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Crush syndrome

MedGen UID:
3671
•Concept ID:
C0010392
•
Disease or Syndrome
Synonyms: Crush Syndrome; Crush Syndromes; Syndrome, Crush; Syndromes, Crush
SNOMED CT: Crush syndrome (23697004); Renal failure following crushing injury (23697004); Ischemic muscular necrosis syndrome (23697004); Bywaters' syndrome (23697004); Crush kidney (23697004)
 
Monarch Initiative: MONDO:0043549

Definition

A medical condition characterized by major shock and renal failure after a crushing injury to skeletal muscle. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCrush syndrome

Professional guidelines

PubMed

Ferroptosis in acute kidney injury following crush syndrome: A novel target for treatment.
Qiao O, Wang X, Wang Y, Li N, Gong Y
J Adv Res 2023 Dec;54:211-222. Epub 2023 Jan 24 doi: 10.1016/j.jare.2023.01.016. PMID: 36702249Free PMC Article
Conservative treatment of thoracic outlet syndrome. A review of the literature.
Vanti C, Natalini L, Romeo A, Tosarelli D, Pillastrini P
Eura Medicophys 2007 Mar;43(1):55-70. Epub 2006 Sep 24 PMID: 16955064
Crush syndrome: pathophysiology and management.
Peck SA
Orthop Nurs 1990 May-Jun;9(3):33-40. PMID: 2198518

Recent clinical studies

Etiology

Double crush syndrome: Epidemiology, diagnosis, and treatment results.
Ochoa-Cacique D, Córdoba-Mosqueda ME, Aguilar-Calderón JR, García-González U, Ibarra-De la Torre A, Reyes-Rodríguez VA, Lomelí-Ramírez JDJ, Medina-Carrillo Ó, Sánchez-Calderón MD, Castañeda-Ramírez EA
Neurochirurgie 2021 Apr;67(2):165-169. Epub 2020 Oct 29 doi: 10.1016/j.neuchi.2020.09.011. PMID: 33130027
Disasters, children and the kidneys.
Sever MS, Sever L, Vanholder R
Pediatr Nephrol 2020 Aug;35(8):1381-1393. Epub 2019 Aug 17 doi: 10.1007/s00467-019-04310-x. PMID: 31422466
Beyond muscle destruction: a systematic review of rhabdomyolysis for clinical practice.
Chavez LO, Leon M, Einav S, Varon J
Crit Care 2016 Jun 15;20(1):135. doi: 10.1186/s13054-016-1314-5. PMID: 27301374Free PMC Article
Drugs and Rhabdomyolysis: From Liver to Kidney.
Barbano B, Sardo L, Gasperini ML, Gigante A, Liberatori M, Di Lazzaro GG, Di Mario F, Dorelli B, Amoroso A, Cianci R
Curr Vasc Pharmacol 2015;13(6):725-37. doi: 10.2174/1570161113666150130151839. PMID: 25633322
Bench-to-bedside review: Rhabdomyolysis -- an overview for clinicians.
Huerta-Alardín AL, Varon J, Marik PE
Crit Care 2005 Apr;9(2):158-69. Epub 2004 Oct 20 doi: 10.1186/cc2978. PMID: 15774072Free PMC Article

Diagnosis

Crush injury and syndrome: A review for emergency clinicians.
Long B, Liang SY, Gottlieb M
Am J Emerg Med 2023 Jul;69:180-187. Epub 2023 Apr 25 doi: 10.1016/j.ajem.2023.04.029. PMID: 37163784
Double crush syndrome: Epidemiology, diagnosis, and treatment results.
Ochoa-Cacique D, Córdoba-Mosqueda ME, Aguilar-Calderón JR, García-González U, Ibarra-De la Torre A, Reyes-Rodríguez VA, Lomelí-Ramírez JDJ, Medina-Carrillo Ó, Sánchez-Calderón MD, Castañeda-Ramírez EA
Neurochirurgie 2021 Apr;67(2):165-169. Epub 2020 Oct 29 doi: 10.1016/j.neuchi.2020.09.011. PMID: 33130027
Beyond muscle destruction: a systematic review of rhabdomyolysis for clinical practice.
Chavez LO, Leon M, Einav S, Varon J
Crit Care 2016 Jun 15;20(1):135. doi: 10.1186/s13054-016-1314-5. PMID: 27301374Free PMC Article
Double Crush Syndrome.
Kane PM, Daniels AH, Akelman E
J Am Acad Orthop Surg 2015 Sep;23(9):558-62. doi: 10.5435/JAAOS-D-14-00176. PMID: 26306807
Rhabdomyolysis.
Sever MS
Acta Clin Belg 2007;62 Suppl 2:375-9. doi: 10.1179/acb.2007.084. PMID: 18284003

Therapy

Traumatic Rhabdomyolysis: Crush Syndrome, Compartment Syndrome, and the 'Found Down' Patient.
Fernandez JJ, Smith SR
J Am Acad Orthop Surg 2024 Feb 15;32(4):e166-e174. Epub 2023 Dec 13 doi: 10.5435/JAAOS-D-23-00734. PMID: 38109720
Beyond muscle destruction: a systematic review of rhabdomyolysis for clinical practice.
Chavez LO, Leon M, Einav S, Varon J
Crit Care 2016 Jun 15;20(1):135. doi: 10.1186/s13054-016-1314-5. PMID: 27301374Free PMC Article
Rhabdomyolysis.
Sever MS
Acta Clin Belg 2007;62 Suppl 2:375-9. doi: 10.1179/acb.2007.084. PMID: 18284003
Conservative treatment of thoracic outlet syndrome. A review of the literature.
Vanti C, Natalini L, Romeo A, Tosarelli D, Pillastrini P
Eura Medicophys 2007 Mar;43(1):55-70. Epub 2006 Sep 24 PMID: 16955064
Bench-to-bedside review: Rhabdomyolysis -- an overview for clinicians.
Huerta-Alardín AL, Varon J, Marik PE
Crit Care 2005 Apr;9(2):158-69. Epub 2004 Oct 20 doi: 10.1186/cc2978. PMID: 15774072Free PMC Article

Prognosis

Destructive disasters, trauma, crush syndrome, and beyond.
Sever MS, Katı YA, Özkaya U
Acta Orthop Traumatol Turc 2023 Nov;57(6):305-314. doi: 10.5152/j.aott.2023.23147. PMID: 38454211Free PMC Article
Acute Kidney Injury in Active Wars and Other Man-Made Disasters.
Sever MS, Vanholder R, Lameire N
Semin Nephrol 2020 Jul;40(4):341-353. doi: 10.1016/j.semnephrol.2020.06.001. PMID: 32800285
Double Crush Syndrome.
Kane PM, Daniels AH, Akelman E
J Am Acad Orthop Surg 2015 Sep;23(9):558-62. doi: 10.5435/JAAOS-D-14-00176. PMID: 26306807
Crush syndrome.
Gonzalez D
Crit Care Med 2005 Jan;33(1 Suppl):S34-41. doi: 10.1097/01.ccm.0000151065.13564.6f. PMID: 15640677
Crush injury--crush syndrome.
Michaelson M, Reis ND
Unfallchirurg 1988 Jul;91(7):330-2. PMID: 3064309

Clinical prediction guides

Mortality Factors in Crush Syndrome.
Onan E, Torun D, Kozanoğlu R, Miçözkadıoğlu H, Beyaz S, Özgözen L, Turgut N, Demiroğlu YZ, Karagün Ö, Ergenoğlu P, Kuşçu ÖÖ, Altan E, Güven AT, Abdullayev A, Karluka İ, Yalçın Ç, Mazıcan M, Balcı İG, Özkan B, Parmaksız G, Avcı B, Noyan A, Çolak T, Tünel HA, Temiz A, Gezer HÖ, Erdoğan C, Bairamoi G, Yünlüel D, Çivi S, Durdağ E, Kardeş Ö, Süner Hİ, Tufan K, Erkan S, Avcı T, Gündoğdu R, Kuş M, Fındıkçıoğlu A, Yıldız O, Alışkan E, Coşkunoğlu C, Haberal M
Ulus Travma Acil Cerrahi Derg 2024 Mar;30(3):174-184. doi: 10.14744/tjtes.2024.20532. PMID: 38506381Free PMC Article
10 Hypotheses in Hand Surgery.
Tang JB
Hand Clin 2022 Aug;38(3):357-366. doi: 10.1016/j.hcl.2022.04.003. PMID: 35985761
Double crush syndrome: Epidemiology, diagnosis, and treatment results.
Ochoa-Cacique D, Córdoba-Mosqueda ME, Aguilar-Calderón JR, García-González U, Ibarra-De la Torre A, Reyes-Rodríguez VA, Lomelí-Ramírez JDJ, Medina-Carrillo Ó, Sánchez-Calderón MD, Castañeda-Ramírez EA
Neurochirurgie 2021 Apr;67(2):165-169. Epub 2020 Oct 29 doi: 10.1016/j.neuchi.2020.09.011. PMID: 33130027
Crush syndrome.
Gonzalez D
Crit Care Med 2005 Jan;33(1 Suppl):S34-41. doi: 10.1097/01.ccm.0000151065.13564.6f. PMID: 15640677
Crush syndrome: pathophysiology and management.
Peck SA
Orthop Nurs 1990 May-Jun;9(3):33-40. PMID: 2198518

Recent systematic reviews

Ferroptosis in acute kidney injury following crush syndrome: A novel target for treatment.
Qiao O, Wang X, Wang Y, Li N, Gong Y
J Adv Res 2023 Dec;54:211-222. Epub 2023 Jan 24 doi: 10.1016/j.jare.2023.01.016. PMID: 36702249Free PMC Article
The Ethical Triage and Management Guidelines of the Entrapped and Mangled Extremity in Resource Scarce Environments: A Systematic Literature Review.
Weinstein E, Gosney JE, Ragazzoni L, Franc J, Herbert T, Weinstein B, Verde M, Zeller J, Wolfson N, Boyce W, Cramer J
Disaster Med Public Health Prep 2021 Jun;15(3):389-397. Epub 2020 May 27 doi: 10.1017/dmp.2020.49. PMID: 32456743
Beyond muscle destruction: a systematic review of rhabdomyolysis for clinical practice.
Chavez LO, Leon M, Einav S, Varon J
Crit Care 2016 Jun 15;20(1):135. doi: 10.1186/s13054-016-1314-5. PMID: 27301374Free PMC Article
Wound management in disaster settings.
Wuthisuthimethawee P, Lindquist SJ, Sandler N, Clavisi O, Korin S, Watters D, Gruen RL
World J Surg 2015 Apr;39(4):842-53. doi: 10.1007/s00268-014-2663-3. PMID: 25085100Free PMC Article
Prevention of kidney injury following rhabdomyolysis: a systematic review.
Scharman EJ, Troutman WG
Ann Pharmacother 2013 Jan;47(1):90-105. Epub 2013 Jan 16 doi: 10.1345/aph.1R215. PMID: 23324509

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