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Cryoglobulinemia

MedGen UID:
3673
•Concept ID:
C0010403
•
Disease or Syndrome
Synonym: Cryoglobulinemias
SNOMED CT: Cryoglobulinemia (30911005); Cryoimmunoglobulinemia (30911005)
 
HPO: HP:0100778
Monarch Initiative: MONDO:0005576

Definition

Increased level of cryoglobulins in the blood. Cryoglobulins are abnormal immunoglobulins, especially IGG or IGM, that precipitate spontaneously when serum is cooled below 37 degrees Celsius. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCryoglobulinemia

Conditions with this feature

Cryoglobulinemic vasculitis
MedGen UID:
343814
•Concept ID:
C1852456
•
Disease or Syndrome
A rare immune complex-mediated vasculitis characterized by the presence of circulating cryoprecipitable immune complexes in the serum, manifesting clinically with the classical triad of purpura, weakness and arthralgia.
See: Condition Record
Cryoglobulinemic vasculitis

Professional guidelines

PubMed

Executive Summary of the KDIGO 2022 Clinical Practice Guideline for the Prevention, Diagnosis, Evaluation, and Treatment of Hepatitis C in Chronic Kidney Disease.
Martin P, Awan AA, Berenguer MC, Bruchfeld A, Fabrizi F, Goldberg DS, Jia J, Kamar N, Mohamed R, Pessôa MG, Pol S, Sise ME, Balk EM, Gordon CE, Adam G, Cheung M, Earley A, Jadoul M
Kidney Int 2022 Dec;102(6):1228-1237. doi: 10.1016/j.kint.2022.07.012. PMID: 36411019
IgM monoclonal gammopathies of clinical significance: diagnosis and management.
Khwaja J, D'Sa S, Minnema MC, Kersten MJ, Wechalekar A, Vos JM
Haematologica 2022 Sep 1;107(9):2037-2050. doi: 10.3324/haematol.2022.280953. PMID: 35770530Free PMC Article
Treatment of HCV-Related Mixed Cryoglobulinemia.
Giuggioli D, Sebastiani M, Colaci M, Fallahi P, Gragnani L, Zignego AL, Antonelli A, Ferri C
Curr Drug Targets 2017;18(7):794-802. doi: 10.2174/1389450116666150825112105. PMID: 26302805

Recent clinical studies

Etiology

A Review on Extrahepatic Manifestations of Chronic Hepatitis C Virus Infection and the Impact of Direct-Acting Antiviral Therapy.
Mazzaro C, Quartuccio L, Adinolfi LE, Roccatello D, Pozzato G, Nevola R, Tonizzo M, Gitto S, Andreone P, Gattei V
Viruses 2021 Nov 9;13(11) doi: 10.3390/v13112249. PMID: 34835054Free PMC Article
Cryoglobulinemia: An update in 2019.
Desbois AC, Cacoub P, Saadoun D
Joint Bone Spine 2019 Nov;86(6):707-713. Epub 2019 Feb 4 doi: 10.1016/j.jbspin.2019.01.016. PMID: 30731128
Cryoglobulinemia Vasculitis.
Cacoub P, Comarmond C, Domont F, Savey L, Saadoun D
Am J Med 2015 Sep;128(9):950-5. Epub 2015 Mar 30 doi: 10.1016/j.amjmed.2015.02.017. PMID: 25837517
Cryofibrinogenemia.
Michaud M, Pourrat J
J Clin Rheumatol 2013 Apr;19(3):142-8. doi: 10.1097/RHU.0b013e318289e06e. PMID: 23519183
The cryoglobulinaemias.
Ramos-Casals M, Stone JH, Cid MC, Bosch X
Lancet 2012 Jan 28;379(9813):348-60. Epub 2011 Aug 23 doi: 10.1016/S0140-6736(11)60242-0. PMID: 21868085

Diagnosis

Cryoglobulinemia.
Retamozo S, Quartuccio L, Ramos-Casals M
Med Clin (Barc) 2022 May 27;158(10):478-487. Epub 2022 Feb 22 doi: 10.1016/j.medcli.2021.11.017. PMID: 35216803
Cryoglobulinemic vasculitis: pathophysiological mechanisms and diagnosis.
Kolopp-Sarda MN, Miossec P
Curr Opin Rheumatol 2021 Jan;33(1):1-7. doi: 10.1097/BOR.0000000000000757. PMID: 33186245
New insights in cryoglobulinemic vasculitis.
Silva F, Pinto C, Barbosa A, Borges T, Dias C, Almeida J
J Autoimmun 2019 Dec;105:102313. Epub 2019 Aug 2 doi: 10.1016/j.jaut.2019.102313. PMID: 31383568
Cryoglobulinemia: An update in 2019.
Desbois AC, Cacoub P, Saadoun D
Joint Bone Spine 2019 Nov;86(6):707-713. Epub 2019 Feb 4 doi: 10.1016/j.jbspin.2019.01.016. PMID: 30731128
Cryoglobulinemia Vasculitis.
Cacoub P, Comarmond C, Domont F, Savey L, Saadoun D
Am J Med 2015 Sep;128(9):950-5. Epub 2015 Mar 30 doi: 10.1016/j.amjmed.2015.02.017. PMID: 25837517

Therapy

Cryoglobulinemia.
Retamozo S, Quartuccio L, Ramos-Casals M
Med Clin (Barc) 2022 May 27;158(10):478-487. Epub 2022 Feb 22 doi: 10.1016/j.medcli.2021.11.017. PMID: 35216803
Understanding the Cryoglobulinemias.
Fuentes A, Mardones C, Burgos PI
Curr Rheumatol Rep 2019 Nov 19;21(11):60. doi: 10.1007/s11926-019-0859-0. PMID: 31741077
New insights in cryoglobulinemic vasculitis.
Silva F, Pinto C, Barbosa A, Borges T, Dias C, Almeida J
J Autoimmun 2019 Dec;105:102313. Epub 2019 Aug 2 doi: 10.1016/j.jaut.2019.102313. PMID: 31383568
Cryoglobulinemic disease.
Retamozo S, Brito-Zerón P, Bosch X, Stone JH, Ramos-Casals M
Oncology (Williston Park) 2013 Nov;27(11):1098-1105, 1110-6. PMID: 24575538
Cryofibrinogenemia.
Michaud M, Pourrat J
J Clin Rheumatol 2013 Apr;19(3):142-8. doi: 10.1097/RHU.0b013e318289e06e. PMID: 23519183

Prognosis

Clinical impact and prognosis of cryoglobulinemia and cryofibrinogenemia in systemic sclerosis.
De Almeida Chaves S, Puissant B, Porel T, Bories E, Adoue D, Alric L, Astudillo L, Huart A, Lairez O, Michaud M, Ribes D, Prévot G, Sailler L, Gaches F, Pugnet G
Autoimmun Rev 2022 Aug;21(8):103133. Epub 2022 Jun 22 doi: 10.1016/j.autrev.2022.103133. PMID: 35752439
Cryoglobulinaemia.
Roccatello D, Saadoun D, Ramos-Casals M, Tzioufas AG, Fervenza FC, Cacoub P, Zignego AL, Ferri C
Nat Rev Dis Primers 2018 Aug 2;4(1):11. doi: 10.1038/s41572-018-0009-4. PMID: 30072738
Cryoglobulinemia Vasculitis.
Cacoub P, Comarmond C, Domont F, Savey L, Saadoun D
Am J Med 2015 Sep;128(9):950-5. Epub 2015 Mar 30 doi: 10.1016/j.amjmed.2015.02.017. PMID: 25837517
The cryoglobulinaemias.
Ramos-Casals M, Stone JH, Cid MC, Bosch X
Lancet 2012 Jan 28;379(9813):348-60. Epub 2011 Aug 23 doi: 10.1016/S0140-6736(11)60242-0. PMID: 21868085
Cryoglobulinemia.
Dispenzieri A, Gorevic PD
Hematol Oncol Clin North Am 1999 Dec;13(6):1315-49. doi: 10.1016/s0889-8588(05)70129-5. PMID: 10626153

Clinical prediction guides

Cryofibrinogenemia: What Rheumatologists Should Know.
Santiago MB, Melo BS
Curr Rheumatol Rev 2022;18(3):186-194. doi: 10.2174/1573397118666220325110737. PMID: 35339184
Hepatitis C virus-related cryoglobulinemic vasculitis.
Mazzaro C, Mauro E, Ermacora A, Doretto P, Fumagalli S, Tonizzo M, Toffolutti F, Gattei V
Minerva Med 2021 Apr;112(2):175-187. Epub 2020 Nov 16 doi: 10.23736/S0026-4806.20.07120-7. PMID: 33198444
Cryoglobulinemic disease.
Retamozo S, Brito-Zerón P, Bosch X, Stone JH, Ramos-Casals M
Oncology (Williston Park) 2013 Nov;27(11):1098-1105, 1110-6. PMID: 24575538
Cryoglobulinemia vasculitis.
Cacoub P, Costedoat-Chalumeau N, Lidove O, Alric L
Curr Opin Rheumatol 2002 Jan;14(1):29-35. doi: 10.1097/00002281-200201000-00006. PMID: 11790993
Chronic hepatitis C.
Sharara AI
South Med J 1997 Sep;90(9):872-7. doi: 10.1097/00007611-199709000-00002. PMID: 9305294

Recent systematic reviews

Systematic Review of Safety and Efficacy of Rituximab in Treating Immune-Mediated Disorders.
Kaegi C, Wuest B, Schreiner J, Steiner UC, Vultaggio A, Matucci A, Crowley C, Boyman O
Front Immunol 2019;10:1990. Epub 2019 Sep 6 doi: 10.3389/fimmu.2019.01990. PMID: 31555262Free PMC Article
Efficacy and safety of Rituximab in vasculitic neuropathy: a systematic review of the literature.
Mena-Vázquez N, Cabezudo-García P, Fuego Varela C, Manrique-Arija S, Fernandez-Nebro A
Reumatol Clin (Engl Ed) 2019 May-Jun;15(3):173-178. Epub 2019 Jan 25 doi: 10.1016/j.reuma.2018.10.007. PMID: 30691946
Non HCV-related infectious cryoglobulinemia vasculitis: Results from the French nationwide CryoVas survey and systematic review of the literature.
Terrier B, Marie I, Lacraz A, Belenotti P, Bonnet F, Chiche L, Graffin B, Hot A, Kahn JE, Michel C, Quemeneur T, de Saint-Martin L, Hermine O, Léger JM, Mariette X, Senet P, Plaisier E, Cacoub P
J Autoimmun 2015 Dec;65:74-81. Epub 2015 Aug 29 doi: 10.1016/j.jaut.2015.08.008. PMID: 26320984
Biologic therapy in ANCA-negative vasculitis.
Loricera J, Blanco R, Hernández JL, Pina T, González-Vela MC, González-Gay MA
Int Immunopharmacol 2015 Aug;27(2):213-9. Epub 2015 Mar 28 doi: 10.1016/j.intimp.2015.03.020. PMID: 25828585
Treatment for cryoglobulinemic and non-cryoglobulinemic peripheral neuropathy associated with hepatitis C virus infection.
Benstead TJ, Chalk CH, Parks NE
Cochrane Database Syst Rev 2014 Dec 20;(12):CD010404. doi: 10.1002/14651858.CD010404.pub2. PMID: 25525951

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