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Hyperandrogenism, Insulin Resistance, Acanthosis Nigricans Syndrome

MedGen UID:
Concept ID:
Disease or Syndrome
Synonyms: HAIR-AN syndrome; Hyperandrogenic, insulin-resistant acanthosis nigricans syndrome; Hyperandrogenism (HA), insulin resistance (IR), and acanthosis nigricans (AN)


A condition characterized by hyperandrogenism, insulin resistance, and acanthosis nigricans, typically associated with obesity in teenage girls. It is considered to be a subtype of polycystic ovarian syndrome, but may occur in male individuals. Etiology is unclear, but some cases may be associated with mutations affecting the tyrosine kinase domain of the insulin receptor. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHyperandrogenism, Insulin Resistance, Acanthosis Nigricans Syndrome

Professional guidelines


Ojaniemi M, Tapanainen P, Morin-Papunen L
Horm Res Paediatr 2010;74(5):372-5. Epub 2010 Sep 22 doi: 10.1159/000320388. PMID: 20861609
Harwood K, Vuguin P, DiMartino-Nardi J
Horm Res 2007;68(5):209-17. Epub 2007 Apr 5 doi: 10.1159/000101538. PMID: 17426408Free PMC Article
Lowenstein EJ
Dermatol Ther 2006 Jul-Aug;19(4):210-23. doi: 10.1111/j.1529-8019.2006.00077.x. PMID: 17004997

Recent clinical studies


Pasquali R, Antenucci D, Casimirri F, Venturoli S, Paradisi R, Fabbri R, Balestra V, Melchionda N, Barbara L
J Clin Endocrinol Metab 1989 Jan;68(1):173-9. doi: 10.1210/jcem-68-1-173. PMID: 2642485


Zouboulis CC
Clin Dermatol 2014 May-Jun;32(3):389-96. Epub 2013 Nov 23 doi: 10.1016/j.clindermatol.2013.11.005. PMID: 24767186

Clinical prediction guides

Ju Q, Tao T, Hu T, Karadağ AS, Al-Khuzaei S, Chen W
Clin Dermatol 2017 Mar-Apr;35(2):130-137. Epub 2016 Oct 27 doi: 10.1016/j.clindermatol.2016.10.004. PMID: 28274349

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