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Prominent U wave

MedGen UID:
369497
Concept ID:
C1969408
Finding
Synonym: Increased U wave amplitude
 
HPO: HP:0025072

Definition

Increased amplitude of the U wave, defined as an amplitude greater than 1-2mm or 25 percent of the height of the T wave. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVProminent U wave

Conditions with this feature

Andersen Tawil syndrome
MedGen UID:
327586
Concept ID:
C1563715
Disease or Syndrome
Andersen-Tawil syndrome (ATS) is characterized by a triad of: episodic flaccid muscle weakness (i.e., periodic paralysis); ventricular arrhythmias and prolonged QT interval; and anomalies including low-set ears, widely spaced eyes, small mandible, fifth-digit clinodactyly, syndactyly, short stature, and scoliosis. Affected individuals present in the first or second decade with either cardiac symptoms (palpitations and/or syncope) or weakness that occurs spontaneously following prolonged rest or following rest after exertion. Mild permanent weakness is common. Mild learning difficulties and a distinct neurocognitive phenotype (i.e., deficits in executive function and abstract reasoning) have been described.

Professional guidelines

PubMed

Zhou H, Wang X, Ma D, Jiang Y, Li F, Sun Y, Chen J, Sun W, Pinkhardt EH, Landwehrmeyer B, Ludolph A, Zhang L, Zhao G, Wang Z
Brain Behav 2021 Jul;11(7):e02184. Epub 2021 May 30 doi: 10.1002/brb3.2184. PMID: 34056874Free PMC Article
Kukla P, Biernacka EK, Baranchuk A, Jastrzebski M, Jagodzinska M
Curr Cardiol Rev 2014 Aug;10(3):222-8. doi: 10.2174/1573403x10666140514102528. PMID: 24827800Free PMC Article
Dabic-Jeftic M, Mikula I
Funct Neurol 1993 Sep-Oct;8(5):335-45. PMID: 8144060

Recent clinical studies

Etiology

Khazan M, Mathis AS
Pharmacotherapy 2002 Dec;22(12):1632-7. doi: 10.1592/phco.22.17.1632.34129. PMID: 12495173

Diagnosis

El-Sherif N, Turitto G
Cardiol J 2011;18(3):233-45. PMID: 21660912
Umami V, Oktavia D, Kunmartini S, Wibisana D, Siregar P
Acta Med Indones 2011 Jan;43(1):53-8. PMID: 21339546
Chikamori T, Takata J, Seo H, Matsumura Y, Kitaoka H, Sugimoto K, Doi Y
Am J Cardiol 1996 Dec 1;78(11):1277-81. doi: 10.1016/s0002-9149(96)00611-x. PMID: 8960590
Mosseri M, Porath A, Ovsyshcher I, Stone D
J Electrocardiol 1990 Jul;23(3):235-41. doi: 10.1016/0022-0736(90)90162-u. PMID: 2384729

Therapy

Umami V, Oktavia D, Kunmartini S, Wibisana D, Siregar P
Acta Med Indones 2011 Jan;43(1):53-8. PMID: 21339546
Irie T, Kaneko Y, Nakajima T, Saito A, Kurabayashi M
Int Heart J 2010;51(5):365-6. doi: 10.1536/ihj.51.365. PMID: 20966611
Khazan M, Mathis AS
Pharmacotherapy 2002 Dec;22(12):1632-7. doi: 10.1592/phco.22.17.1632.34129. PMID: 12495173
Chikamori T, Takata J, Seo H, Matsumura Y, Kitaoka H, Sugimoto K, Doi Y
Am J Cardiol 1996 Dec 1;78(11):1277-81. doi: 10.1016/s0002-9149(96)00611-x. PMID: 8960590
Nicholson WJ, Martin CE, Gracey JG, Knoch HR
Am J Cardiol 1979 May;43(5):1053-5. doi: 10.1016/0002-9149(79)90374-6. PMID: 433766

Clinical prediction guides

Irie T, Kaneko Y, Nakajima T, Saito A, Kurabayashi M
Int Heart J 2010;51(5):365-6. doi: 10.1536/ihj.51.365. PMID: 20966611

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