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Takotsubo cardiomyopathy

MedGen UID:
366029
Concept ID:
C1739395
Disease or Syndrome
Synonyms: Acute stress cardiomyopathy; Apical ballooning syndrome; Left ventricular transient apical ballooning; Stress cardiomyopathy; Stress-induced cardiomyopathy; Tako tsubo syndrome; Tako-tsubo cardiomyopathy; Transient antero-apical dyskinesia
SNOMED CT: Left ventricular ballooning syndrome (441541008); Stress cardiomyopathy (441541008); Takotsubo cardiomyopathy (441541008); Takotsubo syndrome (441541008)
Modes of inheritance:
Unknown inheritance
MedGen UID:
989040
Concept ID:
CN307042
Finding
Source: Orphanet
Hereditary clinical entity whose mode of inheritance is unknown.
 
HPO: HP:0011665
Monarch Initiative: MONDO:0019018
Orphanet: ORPHA66529

Definition

Transient left ventricular apical ballooning syndrome or takotsubo cardiomyopathy is characterized by transient regional systolic dysfunction involving the left ventricular apex and/or mid-ventricle in the absence of obstructive coronary disease on coronary angiography. Patients present with an abrupt onset of angina-like chest pain, and have diffuse T-wave inversion, sometimes preceded by ST-segment elevation, and mild cardiac enzyme elevation. [from HPO]

Term Hierarchy

Professional guidelines

PubMed

Cheema AN, Yanagawa B, Verma S, Bagai A, Liu S
Curr Opin Cardiol 2021 Sep 1;36(5):589-596. doi: 10.1097/HCO.0000000000000886. PMID: 34397465
Luo J, Zhu X, Jian J, Chen X, Yin K
Acta Biochim Biophys Sin (Shanghai) 2021 Mar 2;53(3):273-282. doi: 10.1093/abbs/gmaa176. PMID: 33428706Free PMC Article
Scalone G, Niccoli G, Crea F
Eur Heart J Acute Cardiovasc Care 2019 Feb;8(1):54-62. Epub 2018 Jun 28 doi: 10.1177/2048872618782414. PMID: 29952633

Recent clinical studies

Etiology

John K, Lal A, Mishra A
Monaldi Arch Chest Dis 2021 Mar 23;91(3) doi: 10.4081/monaldi.2021.1710. PMID: 33759445
Watanabe N
Heart 2019 May;105(9):671-677. Epub 2019 Mar 1 doi: 10.1136/heartjnl-2018-313373. PMID: 30824479
Medina de Chazal H, Del Buono MG, Keyser-Marcus L, Ma L, Moeller FG, Berrocal D, Abbate A
J Am Coll Cardiol 2018 Oct 16;72(16):1955-1971. doi: 10.1016/j.jacc.2018.07.072. PMID: 30309474Free PMC Article
Dawson DK
Heart 2018 Jan;104(2):96-102. Epub 2017 Aug 20 doi: 10.1136/heartjnl-2017-311579. PMID: 28824005
Templin C, Ghadri JR, Diekmann J, Napp LC, Bataiosu DR, Jaguszewski M, Cammann VL, Sarcon A, Geyer V, Neumann CA, Seifert B, Hellermann J, Schwyzer M, Eisenhardt K, Jenewein J, Franke J, Katus HA, Burgdorf C, Schunkert H, Moeller C, Thiele H, Bauersachs J, Tschöpe C, Schultheiss HP, Laney CA, Rajan L, Michels G, Pfister R, Ukena C, Böhm M, Erbel R, Cuneo A, Kuck KH, Jacobshagen C, Hasenfuss G, Karakas M, Koenig W, Rottbauer W, Said SM, Braun-Dullaeus RC, Cuculi F, Banning A, Fischer TA, Vasankari T, Airaksinen KE, Fijalkowski M, Rynkiewicz A, Pawlak M, Opolski G, Dworakowski R, MacCarthy P, Kaiser C, Osswald S, Galiuto L, Crea F, Dichtl W, Franz WM, Empen K, Felix SB, Delmas C, Lairez O, Erne P, Bax JJ, Ford I, Ruschitzka F, Prasad A, Lüscher TF
N Engl J Med 2015 Sep 3;373(10):929-38. doi: 10.1056/NEJMoa1406761. PMID: 26332547

Diagnosis

Matta A, Delmas C, Campelo-Parada F, Lhermusier T, Bouisset F, Elbaz M, Nader V, Blanco S, Roncalli J, Carrié D
Rev Cardiovasc Med 2022 Jan 20;23(1):38. doi: 10.31083/j.rcm2301038. PMID: 35092230
Amin HZ, Amin LZ, Pradipta A
J Med Life 2020 Jan-Mar;13(1):3-7. doi: 10.25122/jml-2018-0067. PMID: 32341693Free PMC Article
Boyd B, Solh T
JAAPA 2020 Mar;33(3):24-29. doi: 10.1097/01.JAA.0000654368.35241.fc. PMID: 32039951
Dawson DK
Heart 2018 Jan;104(2):96-102. Epub 2017 Aug 20 doi: 10.1136/heartjnl-2017-311579. PMID: 28824005
Kato K, Lyon AR, Ghadri JR, Templin C
Heart 2017 Sep;103(18):1461-1469. doi: 10.1136/heartjnl-2016-309783. PMID: 28839096

Therapy

Matta A, Delmas C, Campelo-Parada F, Lhermusier T, Bouisset F, Elbaz M, Nader V, Blanco S, Roncalli J, Carrié D
Rev Cardiovasc Med 2022 Jan 20;23(1):38. doi: 10.31083/j.rcm2301038. PMID: 35092230
Boyd B, Solh T
JAAPA 2020 Mar;33(3):24-29. doi: 10.1097/01.JAA.0000654368.35241.fc. PMID: 32039951
Ghadri JR, Wittstein IS, Prasad A, Sharkey S, Dote K, Akashi YJ, Cammann VL, Crea F, Galiuto L, Desmet W, Yoshida T, Manfredini R, Eitel I, Kosuge M, Nef HM, Deshmukh A, Lerman A, Bossone E, Citro R, Ueyama T, Corrado D, Kurisu S, Ruschitzka F, Winchester D, Lyon AR, Omerovic E, Bax JJ, Meimoun P, Tarantini G, Rihal C, Y-Hassan S, Migliore F, Horowitz JD, Shimokawa H, Lüscher TF, Templin C
Eur Heart J 2018 Jun 7;39(22):2047-2062. doi: 10.1093/eurheartj/ehy077. PMID: 29850820Free PMC Article
Kato K, Lyon AR, Ghadri JR, Templin C
Heart 2017 Sep;103(18):1461-1469. doi: 10.1136/heartjnl-2016-309783. PMID: 28839096
Templin C, Ghadri JR, Diekmann J, Napp LC, Bataiosu DR, Jaguszewski M, Cammann VL, Sarcon A, Geyer V, Neumann CA, Seifert B, Hellermann J, Schwyzer M, Eisenhardt K, Jenewein J, Franke J, Katus HA, Burgdorf C, Schunkert H, Moeller C, Thiele H, Bauersachs J, Tschöpe C, Schultheiss HP, Laney CA, Rajan L, Michels G, Pfister R, Ukena C, Böhm M, Erbel R, Cuneo A, Kuck KH, Jacobshagen C, Hasenfuss G, Karakas M, Koenig W, Rottbauer W, Said SM, Braun-Dullaeus RC, Cuculi F, Banning A, Fischer TA, Vasankari T, Airaksinen KE, Fijalkowski M, Rynkiewicz A, Pawlak M, Opolski G, Dworakowski R, MacCarthy P, Kaiser C, Osswald S, Galiuto L, Crea F, Dichtl W, Franz WM, Empen K, Felix SB, Delmas C, Lairez O, Erne P, Bax JJ, Ford I, Ruschitzka F, Prasad A, Lüscher TF
N Engl J Med 2015 Sep 3;373(10):929-38. doi: 10.1056/NEJMoa1406761. PMID: 26332547

Prognosis

Amin HZ, Amin LZ, Pradipta A
J Med Life 2020 Jan-Mar;13(1):3-7. doi: 10.25122/jml-2018-0067. PMID: 32341693Free PMC Article
Lam CSP, Arnott C, Beale AL, Chandramouli C, Hilfiker-Kleiner D, Kaye DM, Ky B, Santema BT, Sliwa K, Voors AA
Eur Heart J 2019 Dec 14;40(47):3859-3868c. doi: 10.1093/eurheartj/ehz835. PMID: 31800034
Scally C, Abbas H, Ahearn T, Srinivasan J, Mezincescu A, Rudd A, Spath N, Yucel-Finn A, Yuecel R, Oldroyd K, Dospinescu C, Horgan G, Broadhurst P, Henning A, Newby DE, Semple S, Wilson HM, Dawson DK
Circulation 2019 Mar 26;139(13):1581-1592. doi: 10.1161/CIRCULATIONAHA.118.037975. PMID: 30586731Free PMC Article
Medina de Chazal H, Del Buono MG, Keyser-Marcus L, Ma L, Moeller FG, Berrocal D, Abbate A
J Am Coll Cardiol 2018 Oct 16;72(16):1955-1971. doi: 10.1016/j.jacc.2018.07.072. PMID: 30309474Free PMC Article
Templin C, Ghadri JR, Diekmann J, Napp LC, Bataiosu DR, Jaguszewski M, Cammann VL, Sarcon A, Geyer V, Neumann CA, Seifert B, Hellermann J, Schwyzer M, Eisenhardt K, Jenewein J, Franke J, Katus HA, Burgdorf C, Schunkert H, Moeller C, Thiele H, Bauersachs J, Tschöpe C, Schultheiss HP, Laney CA, Rajan L, Michels G, Pfister R, Ukena C, Böhm M, Erbel R, Cuneo A, Kuck KH, Jacobshagen C, Hasenfuss G, Karakas M, Koenig W, Rottbauer W, Said SM, Braun-Dullaeus RC, Cuculi F, Banning A, Fischer TA, Vasankari T, Airaksinen KE, Fijalkowski M, Rynkiewicz A, Pawlak M, Opolski G, Dworakowski R, MacCarthy P, Kaiser C, Osswald S, Galiuto L, Crea F, Dichtl W, Franz WM, Empen K, Felix SB, Delmas C, Lairez O, Erne P, Bax JJ, Ford I, Ruschitzka F, Prasad A, Lüscher TF
N Engl J Med 2015 Sep 3;373(10):929-38. doi: 10.1056/NEJMoa1406761. PMID: 26332547

Clinical prediction guides

Arcari L, Núñez Gil IJ, Stiermaier T, El-Battrawy I, Guerra F, Novo G, Musumeci B, Cacciotti L, Mariano E, Caldarola P, Parisi G, Montisci R, Vitale E, Sclafani M, Volpe M, Corbì-Pasqual M, Martinez-Selles M, Almendro-Delia M, Sionis A, Uribarri A, Akin I, Thiele H, Brunetti ND, Eitel I, Santoro F
J Am Coll Cardiol 2022 May 31;79(21):2085-2093. doi: 10.1016/j.jacc.2022.03.366. PMID: 35618345Free PMC Article
Cheema AN, Yanagawa B, Verma S, Bagai A, Liu S
Curr Opin Cardiol 2021 Sep 1;36(5):589-596. doi: 10.1097/HCO.0000000000000886. PMID: 34397465
Cappelletti S, Ciallella C, Aromatario M, Ashrafian H, Harding S, Athanasiou T
Angiology 2017 Apr;68(4):288-303. Epub 2016 Sep 29 doi: 10.1177/0003319716653886. PMID: 27303068
Templin C, Ghadri JR, Diekmann J, Napp LC, Bataiosu DR, Jaguszewski M, Cammann VL, Sarcon A, Geyer V, Neumann CA, Seifert B, Hellermann J, Schwyzer M, Eisenhardt K, Jenewein J, Franke J, Katus HA, Burgdorf C, Schunkert H, Moeller C, Thiele H, Bauersachs J, Tschöpe C, Schultheiss HP, Laney CA, Rajan L, Michels G, Pfister R, Ukena C, Böhm M, Erbel R, Cuneo A, Kuck KH, Jacobshagen C, Hasenfuss G, Karakas M, Koenig W, Rottbauer W, Said SM, Braun-Dullaeus RC, Cuculi F, Banning A, Fischer TA, Vasankari T, Airaksinen KE, Fijalkowski M, Rynkiewicz A, Pawlak M, Opolski G, Dworakowski R, MacCarthy P, Kaiser C, Osswald S, Galiuto L, Crea F, Dichtl W, Franz WM, Empen K, Felix SB, Delmas C, Lairez O, Erne P, Bax JJ, Ford I, Ruschitzka F, Prasad A, Lüscher TF
N Engl J Med 2015 Sep 3;373(10):929-38. doi: 10.1056/NEJMoa1406761. PMID: 26332547
Andrade AA, Stainback RF
Tex Heart Inst J 2014 Jun;41(3):299-303. Epub 2014 Jun 1 doi: 10.14503/THIJ-14-4108. PMID: 24955046Free PMC Article

Recent systematic reviews

Krittanawong C, Maitra NS, Khawaja M, Wang Z, Fogg S, Rozenkrantz L, Virani SS, Levin M, Storch EA, Tobler PN, Charney DS, Levine GN
Prog Cardiovasc Dis 2023 Jan-Feb;76:91-98. Epub 2022 Nov 30 doi: 10.1016/j.pcad.2022.11.018. PMID: 36462555
Fazlollahi A, Zahmatyar M, Noori M, Nejadghaderi SA, Sullman MJM, Shekarriz-Foumani R, Kolahi AA, Singh K, Safiri S
Rev Med Virol 2022 Jul;32(4):e2318. Epub 2021 Dec 17 doi: 10.1002/rmv.2318. PMID: 34921468
Haussner W, DeRosa AP, Haussner D, Tran J, Torres-Lavoro J, Kamler J, Shah K
Am J Emerg Med 2022 Jan;51:150-155. Epub 2021 Oct 22 doi: 10.1016/j.ajem.2021.10.001. PMID: 34739868Free PMC Article
Lu X, Li P, Teng C, Cai P, Jin L, Li C, Liu Q, Pan S, Dixon RAF, Wang B
ESC Heart Fail 2021 Oct;8(5):3663-3689. Epub 2021 Aug 9 doi: 10.1002/ehf2.13531. PMID: 34374223Free PMC Article
Torres-Acosta N, O'Keefe JH, O'Keefe CL, Lavie CJ
J Am Coll Cardiol 2020 Aug 18;76(7):858-866. doi: 10.1016/j.jacc.2020.05.081. PMID: 32792083

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