuto L, Crea F, Dichtl W, Franz WM, Empen K, Felix SB, Delmas C, Lairez O, Erne P, Bax JJ, Ford I, Ruschitzka F, Prasad A, Lüscher TF
N Engl J Med 2015 Sep 3;373(10):929-38. doi: 10.1056/NEJMoa1406761. PMID: 26332547

Clinical prediction guides

Diagnostic and Prognostic Role of Cardiac Magnetic Resonance in MINOCA: Systematic Review and Meta-Analysis.
Mileva N, Paolisso P, Gallinoro E, Fabbricatore D, Munhoz D, Bergamaschi L, Belmonte M, Panayotov P, Pizzi C, Barbato E, Penicka M, Andreini D, Vassilev D
JACC Cardiovasc Imaging 2023 Mar;16(3):376-389. doi: 10.1016/j.jcmg.2022.12.029. PMID: 36889851
Electrocardiographic changes in Takotsubo cardiomyopathy.
Chhabra L, Butt N, Ahmad SA, Kayani WT, Sangong A, Patel V, Bharaj G, Khalid N
J Electrocardiol 2021 Mar-Apr;65:28-33. Epub 2021 Jan 20 doi: 10.1016/j.jelectrocard.2020.12.006. PMID: 33482618
Takotsubo Cardiomyopathy and Sepsis.
Cappelletti S, Ciallella C, Aromatario M, Ashrafian H, Harding S, Athanasiou T
Angiology 2017 Apr;68(4):288-303. Epub 2016 Sep 29 doi: 10.1177/0003319716653886. PMID: 27303068
Clinical Features and Outcomes of Takotsubo (Stress) Cardiomyopathy.
Templin C, Ghadri JR, Diekmann J, Napp LC, Bataiosu DR, Jaguszewski M, Cammann VL, Sarcon A, Geyer V, Neumann CA, Seifert B, Hellermann J, Schwyzer M, Eisenhardt K, Jenewein J, Franke J, Katus HA, Burgdorf C, Schunkert H, Moeller C, Thiele H, Bauersachs J, Tschöpe C, Schultheiss HP, Laney CA, Rajan L, Michels G, Pfister R, Ukena C, Böhm M, Erbel R, Cuneo A, Kuck KH, Jacobshagen C, Hasenfuss G, Karakas M, Koenig W, Rottbauer W, Said SM, Braun-Dullaeus RC, Cuculi F, Banning A, Fischer TA, Vasankari T, Airaksinen KE, Fijalkowski M, Rynkiewicz A, Pawlak M, Opolski G, Dworakowski R, MacCarthy P, Kaiser C, Osswald S, Galiuto L, Crea F, Dichtl W, Franz WM, Empen K, Felix SB, Delmas C, Lairez O, Erne P, Bax JJ, Ford I, Ruschitzka F, Prasad A, Lüscher TF
N Engl J Med 2015 Sep 3;373(10):929-38. doi: 10.1056/NEJMoa1406761. PMID: 26332547
Takotsubo cardiomyopathy.
Andrade AA, Stainback RF
Tex Heart Inst J 2014 Jun;41(3):299-303. Epub 2014 Jun 1 doi: 10.14503/THIJ-14-4108. PMID: 24955046Free PMC Article

Recent systematic reviews

Diagnostic and Prognostic Role of Cardiac Magnetic Resonance in MINOCA: Systematic Review and Meta-Analysis.
Mileva N, Paolisso P, Gallinoro E, Fabbricatore D, Munhoz D, Bergamaschi L, Belmonte M, Panayotov P, Pizzi C, Barbato E, Penicka M, Andreini D, Vassilev D
JACC Cardiovasc Imaging 2023 Mar;16(3):376-389. doi: 10.1016/j.jcmg.2022.12.029. PMID: 36889851
The association between Takotsubo cardiomyopathy and thyrotoxicosis: A systematic review.
Mohamed AA, Basaran T, Othman MH, Andersen NH, Bonnema SJ
Endocrine 2022 Dec;78(3):418-428. Epub 2022 Aug 26 doi: 10.1007/s12020-022-03174-w. PMID: 36018537
Takotsubo cardiomyopathy in post-traumatic brain injury: A systematic review of diagnosis and management.
Gruhl SL, Su J, Chua WC, Tay KV
Clin Neurol Neurosurg 2022 Feb;213:107119. Epub 2022 Jan 4 doi: 10.1016/j.clineuro.2021.107119. PMID: 34998160
Cardiac complications following mRNA COVID-19 vaccines: A systematic review of case reports and case series.
Fazlollahi A, Zahmatyar M, Noori M, Nejadghaderi SA, Sullman MJM, Shekarriz-Foumani R, Kolahi AA, Singh K, Safiri S
Rev Med Virol 2022 Jul;32(4):e2318. Epub 2021 Dec 17 doi: 10.1002/rmv.2318. PMID: 34921468
Cardiovascular Effects of ADHD Therapies: JACC Review Topic of the Week.
Torres-Acosta N, O'Keefe JH, O'Keefe CL, Lavie CJ
J Am Coll Cardiol 2020 Aug 18;76(7):858-866. doi: 10.1016/j.jacc.2020.05.081. PMID: 32792083

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...